Full Text Journal Articles by
Author David L H Bennett

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Cohort profile: DOLORisk Dundee: a longitudinal study of chronic neuropathic pain.

Harry L Hébert, Abirami Veluchamy, Georgios Baskozos, Francesca Fardo, Dimitri M L Van Ryckeghem, Mathilde M V Pascal, Claire Jones, Keith Milburn, Ewan R Pearson, Geert Crombez, David L H Bennett, Weihua Meng, Colin N A Palmer, Blair H Smith,

<h4>Purpose</h4>Neuropathic pain is a common disorder of the somatosensory system that affects 7%-10% of the general population. The disorder places a large social and economic burden on patients as well as healthcare services. However, not everyone with a relevant underlying aetiology develops corresponding pain. DOLORisk Dundee, a European Union-funded cohort, ... Read more >>

BMJ Open (BMJ open)
[2021, 11(5):e042887]

Cited: 1 time

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Somatosensory and psychological phenotypes associated with neuropathic pain in entrapment neuropathy.

Luis Matesanz, Andrea C Hausheer, Georgios Baskozos, David L H Bennett, Annina B Schmid,

<h4>Abstract</h4>It currently remains unclear why some patients with entrapment neuropathies develop neuropathic pain (neuP), whereas others have non-neuP, presumably of nociceptive character. Studying patients with carpal tunnel syndrome (CTS), this cross-sectional cohort study investigated changes in somatosensory structure and function as well as emotional well-being specific to the presence and ... Read more >>

Pain (Pain)
[2021, 162(4):1211-1220]

Cited: 0 times

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Axonal swellings are related to type 2 diabetes, but not to distal diabetic sensorimotor polyneuropathy.

Pall Karlsson, Sandra S Gylfadottir, Alexander G Kristensen, Juan D Ramirez, Pedro Cruz, Nhu Le, Pallai R Shillo, Solomon Tesfaye, Andrew S C Rice, Hatice Tankisi, Nanna B Finnerup, Jens R Nyengaard, Troels S Jensen, David L H Bennett, Andreas C Themistocleous,

<h4>Aims/hypothesis</h4>Distal diabetic sensorimotor polyneuropathy (DSP) is a common complication of diabetes with many patients showing a reduction of intraepidermal nerve fibre density (IENFD) from skin biopsy, a validated and sensitive diagnostic tool for the assessment of DSP. Axonal swelling ratio is a morphological quantification altered in DSP. It is, however, ... Read more >>

Diabetologia (Diabetologia)
[2021, 64(4):923-931]

Cited: 0 times

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Molecular and cellular correlates of human nerve regeneration: ADCYAP1/PACAP enhance nerve outgrowth.

Georgios Baskozos, Oliver Sandy-Hindmarch, Alex J Clark, Katherine Windsor, Pall Karlsson, Greg A Weir, Lucy A McDermott, Joanna Burchall, Akira Wiberg, Dominic Furniss, David L H Bennett, Annina B Schmid,

We only have a rudimentary understanding of the molecular and cellular determinants of nerve regeneration and neuropathic pain in humans. This cohort study uses the most common entrapment neuropathy (carpal tunnel syndrome) as a human model system to prospectively evaluate the cellular and molecular correlates of neural regeneration and its ... Read more >>

Brain (Brain : a journal of neurology)
[2020, 143(7):2009-2026]

Cited: 4 times

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Quantitative Proteomic Analysis of the Central Amygdala in Neuropathic Pain Model Rats.

Kersti Karu, Richard S Swanwick, Amparo Novejarque-Gadea, Ana Antunes-Martins, Benjamin Thomas, Eiji Yoshimi, William Foster, Min Fang, Stephen B McMahon, David L H Bennett, Andrew S C Rice, Kenji Okuse,

Pain and emotional distress have a reciprocal relation. The amygdala has been implicated in emotional processing. The central nucleus of the amygdala (CeA) receives nociceptive information from the dorsal horn of spinal cord and is responsible for the central plasticity in chronic pain. Neuropathic pain is a type of severe ... Read more >>

J Proteome Res (Journal of proteome research)
[2020, 19(4):1592-1619]

Cited: 0 times

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Clinical characteristics of neuropathic pain in leprosy and associated somatosensory profiles: a deep phenotyping study in India.

Omer M O Haroun, Jan Vollert, Diana N Lockwood, David L H Bennett, Vivek V Pai, Vanaja Shetty, Anju V Wakade, Ashish S Khodke, Andreas Schilder, Doreen Pfau, Elena K Enax-Krumova, Christoph Maier, Rolf-Detlef Treede, Andrew S C Rice,

This study investigated the clinical characteristics and somatosensory profiles of patients suffering from leprosy in Mumbai, India. A cross-sectional deep profiling study was conducted in 86 patients with leprosy (with and without pain) using an extensive battery of phenotyping measures including structured clinical examination, psychological state (General Health Questionnaire [GHQ-12]), ... Read more >>

Pain Rep (Pain reports)
[2019, 4(6):e743]

Cited: 2 times

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Membrane metallo-endopeptidase is dispensable for repair after nerve injury.

Ilaria Cervellini, Jorge Galino, Ning Zhu, Florence R Fricker, Lu Bao, David L H Bennett,

Membrane metallo-endopeptidase (MME), also known as neprilysin (NEP), has been of interest for its role in neurodegeneration and pain due to its ability to degrade β-amyloid and substance-P, respectively. In addition to its role in the central nervous system, MME has been reported to be expressed in the peripheral system, ... Read more >>

Glia (Glia)
[2019, 67(10):1990-2000]

Cited: 1 time

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RalGTPases contribute to Schwann cell repair after nerve injury via regulation of process formation.

Jorge Galino, Ilaria Cervellini, Ning Zhu, Nina Stöberl, Meike Hütte, Florence R Fricker, Garrett Lee, Lucy McDermott, Giovanna Lalli, David L H Bennett,

RalA and RalB are small GTPases that are involved in cell migration and membrane dynamics. We used transgenic mice in which one or both GTPases were genetically ablated to investigate the role of RalGTPases in the Schwann cell (SC) response to nerve injury and repair. RalGTPases were dispensable for SC ... Read more >>

J Cell Biol (The Journal of cell biology)
[2019, 218(7):2370-2387]

Cited: 0 times

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Disruption of the Sensory System Affects Sterile Cutaneous Inflammation In Vivo.

Federica La Russa, Douglas M Lopes, Carl Hobbs, Fulye Argunhan, Susan Brain, Stuart Bevan, David L H Bennett, Stephen B McMahon,

Increasing evidence suggests that nerve fibers responding to noxious stimuli (nociceptors) modulate immunity in a variety of tissues, including the skin. Yet, the role of nociceptors in regulating sterile cutaneous inflammation remains unexplored. To address this question, we have developed a detailed description of the sterile inflammation caused by overexposure ... Read more >>

J Invest Dermatol (The Journal of investigative dermatology)
[2019, 139(9):1936-1945.e3]

Cited: 3 times

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Development of MRC Centre MRI calf muscle fat fraction protocol as a sensitive outcome measure in Hereditary Sensory Neuropathy Type 1.

Umaiyal Kugathasan, Matthew R B Evans, Jasper M Morrow, Christopher D J Sinclair, John S Thornton, Tarek A Yousry, Thorsten Hornemann, Saranya Suriyanarayanan, Khadijah Owusu-Ansah, Giuseppe Lauria, Raffaella Lombardi, James M Polke, Emma Wilson, David L H Bennett, Henry Houlden, Michael G Hanna, Julian C Blake, Matilde Laura, Mary M Reilly, Mary M Reilly,

<h4>Objectives</h4>Hereditary sensory neuropathy type 1 (HSN1) is a rare, slowly progressive neuropathy causing profound sensory deficits and often severe motor loss. L-serine supplementation is a possible candidate therapy but the lack of responsive outcome measures is a barrier for undertaking clinical trials in HSN1. We performed a 12-month natural history ... Read more >>

J Neurol Neurosurg Psychiatry (Journal of neurology, neurosurgery, and psychiatry)
[2019, 90(8):895-906]

Cited: 2 times

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Morphological and functional properties distinguish the substance P and gastrin-releasing peptide subsets of excitatory interneuron in the spinal cord dorsal horn.

Allen C Dickie, Andrew M Bell, Noboru Iwagaki, Erika Polgár, Maria Gutierrez-Mecinas, Rosalind Kelly, Heather Lyon, Kirsten Turnbull, Steven J West, Alexander Etlin, Joao Braz, Masahiko Watanabe, David L H Bennett, Allan I Basbaum, John S Riddell, Andrew J Todd,

Excitatory interneurons account for the majority of neurons in the superficial dorsal horn, but despite their presumed contribution to pain and itch, there is still limited information about their organisation and function. We recently identified 2 populations of excitatory interneuron defined by expression of gastrin-releasing peptide (GRP) or substance P ... Read more >>

Pain (Pain)
[2019, 160(2):442-462]

Cited: 21 times

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Pain and the immune system: emerging concepts of IgG-mediated autoimmune pain and immunotherapies.

Min Xu, David L H Bennett, Luis Antonio Querol, Long-Jun Wu, Sarosh R Irani, James C Watson, Sean J Pittock, Christopher J Klein,

The immune system has long been recognised important in pain regulation through inflammatory cytokine modulation of peripheral nociceptive fibres. Recently, cytokine interactions in brain and spinal cord glia as well as dorsal root ganglia satellite glia have been identified important- in pain modulation. The result of these interactions is central ... Read more >>

J Neurol Neurosurg Psychiatry (Journal of neurology, neurosurgery, and psychiatry)
[2020, 91(2):177-188]

Cited: 10 times

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Hereditary sensory neuropathy type 1-associated deoxysphingolipids cause neurotoxicity, acute calcium handling abnormalities and mitochondrial dysfunction in vitro.

Emma R Wilson, Umaiyal Kugathasan, Andrey Y Abramov, Alex J Clark, David L H Bennett, Mary M Reilly, Linda Greensmith, Bernadett Kalmar,

Hereditary sensory neuropathy type 1 (HSN-1) is a peripheral neuropathy most frequently caused by mutations in the SPTLC1 or SPTLC2 genes, which code for two subunits of the enzyme serine palmitoyltransferase (SPT). SPT catalyzes the first step of de novo sphingolipid synthesis. Mutations in SPT result in a change in ... Read more >>

Neurobiol Dis (Neurobiology of disease)
[2018, 117:1-14]

Cited: 7 times

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Analysis of motor dysfunction in Down Syndrome reveals motor neuron degeneration.

Sheona Watson-Scales, Bernadett Kalmar, Eva Lana-Elola, Dorota Gibbins, Federica La Russa, Frances Wiseman, Matthew Williamson, Rachele Saccon, Amy Slender, Anna Olerinyova, Radma Mahmood, Emma Nye, Heather Cater, Sara Wells, Y Eugene Yu, David L H Bennett, Linda Greensmith, Elizabeth M C Fisher, Victor L J Tybulewicz,

Down Syndrome (DS) is caused by trisomy of chromosome 21 (Hsa21) and results in a spectrum of phenotypes including learning and memory deficits, and motor dysfunction. It has been hypothesized that an additional copy of a few Hsa21 dosage-sensitive genes causes these phenotypes, but this has been challenged by observations ... Read more >>

PLoS Genet (PLoS genetics)
[2018, 14(5):e1007383]

Cited: 4 times

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Reply: Non-freezing cold injury: a multi-faceted syndrome.

Tom A Vale, Mkael Symmonds, Michael Polydefkis, Kelly Byrnes, Andrew S C Rice, Andreas C Themistocleous, David L H Bennett,

Brain (Brain : a journal of neurology)
[2018, 141(2):e10]

Cited: 0 times

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Neuropathic pain drives anxiety behavior in mice, results consistent with anxiety levels in diabetic neuropathy patients.

Christine B Sieberg, Caitlin Taras, Aya Gomaa, Chelsea Nickerson, Cindy Wong, Catherine Ward, Georgios Baskozos, David L H Bennett, Juan D Ramirez, Andreas C Themistocleous, Andrew S C Rice, Pallai R Shillo, Solomon Tesfaye, Robert R Edwards, Nick A Andrews, Charles Berde, Michael Costigan,

<h4>Background</h4>Epidemiological studies in patients with neuropathic pain demonstrate a strong association with psychiatric conditions such as anxiety; however, the precipitating pathology between these symptoms remains unclear. To investigate this, we studied the effects of lifelong stress on levels of neuropathic pain-like behavior and conversely, the effects of chronic neuropathic injury ... Read more >>

Pain Rep (Pain reports)
[2018, 3(3):e651]

Cited: 11 times

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Rare NaV1.7 variants associated with painful diabetic peripheral neuropathy.

Iulia Blesneac, Andreas C Themistocleous, Carl Fratter, Linus J Conrad, Juan D Ramirez, James J Cox, Solomon Tesfaye, Pallai R Shillo, Andrew S C Rice, Stephen J Tucker, David L H Bennett,

Diabetic peripheral neuropathy (DPN) is a common disabling complication of diabetes. Almost half of the patients with DPN develop neuropathic pain (NeuP) for which current analgesic treatments are inadequate. Understanding the role of genetic variability in the development of painful DPN is needed for improved understanding of pain pathogenesis for ... Read more >>

Pain (Pain)
[2018, 159(3):469-480]

Cited: 38 times

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A novel human pain insensitivity disorder caused by a point mutation in ZFHX2.

Abdella M Habib, Ayako Matsuyama, Andrei L Okorokov, Sonia Santana-Varela, Jose T Bras, Anna Maria Aloisi, Edward C Emery, Yury D Bogdanov, Maryne Follenfant, Sam J Gossage, Mathilde Gras, Jack Humphrey, Anna Kolesnikov, Kim Le Cann, Shengnan Li, Michael S Minett, Vanessa Pereira, Clara Ponsolles, Shafaq Sikandar, Jesus M Torres, Kenji Yamaoka, Jing Zhao, Yuriko Komine, Tetsuo Yamamori, Nikolas Maniatis, Konstantin I Panov, Henry Houlden, Juan D Ramirez, David L H Bennett, Letizia Marsili, Valeria Bachiocco, John N Wood, James J Cox,

Chronic pain is a major global public health issue causing a severe impact on both the quality of life for sufferers and the wider economy. Despite the significant clinical burden, little progress has been made in terms of therapeutic development. A unique approach to identifying new human-validated analgesic drug targets ... Read more >>

Brain (Brain : a journal of neurology)
[2018, 141(2):365-376]

Cited: 11 times

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DOLORisk: study protocol for a multi-centre observational study to understand the risk factors and determinants of neuropathic pain.

Mathilde M V Pascal, Andreas C Themistocleous, Ralf Baron, Andreas Binder, Didier Bouhassira, Geert Crombez, Nanna B Finnerup, Janne Gierthmühlen, Yelena Granovsky, Leif Groop, Harry L Hebert, Troels S Jensen, Kristinn Johnsen, Mark I McCarthy, Weihua Meng, Colin N A Palmer, Andrew S C Rice, Jordi Serra, Romà Solà, David Yarnitsky, Blair H Smith, Nadine Attal, David L H Bennett,

<b>Background:</b> Neuropathic pain is an increasingly prevalent condition and has a major impact on health and quality of life. However, the risk factors for the development and maintenance of neuropathic pain are poorly understood. Clinical, genetic and psychosocial factors all contribute to chronic pain, but their interactions have not been ... Read more >>

Wellcome Open Res (Wellcome open research)
[2018, 3:63]

Cited: 6 times

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Chronic non-freezing cold injury results in neuropathic pain due to a sensory neuropathy.

Tom A Vale, Mkael Symmonds, Michael Polydefkis, Kelly Byrnes, Andrew S C Rice, Andreas C Themistocleous, David L H Bennett,

Non-freezing cold injury develops after sustained exposure to cold temperatures, resulting in tissue cooling but not freezing. This can result in persistent sensory disturbance of the hands and feet including numbness, paraesthesia and chronic pain. Both vascular and neurological aetiologies of this pain have been suggested but remain unproven. We ... Read more >>

Brain (Brain : a journal of neurology)
[2017, 140(10):2557-2569]

Cited: 7 times

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Stratifying patients with peripheral neuropathic pain based on sensory profiles: algorithm and sample size recommendations.

Jan Vollert, Christoph Maier, Nadine Attal, David L H Bennett, Didier Bouhassira, Elena K Enax-Krumova, Nanna B Finnerup, Rainer Freynhagen, Janne Gierthmühlen, Maija Haanpää, Per Hansson, Philipp Hüllemann, Troels S Jensen, Walter Magerl, Juan D Ramirez, Andrew S C Rice, Sigrid Schuh-Hofer, Märta Segerdahl, Jordi Serra, Pallai R Shillo, Soeren Sindrup, Solomon Tesfaye, Andreas C Themistocleous, Thomas R Tölle, Rolf-Detlef Treede, Ralf Baron,

In a recent cluster analysis, it has been shown that patients with peripheral neuropathic pain can be grouped into 3 sensory phenotypes based on quantitative sensory testing profiles, which are mainly characterized by either sensory loss, intact sensory function and mild thermal hyperalgesia and/or allodynia, or loss of thermal detection ... Read more >>

Pain (Pain)
[2017, 158(8):1446-1455]

Cited: 31 times

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Recessive dystrophic epidermolysis bullosa results in painful small fibre neuropathy.

Sofia von Bischhoffshausen, Dinka Ivulic, Paola Alvarez, Victor C Schuffeneger, Juan Idiaquez, Constanza Fuentes, Pilar Morande, Ignacia Fuentes, Francis Palisson, David L H Bennett, Margarita Calvo,

Small fibres in the skin are vulnerable to damage in metabolic or toxic conditions such as diabetes mellitus or chemotherapy resulting in small fibre neuropathy and associated neuropathic pain. Whether injury to the most distal portion of sensory small fibres due to a primary dermatological disorder can cause neuropathic pain ... Read more >>

Brain (Brain : a journal of neurology)
[2017, 140(5):1238-1251]

Cited: 8 times

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New Horizons in Diabetic Neuropathy: Mechanisms, Bioenergetics, and Pain.

Eva L Feldman, Klaus-Armin Nave, Troels S Jensen, David L H Bennett,

Pre-diabetes and diabetes are a global epidemic, and the associated neuropathic complications create a substantial burden on both the afflicted patients and society as a whole. Given the enormity of the problem and the lack of effective therapies, there is a pressing need to understand the mechanisms underlying diabetic neuropathy ... Read more >>

Neuron (Neuron)
[2017, 93(6):1296-1313]

Cited: 138 times

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A rodent model of HIV protease inhibitor indinavir induced peripheral neuropathy.

Wenlong Huang, Margarita Calvo, Tim Pheby, David L H Bennett, Andrew S C Rice,

HIV-associated sensory neuropathy (HIV-SN) is the most frequent manifestation of HIV disease. It often presents with significant neuropathic pain and is associated with previous exposure to neurotoxic nucleoside reverse transcriptase inhibitors. However, HIV-SN prevalence remains high even in resource-rich settings where these drugs are no longer used. Previous evidence suggests ... Read more >>

Pain (Pain)
[2017, 158(1):75-85]

Cited: 6 times

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Rare Variants in MME, Encoding Metalloprotease Neprilysin, Are Linked to Late-Onset Autosomal-Dominant Axonal Polyneuropathies.

Michaela Auer-Grumbach, Stefan Toegel, Maria Schabhüttl, Daniela Weinmann, Catharina Chiari, David L H Bennett, Christian Beetz, Dennis Klein, Peter M Andersen, Ilka Böhme, Regina Fink-Puches, Michael Gonzalez, Matthew B Harms, William Motley, Mary M Reilly, Wilfried Renner, Sabine Rudnik-Schöneborn, Beate Schlotter-Weigel, Andreas C Themistocleous, Jochen H Weishaupt, Albert C Ludolph, Thomas Wieland, Feifei Tao, Lisa Abreu, Reinhard Windhager, Manuela Zitzelsberger, Tim M Strom, Thomas Walther, Steven S Scherer, Stephan Züchner, Rudolf Martini, Jan Senderek,

Axonal polyneuropathies are a frequent cause of progressive disability in the elderly. Common etiologies comprise diabetes mellitus, paraproteinaemia, and inflammatory disorders, but often the underlying causes remain elusive. Late-onset axonal Charcot-Marie-Tooth neuropathy (CMT2) is an autosomal-dominantly inherited condition that manifests in the second half of life and is genetically largely ... Read more >>

Am J Hum Genet (American journal of human genetics)
[2016, 99(3):607-623]

Cited: 19 times

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