Full Text Journal Articles by
Author David N Cornfield

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Editorial: Covid-19 and respiratory illness in children: seeking knowledge, discerning truth.

David N Cornfield,

Curr Opin Pediatr (Current opinion in pediatrics)
[2021, 33(3):292-293]

Cited: 0 times

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Coronavirus disease 2019 respiratory disease in children: clinical presentation and pathophysiology.

Lea C Steffes, David N Cornfield,

<h4>Purpose of review</h4>Pediatric coronavirus disease 2019 (COVID-19) respiratory disease is a distinct entity from adult illness, most notable in its milder phenotype. This review summarizes the current knowledge of the clinical patterns, cellular pathophysiology, and epidemiology of COVID-19 respiratory disease in children with specific attention toward factors that account for ... Read more >>

Curr Opin Pediatr (Current opinion in pediatrics)
[2021, 33(3):302-310]

Cited: 0 times

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Novel Prescriptions From Medical Schools for Physician-Scientist Training and Engagement in the Twenty-First Century.

Rolly L Simpson, David N Cornfield, John E Burris,

Physicians engaged in biomedical research are well positioned to directly focus the discovery process on human biology. However, the relative proportion of investigators engaged in both caring for patients and conducting research is decreasing. To address the dwindling numbers of physician-scientists nationally, the Burroughs Wellcome Fund created the Physician-Scientist Institutional ... Read more >>

Acad Med (Academic medicine : journal of the Association of American Medical Colleges)
[2021, 96(4):512-515]

Cited: 0 times

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Mentor-Mentee interactions: a 2-way street. The APS-SPR virtual chat series.

David N Cornfield, Tessie W October, Anne M Libby, Steven H Abman,

Pediatr Res (Pediatric research)
[2021, :]

Cited: 0 times

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Three Infants with Pathogenic Variants in the ABCA3 Gene: Presentation, Treatment, and Clinical Course.

Xin Si, Lea C Steffes, Jennifer C Schymick, Florette K Hazard, Michael C Tracy, David N Cornfield,

ABCA3 deficiency is a rare cause of neonatal respiratory failure. Biallelic complete loss of function variants lead to neonatal demise without lung transplantation, but children with partial function variants have variable outcomes. The favorable clinical course of 3 such infants presenting with respiratory distress at birth is described. ... Read more >>

J Pediatr (The Journal of pediatrics)
[2021, 231:278-283.e2]

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Vitamin D: Feel It in More Than Just Your Bones!

David N Cornfield,

Am J Respir Cell Mol Biol (American journal of respiratory cell and molecular biology)
[2020, 63(1):11-12]

Cited: 0 times

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A proposal for the addressing the needs of the pediatric pulmonary work force.

Benjamin Gaston, Theresa A Laguna, Terry L Noah, James Hagood, Judith Voynow, Thomas Ferkol, Marc Hershenson, Katie Boyne, Angela Delecaris, Kristie Ross, David Gozal, Juan C Celedón, Steven H Abman, Paul Moore, Stephanie Davis, David N Cornfield, Thomas Murphy,

Unprecedented opportunities and daunting difficulties are anticipated in the future of pediatric pulmonary medicine. To address these issues and optimize pediatric pulmonary training, a group of faculty from various institutions met in 2019 and proposed specific, long-term solutions to the emerging problems in the field. Input on these ideas was ... Read more >>

Pediatr Pulmonol (Pediatric pulmonology)
[2020, 55(8):1859-1867]

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Diverse homeostatic and immunomodulatory roles of immune cells in the developing mouse lung at single cell resolution.

Racquel Domingo-Gonzalez, Fabio Zanini, Xibing Che, Min Liu, Robert C Jones, Michael A Swift, Stephen R Quake, David N Cornfield, Cristina M Alvira,

At birth, the lungs rapidly transition from a pathogen-free, hypoxic environment to a pathogen-rich, rhythmically distended air-liquid interface. Although many studies have focused on the adult lung, the perinatal lung remains unexplored. Here, we present an atlas of the murine lung immune compartment during early postnatal development. We show that ... Read more >>

Elife (eLife)
[2020, 9:]

Cited: 3 times

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Editorial: Pediatric Pulmonology 2020, replacing fear with hope!

David N Cornfield,

Curr Opin Pediatr (Current opinion in pediatrics)
[2020, 32(3):376-377]

Cited: 0 times

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Mucus plugging, air trapping, and bronchiectasis are important outcome measures in assessing progressive childhood cystic fibrosis lung disease.

Terry E Robinson, Michael L Goris, Richard B Moss, Lu Tian, Peiyi Kan, Mignote Yilma, Karen S McCoy, Beverley Newman, Pim A de Jong, Frederick R Long, Alan S Brody, Rhett Behrje, Denise P Yates, David N Cornfield,

OBJECTIVE:To determine which outcome measures could detect early progression of disease in school-age children with mild cystic fibrosis (CF) lung disease over a two-year time interval utilizing chest computed tomography (CT) scores, quantitative CT air trapping (QAT), and spirometric measurements. METHODS:Thirty-six school-age children with mild CF lung disease (median [interquartile ... Read more >>

Pediatr Pulmonol (Pediatric pulmonology)
[2020, 55(4):929-938]

Cited: 2 times

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Editorial: Pediatric pulmonology, ever changing, but happily in the same, old boat.

David N Cornfield,

Curr Opin Pediatr (Current opinion in pediatrics)
[2019, 31(3):328-329]

Cited: 0 times

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Passive Nocturnal Physiologic Monitoring Enables Early Detection of Exacerbations in Children with Asthma. A Proof-of-Concept Study.

Michelle F Huffaker, Michael Carchia, Bronwyn U Harris, William C Kethman, Todd E Murphy, Charlotte C D Sakarovitch, FeiFei Qin, David N Cornfield,

RATIONALE:Asthma management depends on prompt identification of symptoms, which challenges both patients and providers. In asthma, a misapprehension of health between exacerbations can compromise compliance. Thus, there is a need for a tool that permits objective longitudinal monitoring without increasing the burden of patient compliance. OBJECTIVES:We sought to determine whether ... Read more >>

Am J Respir Crit Care Med (American journal of respiratory and critical care medicine)
[2018, 198(3):320-328]

Cited: 7 times

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The Effect of Combining Business Training, Microfinance, and Support Group Participation on Economic Status and Intimate Partner Violence in an Unplanned Settlement of Nairobi, Kenya.

Clea C Sarnquist, Linda Ouma, Nickson Lang'at, Chrisanthus Lubanga, Jake Sinclair, Michael T Baiocchi, David N Cornfield,

Intimate partner violence (IPV) has myriad negative health and economic consequences for women and families. We hypothesized that empowering women through a combination of formal business training, microfinance, and IPV support groups would decrease IPV and improve women's economic status. The study included adult female survivors of severe IPV. Women ... Read more >>

J Interpers Violence (Journal of interpersonal violence)
[2021, 36(7-8):3903-3921]

Cited: 1 time

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Settling the Score in Pulmonary Hypertension?

Rachel K Hopper, David N Cornfield,

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2018, 19(8):782-783]

Cited: 0 times

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Pulmonary artery smooth muscle cell HIF-1α regulates endothelin expression via microRNA-543.

Ching-Chia Wang, Lihua Ying, Elizabeth A Barnes, Eloa S Adams, Francis Y Kim, Karl W Engel, Cristina M Alvira, David N Cornfield,

Pulmonary artery smooth muscle cells (PASMCs) express endothelin (ET-1), which modulates the pulmonary vascular response to hypoxia. Although cross-talk between hypoxia-inducible factor-1α (HIF-1α), an O2-sensitive transcription factor, and ET-1 is established, the cell-specific relationship between HIF-1α and ET-1 expression remains incompletely understood. We tested the hypotheses that in PASMCs 1) ... Read more >>

Am J Physiol Lung Cell Mol Physiol (American journal of physiology. Lung cellular and molecular physiology)
[2018, 315(3):L422-L431]

Cited: 5 times

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Pediatric pulmonary medicine: at the nexus of care and discovery.

David N Cornfield,

Curr Opin Pediatr (Current opinion in pediatrics)
[2018, 30(3):364-365]

Cited: 0 times

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β1-Subunit of the calcium-sensitive potassium channel modulates the pulmonary vascular smooth muscle cell response to hypoxia.

Elizabeth A Barnes, Lori Lee, Shayna L Barnes, Robert Brenner, Cristina M Alvira, David N Cornfield,

Accessory subunits associated with the calcium-sensitive potassium channel (BK<sub>Ca</sub>), a major determinant of vascular tone, confer functional and anatomical diversity. The β1 subunit increases Ca<sup>2+</sup> and voltagesensitivity of the BK<sub>Ca</sub> channel and is expressed exclusively in smooth muscle cells. Evidence supporting the physiological significance of the β1 subunit includes the ... Read more >>

Am J Physiol Lung Cell Mol Physiol (American journal of physiology. Lung cellular and molecular physiology)
[2018, 315(2):L265-L275]

Cited: 0 times

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The evolution of disease: chronic lung disease of infancy and pulmonary hypertension.

Michael C Tracy, David N Cornfield,

<h4>Purpose of review</h4>Bronchopulmonary dysplasia (BPD) or chronic lung disease of infancy BPD was originally described 50 years ago, in 1967 by Northway et al. This article possesses two fundamental objectives to provide: a brief historical perspective on BPD; and an update relative to current notions of epidemiology, pathophysiology, evaluation, and ... Read more >>

Curr Opin Pediatr (Current opinion in pediatrics)
[2017, 29(3):320-325]

Cited: 2 times

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Children With Bronchiolitis on High-Flow Nasal Cannula: To Feed or Not Feed, That Is Not the Only Question.

Michael C Tracy, David N Cornfield,

Hosp Pediatr (Hospital pediatrics)
[2017, 7(5):297-299]

Cited: 1 time

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Pediatric pulmonary medicine, then and next.

David N Cornfield,

Curr Opin Pediatr (Current opinion in pediatrics)
[2017, 29(3):303-304]

Cited: 1 time

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Unique aspects of the developing lung circulation: structural development and regulation of vasomotor tone.

Yuangsheng Gao, David N Cornfield, Kurt R Stenmark, Bernard Thébaud, Steven H Abman, J Usha Raj,

This review summarizes our current knowledge on lung vasculogenesis and angiogenesis during normal lung development and the regulation of fetal and postnatal pulmonary vascular tone. In comparison to that of the adult, the pulmonary circulation of the fetus and newborn displays many unique characteristics. Moreover, altered development of pulmonary vasculature ... Read more >>

Pulm Circ (Pulmonary circulation)
[2016, 6(4):407-425]

Cited: 16 times

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Loss of smooth muscle cell hypoxia inducible factor-1α underlies increased vascular contractility in pulmonary hypertension.

Elizabeth A Barnes, Chih-Hsin Chen, Oshra Sedan, David N Cornfield,

Pulmonary arterial hypertension (PAH) is an often fatal disease with limited treatment options. Whereas current data support the notion that, in pulmonary artery endothelial cells (PAECs), expression of transcription factor hypoxia inducible factor-1α (HIF-1α) is increased, the role of HIF-1α in pulmonary artery smooth muscle cells (PASMCs) remains controversial. This ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2017, 31(2):650-662]

Cited: 16 times

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There Is No "I" in Team: New Challenges for Career Development in the Era of Team Science.

Anne M Libby, David N Cornfield, Steven H Abman,

J Pediatr (The Journal of pediatrics)
[2016, 177:4-5]

Cited: 4 times

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Hypoxia-inducible factor-1 plays a role in phosphate-induced vascular smooth muscle cell calcification.

Sophie Mokas, Richard Larivière, Laurent Lamalice, Stéphane Gobeil, David N Cornfield, Mohsen Agharazii, Darren E Richard,

Medial vascular calcification is a common complication of chronic kidney disease (CKD). Although elevated inorganic phosphate stimulates vascular smooth muscle cell (VSMC) osteogenic transdifferentiation and calcification, the mechanisms involved in their calcification during CKD are not fully defined. Because hypoxic gene activation is linked to CKD and stimulates bone cell ... Read more >>

Kidney Int (Kidney international)
[2016, 90(3):598-609]

Cited: 22 times

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Pediatric pulmonology: with thin phenotyping and deep genotyping, knowledge is power.

David N Cornfield,

Curr Opin Pediatr (Current opinion in pediatrics)
[2016, 28(3):310-311]

Cited: 0 times

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