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Author David Kaczorowski

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Numerical study of the effect of LVAD inflow cannula positioning on thrombosis risk.

Ge He, Lu Han, Jiafeng Zhang, Aakash Shah, David J Kaczorowski, Bartley P Griffith, Zhongjun Wu,

Left ventricular assist devices (LVADs) have been increasingly used as a therapy for patients with end-stage heart failure. However, a growing number of clinical observations have shown that LVADs are associated with thromboembolic events, which are potentially related to the changes in intraventricular flow. Particularly, the flow fields around the ... Read more >>

Comput Methods Biomech Biomed Engin (Computer methods in biomechanics and biomedical engineering)
[2021, :1-9]

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CENTRIFUGAL-FLOW LVAD INFLOW CANNULA POSITION: PREOPERATIVE INFLUENCES AND POSTOPERATIVE OUTCOMES

Erik Sorensen, Bartley Griffith, Erika Feller, Lynn Dees, David Kaczorowski,

<h4>Background: </h4> We previously demonstrated better inflow cannula (IFC) position and reduced pump thrombosis with a centrifugal-flow LVAD (CF-LVAD) compared to an axial-flow device. We hypothesized that implant technique and patient anatomy would affect CF-LVAD IFC positioning and that malposition would impact LV unloading and outcomes. <h4>Methods:</h4> Pre- and postoperative ... Read more >>

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A descriptive evaluation of causes of death in venovenous extracorporeal membrane oxygenation.

Sagar B Dave, Kristopher B Deatrick, Samuel M Galvagno, Michael A Mazzeffi, David J Kaczorowski, Ronson J Madathil, Raymond Rector, Ali Tabatabai, Daniel J Haase, Daniel Herr, Thomas M Scalea, Jay Menaker,

Veno-venous extracorporeal membrane oxygenation (VV ECMO) has become an important support modality for patients with acute respiratory failure refractory to optimal medical therapy, such as low tidal volume mechanical ventilator support, early paralytic infusion, and early prone positioning. The objective of this cohort study was to investigate the causes and ... Read more >>

Perfusion (Perfusion)
[2021, :2676591211035938]

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Blood Cardioplegia Induction, Perfusion Storage and Graft Dysfunction in Cardiac Xenotransplantation.

Corbin E Goerlich, Bartley Griffith, Avneesh K Singh, Mohamed Abdullah, Shreya Singireddy, Irina Kolesnik, Billeta Lewis, Faith Sentz, Ivan Tatarov, Alena Hershfeld, Tianshu Zhang, Erik Strauss, Patrick Odonkor, Brittney Williams, Ali Tabatabai, Adnan Bhutta, David Ayares, David J Kaczorowski, Muhammad M Mohiuddin,

<h4>Background</h4>Perioperative cardiac xenograft dysfunction (PCXD) describes a rapidly developing loss of cardiac function after xenotransplantation. PCXD occurs despite genetic modifications to increase compatibility of the heart. We report on the incidence of PCXD using static preservation in ice slush following crystalloid or blood-based cardioplegia versus continuous cold perfusion with XVIVO<sup>©</sup> ... Read more >>

Front Immunol (Frontiers in immunology)
[2021, 12:667093]

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Peripheral cannulation for extracorporeal membrane oxygenation yields superior neurologic outcomes in adult patients who experienced cardiac arrest following cardiac surgery.

Lauren E Levy, David J Kaczorowski, Chetan Pasrija, Gregory Boyajian, Michael Mazzeffi, Eric Krause, Aakash Shah, Ronson Madathil, Kristopher B Deatrick, Daniel Herr, Bartley P Griffith, James S Gammie, Bradley S Taylor, Mehrdad Ghoreishi,

<h4>Background</h4>Extracorporeal cardiopulmonary resuscitation (ECPR) for refractory cardiac arrest has improved mortality in post-cardiac surgery patients; however, loss of neurologic function remains one of the main and devastating complications. We reviewed our experience with ECPR and investigated the effect of cannulation strategy on neurologic outcome in adult patients who experienced cardiac ... Read more >>

Perfusion (Perfusion)
[2021, :2676591211018129]

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Catheter-based interventions versus medical and surgical approaches in acute pulmonary embolism.

Rafael S Cires-Drouet, Khanjan Nagarsheth, David J Kaczorowski, Shahab Toursavadkohi, Kristopher Deatrick, Ronson J Madathil, Kevin M Jones, Steven Liskov, Jeffrey Fitch, Michelle Sayad, Chetan Pasrija, Minerva Mayorga-Carlin, Daniel Herr, John D Sorkin, Bartley Griffith, Brajesh K Lal, James S Gammie,

<h4>Objective</h4>Catheter-based intervention (CBI) has become an increasingly popular option for treating pulmonary embolism (PE); however, the real benefits are unknown. The purpose of the present study was to compare the outcomes of patients treated with CBI with the outcomes of those treated with medical or surgical approaches.<h4>Methods</h4>We performed a retrospective ... Read more >>

J Vasc Surg Venous Lymphat Disord (Journal of vascular surgery. Venous and lymphatic disorders)
[2021, :]

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Ultrasound-assisted catheter directed thrombolysis for pulmonary embolus during extracorporeal membrane oxygenation.

Douglas Tran, Nicole Hays, Aakash Shah, Chetan Pasrija, Rafael S Cires-Drouet, Shahab A Toursavadkohi, Michael A Mazzeffi, Daniel L Herr, Ronson J Madathil, James S Gammie, Bartley P Griffith, Kristopher B Deatrick, David J Kaczorowski,

<h4>Background</h4>Acute pulmonary embolism (PE) is the third most common cause of cardiovascular death. For patients who are hemodynamically unstable, veno-arterial extracorporeal membrane oxygenation (VA-ECMO) support has been shown to provide hemodynamic stability, and allow time for definitive treatment and recovery. Ultrasound-assisted catheter directed thrombolysis (USAT) has the potential to be ... Read more >>

J Card Surg (Journal of cardiac surgery)
[2021, 36(8):2685-2691]

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A Dedicated Veno-Venous Extracorporeal Membrane Oxygenation Unit during a Respiratory Pandemic: Lessons Learned from COVID-19 Part II: Clinical Management.

Aakash Shah, Sagar Dave, Samuel Galvagno, Kristen George, Ashley R Menne, Daniel J Haase, Brian McCormick, Raymond Rector, Siamak Dahi, Ronson J Madathil, Kristopher B Deatrick, Mehrdad Ghoreishi, James S Gammie, David J Kaczorowski, Thomas M Scalea, Jay Menaker, Daniel Herr, Ali Tabatabai, Eric Krause,

(1) Background: COVID-19 acute respiratory distress syndrome (CARDS) has several distinctions from traditional acute respiratory distress syndrome (ARDS); however, patients with refractory respiratory failure may still benefit from veno-venous extracorporeal membrane oxygenation (VV-ECMO) support. We report our challenges caring for CARDS patients on VV-ECMO and alterations to traditional management strategies. ... Read more >>

Membranes (Basel) (Membranes)
[2021, 11(5):]

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Veno-Arterial Extracorporeal Membrane Oxygenation for Pulmonary Embolism after Systemic Thrombolysis.

Nikhil K Prasad, Gregory Boyajian, Douglas Tran, Aakash Shah, Kevin M Jones, Ronson J Madathil, K Barry Deatrick, Rafael Cires-Drouet, David J Kaczorowski,

Massive pulmonary embolism (PE) is a life-threatening condition with a high mortality. Both systemic thrombolytics and veno-arterial extracorporeal membrane oxygenation (VA-ECMO) have been used in the management of massive PE. However, the safety of VA- ECMO in the setting of recent thrombolytic administration is not clear. The purpose of this ... Read more >>

Semin Thorac Cardiovasc Surg (Seminars in thoracic and cardiovascular surgery)
[2021, :]

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Progressive Genetic Modifications with Growth Hormone Receptor Knockout Extends Cardiac Xenograft Survival to 9 Months

Muhammad Mohiuddin, Corbin Goerlich, Avneesh Singh, Tianshu Zhang, Ivan Tatarov, Billeta Lewis, Faith Sentz, Alena Hershfeld, Gheorghe Braileanu, Patrick Odonkor, Erik Strauss, Brittney Williams, Allen Burke, Jamie Hittman, Adnan Bhutta, Ali Tabatabai, Anuj Gupta, Todd Vaught, Lorri Sorrells, Kasinath Kuravi, Amy Dandro, Will Eyestone, David Kaczorowski, David Ayares, Bartley Griffith,

We report orthotopic (life-supporting) survival of genetically engineered porcine cardiac xenografts (with 3-9 progressive gene modifications) for almost 9 months in baboon recipients. This work builds on our previously reported heterotopic cardiac xenograft (3 gene modifications) survival up to 945 days with an anti-CD40 monoclonal antibody-based immunosuppression. In this current ... Read more >>

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Venoarterial Extracorporeal Membrane Oxygenation via Direct Axillary Artery Cannulation.

Aakash Shah, Ronson J Madathil, Bartley P Griffith, David J Kaczorowski,

Venoarterial extracorporeal membrane oxygenation (VA-ECMO) is an effective means of support for patients awaiting cardiac or cardiopulmonary transplantation. Typically, peripheral cannulation via the femoral vessels is preferred. However, an alternative is use of the axillary or subclavian artery, which is typically performed via a graft. Here we present the case ... Read more >>

Innovations (Phila) (Innovations (Philadelphia, Pa.))
[2021, 16(3):297-299]

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A Dedicated Veno-Venous Extracorporeal Membrane Oxygenation Unit during a Respiratory Pandemic: Lessons Learned from COVID-19 Part I: System Planning and Care Teams.

Sagar Dave, Aakash Shah, Samuel Galvagno, Kristen George, Ashley R Menne, Daniel J Haase, Brian McCormick, Raymond Rector, Siamak Dahi, Ronson J Madathil, Kristopher B Deatrick, Mehrdad Ghoreishi, James S Gammie, David J Kaczorowski, Thomas M Scalea, Jay Menaker, Daniel Herr, Eric Krause, Ali Tabatabai,

<h4>Background</h4>The most critically ill patients with coronavirus disease 2019 (COVID-19) may require advanced support modalities, such as veno-venous extracorporeal membrane oxygenation (VV-ECMO). A systematic, methodical approach to a respiratory pandemic on a state and institutional level is critical.<h4>Methods</h4>We conducted retrospective review of our institutional response to the COVID-19 pandemic, focusing ... Read more >>

Membranes (Basel) (Membranes)
[2021, 11(4):]

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Inflow Cannula Position Influences Improvement in Mitral Regurgitation After Ventricular Assist Device Implantation.

Chetan Pasrija, Mariem A Sawan, Erik Sorensen, James S Gammie, Ronson Madathil, Douglas Tran, Libin Wang, Van-Khue Ton, Erika Feller, Bartley P Griffith, Zachary N Kon, David J Kaczorowski,

Significant residual mitral regurgitation (MR) after left ventricular assist device (LVAD) implantation has been associated with increased morbidity and mortality. The effect of cannula position on improvement of preexisting MR has yet to be evaluated. Consecutive patients who underwent centrifugal LVAD implantation with >mild preoperative MR and without concomitant mitral ... Read more >>

ASAIO J (ASAIO journal (American Society for Artificial Internal Organs : 1992))
[2021, 67(4):423-429]

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Stellate Ganglion Blockade Should Be Considered for Patients With Drug-Refractory Electrical Storm on Venoarterial Extracorporeal Membrane Oxygenation.

Christine Moshe, David Kaczorowski, Paul Bigeleisen, Whitney Burrows, Michael Mazzeffi,

Crit Care Med (Critical care medicine)
[2021, 49(3):e333-e334]

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Hybrid and parallel extracorporeal membrane oxygenation circuits.

Aakash Shah, Sagar Dave, Corbin E Goerlich, David J Kaczorowski,

JTCVS Tech (JTCVS techniques)
[2021, 8:77-85]

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Clinical Outcomes of Pregnant and Postpartum Extracorporeal Membrane Oxygenation Patients.

Allison S Lankford, Jonathan H Chow, Amanda M Jackson, Marianne Wallis, Samuel M Galvagno, Andrew M Malinow, Ozhan M Turan, Jay A Menaker, Sarah D Crimmins, Raymond Rector, David Kaczorowski, Bartley Griffith, Zachary Kon, Daniel Herr, Michael A Mazzeffi,

<h4>Background</h4>The use of extracorporeal membrane oxygenation (ECMO) as a rescue therapy for cardiopulmonary failure is expanding in critical care medicine. In this case series, we describe the clinical outcomes of 21 consecutive pregnant or postpartum patients that required venovenous (VV) or venoarterial (VA) ECMO. Our objective was to characterize maternal ... Read more >>

Anesth Analg (Anesthesia and analgesia)
[2021, 132(3):777-787]

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Inferior Vena Cava Filter Placement Through a Venovenous Extracorporeal Membrane Oxygenation Circuit.

Joshua L Leibowitz, Gregory J Bittle, Ronson J Madathil, Khanjan Nagarsheth, David J Kaczorowski,

We present a novel technique for performing endovascular procedures by obtaining vascular access directly through a venovenous extracorporeal membrane oxygenation (VV ECMO) circuit. This technique is demonstrated in a lung transplant recipient, supported on VV ECMO, whose course was complicated by an extensive right femoral vein and inferior vena cava ... Read more >>

Ann Thorac Surg (The Annals of thoracic surgery)
[2021, :]

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Clinical Outcomes of Perioperative Desensitization in Heart Transplant Recipients.

Michael E Plazak, Stormi E Gale, Brent N Reed, Sara Hammad, Van-Khue Ton, David J Kaczorowski, Ronson J Madathil, Bharath Ravichandran,

<h4>Background</h4>Sensitization remains a barrier to heart transplantation (HT). Perioperative desensitization strategies have been described; however, a paucity of evidence exists to demonstrate efficacy and safety in HT.<h4>Methods</h4>This single-center, retrospective study consisted of adults who received an HT. Perioperative desensitization was initiated if virtual crossmatch or flow-cytometry crossmatch was positive. Therapy ... Read more >>

Transplant Direct (Transplantation direct)
[2021, 7(2):e658]

Cited: 1 time

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Mortality Risk Assessment in COVID-19 Venovenous Extracorporeal Membrane Oxygenation.

Ali Tabatabai, Mira H Ghneim, David J Kaczorowski, Aakash Shah, Sagar Dave, Daniel J Haase, Roumen Vesselinov, Kristopher B Deatrick, Joseph Rabin, Ronald P Rabinowitz, Samuel Galvagno, James V O'Connor, Jay Menaker, Daniel L Herr, James S Gammie, Thomas M Scalea, Ronson J Madathil,

<h4>Background</h4>A life-threatening complication of coronavirus disease 2019 (COVID-19) is acute respiratory distress syndrome (ARDS) refractory to conventional management. Venovenous (VV) extracorporeal membrane oxygenation (ECMO) (VV-ECMO) is used to support patients with ARDS in whom conventional management fails. Scoring systems to predict mortality in VV-ECMO remain unvalidated in COVID-19 ARDS. This ... Read more >>

Ann Thorac Surg (The Annals of thoracic surgery)
[2021, :]

Cited: 1 time

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Minimally Invasive Left Ventricular Assist Device Insertion Facilitates Subsequent Heart Transplant.

Joseph Rabin, Luke A Ziegler, Sarah Cipriano, Ronson J Madathil, Erika D Feller, Erik N Sorensen, Bartley P Griffith, David J Kaczorowski,

<h4>Objective</h4>We have observed that minimally invasive left ventricular assist device (LVAD) insertion leads to more facile re-entry and easier cardiac transplantation. We hypothesize minimally invasive LVAD implantation results in improved outcomes at the time of subsequent heart transplant.<h4>Methods</h4>All adults undergoing cardiac transplantation between October 2015 and March 2019 at our ... Read more >>

Innovations (Phila) (Innovations (Philadelphia, Pa.))
[2021, 16(2):157-162]

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Ischemia-reperfusion Injury in the Transplanted Lung: A Literature Review.

Tara Talaie, Laura DiChiacchio, Nikhil K Prasad, Chetan Pasrija, Walker Julliard, David J Kaczorowski, Yunge Zhao, Christine L Lau,

Lung ischemia-reperfusion injury (LIRI) and primary graft dysfunction are leading causes of morbidity and mortality among lung transplant recipients. Although extensive research endeavors have been undertaken, few preventative and therapeutic treatments have emerged for clinical use. Novel strategies are still needed to improve outcomes after lung transplantation. In this review, ... Read more >>

Transplant Direct (Transplantation direct)
[2021, 7(2):e652]

Cited: 3 times

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High Right Ventricular Afterload Is Associated with Impaired Exercise Tolerance in Patients with Left Ventricular Assist Devices.

Van-Khue Ton, Gautam Ramani, Steven Hsu, C Danielle Hopkins, David Kaczorowski, Ronson J Madathil, Susanna Mak, Ryan J Tedford,

Patients with left ventricular assist device (LVAD) have poor exercise tolerance. We aimed to characterize relationship between right ventricular (RV) afterload and exercise capacity, RV reserve, and adaptation to load. Twelve well-compensated LVAD subjects underwent right heart catheterization at rest and during symptom-limited exercise. Cardiopulmonary exercise tests were also performed. ... Read more >>

ASAIO J (ASAIO journal (American Society for Artificial Internal Organs : 1992))
[2021, 67(1):39-45]

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A Retrospective Study of Infection in Patients Requiring Extracorporeal Membrane Oxygenation Support.

Megan T Quintana, Michael Mazzeffi, Samuel M Galvagno, Danny Herrera, Gregory P Boyajian, Nicole M Hays, David Kaczorowski, Ronson J Madathil, Raymond P Rector, Ali Tabatabai, Daniel Herr, Joseph Rabin,

<h4>Background</h4>Healthcare-associated infections (HAIs) in critically ill patients are a serious public health problem. Extracorporeal membrane oxygenation (ECMO) has been used increasingly for patients with severe cardiac or respiratory failure, but it may increase HAI risk. The goal of our study was to characterize HAIs in ECMO patients at an ECMO ... Read more >>

Ann Thorac Surg (The Annals of thoracic surgery)
[2021, 112(4):1168-1175]

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Complete percutaneous decannulation from femoral venoarterial extracorporeal membrane oxygenation.

Aakash Shah, Mehrdad Ghoreishi, Bradley S Taylor, Shahab Toursavadkohi, David J Kaczorowski, ,

<h4>Objectives</h4>To evaluate the clinical outcomes and perioperative complications associated with complete percutaneous decannulation of femoral venoarterial extracorporeal membrane oxygenation (VA-ECMO) with the MANTA closure device.<h4>Methods</h4>This is a retrospective analysis of a single surgeon consecutive series of 14 patients at a single center who underwent decannulation from VA-ECMO, 10 of whom ... Read more >>

JTCVS Tech (JTCVS techniques)
[2021, 6:75-81]

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A Minimally Invasive Approach to Left Ventricular Assist Device Insertion Facilitates Subsequent Explant.

Luke A Ziegler, Gregory J Bittle, Wyatt J Klass, Erik N Sorensen, Ronson J Madathil, Erika D Feller, Bartley P Griffith, David J Kaczorowski,

A minimally invasive approach to left ventricular assist device (LVAD) insertion may benefit patients at the time of implant, but whether the approach to LVAD insertion influences the outcome of subsequent cardiovascular reoperations is unknown. Here we present the case of a 50-year-old male who underwent LVAD insertion through a ... Read more >>

Innovations (Phila) (Innovations (Philadelphia, Pa.))
[2021, 16(1):104-107]

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