Full Text Journal Articles by
Author David T Rubin

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Worldwide post-marketing safety surveillance experience with tofacitinib in ulcerative colitis.

David T Rubin, Irene Modesto, Séverine Vermeire, Silvio Danese, Siew C Ng, Kenneth K Kwok, Nana Koram, Thomas V Jones,

<h4>Background</h4>Tofacitinib is an oral Janus kinase inhibitor for the treatment of ulcerative colitis (UC). Post-marketing surveillance (PMS) is an important part of monitoring adverse events (AEs).<h4>Aims</h4>To report an analysis of PMS case safety reports for tofacitinib in patients with UC METHODS: Worldwide tofacitinib PMS reports received in the Pfizer safety ... Read more >>

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2021, :]

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Vedolizumab and Anti-Tumour Necrosis Factor α Real-World Outcomes in Biologic-Naïve Inflammatory Bowel Disease Patients: Results from the EVOLVE Study.

Brian Bressler, Andres Yarur, Mark S Silverberg, Marielle Bassel, Emanuelle Bellaguarda, Chris Fourment, Anthie Gatopoulou, Pantelis Karatzas, Uri Kopylov, George Michalopoulos, Spyridon Michopoulos, Udayakumar Navaneethan, David T Rubin, Jesse Siffledeen, Andrew Singh, Konstantinos Soufleris, Dara Stein, Dirk Demuth, Gerassimos J Mantzaris,

<h4>Background and aims</h4>This study aimed to compare real-world clinical effectiveness and safety of vedolizumab, an α4β7-integrin inhibitor, and anti-tumour necrosis factor-α [anti-TNFα] agents in biologic-naïve ulcerative colitis [UC] and Crohn's disease [CD] patients.<h4>Methods</h4>This was a 24-month retrospective medical chart study in adult UC and CD patients treated with vedolizumab or ... Read more >>

J Crohns Colitis (Journal of Crohn's & colitis)
[2021, 15(10):1694-1706]

Cited: 2 times

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Inclusion of Under-Represented Racial and Ethnic Minorities in Randomized Clinical Trials for Inflammatory Bowel Disease.

Nathaniel A Cohen, Alexa Silfen, David T Rubin,

Gastroenterology (Gastroenterology)
[2021, :]

Cited: 0 times

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Dissemination of Gastroenterology and Hepatology Research on Social Media Platforms Is Associated With Increased Citation Count.

Fares Ayoub, Ahmed Ouni, Robert Case, Michael Ladna, Harsh Shah, David T Rubin,

<h4>Introduction</h4>The purpose of this study was to find out whether dissemination of gastroenterology and hepatology (GI) research on social media networks correlates with citation count at 5 years.<h4>Methods</h4>We correlated the Altmetric Attention Score with Web of Science citation counts at 5 years for scholarly work published in the 10 highest ... Read more >>

Am J Gastroenterol (The American journal of gastroenterology)
[2021, 116(10):2137-2139]

Cited: 1 time

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ULCERATIVE COLITIS PATIENTS HAVE REDUCED RECTAL COMPLIANCE COMPARED WITH NON-IBD CONTROLS.

Noa Krugliak Cleveland, Victoria Rai, Katia El Jurdi, Satish S Rao, Mihai C Giurcanu, David T Rubin,

Gastroenterology (Gastroenterology)
[2021, :]

Cited: 0 times

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Stratifying Risks of Ileal Pouch Outcomes.

Shintaro Akiyama, Tina G Rodriguez, David T Rubin,

Clin Gastroenterol Hepatol (Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association)
[2021, :]

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Response to Tetangco and Hanauer.

Seth R Shaffer, David T Rubin,

Am J Gastroenterol (The American journal of gastroenterology)
[2021, 116(9):1959-1960]

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International consensus on the prevention of venous and arterial thrombotic events in patients with inflammatory bowel disease.

Pablo A Olivera, Stephane Zuily, Paulo G Kotze, Veronique Regnault, Sameer Al Awadhi, Peter Bossuyt, Richard B Gearry, Subrata Ghosh, Taku Kobayashi, Patrick Lacolley, Edouard Louis, Fernando Magro, Siew C Ng, Alfredo Papa, Tim Raine, Fabio V Teixeira, David T Rubin, Silvio Danese, Laurent Peyrin-Biroulet,

Patients with inflammatory bowel disease (IBD) are at increased risk of thrombotic events. Therapies for IBD have the potential to modulate this risk. The aims of this Evidence-Based Guideline were to summarize available evidence and to provide practical recommendations regarding epidemiological aspects, prevention and drug-related risks of venous and arterial ... Read more >>

Nat Rev Gastroenterol Hepatol (Nature reviews. Gastroenterology & hepatology)
[2021, :]

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How to Navigate National Societal Organizations for Leadership Development and Academic Promotion: A Guide for Trainees and Young Faculty.

Elizabeth S Aby, Michael Kriss, David T Rubin, Anjana Pillai,

Gastroenterology (Gastroenterology)
[2021, :]

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Factors associated with anti-tumor necrosis factor effectiveness to prevent postoperative recurrence in Crohn's disease.

Anthony Buisson, Lisa Cannon, Konstantin Umanskiy, Roger D Hurst, Neil H Hyman, Atsushi Sakuraba, Joel Pekow, Sushila Dalal, Russell D Cohen, Bruno Pereira, David T Rubin,

<h4>Background/aims</h4>We assessed the effectiveness of anti-TNF agents and its associated factors to prevent endoscopic and clinical postoperative recurrence (POR) in Crohn's disease (CD).<h4>Methods</h4>From a prospectively-maintained database, we retrieved 316 CD patients who underwent intestinal resection (2011-2017). Endoscopic (Rutgeerts index ≥ i2 at 6 months) and clinical (recurrence of symptoms leading ... Read more >>

Intest Res (Intestinal research)
[2021, :]

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Diagnosis and classification of ileal pouch disorders: consensus guidelines from the International Ileal Pouch Consortium.

Bo Shen, Gursimran S Kochhar, Revital Kariv, Xiuli Liu, Udayakumar Navaneethan, David T Rubin, Raymond K Cross, Akira Sugita, André D'Hoore, Jason Schairer, Francis A Farraye, Ravi P Kiran, Philip Fleshner, Joel Rosh, Samir A Shah, Shannon Chang, Ellen Scherl, Darrell S Pardi, David A Schwartz, Paulo G Kotze, David H Bruining, Sunanda V Kane, Jessica Philpott, Bincy Abraham, Jonathan Segal, Rocio Sedano, Maia Kayal, Stuart Bentley-Hibbert, Dino Tarabar, Sandra El-Hachem, Priya Sehgal, James T McCormick, Joseph A Picoraro, Mark S Silverberg, Charles N Bernstein, William J Sandborn, Séverine Vermeire,

Restorative proctocolectomy with ileal pouch-anal anastomosis is an option for most patients with ulcerative colitis or familial adenomatous polyposis who require colectomy. Although the construction of an ileal pouch substantially improves patients' health-related quality of life, the surgery is, directly or indirectly, associated with various structural, inflammatory, and functional adverse ... Read more >>

Lancet Gastroenterol Hepatol (The lancet. Gastroenterology & hepatology)
[2021, 6(10):826-849]

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Extraintestinal Manifestations of Inflammatory Bowel Disease: Current Concepts, Treatment, and Implications for Disease Management.

Gerhard Rogler, Abha Singh, Arthur Kavanaugh, David T Rubin,

Inflammatory bowel diseases (IBDs) are systemic diseases that manifest not only in the gut and gastrointestinal tract, but also in the extraintestinal organs in many patients. The quality of life for patients with IBD can be substantially affected by these extraintestinal manifestations (EIMs). It is important to have knowledge of ... Read more >>

Gastroenterology (Gastroenterology)
[2021, 161(4):1118-1132]

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Optimal inflammatory bowel disease management during the global coronavirus disease 2019 pandemic.

Sara El Ouali, David T Rubin, Benjamin L Cohen, Miguel D Regueiro, Florian Rieder,

<h4>Purpose of review</h4>This review aims to summarize the current evidence regarding the risks and implications of coronavirus disease 2019 (COVID-19) in patients with inflammatory bowel disease (IBD) and discuss optimal management of IBD during this pandemic.<h4>Recent findings</h4>Patients with IBD are not at increased risk of COVID-19 but several risk factors ... Read more >>

Curr Opin Gastroenterol (Current opinion in gastroenterology)
[2021, 37(4):313-319]

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Outcomes of Tofacitinib Dose Reduction in Patients with Ulcerative Colitis in Stable Remission from the Randomised RIVETING Trial.

Séverine Vermeire, Chinyu Su, Nervin Lawendy, Taku Kobayashi, William J Sandborn, David T Rubin, Irene Modesto, Sean Gardiner, Nicole Kulisek, Haiying Zhang, Wenjin Wang, Julian Panés,

<h4>Background and aims</h4>Tofacitinib is an oral, small molecule Janus kinase inhibitor for the treatment of ulcerative colitis. We present primary completion analysis from RIVETING, an ongoing, double-blind, randomised, parallel-group trial evaluating efficacy and safety of tofacitinib dose reduction to 5 mg twice daily [BID] versus remaining on 10 mg BID ... Read more >>

J Crohns Colitis (Journal of Crohn's & colitis)
[2021, 15(7):1130-1141]

Cited: 1 time

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New targets in inflammatory bowel disease therapy: 2021.

Nathaniel A Cohen, David T Rubin,

<h4>Purpose of review</h4>In the rapidly progressing world of inflammatory bowel disease, this review discusses and summarizes new drug targets and results from major clinical trials in order to provide an update to physicians treating patients with inflammatory bowel diseases (IBD).<h4>Recent findings</h4>Multiple new mechanisms in the treatment of IBD are being ... Read more >>

Curr Opin Gastroenterol (Current opinion in gastroenterology)
[2021, 37(4):357-363]

Cited: 0 times

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The Impact of Intestinal Complications on Health Care Costs Among Patients With Inflammatory Bowel Disease Treated With Anti-Tumor Necrosis Factor Therapies.

David T Rubin, Jenny Griffith, Qisu Zhang, Zsolt Hepp, Allison Keshishian,

<h4>Background</h4>Although there is evidence that anti-tumor necrosis factor (TNF) utilization earlier in the inflammatory bowel disease (IBD) course and before the onset of disease-related complications leads to improved patient outcomes, the health care costs and utilization impact have not been well defined. This study assessed differences in health care utilization ... Read more >>

Inflamm Bowel Dis (Inflammatory bowel diseases)
[2021, 27(8):1201-1209]

Cited: 1 time

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Older Adult Patients Use More Aminosalicylate Monotherapy Compared With Younger Patients With Inflammatory Bowel Disease: TARGET-IBD.

Edward L Barnes, John S Hanson, Miguel D Regueiro, Sumona Saha, Bruce E Sands, David T Rubin, Marla C Dubinsky, Corey A Siegel, Derek R Gazis, Julie M Crawford, Millie D Long,

<h4>Goal</h4>The goal of this study was to describe medication utilization patterns in older inflammatory bowel disease (IBD) patients.<h4>Background</h4>Despite a growing population of older patients with Crohn's disease (CD) and ulcerative colitis (UC), questions remain regarding medication utilization patterns in comparison to younger populations.<h4>Materials and methods</h4>We collected data from the 34 ... Read more >>

J Clin Gastroenterol (Journal of clinical gastroenterology)
[2021, :]

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Burden of comorbid anxiety and depression in patients with inflammatory bowel disease: a systematic literature review.

Marla C Dubinsky, Iris Dotan, David T Rubin, Mark Bernauer, Dipen Patel, Raymond Cheung, Irene Modesto, Mark Latymer, Laurie Keefer,

<h4>Introduction</h4>Patients with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, often have comorbid anxiety and depression that affects their quality of life (QoL) and management of their IBD.<h4>Areas covered</h4>A systematic literature review (SLR) was conducted to identify articles and conference abstracts on comorbid anxiety and depression in IBD ... Read more >>

Expert Rev Gastroenterol Hepatol (Expert review of gastroenterology & hepatology)
[2021, 15(9):985-997]

Cited: 0 times

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Achieving Histologic Normalization in Ulcerative Colitis Is Associated With a Reduced Risk of Subsequent Dysplasia.

Seth R Shaffer, Amarachi I Erondu, Cindy Traboulsi, Victoria Rai, Noa Krugliak Cleveland, Amanda Israel, Britt Christensen, David T Rubin,

<h4>Background</h4>Complete histologic normalization is associated with improved clinical outcomes in ulcerative colitis (UC). However, it is currently unknown what effect achieving histologic normalization has on the development of dysplasia.<h4>Methods</h4>We performed a retrospective analysis of 495 patients with a confirmed diagnosis of UC from a tertiary center. Patients were categorized according ... Read more >>

Inflamm Bowel Dis (Inflammatory bowel diseases)
[2021, :]

Cited: 0 times

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Fecal Microbiota Transplantation for Recurrent C difficile Infection During the COVID-19 Pandemic: Experience and Recommendations.

Sahil Khanna, Aaron Tande, David T Rubin, Alexander Khoruts, Stacy A Kahn, Darrell S Pardi,

<h4>Objective</h4>To report experience with fecal microbiota transplantation (FMT) for recurrent Clostridioides difficile infection (rCDI) and provide recommendations for management of rCDI and donor testing during the COVID-19 pandemic.<h4>Methods</h4>A retrospective study of patients with rCDI who underwent FMT from May 26, 2020, to September 30, 2020, with stool from well-screened donors ... Read more >>

Mayo Clin Proc (Mayo Clinic proceedings)
[2021, 96(6):1418-1425]

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Fecal Calprotectin Is Highly Effective to Detect Endoscopic Ulcerations in Crohn's Disease Regardless of Disease Location.

Anthony Buisson, Wing Yan Mak, Michael J Andersen, Donald Lei, Joel Pekow, Russell D Cohen, Stacy A Kahn, Bruno Pereira, David T Rubin,

<h4>Background</h4>As the reliability of fecal calprotectin (Fcal) remains debatable to detect endoscopic ulcerations in patients with pure ileal Crohn's disease (CD), we aimed to compare its performances with those observed in patients with colonic or ileocolonic location.<h4>Methods</h4>Using a prospectively maintained database, we analyzed 123 CD patients with Fcal measurement and ... Read more >>

Inflamm Bowel Dis (Inflammatory bowel diseases)
[2021, 27(7):1008-1016]

Cited: 0 times

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Ulcerative Colitis Narrative Global Survey Findings: Communication Gaps and Agreements Between Patients and Physicians.

David T Rubin, Ailsa Hart, Remo Panaccione, Alessandro Armuzzi, Ulla Suvanto, J Jasper Deuring, John Woolcott, Joseph C Cappelleri, Kathy Steinberg, Laura Wingate, Stefan Schreiber,

<h4>Background</h4>The Ulcerative Colitis (UC) Narrative global surveys examined patient and physician perspectives on living with UC and tried to identify gaps in optimal care. Questions explored patient-physician interactions, UC management goals, and resources for improving communication.<h4>Methods</h4>Questionnaires were conducted across 10 countries, covering aspects of UC including diagnosis, treatment, and impact ... Read more >>

Inflamm Bowel Dis (Inflammatory bowel diseases)
[2021, 27(7):1096-1106]

Cited: 2 times

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Predictability of simple endoscopic score for Crohn's disease for postoperative outcomes in Crohn's disease.

Shintaro Akiyama, Akihiro Yamada, Jacob E Ollech, Yuga Komaki, Fukiko Komaki, Joel Pekow, Sushila R Dalal, Russell D Cohen, David T Rubin, Atsushi Sakuraba,

<h4>Background and aim</h4>Approximately half of patients with Crohn's disease (CD) who have surgery will experience clinical recurrence within 10 years of their surgery. This study aimed to assess the postoperative outcomes according to disease location and validated the simple endoscopic score for CD (SES-CD) to predict disease-related outcomes.<h4>Methods</h4>We retrospectively assessed medical ... Read more >>

J Gastroenterol Hepatol (Journal of gastroenterology and hepatology)
[2021, 36(10):2785-2793]

Cited: 0 times

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Extraintestinal manifestations at baseline, and the effect of tofacitinib, in patients with moderate to severe ulcerative colitis.

David T Rubin, Walter Reinisch, Thomas Greuter, Paulo G Kotze, Marcia Pinheiro, Rajiv Mundayat, Eric Maller, Marc Fellmann, Nervin Lawendy, Irene Modesto, Stephan R Vavricka, Gary R Lichtenstein,

<h4>Introduction</h4>Extraintestinal manifestations (EIMs) in patients with ulcerative colitis (UC) are common. Tofacitinib is an oral, small molecule Janus kinase inhibitor for the treatment of UC. We evaluated the efficacy of tofacitinib in patients with EIMs, and the impact of tofacitinib on EIMs in patients with UC in the OCTAVE clinical ... Read more >>

Therap Adv Gastroenterol (Therapeutic advances in gastroenterology)
[2021, 14:17562848211005708]

Cited: 0 times

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Worldwide Management of Inflammatory Bowel Disease During the COVID-19 Pandemic: An International Survey.

Charles N Bernstein, Siew C Ng, Rupa Banerjee, Flavio Steinwurz, Bo Shen, Franck Carbonnel, Saeed Hamid, Ajit Sood, Jesus K Yamamoto-Furusho, Anne Griffiths, Eric I Benchimol, Simon Travis, Susana Lopes, David T Rubin, Gilaad G Kaplan, David Armstrong, Richard Gearry, ,

<h4>Background and aims</h4>Persons with inflammatory bowel disease (IBD) may be particularly vulnerable to COVID-19 either because of their underlying disease or its management. Guidance has been presented on the management of persons with IBD in the time of this pandemic by different groups. We aimed to determine how gastroenterologists around ... Read more >>

Inflamm Bowel Dis (Inflammatory bowel diseases)
[2021, 27(6):836-847]

Cited: 5 times

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