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Association between convalescent plasma treatment and mortality in COVID-19: a collaborative systematic review and meta-analysis of randomized clinical trials.

Cathrine Axfors, Perrine Janiaud, Andreas M Schmitt, Janneke Van't Hooft, Emily R Smith, Noah A Haber, Akin Abayomi, Manal Abduljalil, Abdulkarim Abdulrahman, Yeny Acosta-Ampudia, Manuela Aguilar-Guisado, Farah Al-Beidh, Marissa M Alejandria, Rachelle N Alfonso, Mohammad Ali, Manaf AlQahtani, Alaa AlZamrooni, Juan-Manuel Anaya, Mark Angelo C Ang, Ismael F Aomar, Luis E Argumanis, Alexander Averyanov, Vladimir P Baklaushev, Olga Balionis, Thomas Benfield, Scott Berry, Nadia Birocco, Lynn B Bonifacio, Asha C Bowen, Abbie Bown, Carlos Cabello-Gutierrez, Bernardo Camacho, Adrian Camacho-Ortiz, Sally Campbell-Lee, Damon H Cao, Ana Cardesa, Jose M Carnate, German Jr J Castillo, Rossana Cavallo, Fazle R Chowdhury, Forhad U H Chowdhury, Giovannino Ciccone, Antonella Cingolani, Fresthel Monica M Climacosa, Veerle Compernolle, Carlo Francisco N Cortez, Abel Costa Neto, Sergio D'Antico, James Daly, Franca Danielle, Joshua S Davis, Francesco Giuseppe De Rosa, Justin T Denholm, Claudia M Denkinger, Daniel Desmecht, Juan C Díaz-Coronado, Juan A Díaz Ponce-Medrano, Anne-Françoise Donneau, Teresita E Dumagay, Susanna Dunachie, Cecile C Dungog, Olufemi Erinoso, Ivy Mae S Escasa, Lise J Estcourt, Amy Evans, Agnes L M Evasan, Christian J Fareli, Veronica Fernandez-Sanchez, Claudia Galassi, Juan E Gallo, Patricia J Garcia, Patricia L Garcia, Jesus A Garcia, Mutien Garigliany, Elvira Garza-Gonzalez, Deonne Thaddeus V Gauiran, Paula A Gaviria García, Jose-Antonio Giron-Gonzalez, David Gómez-Almaguer, Anthony C Gordon, André Gothot, Jeser Santiago Grass Guaqueta, Cameron Green, David Grimaldi, Naomi E Hammond, Heli Harvala, Francisco M Heralde, Jesica Herrick, Alisa M Higgins, Thomas E Hills, Jennifer Hines, Karin Holm, Ashraful Hoque, Eric Hoste, Jose M Ignacio, Alexander V Ivanov, Maike Janssen, Jeffrey H Jennings, Vivekanand Jha, Ruby Anne N King, Jens Kjeldsen-Kragh, Paul Klenerman, Aditya Kotecha, Fiorella Krapp, Luciana Labanca, Emma Laing, Mona Landin-Olsson, Pierre-François Laterre, Lyn-Li Lim, Jodor Lim, Oskar Ljungquist, Jorge M Llaca-Díaz, Concepción López-Robles, Salvador López-Cárdenas, Ileana Lopez-Plaza, Josephine Anne C Lucero, Maria Lundgren, Juan Macías, Sandy C Maganito, Anna Flor G Malundo, Rubén D Manrique, Paola M Manzini, Miguel Marcos, Ignacio Marquez, Francisco Javier Martínez-Marcos, Ana M Mata, Colin J McArthur, Zoe K McQuilten, Bryan J McVerry, David K Menon, Geert Meyfroidt, Ma Angelina L Mirasol, Benoît Misset, James S Molton, Alric V Mondragon, Diana M Monsalve, Parastoo Moradi Choghakabodi, Susan C Morpeth, Paul R Mouncey, Michel Moutschen, Carsten Müller-Tidow, Erin Murphy, Tome Najdovski, Alistair D Nichol, Henrik Nielsen, Richard M Novak, Matthew V N O'Sullivan, Julian Olalla, Akin Osibogun, Bodunrin Osikomaiya, Salvador Oyonarte, Juan M Pardo-Oviedo, Mahesh C Patel, David L Paterson, Carlos A Peña-Perez, Angel A Perez-Calatayud, Eduardo Pérez-Alba, Anastasia Perkina, Naomi Perry, Mandana Pouladzadeh, Inmaculada Poyato, David J Price, Anne Kristine H Quero, Md M Rahman, Md S Rahman, Mayur Ramesh, Carolina Ramírez-Santana, Magnus Rasmussen, Megan A Rees, Eduardo Rego, Jason A Roberts, David J Roberts, Yhojan Rodríguez, Jesús Rodríguez-Baño, Benjamin A Rogers, Manuel Rojas, Alberto Romero, Kathryn M Rowan, Fabio Saccona, Mehdi Safdarian, Maria Clariza M Santos, Joe Sasadeusz, Gitana Scozzari, Manu Shankar-Hari, Gorav Sharma, Thomas Snelling, Alonso Soto, Pedrito Y Tagayuna, Amy Tang, Geneva Tatem, Luciana Teofili, Steven Y C Tong, Alexis F Turgeon, Januario D Veloso, Balasubramanian Venkatesh, Yanet Ventura-Enriquez, Steve A Webb, Lothar Wiese, Christian Wikén, Erica M Wood, Gaukhar M Yusubalieva, Kai Zacharowski, Ryan Zarychanski, Nina Khanna, David Moher, Steven N Goodman, John P A Ioannidis, Lars G Hemkens,

<h4>Background</h4>Convalescent plasma has been widely used to treat COVID-19 and is under investigation in numerous randomized clinical trials, but results are publicly available only for a small number of trials. The objective of this study was to assess the benefits of convalescent plasma treatment compared to placebo or no treatment ... Read more >>

BMC Infect Dis (BMC infectious diseases)
[2021, 21(1):1170]

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A survey of biomedical journals to detect editorial bias and nepotistic behavior.

Alexandre Scanff, Florian Naudet, Ioana A Cristea, David Moher, Dorothy V M Bishop, Clara Locher,

Alongside the growing concerns regarding predatory journal growth, other questionable editorial practices have gained visibility recently. Among them, we explored the usefulness of the Percentage of Papers by the Most Prolific author (PPMP) and the Gini index (level of inequality in the distribution of authorship among authors) as tools to ... Read more >>

PLoS Biol (PLoS biology)
[2021, 19(11):e3001133]

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Sex and gender considerations in reporting guidelines for health research: a systematic review.

Amédé Gogovor, Hervé Tchala Vignon Zomahoun, Giraud Ekanmian, Évèhouénou Lionel Adisso, Alèxe Deom Tardif, Lobna Khadhraoui, Nathalie Rheault, David Moher, France Légaré,

<h4>Background</h4>Despite growing recognition of the importance of sex and gender considerations in health research, they are rarely integrated into research design and reporting. We sought to assess the integration of sex, as a biological attribute, and gender, as a socially constructed identity, in published reporting guidelines.<h4>Methods</h4>We conducted a systematic review ... Read more >>

Biol Sex Differ (Biology of sex differences)
[2021, 12(1):62]

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Improving peer review of systematic reviews by involving librarians and information specialists: protocol for a randomized controlled trial.

Melissa L Rethlefsen, Sara Schroter, Lex M Bouter, David Moher, Ana Patricia Ayala, Jamie J Kirkham, Maurice P Zeegers,

<h4>Background</h4>Problems continue to exist with the reporting quality and risk of bias in search methods and strategies in systematic reviews and related review types. Peer reviewers who are not familiar with what is required to transparently and fully report a search may not be prepared to review the search components ... Read more >>

Trials (Trials)
[2021, 22(1):791]

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Implementing Incentives and Rewards to Improve the Research Ecosystem.

David Moher,

JAMA Netw Open (JAMA network open)
[2021, 4(11):e2138622]

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Commentary: Reporting Guidelines for Studies on Artificial Intelligence: What Neurosurgeons Should Know.

Nathan A Shlobin, David Moher,

Neurosurgery (Neurosurgery)
[2021, 89(6):E316-E317]

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Reporting Policies in Neurosurgical Journals: A Meta-Science Study of the Current State and Case for Standardization.

Nathan A Shlobin, Andrew Wang, Christopher S Graffeo, David Moher,

<h4>Background</h4>Reporting quality within the neurosurgical literature is low, limiting the ability of journals to act as gatekeepers for evidence-based neurosurgical care. Journal policies during article submission aim to improve reporting quality. We conducted a meta-science study characterizing the reporting policies of neurosurgical journals and other related peer-reviewed publications.<h4>Methods</h4>Journals were retrieved ... Read more >>

World Neurosurg (World neurosurgery)
[2021, 158:11-23]

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Introduction to PRISMA 2020 and implications for research synthesis methodologists.

Matthew J Page, David Moher, Joanne E McKenzie,

Systematic reviews should be reported completely and accurately so that users can interpret and appraise the review findings appropriately. In this commentary, we describe key features of a major update of the Preferred Reporting Items for Systematic reviews and Meta-Analyses statement-PRISMA 2020-and discuss its implications for research synthesis methodologists. ... Read more >>

Res Synth Methods (Research synthesis methods)
[2021, :]

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Medical journal requirements for clinical trial data sharing: Ripe for improvement.

Florian Naudet, Maximilian Siebert, Claude Pellen, Jeanne Gaba, Cathrine Axfors, Ioana Cristea, Valentin Danchev, Ulrich Mansmann, Christian Ohmann, Joshua D Wallach, David Moher, John P A Ioannidis,

Florian Naudet and co-authors discuss strengthening requirements for sharing clinical trial data. ... Read more >>

PLoS Med (PLoS medicine)
[2021, 18(10):e1003844]

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Correction to: Anesthesia interventions that alter perioperative mortality: a scoping review.

Sylvain Boet, Cole Etherington, David Nicola, Andrew Beck, Susan Bragg, Ian D Carrigan, Sarah Larrigan, Cassandra T Mendonca, Isaac Miao, Tatyana Postonogova, Benjamin Walker, José De Wit, Karim Mohamed, Nadia Balaa, Manoj Mathew Lalu, Daniel I McIsaac, David Moher, Adrienne Stevens, Donald Miller, ,

Syst Rev (Systematic reviews)
[2021, 10(1):272]

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Commentary: Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 Statement: What Neurosurgeons Should Know.

Nathan A Shlobin, David Moher,

Neurosurgery (Neurosurgery)
[2021, 89(5):E267-E268]

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A quality assessment tool for artificial intelligence-centered diagnostic test accuracy studies: QUADAS-AI.

Viknesh Sounderajah, Hutan Ashrafian, Sherri Rose, Nigam H Shah, Marzyeh Ghassemi, Robert Golub, Charles E Kahn, Andre Esteva, Alan Karthikesalingam, Bilal Mateen, Dale Webster, Dan Milea, Daniel Ting, Darren Treanor, Dominic Cushnan, Dominic King, Duncan McPherson, Ben Glocker, Felix Greaves, Leanne Harling, Johan Ordish, Jérémie F Cohen, Jon Deeks, Mariska Leeflang, Matthew Diamond, Matthew D F McInnes, Melissa McCradden, Michael D Abràmoff, Pasha Normahani, Sheraz R Markar, Stephanie Chang, Xiaoxuan Liu, Susan Mallett, Shravya Shetty, Alastair Denniston, Gary S Collins, David Moher, Penny Whiting, Patrick M Bossuyt, Ara Darzi,

Nat Med (Nature medicine)
[2021, 27(10):1663-1665]

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Implementing the 27 PRISMA 2020 Statement items for systematic reviews in the sport and exercise medicine, musculoskeletal rehabilitation and sports science fields: the PERSiST (implementing Prisma in Exercise, Rehabilitation, Sport medicine and SporTs science) guidance.

Clare L Ardern, Fionn Büttner, Renato Andrade, Adam Weir, Maureen C Ashe, Sinead Holden, Franco M Impellizzeri, Eamonn Delahunt, H Paul Dijkstra, Stephanie Mathieson, Michael Skovdal Rathleff, Guus Reurink, Catherine Sherrington, Emmanuel Stamatakis, Bill Vicenzino, Jackie L Whittaker, Alexis A Wright, Mike Clarke, David Moher, Matthew J Page, Karim M Khan, Marinus Winters,

Poor reporting of medical and healthcare systematic reviews is a problem from which the sports and exercise medicine, musculoskeletal rehabilitation, and sports science fields are not immune. Transparent, accurate and comprehensive systematic review reporting helps researchers replicate methods, readers understand what was done and why, and clinicians and policy-makers implement ... Read more >>

Br J Sports Med (British journal of sports medicine)
[2021, :]

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Reporting transparency and completeness in trials: Paper 3 - trials conducted using administrative databases do not adequately report elements related to use of databases.

Mahrukh Imran, Kimberly Mc Cord, Stephen J McCall, Linda Kwakkenbos, Margaret Sampson, Ole Fröbert, Chris Gale, Lars G Hemkens, Sinéad M Langan, David Moher, Clare Relton, Merrick Zwarenstein, Edmund Juszczak, Brett D Thombs, ,

<h4>Objective</h4>We evaluated reporting completeness and transparency in randomized controlled trials (RCTs) conducted using administrative data based on 2021 CONSORT Extension for Trials Conducted Using Cohorts and Routinely Collected Data (CONSORT-ROUTINE) criteria.<h4>Study design and setting</h4>MEDLINE and the Cochrane Methodology Register were searched (2011 and 2018). Eligible RCTs used administrative databases for ... Read more >>

J Clin Epidemiol (Journal of clinical epidemiology)
[2021, :]

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Reporting transparency and completeness in trials: Paper 4 - reporting of randomised controlled trials conducted using routinely collected electronic records - room for improvement.

Stephen J McCall, Mahrukh Imran, Lars G Hemkens, Kimberly Mc Cord, Linda Kwakkenbos, Margaret Sampson, Sena Jawad, Merrick Zwarenstein, Clare Relton, Sinéad M Langan, David Moher, Ole Fröbert, Brett D Thombs, Chris Gale, Edmund Juszczak, ,

<h4>Objective</h4>To describe characteristics of randomized controlled trials (RCTs) conducted using electronic health records (EHRs), including completeness and transparency of reporting assessed against the 2021 CONSORT Extension for RCTs Conducted Using Cohorts and Routinely Collected Data (CONSORT-ROUTINE) criteria.<h4>Study design</h4>MEDLINE and Cochrane Methodology Register were searched for a sample of RCTs published ... Read more >>

J Clin Epidemiol (Journal of clinical epidemiology)
[2021, :]

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Reporting transparency and completeness in Trials: Paper 2 - reporting of randomised trials using registries was often inadequate and hindered the interpretation of results.

Kimberly A Mc Cord, Mahrukh Imran, Danielle B Rice, Stephen J McCall, Linda Kwakkenbos, Margaret Sampson, Ole Fröbert, Chris Gale, Sinéad M Langan, David Moher, Clare Relton, Merrick Zwarenstein, Edmund Juszczak, Brett D Thombs, Lars G Hemkens, ,

<h4>Objective</h4>Registries are important data sources for randomized controlled trials (RCTs), but reporting of how they are used may be inadequate. The objective was to describe the current adequacy of reporting of RCTs using registries.<h4>Study design and setting</h4>We used a database of trials using registries from a scoping review supporting the ... Read more >>

J Clin Epidemiol (Journal of clinical epidemiology)
[2021, :]

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Tranexamic acid for prevention of bleeding in cesarean delivery: An overview of systematic reviews.

Tomi Hurskainen, Mimi X Deng, Cole Etherington, Joseph K Burns, Leonardo Martin Calderon, David Moher, Wesley Edwards, Sylvain Boet,

<h4>Background</h4>Bleeding is the leading cause of maternal mortality in the world. Tranexamic acid reduces bleeding in trauma and surgery. Several systematic reviews of randomized trials have investigated tranexamic acid in the prevention of bleeding in cesarean delivery. However, the conclusions from systematic reviews are conflicting. This overview aims to summarize ... Read more >>

Acta Anaesthesiol Scand (Acta anaesthesiologica Scandinavica)
[2021, :]

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Establishing Patient Perceptions and Preferences for a Journal Authenticator Tool To Support Health Literacy: A Mixed-Methods Survey and Focus Group Study

Alicia Ricketts, Manoj Lalu, Laurie Proulx, Michael Halas, Gisell Castillo, Elham Almoli, Agnes Grudniewicz, Gregory Bryson, David Moher, Kelly Cobey,

<h4>Background: </h4> Predatory journals are illegitimate journals that do not meet expected publication best practices. Many of these journals can be found using Google, making them readily available to patients searching online for health information. The goal of this study was to obtain information about how patients use the internet ... Read more >>

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Status, use and impact of sharing individual participant data from clinical trials: a scoping review.

Christian Ohmann, David Moher, Maximilian Siebert, Edith Motschall, Florian Naudet,

<h4>Objectives</h4>To explore the impact of data-sharing initiatives on the intent to share data, on actual data sharing, on the use of shared data and on research output and impact of shared data.<h4>Eligibility criteria</h4>All studies investigating data-sharing practices for individual participant data (IPD) from clinical trials.<h4>Sources of evidence</h4>We searched the Medline ... Read more >>

BMJ Open (BMJ open)
[2021, 11(8):e049228]

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Do overly complex reporting guidelines remove the focus from good clinical trials?

Jeremy Howick, Rebecca Webster, J André Knottnerus, David Moher,

BMJ (BMJ (Clinical research ed.))
[2021, 374:n1793]

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A study protocol for the development of a SPIRIT extension for trials conducted using cohorts and routinely collected data (SPIRIT-ROUTINE)

Megan McCarthy, Linda O'Keeffe, Paula Williamson, Matthew Sydes, Amanda Farrin, Fiona Lugg-Widger, Gwyneth Davies, Kerry Avery, An-Wen Chan, Linda Kwakkenbos, Brett Thombs, Alan Watkins, Lars Hemkens, Chris Gale, Merrick Zwarenstein, Sinead Langan, Lehana Thabane, Edmund Juszczak, David Moher, Patricia Kearney,

Background:  Protocols are an essential document for conducting randomised controlled trials (RCTs). However, the completeness of the information provided is often inadequate. To help improve the content of trial protocols, an international group of stakeholders published the Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT) Initiative in 2013. Presently, there is ... Read more >>

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What difference might retractions make? An estimate of the potential epistemic cost of retractions on meta-analyses.

Daniele Fanelli, Julie Wong, David Moher,

The extent to which a retraction might require revising previous scientific estimates and beliefs - which we define as the epistemic cost - is unknown. We collected a sample of 229 meta-analyses published between 2013 and 2016 that had cited a retracted study, assessed whether this study was included in ... Read more >>

Account Res (Accountability in research)
[2021, :1-18]

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Operational Definition of Complementary, Alternative, and Integrative Medicine Derived from a Systematic Search

Jeremy Ng, Tushar Dhawan, Ekaterina Dogadova, Zhala Taghi-Zada, Alexandra Vacca, Susan Wieland, David Moher,

<h4>Background: </h4> Identifying what therapies constitute complementary, alternative, and/or integrative medicine (CAIM) is complex for a multitude of reasons. An operational definition is dynamic, and changes based on both historical time period and geographical location whereby many jurisdictions may integrate or consider their traditional system(s) of medicine as conventional care. ... Read more >>

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Recommendations for including or reviewing patient reported outcome endpoints in grant applications.

Claire Snyder, Alexandra Gilbert, David Moher, Derek Kyte, Ellie Daniels, Madeleine King, Melanie Calvert, Ronald C Chen, Michael Brundage, ,

BMJ (BMJ (Clinical research ed.))
[2021, 373:n1367]

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Guidelines for Reporting Trial Protocols and Completed Trials Modified Due to the COVID-19 Pandemic and Other Extenuating Circumstances: The CONSERVE 2021 Statement.

Aaron M Orkin, Peter J Gill, Davina Ghersi, Lisa Campbell, Jeremy Sugarman, Richard Emsley, Philippe Gabriel Steg, Charles Weijer, John Simes, Tanja Rombey, Hywel C Williams, Janet Wittes, David Moher, Dawn P Richards, Yvette Kasamon, Kenneth Getz, Sally Hopewell, Kay Dickersin, Taixiang Wu, Ana Patricia Ayala, Kenneth F Schulz, Sabine Calleja, Isabelle Boutron, Joseph S Ross, Robert M Golub, Karim M Khan, Cindy Mulrow, Nandi Siegfried, Joerg Heber, Naomi Lee, Pamela Reed Kearney, Rhoda K Wanyenze, Asbjørn Hróbjartsson, Rebecca Williams, Nita Bhandari, Peter Jüni, An-Wen Chan, ,

<h4>Importance</h4>Extenuating circumstances can trigger unplanned changes to randomized trials and introduce methodological, ethical, feasibility, and analytical challenges that can potentially compromise the validity of findings. Numerous randomized trials have required changes in response to the COVID-19 pandemic, but guidance for reporting such modifications is incomplete.<h4>Objective</h4>As a joint extension for the ... Read more >>

JAMA (JAMA)
[2021, 326(3):257-265]

Cited: 1 time

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