Full Text Journal Articles by
Author David Russell

Advertisement

Find full text journal articles






Harnessing chemical energy for the activation and joining of prebiotic building blocks.

Ziwei Liu, Long-Fei Wu, Jianfeng Xu, Claudia Bonfio, David A Russell, John D Sutherland,

Life is an out-of-equilibrium system sustained by a continuous supply of energy. In extant biology, the generation of the primary energy currency, adenosine 5'-triphosphate and its use in the synthesis of biomolecules require enzymes. Before their emergence, alternative energy sources, perhaps assisted by simple catalysts, must have mediated the activation ... Read more >>

Nat Chem (Nature chemistry)
[2020, 12(11):1-6]

Cited: 0 times

View full text PDF listing >>



Active targeting of gold nanoparticles as cancer therapeutics.

Zoë Rachael Goddard, María J Marín, David A Russell, Mark Searcey,

Gold nanoparticles (AuNPs) are of increasing interest for their unique properties and their biocompatability, minimal toxicity, multivalency and size tunability make them exciting drug carriers. The functionalisaton of AuNPs with targeting moieties allows for their selective delivery to cancers, with antibodies, proteins, peptides, aptamers, carbohydrates and small molecules all exploited. ... Read more >>

Chem Soc Rev (Chemical Society reviews)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Advertisement

Selective regulation of human TRAAK channels by biologically active phospholipids.

Samantha Schrecke, Yun Zhu, Jacob W McCabe, Mariah Bartz, Charles Packianathan, Minglei Zhao, Ming Zhou, David Russell, Arthur Laganowsky,

TRAAK is an ion channel from the two-pore domain potassium (K2P) channel family with roles in maintaining the resting membrane potential and fast action potential conduction. Regulated by a wide range of physical and chemical stimuli, the affinity and selectivity of K2P4.1 toward lipids remains poorly understood. Here we show ... Read more >>

Nat Chem Biol (Nature chemical biology)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Recapitulating the frataxin activation mechanism in an engineered bacterial cysteine desulfurase supports the architectural switch model

Shachin Patra, Cheng-Wei Lin, Manas Ghosh, Steven Havens, Seth Cory, David Russell, David Barondeau,

ABSTRACT Iron-sulfur (Fe-S) clusters have a key role in many biochemical processes and are essential for most life forms. Despite recent mechanistic advances in understanding the Fe-S cluster biosynthetic pathway, critical questions remain unresolved. Although human NFS1 and E. coli IscS share ∼60% sequence identity, NFS1 exhibits low activity and ... Read more >>

()
[, :]

Cited: 0 times

View full text PDF listing >>



Evidence for Many Unique Solution Structures for Chymotrypsin Inhibitor 2: A Thermodynamic Perspective Derived from vT-ESI-IMS-MS Measurements.

Shannon A Raab, Tarick J El-Baba, Daniel W Woodall, Wen Liu, Yang Liu, Zane Baird, David A Hales, Arthur Laganowsky, David H Russell, David E Clemmer,

Chymotrypsin inhibitor 2 (CI-2) is a classic model for two-state cooperative protein folding and is one of the most extensively studied systems. Alan Fersht, a pioneer in the field of structural biology, has studied the wild-type (wt) and over 100 mutant forms of CI-2 with traditional analytical and biochemical techniques. ... Read more >>

J Am Chem Soc (Journal of the American Chemical Society)
[2020, 142(41):17372-17383]

Cited: 0 times

View full text PDF listing >>



"Doing the Right Thing": Family Caregivers Managing Medical and Nursing Tasks in the Postacute Home Health Care Setting.

Jo-Ana D Chase, David Russell, Daniel B Kaplan, Michael V Bueno, Rungnapha Khiewchaum, Penny H Feldman,

Family caregivers often manage complex medical and nursing tasks (MNTs) for older adults transitioning from hospital to home. To explore caregivers' experiences managing MNTs in the postacute home health care (HHC) setting, we interviewed by phone 20 caregivers of older adults who received HHC following a hospitalization. Interviews were recorded, ... Read more >>

J Appl Gerontol (Journal of applied gerontology : the official journal of the Southern Gerontological Society)
[2020, :733464820961259]

Cited: 0 times

View full text PDF listing >>



On Board: Interdisciplinary Team Member Perspectives of How Patients With Heart Failure and Their Families Navigate Hospice Care.

David Russell, Elizabeth A Luth, Dawon Baik, Lizeyka Jordan, Ruth Masterson Creber,

Hospice agencies serve an expanding population of patients with varying disease conditions and sociodemographic characteristics. Patients with heart failure represent a growing share of hospice deaths in the United States. However, limited research has explored the perspectives of hospice interdisciplinary team members regarding how patients with heart failure and their ... Read more >>

J Hosp Palliat Nurs (Journal of hospice and palliative nursing : JHPN : the official journal of the Hospice and Palliative Nurses Association)
[2020, 22(5):351-358]

Cited: 0 times

View full text PDF listing >>



Nutrition and the Gut Microbiota in 10- to 18-Month-Old Children Living in Urban Slums of Mumbai, India.

Samantha L Huey, Lingjing Jiang, Marcus W Fedarko, Daniel McDonald, Cameron Martino, Farhana Ali, David G Russell, Shobha A Udipi, Aparna Thorat, Varsha Thakker, Padmini Ghugre, R D Potdar, Harsha Chopra, Kripa Rajagopalan, Jere D Haas, Julia L Finkelstein, Rob Knight, Saurabh Mehta,

In this cross-sectional study, we describe the composition and diversity of the gut microbiota among undernourished children living in urban slums of Mumbai, India, and determine how nutritional status, including anthropometric measurements, dietary intakes from complementary foods, feeding practices, and micronutrient concentrations, is associated with their gut microbiota. We collected ... Read more >>

mSphere (mSphere)
[2020, 5(5):]

Cited: 0 times

View full text PDF listing >>



Observation of Hand Hygiene Practices in Home Health Care.

Margaret V McDonald, Carlin Brickner, David Russell, Dawn Dowding, Elaine L Larson, Marygrace Trifilio, Irene Y Bick, Sridevi Sridharan, Jiyoun Song, Victoria Adams, Kyungmi Woo, Jingjing Shang,

OBJECTIVE:To describe nurse hand hygiene practices in the home health care (HHC) setting, nurse adherence to hand hygiene guidelines, and factors associated with hand hygiene opportunities during home care visits. DESIGN:Observational study of nurse hand hygiene practices. SETTING:and Participants: Licensed practical/vocational and registered nurses were observed in the homes of ... Read more >>

J Am Med Dir Assoc (Journal of the American Medical Directors Association)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Longitudinal Measurements of Glucocerebrosidase activity in Parkinson's patients.

Roy N Alcalay, Pavlina Wolf, Ming Sum Ruby Chiang, Karolina Helesicova, Xiaokui Kate Zhang, Kalpana Merchant, Samantha J Hutten, Clemens Scherzer, Chelsea Caspell-Garcia, Cornelis Blauwendraat, Tatiana Foroud, Kelly Nudelman, Ziv Gan-Or, Tanya Simuni, Lana M Chahine, Oren Levy, Dandi Zheng, Gen Li, Sergio Pablo Sardi, ,

OBJECTIVE:Reduction in glucocerebrosidase (GCase; encoded by GBA) enzymatic activity has been linked to Parkinson's disease (PD). Here, we correlated GCase activity and PD phenotype in the Parkinson's Progression Markers Initiative (PPMI) cohort. METHODS:We measured GCase activity in dried blood spots from 1559 samples of participants in the inception PPMI cohort, ... Read more >>

Ann Clin Transl Neurol (Annals of clinical and translational neurology)
[2020, 7(10):1816-1830]

Cited: 0 times

View full text PDF listing >>



A SPECIAL ISSUE DEDICATED TO THE OUTSTANDING SCIENTIFIC CAREER OF PROF. MICHAEL L. GROSS.

Yinsheng Wang, David Russell,

Mass Spectrom Rev (Mass spectrometry reviews)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Discovery of Potent Charge-Reducing Molecules for Native Ion Mobility Mass Spectrometry Studies.

Jixing Lyu, Yang Liu, Jacob W McCabe, Samantha Schrecke, Lei Fang, David H Russell, Arthur Laganowsky,

There is growing interest in the characterization of protein complexes and their interactions with ligands using native ion mobility mass spectrometry. A particular challenge, especially for membrane proteins, is preserving noncovalent interactions and maintaining native-like structures. Different approaches have been developed to minimize activation of protein complexes by manipulating charge ... Read more >>

Anal. Chem. (Analytical chemistry)
[2020, 92(16):11242-11249]

Cited: 0 times

View full text PDF listing >>



Assessment of 18F-PI-2620 as a Biomarker in Progressive Supranuclear Palsy.

Matthias Brendel, Henryk Barthel, Thilo van Eimeren, Ken Marek, Leonie Beyer, Mengmeng Song, Carla Palleis, Mona Gehmeyr, Urban Fietzek, Gesine Respondek, Julia Sauerbeck, Alexander Nitschmann, Christian Zach, Jochen Hammes, Michael T. Barbe, Oezguer Onur, Frank Jessen, Dorothee Saur, Matthias L. Schroeter, Jost-Julian Rumpf, Michael Rullmann, Andreas Schildan, Marianne Patt, Bernd Neumaier, Olivier Barret, Jennifer Madonia, David S. Russell, Andrew Stephens, Sigrun Roeber, Jochen Herms, Kai Bötzel, Joseph Classen, Peter Bartenstein, Victor Villemagne, Johannes Levin, Günter U. Höglinger, Alexander Drzezga, John Seibyl, Osama Sabri,

ImportanceProgressive supranuclear palsy (PSP) is a 4-repeat tauopathy. Region-specific tau aggregates establish the neuropathologic diagnosis of definite PSP post mortem. Future interventional trials against tau in PSP would strongly benefit from biomarkers that support diagnosis.ObjectiveTo investigate the potential of the novel tau radiotracer 18F-PI-2620 as a biomarker in patients with ... Read more >>

JAMA Neurol (JAMA neurology)
[0, :]

Cited: 0 times

View full text PDF listing >>



Clinical evaluation of [18F] JNJ-64326067, a novel candidate PET tracer for the detection of tau pathology in Alzheimer's disease.

Mark E Schmidt, Luc Janssens, Diederik Moechars, Frederik J R Rombouts, Maarten Timmers, Olivier Barret, Cristian C Constantinescu, Jennifer Madonia, David S Russell, Christine M Sandiego, Hartmuth Kolb,

PURPOSE:The accumulation of misfolded tau is a common feature of several neurodegenerative disorders, with Alzheimer's disease (AD) being the most common. Earlier we identified JNJ-64326067, a novel isoquinoline derivative with high affinity and selectivity for tau aggregates from human AD brain. We report the dosimetry of [18F] JNJ-64326067 and results ... Read more >>

Eur. J. Nucl. Med. Mol. Imaging (European journal of nuclear medicine and molecular imaging)
[2020, :]

Cited: 0 times

View full text PDF listing >>



A Peptide-Duocarmycin Conjugate Targeting the Thomsen-Friedenreich Antigen Has Potent and Selective Antitumor Activity.

Oliver Charles Cartwright, Andrew Michael Beekman, Marco M D Cominetti, David A Russell, Mark Searcey,

Solid-phase synthesis allowed the rapid generation of a peptide-drug conjugate. A peptide targeting the Thomsen-Friedenreich antigen (TFα) was conjugated to the alkylating subunit of the potent cytotoxin duocarmycin SA. The compound, containing a cathepsin B cleavable linker, was shown to be active and selective against TFα expressing tumor cell lines. ... Read more >>

Bioconjug. Chem. (Bioconjugate chemistry)
[2020, 31(7):1745-1749]

Cited: 0 times

View full text PDF listing >>



Selective prebiotic formation of RNA pyrimidine and DNA purine nucleosides.

Jianfeng Xu, Václav Chmela, Nicholas J Green, David A Russell, Mikołaj J Janicki, Robert W Góra, Rafał Szabla, Andrew D Bond, John D Sutherland,

The nature of the first genetic polymer is the subject of major debate1. Although the 'RNA world' theory suggests that RNA was the first replicable information carrier of the prebiotic era-that is, prior to the dawn of life2,3-other evidence implies that life may have started with a heterogeneous nucleic acid ... Read more >>

Nature (Nature)
[2020, 582(7810):60-66]

Cited: 0 times

View full text PDF listing >>



Nutritional Status and Measles Antibody Titer in Children Living in Urban Slums of Mumbai.

Samantha Huey, David Russell, Jere Haas, Sudha Venkatramanan, Julia Finkelstein, Saurabh Mehta,

AbstractObjectivesTo determine a) the prevalence of protective measles IgG titers in young children living in urban slums of Mumbai, and b) the association of nutritional status assessed through a combination of anthropometry and micronutrient biomarker concentrations with these titers at baseline and after 9 months of follow-up.MethodsAnthropometry and serum concentrations ... Read more >>

(Current developments in nutrition)
[2020, 4(Suppl 2):1524-1524]

Cited: 0 times

View full text PDF listing >>



Hydroxylated Rotenoids Selectively Inhibit the Proliferation of Prostate Cancer Cells.

David A Russell, Hannah R Bridges, Riccardo Serreli, Sarah L Kidd, Natalia Mateu, Thomas J Osberger, Hannah F Sore, Judy Hirst, David R Spring,

Prostate cancer is one of the leading causes of cancer-related death in men. The identification of new therapeutics to selectively target prostate cancer cells is therefore vital. Recently, the rotenoids rotenone (1) and deguelin (2) were reported to selectively kill prostate cancer cells, and the inhibition of mitochondrial complex I ... Read more >>

J Nat Prod (Journal of natural products)
[2020, 83(6):1829-1845]

Cited: 0 times

View full text PDF listing >>



Nutritional assessment among adult patients with suspected or confirmed active tuberculosis disease in rural India.

Elaine A Yu, Julia L Finkelstein, Patsy M Brannon, Wesley Bonam, David G Russell, Marshall J Glesby, Saurabh Mehta,

OBJECTIVES:Our study goal was to evaluate a set of nutritional indicators among adults with confirmed or suspected active tuberculosis disease in southern India, given the limited literature on this topic. Study objectives were to assess the: I) double burden of malnutrition at individual and population levels; II) relative performance of ... Read more >>

PLoS One (PloS one)
[2020, 15(5):e0233306]

Cited: 0 times

View full text PDF listing >>



The Development and Implementation of a Cardiac Home Hospice Program: Results of a RE-AIM Analysis.

Lizeyka Jordan, David Russell, Dawon Baik, Frances Dooley, Ruth M Masterson Creber,

BACKGROUND:Use of hospice has grown among patients with heart failure; however, gaps remain in the ability of agencies to tailor services to meet their needs. AIM:This study describes the implementation of a cardiac home hospice program and insights for dissemination to other hospice programs. DESIGN:We conducted a multimethod analysis structured ... Read more >>

Am J Hosp Palliat Care (The American journal of hospice & palliative care)
[2020, 37(11):925-935]

Cited: 0 times

View full text PDF listing >>



Home care nurses' identification of patients at risk of infection and their risk mitigation strategies: A qualitative interview study.

Dawn Dowding, David Russell, Marygrace Trifilio, Margaret V McDonald, Jingjing Shang,

BACKGROUND:There is an increase in the number of individuals who receive care at home. A significant proportion of these patients acquire infections during their care episode. Whilst there has been significant focus on strategies for infection prevention and control in acute care environments, there is a lack of research into ... Read more >>

Int J Nurs Stud (International journal of nursing studies)
[2020, 107:103617]

Cited: 0 times

View full text PDF listing >>



Building trust and facilitating goals of care conversations: A qualitative study in people with heart failure receiving home hospice care.

Dawon Baik, David Russell, Lizeyka Jordan, Daniel D Matlock, Frances Dooley, Ruth Masterson Creber,

BACKGROUND:Despite a majority of persons receiving hospice care in their homes, there are gaps in understanding how to facilitate goals of care conversations between persons with heart failure and healthcare providers. AIM:To identify barriers and facilitators which shape goals of care conversations for persons with heart failure in the context ... Read more >>

Palliat Med (Palliative medicine)
[2020, 34(7):925-933]

Cited: 0 times

View full text PDF listing >>



A Predictive Risk Model for Infection-Related Hospitalization Among Home Healthcare Patients.

Jingjing Shang, David Russell, Dawn Dowding, Margaret V McDonald, Christopher Murtaugh, Jianfang Liu, Elaine L Larson, Sridevi Sridharan, Carlin Brickner,

Infection prevention is a high priority for home healthcare (HHC), but tools are lacking to identify patients at highest risk of developing infections. The purpose of this study was to develop and test a predictive risk model to identify HHC patients at risk of an infection-related hospitalization or emergency department ... Read more >>

J Healthc Qual (Journal for healthcare quality : official publication of the National Association for Healthcare Quality)
[2020, 42(3):136-147]

Cited: 0 times

View full text PDF listing >>



Multicenter Efficacy Trial of a Percutaneous Radiofrequency System for the Reduction of Glabellar Lines.

James Newman, James Chan, Z Paul Lorenc, Braden C Stridde, David James Russell,

BACKGROUND:Bipolar percutaneous radiofrequency (RF) is an established method for ablation of distal peripheral branches of the facial nerve to produce weakness of the corrugator muscle. Recent developments to the Serene RF system (Serene Medical, Inc., Pleasanton, CA) allowing for safer and more predictable results highlighted a need for prospective clinical ... Read more >>

Aesthet Surg J (Aesthetic surgery journal)
[2020, 40(6):650-664]

Cited: 0 times

View full text PDF listing >>



Multiple Interventions for Diabetic Foot Ulcer Treatment Trial (MIDFUT): study protocol for a randomised controlled trial.

Sarah Brown, Jane Nixon, Myka Ransom, Rachael Gilberts, Nikki Dewhirst, Elizabeth McGinnis, Roberta Longo, Frances Game, Chris Bojke, Paul Chadwick, Akila Chandrasekar, Ian Chetter, Howard Collier, Catherine Fernandez, Shervanthi Homer-Vanniasinkam, Edward Jude, Richard Leigh, Richard Lomas, Peter Vowden, James Wason, Linda Sharples, David Russell,

INTRODUCTION:Diabetes affects more than 425 million people worldwide with a lifetime risk of diabetic foot ulcer (DFU) of up to 25%. Management includes wound debridement, wound dressings, offloading, treatment of infection and ischaemia, optimising glycaemic control; use of advanced adjuvant therapies is limited by high cost and lack of robust evidence. ... Read more >>

BMJ Open (BMJ open)
[2020, 10(4):e035947]

Cited: 0 times

View full text PDF listing >>



Advertisement

Disclaimer
1.3005 s