Full Text Journal Articles by
Author David Reynolds

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Electrokinetically-enhanced emplacement of lactate in a chlorinated solvent contaminated clay site to promote bioremediation.

Ainsley M Inglis, Nicholas A Head, Ahmed I A Chowdhury, Ariel Nunez Garcia, David A Reynolds, Dave Hogberg, Elizabeth Edwards, Line Lomheim, Kela Weber, Sarah J Wallace, Leanne M Austrins, Jennifer Hayman, Marlaina Auger, Audrey Sidebottom, Jake Eimers, Jason I Gerhard, Denis M O'Carroll,

Bioremediation through the injection of electron donors and bacterial cultures is effective at treating chlorinated solvent contamination. However, it has had limited application in low permeability zones where amendments cannot be delivered successfully. This field-scale study investigated the application of electrokinetics to enhance the delivery of lactate at a clay ... Read more >>

Water Res (Water research)
[2021, 201:117305]

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A clinical investigation into the ability of subjects with lung disease to provide breath specimens using the EvidenzerIRL evidential breath analyser in alcohol intoxicant driving in criminal justice evidence.

Sarah Dowling, David Reynolds, Aoife O'Reilly, Geraldine Nolan, Athiná Kranidi, Charles G Gallagher, Denis Cusack,

The EvidenzerIRL instrument has been in use as an evidential breath analyser in the application of drink driving laws in the Republic of Ireland since 2011. The result of the analysis is used as evidence in prosecutions before the Courts in per se offences of driving under the influence of ... Read more >>

J Forensic Leg Med (Journal of forensic and legal medicine)
[2021, 80:102175]

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RingdateR: A statistical and graphical tool for crossdating

David J Reynolds, David C Edge, Bryan A Black,

Crossdating is the defining technique of dendrochronology, ensuring that all measurements in a dataset are annually resolved and absolutely dated. This level of accuracy allows for the development of high-resolution environmental reconstructions of climate, disturbance, and productivity not only in trees, but also in other ring-forming organisms including fish, corals, ... Read more >>

(Dendrochronologia.)
[2021, 65:Not Available]

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Drugging DNA Damage Repair Pathways for Trinucleotide Repeat Expansion Diseases.

Caroline L Benn, Karl R Gibson, David S Reynolds,

DNA damage repair (DDR) mechanisms have been implicated in a number of neurodegenerative diseases (both genetically determined and sporadic). Consistent with this, recent genome-wide association studies in Huntington's disease (HD) and other trinucleotide repeat expansion diseases have highlighted genes involved in DDR mechanisms as modifiers for age of onset, rate ... Read more >>

J Huntingtons Dis (Journal of Huntington's disease)
[2021, 10(1):203-220]

Cited: 6 times

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Reduced Axial Scan Length Coronary Calcium Scoring Reduces Radiation Dose and Provides Adequate Clinical Decision-Making Before Coronary CT Angiography.

Colin R Young, David A Reynolds, Neil Gambill, Daniel I Brooks, Todd C Villines,

Extensive coronary artery calcium (CAC) diminishes the accuracy of coronary computed tomography angiography (CCTA). Many imagers adjust CCTA acquisition parameters depending on a preCCTA Agatston CAC score to optimize diagnostic accuracy. Typical preCCTA CAC imaging adds considerably to radiation exposure, partially attributable to imaging beyond the area known for highest ... Read more >>

Tomography (Tomography (Ann Arbor, Mich.))
[2020, 6(4):356-361]

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The Clinical Application of Polarization Pattern Perception.

Gary P Misson, Stephen J Anderson, Richard A Armstrong, Mark Gillett, David Reynolds,

<h4>Purpose</h4>Determine the repeatability of and optimum stimulus parameters for testing polarization pattern perception in a real-world clinical population, and assess the ability of polarization perception to distinguish normal from abnormal eyes.<h4>Methods</h4>Polarization perception was evaluated in staff and patients attending ophthalmology clinics at Warwick Hospital, UK. A series of visual stimuli ... Read more >>

Transl Vis Sci Technol (Translational vision science & technology)
[2020, 9(11):31]

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Multimodal Analysis of Composition and Spatial Architecture in Human Squamous Cell Carcinoma.

Andrew L Ji, Adam J Rubin, Kim Thrane, Sizun Jiang, David L Reynolds, Robin M Meyers, Margaret G Guo, Benson M George, Annelie Mollbrink, Joseph Bergenstråhle, Ludvig Larsson, Yunhao Bai, Bokai Zhu, Aparna Bhaduri, Jordan M Meyers, Xavier Rovira-Clavé, S Tyler Hollmig, Sumaira Z Aasi, Garry P Nolan, Joakim Lundeberg, Paul A Khavari,

Cell (Cell)
[2020, 182(6):1661-1662]

Cited: 6 times

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The dynamic, combinatorial cis-regulatory lexicon of epidermal differentiation

Daniel Kim, Viviana Risca, David Reynolds, James Chappell, Adam Rubin, Namyoung Jung, Laura Donohue, Arwa Kathiria, Minyi Shi, Zhixin Zhao, Harsh Deep, Howard Chang, Michael Snyder, William Greenleaf, Anshul Kundaje, Paul Khavari,

Transcription factors (TFs) bind DNA sequence motif vocabularies in cis-regulatory elements (CREs) to modulate chromatin state and gene expression during cell state transitions. A quantitative understanding of how motif lexicons influence dynamic regulatory activity has been elusive due to the combinatorial nature of the cis-regulatory code. To address this, we ... Read more >>

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Field test of electrokinetically-delivered thermally activated persulfate for remediation of chlorinated solvents in clay.

Nicholas A Head, Jason I Gerhard, Ainsley M Inglis, Ariel Nunez Garcia, Ahmed I A Chowdhury, David A Reynolds, Cjestmir V de Boer, Audrey Sidebottom, Leanne M Austrins, Jake Eimers, Denis M O'Carroll,

In situ chemical oxidation (ISCO) has demonstrated success in remediating soil and groundwater contaminated with chlorinated volatile organic compounds (CVOCs). However, its performance is often hindered in low-permeability or heterogeneous media due to an inability to effectively deliver the oxidants. This field-scale study investigated the novel approach of applying electrokinetics ... Read more >>

Water Res (Water research)
[2020, 183:116061]

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Multimodal Analysis of Composition and Spatial Architecture in Human Squamous Cell Carcinoma.

Andrew L Ji, Adam J Rubin, Kim Thrane, Sizun Jiang, David L Reynolds, Robin M Meyers, Margaret G Guo, Benson M George, Annelie Mollbrink, Joseph Bergenstråhle, Ludvig Larsson, Yunhao Bai, Bokai Zhu, Aparna Bhaduri, Jordan M Meyers, Xavier Rovira-Clavé, S Tyler Hollmig, Sumaira Z Aasi, Garry P Nolan, Joakim Lundeberg, Paul A Khavari,

To define the cellular composition and architecture of cutaneous squamous cell carcinoma (cSCC), we combined single-cell RNA sequencing with spatial transcriptomics and multiplexed ion beam imaging from a series of human cSCCs and matched normal skin. cSCC exhibited four tumor subpopulations, three recapitulating normal epidermal states, and a tumor-specific keratinocyte ... Read more >>

Cell (Cell)
[2020, 182(2):497-514.e22]

Cited: 32 times

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Maternally administered naltrexone and its major active metabolite 6β-naltrexol transport across the placental barrierin vitro

Rajeendra Pemathilaka, David Reynolds, Nicole Hashemi,

Opioid use disorder (OUD) has become a growing concern in the U.S. and has been a dominant presence among pregnant women, resulting in an unprecedented amount of prescription medications, particularly naltrexone (NTX), prescribed for pregnant women. Because of unknown potential harm that NTX can impose on the fetus and its ... Read more >>

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A clinical investigation into the ability of subjects with a lung disease to provide breath specimens using the Dräger 6510.

Sarah Dowling, David Reynolds, Aoife O'Reilly, Geraldine Nolan, Charles Gallagher, Denis Cusack,

In the enforcement of drink driving laws failing to provide a breath specimen for alcohol analysis at the roadside when requested by a Police Officer is an offence in many countries. Some drivers claim that a lung disease prevented their ability to be successful. This study aims to investigate the ... Read more >>

J Forensic Leg Med (Journal of forensic and legal medicine)
[2020, 72:101962]

Cited: 0 times

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Natural drivers of multidecadal Arctic sea ice variability over the last millennium.

Paul R Halloran, Ian R Hall, Matthew Menary, David J Reynolds, James D Scourse, James A Screen, Alessio Bozzo, Nick Dunstone, Steven Phipps, Andrew P Schurer, Tetsuo Sueyoshi, Tianjun Zhou, Freya Garry,

The climate varies due to human activity, natural climate cycles, and natural events external to the climate system. Understanding the different roles played by these drivers of variability is fundamental to predicting near-term climate change and changing extremes, and to attributing observed change to anthropogenic or natural factors. Natural drivers ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):688]

Cited: 1 time

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Design and Identification of a Novel, Functionally Subtype Selective GABAA Positive Allosteric Modulator (PF-06372865).

Robert M Owen, David Blakemore, Lishuang Cao, Neil Flanagan, Rebecca Fish, Karl R Gibson, Rachel Gurrell, Chan Woo Huh, Juha Kammonen, Elisabeth Mortimer-Cassen, Sarah A Nickolls, Kiyoyuki Omoto, Dafydd Owen, Andy Pike, David C Pryde, David S Reynolds, Rosemarie Roeloffs, Colin Rose, Clara Stead, Mifune Takeuchi, Joseph S Warmus, Christine Watson,

The design, optimization, and evaluation of a series of novel imidazopyridazine-based subtype-selective positive allosteric modulators (PAMs) for the GABA<sub>A</sub> ligand-gated ion channel are described. From a set of initial hits multiple subseries were designed and evaluated based on binding affinity and functional activity. As designing in the desired level of ... Read more >>

J Med Chem (Journal of medicinal chemistry)
[2019, 62(12):5773-5796]

Cited: 1 time

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Tackling gaps in developing life-changing treatments for dementia.

Rui Mauricio, Caroline Benn, John Davis, Gerry Dawson, Lee A Dawson, Alison Evans, Nick Fox, John Gallacher, Mike Hutton, John Isaac, Declan N C Jones, Lesley Jones, Giovanna Lalli, Vincenzo Libri, Simon Lovestone, Catherine Moody, Wendy Noble, Hugh Perry, James Pickett, David Reynolds, Craig Ritchie, Jonathan D Rohrer, Carol Routledge, James Rowe, Heather Snyder, Tara Spires-Jones, Jina Swartz, Luc Truyen, Paul Whiting, ,

Since the G8 dementia summit in 2013, a number of initiatives have been established with the aim of facilitating the discovery of a disease-modifying treatment for dementia by 2025. This report is a summary of the findings and recommendations of a meeting titled "Tackling gaps in developing life-changing treatments for ... Read more >>

Alzheimers Dement (N Y) (Alzheimer's & dementia (New York, N. Y.))
[2019, 5:241-253]

Cited: 1 time

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Curriculum-based outdoor learning for children aged 9-11: A qualitative analysis of pupils' and teachers' views.

Emily Marchant, Charlotte Todd, Roxanne Cooksey, Samuel Dredge, Hope Jones, David Reynolds, Gareth Stratton, Russell Dwyer, Ronan Lyons, Sinead Brophy,

The relationship between child health, wellbeing and education demonstrates that healthier and happier children achieve higher educational attainment. An engaging curriculum that facilitates children in achieving their academic potential has strong implications for educational outcomes, future employment prospects, and health and wellbeing during adulthood. Outdoor learning is a pedagogical approach ... Read more >>

PLoS One (PloS one)
[2019, 14(5):e0212242]

Cited: 3 times

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Publisher Correction: Myelodysplastic syndrome progression to acute myeloid leukemia at the stem cell level.

Jiahao Chen, Yun-Ruei Kao, Daqian Sun, Tihomira I Todorova, David Reynolds, Swathi-Rao Narayanagari, Cristina Montagna, Britta Will, Amit Verma, Ulrich Steidl,

In the version of this article originally published, Ulrich Steidl's name was listed as "and Ulrich Steidl." His name has been updated to "Ulrich Steidl." The error has been fixed in the print, PDF and HTML versions of this article. ... Read more >>

Nat Med (Nature medicine)
[2019, 25(3):529]

Cited: 0 times

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Photosensitive epilepsy: Robust clinical efficacy of a selective GABA potentiator.

Rachel Gurrell, Donal Gorman, Mark Whitlock, Adam Ogden, David S Reynolds, Bree DiVentura, Bassel Abou-Khalil, Michael Gelfand, John Pollard, R Edward Hogan, Gregory Krauss, Michael Sperling, Blanca Vazquez, Robert T Wechsler, Daniel Friedman, Richard P Butt, Jacqueline French,

<h4>Objective</h4>The objective of this phase 2a study was to assess the activity of PF-06372865, a positive allosteric modulator (PAM) of α2/3/5 subunit-containing GABA<sub>A</sub> receptors with minimal activity at α1-containing receptors, which are believed to mediate many of the adverse events associated with benzodiazepines, in the epilepsy photosensitivity model as a ... Read more >>

Neurology (Neurology)
[2019, 92(15):e1786-e1795]

Cited: 1 time

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A short perspective on the long road to effective treatments for Alzheimer's disease.

David S Reynolds,

Globally, there are approximately 47 million people living with dementia, and about two thirds of those have Alzheimer's disease (AD). Age is the single biggest risk factor for the vast majority of sporadic AD cases, and because the world's population is aging, the number of people living with AD is ... Read more >>

Br J Pharmacol (British journal of pharmacology)
[2019, 176(18):3636-3648]

Cited: 3 times

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Human Pluripotent Stem Cell-Derived Multipotent Vascular Progenitors of the Mesothelium Lineage Have Utility in Tissue Engineering and Repair.

Thomas Colunga, Miranda Hayworth, Sebastian Kreß, David M Reynolds, Luoman Chen, Kristopher L Nazor, Johannes Baur, Amar M Singh, Jeanne F Loring, Marco Metzger, Stephen Dalton,

In this report we describe a human pluripotent stem cell-derived vascular progenitor (MesoT) cell of the mesothelium lineage. MesoT cells are multipotent and generate smooth muscle cells, endothelial cells, and pericytes and self-assemble into vessel-like networks in vitro. MesoT cells transplanted into mechanically damaged neonatal mouse heart migrate into the injured ... Read more >>

Cell Rep (Cell reports)
[2019, 26(10):2566-2579.e10]

Cited: 5 times

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Mapping Solar System chaos with the Geological Orrery.

Paul E Olsen, Jacques Laskar, Dennis V Kent, Sean T Kinney, David J Reynolds, Jingeng Sha, Jessica H Whiteside,

The Geological Orrery is a network of geological records of orbitally paced climate designed to address the inherent limitations of solutions for planetary orbits beyond 60 million years ago due to the chaotic nature of Solar System motion. We use results from two scientific coring experiments in Early Mesozoic continental ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2019, 116(22):10664-10673]

Cited: 2 times

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Curriculum-based outdoor learning for children aged 9-11: A qualitative analysis of pupils’ and teachers’ views

Emily Marchant, Charlotte Todd, Roxanne Cooksey, Samuel Dredge, Hope Jones, David Reynolds, Gareth Stratton, Russell Dwyer, Ronan Lyons, Sinead Brophy,

The relationship between child health, wellbeing and education demonstrates that healthier and happier children achieve higher educational attainment. An engaging curriculum that facilitates children in achieving their academic potential has strong implications for educational outcomes, future employment prospects and health and wellbeing during adulthood. Outdoor learning is a pedagogical approach ... Read more >>

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The revolution of crossdating in marine palaeoecology and palaeoclimatology.

Bryan A Black, Carin Andersson, Paul G Butler, Michael L Carroll, Kristine L DeLong, David J Reynolds, Bernd R Schöne, James Scourse, Peter van der Sleen, Alan D Wanamaker, Rob Witbaard,

Over the past century, the dendrochronology technique of crossdating has been widely used to generate a global network of tree-ring chronologies that serves as a leading indicator of environmental variability and change. Only recently, however, has this same approach been applied to growth increments in calcified structures of bivalves, fish ... Read more >>

Biol Lett (Biology letters)
[2019, 15(1):20180665]

Cited: 0 times

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Myelodysplastic syndrome progression to acute myeloid leukemia at the stem cell level.

Jiahao Chen, Yun-Ruei Kao, Daqian Sun, Tihomira I Todorova, David Reynolds, Swathi-Rao Narayanagari, Cristina Montagna, Britta Will, Amit Verma, Ulrich Steidl,

Myelodysplastic syndromes (MDS) frequently progress to acute myeloid leukemia (AML); however, the cells leading to malignant transformation have not been directly elucidated. As progression of MDS to AML in humans provides a biological system to determine the cellular origins and mechanisms of neoplastic transformation, we studied highly fractionated stem cell ... Read more >>

Nat Med (Nature medicine)
[2019, 25(1):103-110]

Cited: 46 times

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A randomised, placebo-controlled clinical trial with the α2/3/5 subunit selective GABAA positive allosteric modulator PF-06372865 in patients with chronic low back pain.

Rachel Gurrell, Pinky Dua, Gang Feng, Maria Sudworth, Mark Whitlock, David S Reynolds, Richard P Butt,

The effect of PF-06372865, a subtype-selective positive allosteric modulator of the γ-aminobutyric acid type A (GABAA) receptor, on chronic low back pain was investigated in a randomised, placebo- and active-controlled phase 2 clinical trial. The parallel treatment group trial consisted of a 1-week single-blind placebo run in the phase, followed ... Read more >>

Pain (Pain)
[2018, 159(9):1742-1751]

Cited: 6 times

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