Full Text Journal Articles by
Author David Sievert

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A human three-dimensional neural-perivascular 'assembloid' promotes astrocytic development and enables modeling of SARS-CoV-2 neuropathology.

Lu Wang, David Sievert, Alex E Clark, Sangmoon Lee, Hannah Federman, Benjamin D Gastfriend, Eric V Shusta, Sean P Palecek, Aaron F Carlin, Joseph G Gleeson,

Clinical evidence suggests the central nervous system is frequently impacted by SARS-CoV-2 infection, either directly or indirectly, although the mechanisms are unclear. Pericytes are perivascular cells within the brain that are proposed as SARS-CoV-2 infection points. Here we show that pericyte-like cells (PLCs), when integrated into a cortical organoid, are ... Read more >>

Nat Med (Nature medicine)
[2021, 27(9):1600-1606]

Cited: 3 times

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The Neurobiology of Modern Viral Scourges: ZIKV and COVID-19.

Swapnil Mittal, Hannah G Federman, David Sievert, Joseph G Gleeson,

The interactions of viruses with the nervous system were thought to be well understood until the recent outbreaks of Zika and SARS-CoV-2. In this review, we consider these emerging pathogens, the range and mechanisms of the neurological disease in humans, and how the biomedical research enterprise has pivoted to answer ... Read more >>

Neuroscientist (The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry)
[2021, :10738584211009149]

Cited: 0 times

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Author Correction: Loss of NARS1 impairs progenitor proliferation in cortical brain organoids and leads to microcephaly.

Lu Wang, Zhen Li, David Sievert, Desirée E C Smith, Marisa I Mendes, Dillon Y Chen, Valentina Stanley, Shereen Ghosh, Yulu Wang, Majdi Kara, Ayca Dilruba Aslanger, Rasim O Rosti, Henry Houlden, Gajja S Salomons, Joseph G Gleeson,

Nat Commun (Nature communications)
[2021, 12(1):1192]

Cited: 0 times

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Loss of NARS1 impairs progenitor proliferation in cortical brain organoids and leads to microcephaly.

Lu Wang, Zhen Li, David Sievert, Desirée E C Smith, Marisa I Mendes, Dillon Y Chen, Valentina Stanley, Shereen Ghosh, Yulu Wang, Majdi Kara, Ayca Dilruba Aslanger, Rasim O Rosti, Henry Houlden, Gajja S Salomons, Joseph G Gleeson,

Asparaginyl-tRNA synthetase1 (NARS1) is a member of the ubiquitously expressed cytoplasmic Class IIa family of tRNA synthetases required for protein translation. Here, we identify biallelic missense and frameshift mutations in NARS1 in seven patients from three unrelated families with microcephaly and neurodevelopmental delay. Patient cells show reduced NARS1 protein, impaired ... Read more >>

Nat Commun (Nature communications)
[2020, 11(1):4038]

Cited: 8 times

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