Full Text Journal Articles by
Author David Sp Tan

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Cost-effectiveness of olaparib versus routine surveillance in the maintenance setting for patients with BRCA-mutated advanced ovarian cancer after response to first-line platinum-based chemotherapy in Singapore.

David Sp Tan, Jack Junjie Chan, Robert Hettle, Wrik Ghosh, Amrita Viswambaram, Cindy Chen Yu,

<h4>Objective</h4>To evaluate the cost-effectiveness of olaparib as a maintenance treatment versus routine surveillance (RS) in patients with <i>BRCA</i> mutated (<i>BRCA</i>m) advanced ovarian cancer (OC) following response to first-line platinum-based chemotherapy in Singapore.<h4>Methods</h4>A 4-health state partitioned survival model was developed to simulate the lifetime (50 years) incremental cost-effectiveness ratio (ICER) of ... Read more >>

J Gynecol Oncol (Journal of gynecologic oncology)
[2021, 32(2):e27]

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A single-arm phase II study of olaparib maintenance with pembrolizumab and bevacizumab in BRCA non-mutated patients with platinum-sensitive recurrent ovarian cancer (OPEB-01).

Yong Jae Lee, Myong Cheol Lim, Byoung Gie Kim, Natalie Yl Ngoi, Chel Hun Choi, Sang Yoon Park, David Sp Tan, Yunjung Go, Jung Yun Lee,

<h4>Background</h4>The optimal treatment of <i>BRCA</i> wild-type patients with platinum-sensitive recurrent ovarian cancer remains unknown. Recently, there is an increase in the evidence to support the role of the combination of a poly(adenosine diphosphate-ribose) polymerase inhibitor, anti-angiogenic agents, and immunotherapy as maintenance therapy in <i>BRCA</i> wild-type patients with platinum-sensitive recurrence. We ... Read more >>

J Gynecol Oncol (Journal of gynecologic oncology)
[2021, 32(2):e31]

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A multicenter phase II randomized trial of durvalumab (MEDI-4736) versus physician's choice chemotherapy in recurrent ovarian clear cell adenocarcinoma (MOCCA).

Natalie Yl Ngoi, Valerie Heong, Samuel Ow, Wen Yee Chay, Hee Seung Kim, Chel Hun Choi, Geraldine Goss, Jeffrey C Goh, Bee Choo Tai, Diana Gz Lim, Nivashini Kaliaperumal, Veonice B Au, John E Connolly, Jae-Weon Kim, Michael Friedlander, Kidong Kim, David Sp Tan,

<h4>Background</h4>The optimal treatment of recurrent ovarian clear cell carcinoma remains unknown. There is increasing rationale to support the role of immune checkpoint inhibitors targeting the programmed cell death protein 1 (PD<i>-</i>1)/programmed death-ligand 1 (PD-L1) axis in ovarian clear cell carcinoma.<h4>Primary objective</h4>To evaluate the efficacy of durvalumab (MEDI-4736) compared with standard ... Read more >>

Int J Gynecol Cancer (International journal of gynecological cancer : official journal of the International Gynecological Cancer Society)
[2020, 30(8):1239-1242]

Cited: 1 time

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Exploiting replicative stress in gynecological cancers as a therapeutic strategy.

Natalie Yl Ngoi, Vignesh Sundararajan, David Sp Tan,

Elevated levels of replicative stress in gynecological cancers arising from uncontrolled oncogenic activation, loss of key tumor suppressors, and frequent defects in the DNA repair machinery are an intrinsic vulnerability for therapeutic exploitation. The presence of replication stress activates the DNA damage response and downstream checkpoint proteins including ataxia telangiectasia ... Read more >>

Int J Gynecol Cancer (International journal of gynecological cancer : official journal of the International Gynecological Cancer Society)
[2020, 30(8):1224-1238]

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Whole Exome Sequencing of Multi-Regional Biopsies from Metastatic Lesions to Evaluate Actionable Truncal Mutations Using a Single-Pass Percutaneous Technique.

Valerie Heong, Darwin Tay, Shane Ee Goh, Bernard Wee, Tuan Zea Tan, Ross Soo, Brendan Pang, Diana Lim, Anil Gopinathan, Samuel Ow, Cheng Ean Chee, Boon Cher Goh, Soo Chin Lee, Wei Peng Yong, Andrea Wong, Mohamed Feroz Mohd Omar, Richie Soong, David Sp Tan,

We investigate the feasibility of obtaining multiple spatially-separated biopsies from a single lesion to explore intratumor heterogeneity and identify actionable truncal mutations using whole exome sequencing (WES). A single-pass radiologically-guided percutaneous technique was used to obtain four spatially-separated biopsies from a single metastatic lesion. WES was performed to identify putative ... Read more >>

Cancers (Basel) (Cancers)
[2020, 12(6):]

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Primary platinum resistance and immune exclusion in ovarian carcinomas with high expression of the homologous recombination mediator RAD51

Michal Hoppe, Tuan Zea Tan, Stefanus Lie, Sherlly Lim, Joe PS Yeong, Joanna Wardyn, Patrick Jaynes, Diana GZ Lim, Brendan NK Pang, Anthony Karnezis, Derek Chiu, Samuel Leung, David Huntsman, Anna Sedukhina, Ko Sato, Stan Kaye, Hyungwon Choi, Naina Patel, Robert Brown, Jason Pitt, David SP Tan, Anand Jeyasekharan,

<h4>Background</h4> Homologous recombination deficiency (HRD) in ovarian cancer confers increased sensitivity to Poly-ADP-Ribose-Polymerase (PARP) inhibitors and platinum. The homologous recombination (HR) mediator RAD51, however, is commonly overexpressed, potentially driving unregulated HR. Due to non-quantitative measurements and heterogeneous cohorts, the clinical relevance of RAD51 expression in ovarian cancer is unclear. <h4>Methods</h4> ... Read more >>

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The 4th European Society for Medical Oncology Asia Congress: bridging ultimate cancer care with real-world practice for the Asian practitioner in gynecological cancers.

Natalie Yl Ngoi, David Sp Tan,

J Gynecol Oncol (Journal of gynecologic oncology)
[2019, 30(2):e48]

Cited: 0 times

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Asian Society of Gynecologic Oncology International Workshop 2018.

Tae Wook Kong, Hee Sug Ryu, Seung Cheol Kim, Takayuki Enomoto, Jin Li, Kenneth H Kim, Seung Hyuk Shim, Peng Hui Wang, Suwanit Therasakvichya, Yusuke Kobayashi, Maria Lee, Tingyan Shi, Shin Wha Lee, Mikio Mikami, Satoru Nagase, Satoru Nagase, Myong Cheol Lim, Jianliu Wang, Sarikapan Wilailak, Sang Wun Kim, Sook Hee Hong, David Sp Tan, Masaki Mandai, Suk Joon Chang, Ruby Yun Ju Huang, Kimio Ushijima, Jung Yun Lee, Xiaojun Chen, Kazunori Ochiai, Taek Sang Lee, Bingyi Yang, Farhana Kalam, Qiaoying Lv, Mohd Faizal Ahmad, Muhammad Rizki Yaznil, Kanika Batra Modi, Manatsawee Manopunya, Dae Hoon Jeong, Arb Aroon Lertkhachonsuk, Hyun Hoon Chung, Hidemichi Watari, Seob Jeon,

The Asian Society of Gynecologic Oncology International Workshop 2018 on gynecologic oncology was held in the Ajou University Hospital, Suwon, Korea on the 24th to 25th August 2018. The workshop was an opportunity for Asian doctors to discuss the latest findings of gynecologic cancer, including cervical, ovarian, and endometrial cancers, ... Read more >>

J Gynecol Oncol (Journal of gynecologic oncology)
[2019, 30(2):e39]

Cited: 2 times

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Weekly versus 3-weekly paclitaxel in combination with carboplatin in advanced ovarian cancer: which is the optimal adjuvant chemotherapy regimen?

Matilda X Lee, David Sp Tan,

The 3-weekly regimen of carboplatin and paclitaxel is the backbone of first line adjuvant chemotherapy for advanced ovarian cancer. The landmark Japanese Gynaecologic Oncology Group (JGOG) 3016 study demonstrated significant improvements in progression-free survival and overall survival with dose dense weekly administration of paclitaxel in combination with 3-weekly carboplatin. However, ... Read more >>

J Gynecol Oncol (Journal of gynecologic oncology)
[2018, 29(6):e96]

Cited: 5 times

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Weekly versus tri‐weekly paclitaxel with carboplatin for first‐line treatment in women with ovarian cancer

Nicholas LX Syn, Robby M Goh, Boon Cher Goh, Yu Yang Soon, David SP Tan,

Abstract This is the protocol for a review and there is no abstract. The objectives are as follows: To compare the effectiveness and safety of weekly paclitaxel with that of three‐weekly paclitaxel, in combination with carboplatin, as first‐line chemotherapy treatment for ovarian cancer. ... Read more >>

Cochrane Database Syst Rev (The Cochrane database of systematic reviews)
[2015, 2015(12):]

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Are triple-negative tumours and basal-like breast cancer synonymous?

Emad A Rakha, David S P Tan, William D Foulkes, Ian O Ellis, Andrew Tutt, Torsten O Nielsen, Jorge S Reis-Filho,

Breast Cancer Res (Breast cancer research : BCR)
[2007, 9(6):404; author reply 405]

Cited: 48 times

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