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Risk of Postoperative Bleeding in Tonsillectomy for Peritonsillar Abscess, as Opposed to in Recurrent and Chronic Tonsillitis-A Retrospective Study.

David Slouka, Štěpánka Čejková, Jana Hanáková, Petr Hrabačka, Stanislav Kormunda, David Kalfeřt, Alena Skálová, Václav Šimánek, Radek Kucera,

Tonsillectomy is a routine surgery in otorhinolaryngology and the occurrence of postoperative bleeding is not a rare complication. The aim of this retrospective, observational, analytic, cohort study is to compare the incidence of this complication for the most common indications. A group of patients indicated for tonsillectomies for peritonsillar abscess ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2021, 18(4):]

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Five Commercial Immunoassays for SARS-CoV-2 Antibody Determination and Their Comparison and Correlation with the Virus Neutralization Test.

Václav Šimánek, Ladislav Pecen, Zuzana Krátká, Tomáš Fürst, Hana Řezáčková, Ondřej Topolčan, Karel Fajfrlík, Dalibor Sedláček, Robin Šín, Petr Pazdiora, Hana Zelená, David Slouka, Radek Kučera,

There is an ongoing debate as to whether SARS-CoV-2 antibodies can be found in patients who have recovered from COVID-19 disease. Currently, there is no consensus on whether the antibodies, if present, are protective. Our regular measurements of SARS-CoV-2 antibodies, starting in July 2020, have provided us with the opportunity ... Read more >>

Diagnostics (Basel) (Diagnostics (Basel, Switzerland))
[2021, 11(4):]

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High-grade Transformation/Dedifferentiation in Salivary Gland Carcinomas: Occurrence Across Subtypes and Clinical Significance.

Alena Skalova, Ilmo Leivo, Henrik Hellquist, Abbas Agaimy, Roderick H W Simpson, Göran Stenman, Vincent Vander Poorten, Justin A Bishop, Alessandro Franchi, Juan C Hernandez-Prera, David Slouka, Stefan M Willems, Kerry D Olsen, Alfio Ferlito,

High-grade transformation (HGT) or dedifferentiation has been described in a variety of salivary gland carcinomas, including acinic cell carcinoma, secretory carcinoma, adenoid cystic carcinoma, epithelial-myoepithelial carcinoma, polymorphous adenocarcinoma, low-grade mucoepidermoid carcinoma, and hyalinizing clear cell carcinoma. High-grade (HG) transformed tumors are composed of a conventional low-grade component characterized by specific ... Read more >>

Adv Anat Pathol (Advances in anatomic pathology)
[2021, 28(3):107-118]

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A Comparison of 18F-FDG-PET/MRI and 18F-FDG-PET/CT in the Cancer Staging of Locoregional Lymph Nodes.

David Slouka, Jiri Krcal, Tomas Kostlivy, Petr Hrabacka, Alena Skalova, Hynek Mirka, Ondrej Topolcan, Radek Kucera,

<h4>Aim</h4>The aim of the study was to evaluate the yields of 2-deoxy-2-[<sup>18</sup>F]-fluoro-D-glucose positron-emission tomography/magnetic resonance imaging (<sup>18</sup>F-FDG-PET/MRI) and <sup>18</sup>F-FDG-PET/computed tomography (CT) for the detection of metastatic involvement of locoregional neck nodes in patients with head and neck malignancy.<h4>Patients and methods</h4>A total of 90 patients (66 men and 24 women) met ... Read more >>

In Vivo (In vivo (Athens, Greece))
[2020, 34(4):2029-2032]

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The Level of Preoperative Plasma KRAS Mutations and CEA Predict Survival of Patients Undergoing Surgery for Colorectal Cancer Liver Metastases.

Jiri Polivka, Jindra Windrichova, Martin Pesta, Katerina Houfkova, Hana Rezackova, Tereza Macanova, Ondrej Vycital, Radek Kucera, David Slouka, Ondrej Topolcan,

Colorectal cancer (CRC) belongs to the most common cancers. The liver is a predominant site of CRC dissemination. Novel biomarkers for predicting the survival of CRC patients with liver metastases (CLM) undergoing metastasectomy are needed. We examined KRAS mutated circulating cell-free tumor DNA (ctDNA) in CLM patients as a prognostic ... Read more >>

Cancers (Basel) (Cancers)
[2020, 12(9):]

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Epidemiological and Microbiological Aspects of the Peritonsillar Abscess.

David Slouka, Jana Hanakova, Tomas Kostlivy, Petr Skopek, Vojtech Kubec, Vaclav Babuska, Ladislav Pecen, Ondřej Topolcan, Radek Kucera,

Peritonsillar abscess (PTA) is the most common complication of tonsillitis. Cultivation usually reveals a wide spectrum of aerobic and anaerobic microbiota. This retrospective study compared PTA incidence and the spectrum of individual microbial findings in groups of patients divided by gender, age, and season. Of the 966 samples cultivated, a ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2020, 17(11):]

Cited: 2 times

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PIVKA-II as a Potential New Biomarker for Hepatocellular Carcinoma - A Pilot Study.

Sarka Svobodova, Marie Karlikova, Ondrej Topolcan, Ladislav Pecen, Martina Pestova, Otto Kott, Vladislav Treska, David Slouka, Radek Kucera,

<h4>Aim</h4>The aim of this study was to evaluate the clinical contribution of protein induced by vitamin K absence (PIVKA-II) for hepatocellular carcinoma (HCC) diagnostics and compare it with alpha-foetoprotein (AFP), a routinely used tumour marker.<h4>Materials and methods</h4>A total of 332 participants were enrolled in this study: 64 with HCC, 48 ... Read more >>

In Vivo (In vivo (Athens, Greece))
[2018, 32(6):1551-1554]

Cited: 3 times

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Biomarkers - a possibility for monitoring of obstructive sleep apnea syndrome.

David Slouka, Radek Kucera, Bretislav Gal, Jaroslav Betka, Alena Skalova,

OBJECTIVES:Sleep apnea syndrome affects approximately 4% of adult males and 2% of adult females. It is associated with significant cardio-, cerebrovascular, metabolic and hormonal comorbidities and ranks among the more expensive medical specialties due to the requirement of high-quality technical diagnostic and therapeutic equipment as well as well-educated and experienced ... Read more >>

Neuro Endocrinol Lett (Neuro endocrinology letters)
[2019, 40(2):85-92]

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Plasma microRNA Levels Combined with CEA and CA19-9 in the Follow-Up of Colorectal Cancer Patients.

Martin Pesta, Radek Kucera, Ondrej Topolcan, Marie Karlikova, Katerina Houfkova, Jiri Polivka, Tereza Macanova, Iva Machova, David Slouka, Vlastimil Kulda,

Colorectal cancer (CRC) ranks among the most common cancers worldwide. Surgical removal remains the best strategy for treatment of resectable tumors. An important part of caring for patients after surgery is monitoring for early detection of a possible relapse of the disease. Efforts are being made to improve the sensitivity ... Read more >>

Cancers (Basel) (Cancers)
[2019, 11(6):]

Cited: 7 times

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Blood biomarker panel recommended for personalized prediction, prognosis, and prevention of complications associated with abdominal aortic aneurysm.

Jiri Molacek, Vladislav Treska, Jan Zeithaml, Ivana Hollan, Ondrej Topolcan, Ladislav Pecen, David Slouka, Marie Karlikova, Radek Kucera,

The aim of the study was to evaluate the ability of following biomarkers as diagnostic tools and risk predictors of AAA: C-reactive protein, interleukin-6, pentraxin-3, galectin-3, procollagen type III N-terminal peptide, C-terminal telopeptide of type I collagen, high-sensitive troponin I, and brain natriuretic peptide. Seventy-two patients with an AAA and ... Read more >>

EPMA J (The EPMA journal)
[2019, 10(2):125-135]

Cited: 4 times

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"High-grade oncocytic renal tumor": morphologic, immunohistochemical, and molecular genetic study of 14 cases.

Huiying He, Kiril Trpkov, Petr Martinek, Ozlem Tanas Isikci, Cristina Maggi-Galuzzi, Reza Alaghehbandan, Anthony J Gill, Maria Tretiakova, Jose Ignacio Lopez, Sean R Williamson, Delia Perez Montiel, Maris Sperga, Eva Comperat, Fadi Brimo, Ali Yilmaz, Kristyna Pivovarcikova, Kveta Michalova, David Slouka, Kristyna Prochazkova, Milan Hora, Michael Bonert, Michal Michal, Ondrej Hes,

The spectrum of the renal oncocytic tumors has been expanded in recent years to include several novel and emerging entities. We describe a cohort of novel, hitherto unrecognized and morphologically distinct high-grade oncocytic tumors (HOT), currently diagnosed as "unclassified" in the WHO classification. We identified 14 HOT by searching multiple ... Read more >>

Virchows Arch (Virchows Archiv : an international journal of pathology)
[2018, 473(6):725-738]

Cited: 5 times

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Risk factors for failure of continuous positive airway pressure treatment in patients with ostructive sleep apnoea.

David Slouka, Monika Honnerova, Petr Hosek, Ales Matas, Karel Slama, Jana Landsmanova, Radek Kucera,

BACKGROUND AND AIMS:Obstructive sleep apnoea is a potentially serious sleep disorder associated with the risk of cardiovascular disease. It is treated with continuous airway pressure (CPAP) but this is not always successful. Unsuccessful cases should be treated by bilevel positive airway pressure (BiPAP). The aim of this study was to ... Read more >>

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub (Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia)
[2018, 162(2):134-138]

Cited: 0 times

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OPG, OPN, EGF and VEGF Levels at Individual Breslow Score Stages in Malignant Melanoma.

Inka Treskova, Ondrej Topolcan, Jindra Windrichova, Vaclav Simanek, David Slouka, Vladislav Treska, Radek Kucera,

<h4>Background/aim</h4>Melanoma represents one of the most aggressive forms of cancer. With the rapid increases in the incidence of melanoma in the United States, Australia and Europe over the last decades, melanoma has been considered an epidemic cancer in these areas. The aim of our study was to evaluate the utility ... Read more >>

Anticancer Res (Anticancer research)
[2018, 38(8):4907-4911]

Cited: 3 times

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Stability of total prostate-specific antigen and free prostate-specific antigen after 10 years' storage.

Vaclav Simanek, Ondrej Topolcan, Marie Karlikova, Olga Dolejsova, Radka Fuchsova, Judita Kinkorova, David Slouka, Radek Kucera,

<h4>Introduction</h4>PSA is a serine protease composed of 240 amino acids in a single polypeptide chain and is a routine parameter in prostate cancer diagnostics. The aim of our study was to test the long-term stability of tPSA and fPSA after 10 years' storage at -80°C.<h4>Materials and methods</h4>We analyzed two aliquots ... Read more >>

Int J Biol Markers (The International journal of biological markers)
[2018, 33(4):463-466]

Cited: 0 times

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Mammary Analog Secretory Carcinoma of the Nasal Cavity: Characterization of 2 Cases and Their Distinction From Other Low-grade Sinonasal Adenocarcinomas.

Martina Baneckova, Abbas Agaimy, Simon Andreasen, Tomas Vanecek, Petr Steiner, David Slouka, Tomas Svoboda, Marketa Miesbauerova, Michael Michal, Alena Skálová,

Secretory carcinoma, originally described as mammary analog secretory carcinoma (MASC), is a low-grade salivary gland tumor characterized by a t(12;15)(p13;q25) translocation, resulting in an ETV6-NTRK3 gene fusion. Most MASCs are localized to the parotid gland and intraoral minor salivary glands. Moreover, ETV6-rearranged carcinomas with secretory features have been reported recently ... Read more >>

Am J Surg Pathol (The American journal of surgical pathology)
[2018, 42(6):735-743]

Cited: 7 times

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Prognostic significance of 1p36 locus deletion in adenoid cystic carcinoma of the salivary glands.

Petr Šteiner, Simon Andreasen, Petr Grossmann, Lukáš Hauer, Tomáš Vaněček, Markéta Miesbauerová, Thalita Santana, Katalin Kiss, David Slouka, Alena Skálová,

Adenoid cystic carcinoma (AdCC) of the salivary glands is characterized by MYB-NFIB or MYBL1-NFIB fusion, prolonged but relentlessly progressive clinical course with frequent recurrences, and development of distant metastasis resulting in high long-term mortality. Currently, no effective therapy is available for patients with advanced non-resectable and/or metastatic disease. Complicating the ... Read more >>

Virchows Arch (Virchows Archiv : an international journal of pathology)
[2018, 473(4):471-480]

Cited: 4 times

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Molecular Profiling of Mammary Analog Secretory Carcinoma Revealed a Subset of Tumors Harboring a Novel ETV6-RET Translocation: Report of 10 Cases.

Alena Skalova, Tomas Vanecek, Petr Martinek, Ilan Weinreb, Todd M Stevens, Roderick H W Simpson, Martin Hyrcza, Niels J Rupp, Martina Baneckova, Michael Michal, David Slouka, Tomas Svoboda, Alena Metelkova, Arghavan Etebarian, Jaroslav Pavelka, Steven J Potts, Jason Christiansen, Petr Steiner, Michal Michal,

ETV6 gene abnormalities are well described in tumor pathology. Many fusion partners of ETV6 have been reported in a variety of epithelial, mesenchymal, and hematological malignancies. In salivary gland tumor pathology, however, the ETV6-NTRK3 translocation is specific for (mammary analog) secretory carcinoma, and has not been documented in any other ... Read more >>

Am J Surg Pathol (The American journal of surgical pathology)
[2018, 42(2):234-246]

Cited: 28 times

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The Role of Molecular Testing in the Differential Diagnosis of Salivary Gland Carcinomas.

Alena Skálová, Göran Stenman, Roderick H W Simpson, Henrik Hellquist, David Slouka, Tomas Svoboda, Justin A Bishop, Jennifer L Hunt, Ken-Ichi Nibu, Alessandra Rinaldo, Vincent Vander Poorten, Kenneth O Devaney, Petr Steiner, Alfio Ferlito,

Salivary gland neoplasms are a morphologically heterogenous group of lesions that are often diagnostically challenging. In recent years, considerable progress in salivary gland taxonomy has been reached by the discovery of tumor type-specific fusion oncogenes generated by chromosome translocations. This review describes the clinicopathologic features of a selected group of ... Read more >>

Am J Surg Pathol (The American journal of surgical pathology)
[2018, 42(2):e11-e27]

Cited: 21 times

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CEA, CA 15-3, and TPS as Prognostic Factors in the Follow-up Monitoring of Patients After Radical Surgery for Breast Cancer.

Sarka Svobodova, Radek Kucera, Ondrej Fiala, Marie Karlikova, Andrea Narsanska, Ilona Zedníková, Vladislav Treska, David Slouka, Milena Rousarova, Ondrej Topolcan, Jindrich Finek,

The aim of this study was to evaluate the ability of tissue polypeptide-specific antigen (TPS), carcinoembryonic antigen (CEA), and cancer antigen 15-3 (CA 15-3) to predict relapse in breast cancer patients, when the measurement of biomarkers is performed within 6 months after surgery.Four hundred and seventy-two patients with breast cancer ... Read more >>

Anticancer Res (Anticancer research)
[2018, 38(1):465-469]

Cited: 3 times

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Molecular Genetic Alterations in Renal Cell Carcinomas With Tubulocystic Pattern: Tubulocystic Renal Cell Carcinoma, Tubulocystic Renal Cell Carcinoma With Heterogenous Component and Familial Leiomyomatosis-associated Renal Cell Carcinoma. Clinicopathologic and Molecular Genetic Analysis of 15 Cases.

Monika Ulamec, Faruk Skenderi, Ming Zhou, Božo Krušlin, Petr Martínek, Petr Grossmann, Kvetoslava Peckova, Isabel Alvarado-Cabrero, Kristyna Kalusova, Bohuslava Kokoskova, Pavla Rotterova, Milan Hora, Ondrej Daum, Magdalena Dubova, Kevin Bauleth, David Slouka, Maris Sperga, Whitney Davidson, Boris Rychly, Delia Perez Montiel, Michal Michal, Ondrej Hes,

The characteristic morphologic spectrum of tubulocystic renal cell carcinoma (TC-RCC) may include areas resembling papillary RCC (PRCC). Our study includes 15 RCCs with tubulocystic pattern: 6 TC-RCCs, 1 RCC-high grade with tubulocystic architecture, 5 TC-RCCs with foci of PRCC, 2 with high-grade RCC (HGRCC) not otherwise specified, and 1 with ... Read more >>

Appl Immunohistochem Mol Morphol (Applied immunohistochemistry & molecular morphology : AIMM)
[2016, 24(7):521-530]

Cited: 4 times

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Searching for New Biomarkers and the Use of Multivariate Analysis in Gastric Cancer Diagnostics.

Radek Kucera, David Smid, Ondrej Topolcan, Marie Karlikova, Ondrej Fiala, David Slouka, Tomas Skalicky, Vladislav Treska, Vlastimil Kulda, Vaclav Simanek, Martin Safanda, Martin Pesta,

<h4>Aim</h4>The first aim of this study was to search for new biomarkers to be used in gastric cancer diagnostics. The second aim was to verify the findings presented in literature on a sample of the local population and investigate the risk of gastric cancer in that population using a multivariant ... Read more >>

Anticancer Res (Anticancer research)
[2016, 36(4):1967-1971]

Cited: 2 times

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Short-term postoperative distress associated with open vs. transoral robotic surgery (TORS) in patients with T1-T2 carcinomas of the tongue base and supraglottis.

Karel Slama, David Slouka, Jaroslav Slipka, Slavomil Fischer,

<h4>Background</h4>This study compared the adverse effects of open surgery (OS) including lateral pharyngotomy and supraglottic laryngectomy vs. transoral robotic surgery (TORS) in the treatment of stage T1 and T2 carcinomas of the tongue base and supraglottis.<h4>Methods</h4>A retrospective study involving a 49 (13 female and 36 male) patients with untreated T1 ... Read more >>

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub (Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia)
[2016, 160(3):423-428]

Cited: 1 time

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The Role of TPS and TPA in the Diagnostics of Distant Metastases.

Radek Kucera, Ondrej Topolcan, Ondrej Fiala, Judita Kinkorova, Vladislav Treska, Ilona Zedníková, David Slouka, Vaclav Simanek, Martin Safanda, Vaclav Babuska,

<h4>Aim</h4>The aim of the study was to assess the degree to which tissue polypeptide antigen (TPA) and tissue polypeptide-specific antigen (TPS), as well as carcinoembryonic antigen (CEA), can assist in the detection of distant metastases.<h4>Patients and methods</h4>We assessed 157 patients with colorectal and breast cancer divided into two groups. The ... Read more >>

Anticancer Res (Anticancer research)
[2016, 36(2):773-777]

Cited: 2 times

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Chromophobe renal cell carcinoma with neuroendocrine and neuroendocrine-like features. Morphologic, immunohistochemical, ultrastructural, and array comparative genomic hybridization analysis of 18 cases and review of the literature.

Kvetoslava Peckova, Petr Martinek, Chisato Ohe, Naoto Kuroda, Stela Bulimbasic, Enric Condom Mundo, Delia Perez Montiel, Jose I Lopez, Ondrej Daum, Pavla Rotterova, Bohuslava Kokoskova, Magdalena Dubova, Kristyna Pivovarcikova, Kevin Bauleth, Petr Grossmann, Milan Hora, Kristyna Kalusova, Whitney Davidson, David Slouka, Sulc Miroslav, Petr Buzrla, Mirka Hynek, Michal Michal, Ondrej Hes,

Chromophobe renal cell carcinoma (CRCC) with neuroendocrine differentiation (CRCCND) has only recently been described. Eighteen cases of CRCC with morphologic features suggestive of neuroendocrine differentiation were selected from among 624 CRCCs in our registry. The tissues were fixed in neutral formalin, embedded in paraffin, cut into 4- to 5-μm-thick sections, ... Read more >>

Ann Diagn Pathol (Annals of diagnostic pathology)
[2015, 19(4):261-268]

Cited: 6 times

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Large germline deletions of the CYLD gene in patients with Brooke-Spiegler syndrome and multiple familial trichoepithelioma.

Tomas Vanecek, Zbynek Halbhuber, Denisa Kacerovska, Petr Martinek, Monika Sedivcova, Richard A Carr, David Slouka, Michal Michal, Dmitry V Kazakov,

Brooke-Spiegler syndrome (BSS) and its phenotypic variants, multiple familial trichoepithelioma (MFT) and familial cylindromatosis, are rare autosomal dominant hereditary diseases. They are characterized by the presence of multiple adnexal tumors, especially cylindromas, spiradenomas, spiradenocylindromas, and trichoepitheliomas. Implicated in the pathogenesis of the disease is the gene CYLD, which is localized ... Read more >>

Am J Dermatopathol (The American Journal of dermatopathology)
[2014, 36(11):868-874]

Cited: 10 times

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