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A Conceptual Discussion about R0 of SARS-COV-2 in Healthcare Settings.

Laura Temime, Marie-Paule Gustin, Audrey Duval, Niccolò Buetti, Pascal Crépey, Didier Guillemot, Rodolphe Thiébaut, Philippe Vanhems, Jean-Ralph Zahar, David R M Smith, Lulla Opatowski,

To date, no specific estimate of R0 for SARS-CoV-2 is available for healthcare settings. Using inter-individual contact data, we highlight that R0 estimates from the community cannot translate directly to healthcare settings, with pre-pandemic R0 values ranging 1.3-7.7 in three illustrative healthcare institutions. This has implications for nosocomial Covid-19 control. ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2020, :]

Cited: 3 times

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Using expert knowledge to support Endangered Species Act decision-making for data-deficient species.

Daniel B Fitzgerald, David R Smith, David C Culver, Daniel Feller, Daniel W Fong, Jeff Hajenga, Matthew L Niemiller, Daniel C Nolfi, Wil D Orndorff, Barbara Douglas, Kelly O Maloney, John A Young,

Many questions relevant to conservation decision making are characterized by extreme uncertainty due to lack of empirical data and complexity of the underlying ecological processes, leading to a rapid increase in the use of structured protocols to elicit expert knowledge. Published ecological applications often employ a modified Delphi method, where ... Read more >>

Conserv Biol (Conservation biology : the journal of the Society for Conservation Biology)
[2021, :]

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Role of MALDI-MSI in Combination with 3D Tissue Models for Early Stage Efficacy and Safety Testing of Drugs and Toxicants.

Chloe E Spencer, Lucy E Flint, Catherine J Duckett, Laura M Cole, Neil Cross, David P Smith, Malcolm R Clench,

Introduction Three-dimensional (3D) cell cultures have become increasingly important materials to investigate biological processes and drug efficacy and toxicity. The ability of 3D cultures to mimic the physiology of primary tissues and organs in the human body enables further insight into cellular behaviour and is hence highly desirable in early ... Read more >>

Expert Rev Proteomics (Expert review of proteomics)
[2021, :]

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Monitoring sick leave data for early detection of influenza outbreaks.

Tom Duchemin, Jonathan Bastard, Pearl Anne Ante-Testard, Rania Assab, Oumou Salama Daouda, Audrey Duval, Jérôme-Philippe Garsi, Radowan Lounissi, Narimane Nekkab, Helene Neynaud, David R M Smith, William Dab, Kevin Jean, Laura Temime, Mounia N Hocine,

<h4>Background</h4>Workplace absenteeism increases significantly during influenza epidemics. Sick leave records may facilitate more timely detection of influenza outbreaks, as trends in increased sick leave may precede alerts issued by sentinel surveillance systems by days or weeks. Sick leave data have not been comprehensively evaluated in comparison to traditional surveillance methods. ... Read more >>

BMC Infect Dis (BMC infectious diseases)
[2021, 21(1):52]

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Hind limb muscle reconstruction in the incipiently opisthopubic large therizinosaur Nothronychus (Theropoda; Maniraptora).

David K Smith,

Therizinosaurs are highly modified, probably herbivorous, theropods from the Upper Cretaceous of Asia and North America. They are characterized by an extensively pneumatized axial skeleton, and in the derived forms, an incipiently opisthopubic pelvis. The evolution of such a pelvis is expected to be associated with extensive modification of the ... Read more >>

J Anat (Journal of anatomy)
[2021, :]

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Patient-Derived Organotypic Epithelial Rafts Model Phenotypes in Juvenile-Onset Recurrent Respiratory Papillomatosis.

Mary C Bedard, Marion G Brusadelli, Adrean Carlile, Sonya Ruiz-Torres, Hannah Lodin, Denis Lee, Matthew Kofron, Paul F Lambert, Adam Lane, Najim Ameziane, El Mustapha Bahassi, Kathryn A Wikenheiser-Brokamp, Alessandro de Alarcon, David F Smith, Susanne I Wells,

Juvenile-onset recurrent respiratory papillomatosis (JoRRP) is driven by human papillomavirus (HPV) low-risk strains and is associated with significant morbidity. While previous studies of 2D cultures have shed light on disease pathogenesis and demonstrated the utility of personalized medicine approaches, monolayer cultures lack the 3D tissue architecture and physiology of stratified, ... Read more >>

Viruses (Viruses)
[2021, 13(1):]

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Systemic Bevacizumab for Treatment of Respiratory Papillomatosis: International Consensus Statement.

Douglas R Sidell, Karthik Balakrishnan, Simon R Best, Karen Zur, Julia Buckingham, Alessandro De Alarcon, Fuad M Baroody, Jonathan M Bock, Emily F Boss, Charles M Bower, Paolo Campisi, Sharon F Chen, Jeffrey M Clarke, Kevin D Clarke, Alejandro Cocciaglia, Robin T Cotton, Giselle Cuestas, Kara L Davis, Victor H DeFago, Frederik G Dikkers, Ines Dossans, Walter Florez, Elizabeth Fox, Aaron D Friedman, Nazaneen Grant, Osama Hamdi, Norman D Hogikyan, Kaalan Johnson, Liane B Johnson, Romaine F Johnson, Peggy Kelly, Adam M Klein, Claire M Lawlor, Nicolas Leboulanger, Alejandro G Levy, Derek Lam, Greg R Licameli, Steve Long, David G Lott, Dayse Manrique, James Scott McMurray, Kara D Meister, Anna H Messner, Michael Mohr, Pamela Mudd, Anthony J Mortelliti, Daniel Novakovic, Julian Ongkasuwan, Shazia Peer, Krysztof Piersiala, Jeremy D Prager, Seth M Pransky, Diego Preciado, Tiffany Raynor, Rico N P M Rinkel, Hugo Rodriguez, Verónica P Rodríguez, John Russell, María Laura Scatolini, Patrick Scheffler, David F Smith, Lee P Smith, Marshall E Smith, Richard J H Smith, Abraham Sorom, Amalia Steinberg, John A Stith, Dana Thompson, Jerome W Thompson, Patricio Varela, David R White, Andre M Wineland, Christina J Yang, Carlton J Zdanski, Craig S Derkay,

<h4>Objectives/hypothesis</h4>The purpose of this study is to develop consensus on key points that would support the use of systemic bevacizumab for the treatment of recurrent respiratory papillomatosis (RRP), and to provide preliminary guidance surrounding the use of this treatment modality.<h4>Study design</h4>Delphi method-based survey series.<h4>Methods</h4>A multidisciplinary, multi-institutional panel of physicians with ... Read more >>

Laryngoscope (The Laryngoscope)
[2021, :]

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Response to Letter to the Editor from Chee et al: "Prevention of Adrenal Crisis: Cortisol Response to Major Stress Compared to Stress Dose Hydrocortisone Delivery".

Alessandro Prete, Angela E Taylor, Irina Bancos, David J Smith, Mark A Foster, Sibylle Kohler, Violet Fazal-Sanderson, John Komninos, Donna M O'Neil, Dimitra A Vassiliadi, Christopher J Mowatt, Radu Mihai, Joanne L Fallowfield, Djillali Annane, Janet M Lord, Brian G Keevil, John A H Wass, Niki Karavitaki, Wiebke Arlt,

J Clin Endocrinol Metab (The Journal of clinical endocrinology and metabolism)
[2021, 106(1):e407-e408]

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Limitations of rapid diagnostic tests in malaria surveys in areas with varied transmission intensity in Uganda 2017-2019: Implications for selection and use of HRP2 RDTs.

Agaba B Bosco, Joaniter I Nankabirwa, Adoke Yeka, Sam Nsobya, Karryn Gresty, Karen Anderson, Paul Mbaka, Christiane Prosser, David Smith, Jimmy Opigo, Rhoda Namubiru, Emmanuel Arinaitwe, John Kissa, Samuel Gonahasa, Sungho Won, Bora Lee, Chae Seung Lim, Charles Karamagi, Qin Cheng, Joan K Nakayaga, Moses R Kamya,

<h4>Background</h4>Plasmodium falciparum histidine-rich protein 2 (HRP2)-based rapid diagnostic tests (RDTs) are exclusively recommended for malaria diagnosis in Uganda; however, their functionality can be affected by parasite-related factors that have not been investigated in field settings.<h4>Methods</h4>Using a cross-sectional design, we analysed 219 RDT-/microscopy+ and 140 RDT+/microscopy+ dried blood spots obtained from ... Read more >>

PLoS One (PloS one)
[2020, 15(12):e0244457]

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Do scientists read enough fiction?

David R Smith,

Reading the academic literature is an essential part of a scientist's job. David Smith argues that reading fiction can be even more important for creativity and productivity than papers and reviews. ... Read more >>

EMBO Rep (EMBO reports)
[2021, :e52206]

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Dual-Factor Representation of the Environmental Context in the Retrosplenial Cortex.

Adam M P Miller, Anna C Serrichio, David M Smith,

The retrosplenial cortex (RSC) is thought to be involved in a variety of spatial and contextual memory processes. However, we do not know how contextual information might be encoded in the RSC or whether the RSC representations may be distinct from context representations seen in other brain regions such as ... Read more >>

Cereb Cortex (Cerebral cortex (New York, N.Y. : 1991))
[2020, :]

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Dynamic perioperative variation of neutrophil-to-lymphocyte ratio as an independent prognosis factor following lobectomy for NSCLC.

Raices Micaela, Caram Lucas, Corvatta Franco, Cayol Federico, Dietrich Agustín, Smith David,

Inflammation plays a key role in malignant tumor progression. The neutrophil-to-lymphocyte ratio (NLR) is a marker of systemic inflammation and, as such, high isolated pretreatment NLR has been shown to be associated with worse long-term outcomes. The aim of the present study is to evaluate the prognostic value of pre- ... Read more >>

Updates Surg (Updates in surgery)
[2021, :]

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Response to Letter to the Editor: "Prevention of Adrenal Crisis: Cortisol Response to Major Stress Compared to Stress Dose Hydrocortisone Delivery".

Alessandro Prete, Angela E Taylor, Irina Bancos, David J Smith, Mark A Foster, Sibylle Kohler, Violet Fazal-Sanderson, John Komninos, Donna M O'Neil, Dimitra A Vassiliadi, Christopher J Mowatt, Radu Mihai, Joanne L Fallowfield, Djillali Annane, Janet M Lord, Brian G Keevil, John A H Wass, Niki Karavitaki, Wiebke Arlt,

J Clin Endocrinol Metab (The Journal of clinical endocrinology and metabolism)
[2021, 106(1):e404-e406]

Cited: 0 times

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Impact of Seasonality and Malaria Control Interventions on Anopheles Density and Species Composition From Three Areas of Uganda With Differing Malaria Endemicity.

Henry Mawejje, Maxwell Kilama, Simon Kigozi, Alex Musiime, Moses Kamya, Jo Lines, Steven Lindsay, David Smith, Grant Dorsey, Martin Donnelly, Sarah Staedke,

<h4>Background: </h4> Long lasting insecticidal nets (LLINs) and indoor residual spraying (IRS) are malaria control interventions primarily responsible for reductions in transmission intensity across sub-Saharan Africa. These interventions, however, may have differential impact on Anopheles species composition and density. Here, we studied the changing pattern of Anopheles species in three ... Read more >>

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Measuring psychosocial outcomes of men living with prostate cancer: feasibility of regular assessment of patient-reported outcomes.

Kerry Ettridge, Kathleen Wright, David Smith, Suzanne Chambers, Nadia Corsini, Susan Evans, Kim Moretti, David Roder, Paul Scuffham, Caroline Miller,

<h4>Objective</h4>To trial collecting patient-reported outcome measures (PROMs) to assess psychosocial outcomes in men with prostate cancer (PC).<h4>Methods</h4>A cross-sectional postal survey was sent to three groups of 160 men with PC (6, 12 and 24 months post-initial treatment; n<sub>total </sub> = 480), through the South Australian Prostate Cancer Clinical Outcomes Collaborative (SAPCCOC) registry (2017). ... Read more >>

Eur J Cancer Care (Engl) (European journal of cancer care)
[2020, :e13393]

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Bringing COVID-19 home for Christmas: a need for enhanced testing in healthcare institutions after the holidays

David Smith, Audrey Duval, Jean Ralph Zahar, Lulla Opatowski, Laura Temime,

Festive gatherings this 2020 holiday season threaten to cause a surge in new cases of novel coronavirus disease 2019 (COVID-19). Hospitals and long-term care facilities are key hotspots for COVID-19 outbreaks, and may be at elevated risk as patients and staff return from holiday celebrations in the community. Some settings ... Read more >>

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T cell and antibody responses induced by a single dose of ChAdOx1 nCoV-19 (AZD1222) vaccine in a phase 1/2 clinical trial.

Katie J Ewer, Jordan R Barrett, Sandra Belij-Rammerstorfer, Hannah Sharpe, Rebecca Makinson, Richard Morter, Amy Flaxman, Daniel Wright, Duncan Bellamy, Mustapha Bittaye, Christina Dold, Nicholas M Provine, Jeremy Aboagye, Jamie Fowler, Sarah E Silk, Jennifer Alderson, Parvinder K Aley, Brian Angus, Eleanor Berrie, Sagida Bibi, Paola Cicconi, Elizabeth A Clutterbuck, Irina Chelysheva, Pedro M Folegatti, Michelle Fuskova, Catherine M Green, Daniel Jenkin, Simon Kerridge, Alison Lawrie, Angela M Minassian, Maria Moore, Yama Mujadidi, Emma Plested, Ian Poulton, Maheshi N Ramasamy, Hannah Robinson, Rinn Song, Matthew D Snape, Richard Tarrant, Merryn Voysey, Marion E E Watson, Alexander D Douglas, Adrian V S Hill, Sarah C Gilbert, Andrew J Pollard, Teresa Lambe, ,

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of Coronavirus Disease 2019 (COVID-19), has caused a global pandemic, and safe, effective vaccines are urgently needed<sup>1</sup>. Strong, Th1-skewed T cell responses can drive protective humoral and cell-mediated immune responses<sup>2</sup> and might reduce the potential for disease enhancement<sup>3</sup>. Cytotoxic T ... Read more >>

Nat Med (Nature medicine)
[2020, :]

Cited: 1 time

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Principled simulation of agent-based models in epidemiology

Sean Wu, Andrew Dolgert, Joseph Lewnard, John Marshall, David Smith,

After more than a century of sustained work by mathematicians, biologists, epidemiologists, probabilists, and other experts, dynamic models have become a vital tool for understanding and describing epidemics and disease transmission systems. Such models fulfill a variety of crucial roles including data integration, estimation of disease burden, forecasting trends, counterfactual ... Read more >>

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Anticoagulant Selection in Relation to SAMe-TT2R2 Score in Patients with Atrial Fibrillation: The GLORIA-AF Registry.

George Ntaios, Menno V Huisman, Hans-Christoph Diener, Jonathan L Halperin, Christine Teutsch, Sabrina Marler, Venkatesh K Gurusamy, Milla Thompson, Gregory Y H Lip, Brian Olshansky, ,

<h4>Aim</h4>The SAMe-TT<sub>2</sub>R<sub>2</sub> score helps identify patients with atrial fibrillation (AF) likely to have poor anticoagulation control during anticoagulation with vitamin K antagonists (VKA), and those with scores >2 might be better managed with a target-specific oral anticoagulant (NOAC). We hypothesized that in clinical practice, VKAs may be prescribed less frequently ... Read more >>

Hellenic J Cardiol (Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese)
[2020, :]

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Pluripotent Stem Cell-Derived Hepatocytes Phenotypic Screening Reveals Small Molecules Targeting the CDK2/4-C/EBPα/DGAT2 Pathway Preventing ER-Stress Induced Lipid Accumulation.

Maddalena Parafati, Sang Hyo Bae, R Jason Kirby, Martina Fitzek, Preeti Iyer, Ola Engkvist, David M Smith, Siobhan Malany,

Non-alcoholic fatty liver disease (NAFLD) has a large impact on global health. At the onset of disease, NAFLD is characterized by hepatic steatosis defined by the accumulation of triglycerides stored as lipid droplets. Developing therapeutics against NAFLD and progression to non-alcoholic steatohepatitis (NASH) remains a high priority in the medical ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(24):]

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The relationship between Eastern Cooperative Oncology Group performance status and healthcare resource utilization among patients with advanced or metastatic colorectal, lung or gastric cancer.

Lisa M Hess, David Smith, Zhanglin L Cui, Leslie Montejano, Astra M Liepa, William Schelman, Lee Bowman,

<h4>Aims</h4>The ability of a patient to receive anti-cancer treatment depends on a variety of factors, including performance status (PS), which is typically measured using the Eastern Cooperative Oncology Group (ECOG) scale. This study hypothesized that there would be a strong and positive correlation between ECOG PS values and healthcare resource ... Read more >>

J Drug Assess (Journal of drug assessment)
[2020, 10(1):10-17]

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Phase 1/2 trial of SARS-CoV-2 vaccine ChAdOx1 nCoV-19 with a booster dose induces multifunctional antibody responses.

Jordan R Barrett, Sandra Belij-Rammerstorfer, Christina Dold, Katie J Ewer, Pedro M Folegatti, Ciaran Gilbride, Rachel Halkerston, Jennifer Hill, Daniel Jenkin, Lisa Stockdale, Marije K Verheul, Parvinder K Aley, Brian Angus, Duncan Bellamy, Eleanor Berrie, Sagida Bibi, Mustapha Bittaye, Miles W Carroll, Breeze Cavell, Elizabeth A Clutterbuck, Nick Edwards, Amy Flaxman, Michelle Fuskova, Andrew Gorringe, Bassam Hallis, Simon Kerridge, Alison M Lawrie, Aline Linder, Xinxue Liu, Meera Madhavan, Rebecca Makinson, Jack Mellors, Angela Minassian, Maria Moore, Yama Mujadidi, Emma Plested, Ian Poulton, Maheshi N Ramasamy, Hannah Robinson, Christine S Rollier, Rinn Song, Matthew D Snape, Richard Tarrant, Stephen Taylor, Kelly M Thomas, Merryn Voysey, Marion E E Watson, Daniel Wright, Alexander D Douglas, Catherine M Green, Adrian V S Hill, Teresa Lambe, Sarah Gilbert, Andrew J Pollard, ,

More than 190 vaccines are currently in development to prevent infection by the novel severe acute respiratory syndrome coronavirus 2. Animal studies suggest that while neutralizing antibodies against the viral spike protein may correlate with protection, additional antibody functions may also be important in preventing infection. Previously, we reported early ... Read more >>

Nat Med (Nature medicine)
[2020, :]

Cited: 2 times

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Lightening the viral load to lessen covid-19 severity.

Stephen Burgess, David Smith, Julia C Kenyon, Dipender Gill,

BMJ (BMJ (Clinical research ed.))
[2020, 371:m4763]

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Optimizing COVID-19 surveillance in long-term care facilities: a modelling study.

David R M Smith, Audrey Duval, Koen B Pouwels, Didier Guillemot, Jérôme Fernandes, Bich-Tram Huynh, Laura Temime, Lulla Opatowski, ,

<h4>Background</h4>Long-term care facilities (LTCFs) are vulnerable to outbreaks of coronavirus disease 2019 (COVID-19). Timely epidemiological surveillance is essential for outbreak response, but is complicated by a high proportion of silent (non-symptomatic) infections and limited testing resources.<h4>Methods</h4>We used a stochastic, individual-based model to simulate transmission of severe acute respiratory syndrome coronavirus ... Read more >>

BMC Med (BMC medicine)
[2020, 18(1):386]

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The Number of Dogs Entering Shelters in Five States, and Factors that Affect Their Outcomes: A Study of the Sheltering System.

Kimberly Woodruff, David R Smith, Cassandra Cain, Christina Loftin,

As there are few requirements for mandatory registration or reporting for humane animal organizations, it is difficult to quantify how many dogs enter such organizations annually, or know their outcomes. Our objectives were to quantify the number of dogs entering animal shelters in five states in 2017, and determine factors ... Read more >>

J Appl Anim Welf Sci (Journal of applied animal welfare science : JAAWS)
[2020, :1-15]

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