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Author David K Wright

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Diffusion Imaging Reveals Sex Differences in the White Matter Following Sports-Related Concussion.

David K Wright, Georgia F Symons, William T O'Brien, Stuart J McDonald, Akram Zamani, Brendan Major, Zhibin Chen, Daniel Costello, Rhys D Brady, Mujun Sun, Meng Law, Terence J O'Brien, Richelle Mychasiuk, Sandy R Shultz,

Sports-related concussion (SRC) is a serious health concern. However, the temporal profile of neuropathophysiological changes after SRC and how these relate to biological sex are still poorly understood. This preliminary study investigated whether diffusion-weighted magnetic resonance imaging (dMRI) was sensitive to neuropathophysiological changes following SRC; whether these changes were sex-specific; ... Read more >>

Cereb Cortex (Cerebral cortex (New York, N.Y. : 1991))
[2021, 31(10):4411-4419]

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7T Magnetic Resonance Imaging Quantification of Brain Glutamate in Acute Ischaemic Stroke.

John-Paul Nicolo, Bradford Moffat, David K Wright, Benjamin Sinclair, Andrew Neal, Elaine Lui, Patricia Desmond, Rebecca Glarin, Kathryn A Davis, Ravinder Reddy, Bernard Yan, Terence J O'Brien, Patrick Kwan,

J Stroke (Journal of stroke)
[2021, 23(2):281-284]

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Longitudinal hippocampal volumetric changes in mice following brain infarction.

Vanessa H Brait, David K Wright, Mohsen Nategh, Alexander Oman, Warda T Syeda, Charlotte M Ermine, Katrina R O'Brien, Emilio Werden, Leonid Churilov, Leigh A Johnston, Lachlan H Thompson, Jess Nithianantharajah, Katherine A Jackman, Amy Brodtmann,

Hippocampal atrophy is increasingly described in many neurodegenerative syndromes in humans, including stroke and vascular cognitive impairment. However, the progression of brain volume changes after stroke in rodent models is poorly characterized. We aimed to monitor hippocampal atrophy occurring in mice up to 48-weeks post-stroke. Male C57BL/6J mice were subjected to an ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):10269]

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Study protocol for a phase II randomised, double-blind, placebo-controlled trial of perampanel as an antiepileptogenic treatment following acute stroke.

John-Paul Nicolo, Zhibin Chen, Bradford Moffat, David K Wright, Benjamin Sinclair, Rebecca Glarin, Andrew Neal, Vincent Thijs, Udaya Seneviratne, Bernard Yan, Geoffrey Cloud, Terence J O'Brien, Patrick Kwan,

<h4>Introduction</h4>Stroke is a common cause of epilepsy that may be mediated via glutamate dysregulation. There is currently no evidence to support the use of antiseizure medications as primary prevention against poststroke epilepsy. Perampanel has a unique antiglutamatergic mechanism of action and may have antiepileptogenic properties. This study aims to evaluate ... Read more >>

BMJ Open (BMJ open)
[2021, 11(5):e043488]

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Targeting the Cerebrovascular System: Next-Generation Biomarkers and Treatment for Mild Traumatic Brain Injury.

Tamara L Baker, Denes V Agoston, Rhys D Brady, Brendan Major, Stuart J McDonald, Richelle Mychasiuk, David K Wright, Glenn R Yamakawa, Mujun Sun, Sandy R Shultz,

The diagnosis, prognosis, and treatment of mild traumatic brain injuries (mTBIs), such as concussions, are significant unmet medical issues. The kinetic forces that occur in mTBI adversely affect the cerebral vasculature, making cerebrovascular injury (CVI) a pathophysiological hallmark of mTBI. Given the importance of a healthy cerebrovascular system in overall ... Read more >>

Neuroscientist (The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry)
[2021, :10738584211012264]

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Pain in the Developing Brain: Early Life Factors Alter Nociception and Neurobiological Function in Adolescent Rats.

Sabrina Salberg, Glenn R Yamakawa, Yannick Griep, Jesse Bain, Jaimie K Beveridge, Mujun Sun, Stuart J McDonald, Sandy R Shultz, Rhys D Brady, David K Wright, Melanie Noel, Richelle Mychasiuk,

Although adverse early experiences prime individuals to be at increased risk for chronic pain, little research has examined the trauma-pain relationship in early life or the underlying mechanisms that drive pathology over time. Given that early experiences can potentiate the nociceptive response, this study aimed to examine the effects of ... Read more >>

Cereb Cortex Commun (Cerebral cortex communications)
[2021, 2(2):tgab014]

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White matter changes following experimental pediatric traumatic brain injury: an advanced diffusion-weighted imaging investigation.

Akram Zamani, Terence J O'Brien, Jeff Kershaw, Leigh A Johnston, Bridgette D Semple, David K Wright,

Pediatric traumatic brain injury (pTBI) is a major community health concern. Due to ongoing maturation, injury to the brain at a young age can have devastating consequences in later life. However, how pTBI affects brain development, including white matter maturation, is still poorly understood. Here, we used advanced diffusion weighted ... Read more >>

Brain Imaging Behav (Brain imaging and behavior)
[2021, :]

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QSMART: Quantitative susceptibility mapping artifact reduction technique.

Negin Yaghmaie, Warda T Syeda, Chengchuan Wu, Yicheng Zhang, Tracy D Zhang, Emma L Burrows, Amy Brodtmann, Bradford A Moffat, David K Wright, Rebecca Glarin, Scott Kolbe, Leigh A Johnston,

<h4>Purpose</h4>Quantitative susceptibility mapping (QSM) is a novel MR technique that allows mapping of tissue susceptibility values from MR phase images. QSM is an ill-conditioned inverse problem, and although several methods have been proposed in the field, in the presence of a wide range of susceptibility sources, streaking artifacts appear around ... Read more >>

Neuroimage (NeuroImage)
[2021, 231:117701]

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The emergence and intensification of early hunter-gatherer niche construction.

Jessica C Thompson, David K Wright, Sarah J Ivory,

Hunter-gatherers, especially Pleistocene examples, are not well-represented in archeological studies of niche construction. However, as the role of humans in shaping environments over long time scales becomes increasingly apparent, it is critical to develop archeological proxies and testable hypotheses about early hunter-gatherer impacts. Modern foragers engage in niche constructive behaviors ... Read more >>

Evol Anthropol (Evolutionary anthropology)
[2021, 30(1):17-27]

Cited: 1 time

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Contrast enhanced magnetic resonance imaging highlights neurovasculature changes following experimental traumatic brain injury in the rat.

David K Wright, Jamie N Mayo, Mujun Sun, Terence J O'Brien, Sandy R Shultz,

Neurovascular injury has been proposed as a universal pathological hallmark of traumatic brain injury (TBI) with molecular markers of angiogenesis and endothelial function associated with injury severity and morbidity. Sex differences in the neurovasculature response post-TBI may contribute to the differences seen in how males and females respond to injury. ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):21252]

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Characterization of a novel model of global forebrain ischaemia-reperfusion injury in mice and comparison with focal ischaemic and haemorrhagic stroke.

Natasha Ting Lee, Carly Selan, Joanne S J Chia, Sharelle A Sturgeon, David K Wright, Akram Zamani, Melrine Pereira, Harshal H Nandurkar, Maithili Sashindranath,

Stroke is caused by obstructed blood flow (ischaemia) or unrestricted bleeding in the brain (haemorrhage). Global brain ischaemia occurs after restricted cerebral blood flow e.g. during cardiac arrest. Following ischaemic injury, restoration of blood flow causes ischaemia-reperfusion (I/R) injury which worsens outcome. Secondary injury mechanisms after any stroke are similar, ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):18170]

Cited: 1 time

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Behavioral, axonal, and proteomic alterations following repeated mild traumatic brain injury: Novel insights using a clinically relevant rat model.

Louise Pham, David K Wright, William T O'Brien, Jesse Bain, Cheng Huang, Mujun Sun, Pablo M Casillas-Espinosa, Anup D Shah, Ralf B Schittenhelm, Christopher G Sobey, Rhys D Brady, Terence J O'Brien, Richelle Mychasiuk, Sandy R Shultz, Stuart J McDonald,

A history of mild traumatic brain injury (mTBI) is linked to a number of chronic neurological conditions, however there is still much unknown about the underlying mechanisms. To provide new insights, this study used a clinically relevant model of repeated mTBI in rats to characterize the acute and chronic neuropathological ... Read more >>

Neurobiol Dis (Neurobiology of disease)
[2021, 148:105151]

Cited: 4 times

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Repetitive Mild Traumatic Brain Injury Alters Glymphatic Clearance Rates in Limbic Structures of Adolescent Female Rats.

Jennaya Christensen, David K Wright, Glenn R Yamakawa, Sandy R Shultz, Richelle Mychasiuk,

The glymphatic system is the macroscopic waste clearance system for the central nervous system. Glymphatic dysfunction has been linked to several neurological conditions, including traumatic brain injury (TBI). Adolescents are at particularly high risk for experiencing a TBI, particularly mild TBI (mTBI) and repetitive mTBI (RmTBI); however, glymphatic clearance, and ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):6254]

Cited: 3 times

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The Impact of Traumatic Injury to the Immature Human Brain: A Scoping Review with Insights from Advanced Structural Neuroimaging.

Akram Zamani, Nicholas P Ryan, David K Wright, Karen Caeyenberghs, Bridgette D Semple,

Traumatic brain injury (TBI) during critical periods of early-life brain development can affect the normal formation of brain networks responsible for a range of complex social behaviors. Because of the protracted nature of brain and behavioral development, deficits in cognitive and socioaffective behaviors may not become evident until late adolescence ... Read more >>

J Neurotrauma (Journal of neurotrauma)
[2020, 37(5):724-738]

Cited: 4 times

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Bone Marrow Adipose Tissue Quantification by Imaging.

Ebrahim Bani Hassan, Ali Ghasem-Zadeh, Mahdi Imani, Numan Kutaiba, David K Wright, Tara Sepehrizadeh, Gustavo Duque,

<h4>Purpose of review</h4>The significance and roles of marrow adipose tissue (MAT) are increasingly known, and it is no more considered a passive fat storage but a tissue with significant paracrine and endocrine activities that can cause lipotoxicity and inflammation.<h4>Recent findings</h4>Changes in the MAT volume and fatty acid composition appear to ... Read more >>

Curr Osteoporos Rep (Current osteoporosis reports)
[2019, 17(6):416-428]

Cited: 1 time

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Internal Subdivisions of the Marmoset Claustrum Complex: Identification by Myeloarchitectural Features and High Field Strength Imaging.

Xiuxian Pham, David K Wright, Nafiseh Atapour, Jonathan M-H Chan, Kirsty J Watkins, Katrina H Worthy, Marcello Rosa, Amy Reichelt, David H Reser,

There has been a surge of interest in the structure and function of the mammalian claustrum in recent years. However, most anatomical and physiological studies treat the claustrum as a relatively homogenous structure. Relatively little attention has been directed toward possible compartmentalization of the claustrum complex into anatomical subdivisions, and ... Read more >>

Front Neuroanat (Frontiers in neuroanatomy)
[2019, 13:96]

Cited: 1 time

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Repeated mild traumatic brain injuries induce persistent changes in plasma protein and magnetic resonance imaging biomarkers in the rat.

David K Wright, Rhys D Brady, Alaa Kamnaksh, Jack Trezise, Mujun Sun, Stuart J McDonald, Richelle Mychasiuk, Scott C Kolbe, Meng Law, Leigh A Johnston, Terence J O'Brien, Denes V Agoston, Sandy R Shultz,

A single mild traumatic brain injury (mTBI) typically causes only transient symptoms, but repeated mTBI (RmTBI) is associated with cumulative and chronic neurological abnormalities. Clinical management of mTBI is challenging due to the heterogeneous, subjective and transient nature of symptoms, and thus would be aided by objective biomarkers. Promising biomarkers ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):14626]

Cited: 5 times

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Tranexamic acid modulates the cellular immune profile after traumatic brain injury in mice without hyperfibrinolysis.

Dominik F Draxler, Maria Daglas, Anushka Fernando, Gryselda Hanafi, Fiona McCutcheon, Heidi Ho, Adam Galle, Julia Gregory, Pia Larsson, Charithani Keragala, David K Wright, Elnaz Tavancheh, Amanda E Au, Be'eri Niego, Kirsty Wilson, Magdalena Plebanski, Maithili Sashindranath, Robert L Medcalf,

<h4>Background</h4>Traumatic brain injury (TBI) is known to promote immunosuppression, making patients more susceptible to infection, yet potentially exerting protective effects by inhibiting central nervous system (CNS) reactivity. Plasmin, the effector protease of the fibrinolytic system, is now recognized for its involvement in modulating immune function.<h4>Objective</h4>To evaluate the effects of plasmin ... Read more >>

J Thromb Haemost (Journal of thrombosis and haemostasis : JTH)
[2019, 17(12):2174-2187]

Cited: 4 times

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The genetic ablation of tau improves long-term, but not short-term, functional outcomes after experimental traumatic brain injury in mice.

Xin Lin Tan, Ping Zheng, David K Wright, Mujun Sun, Rhys D Brady, Shijie Liu, Stuart J McDonald, Richelle Mychasiuk, Sitare Cenap, Nigel C Jones, Terence J O'Brien, Sandy R Shultz,

<h4>Primary objective</h4>This study characterized the acute and chronic effects of tau reduction in traumatic brain injury (TBI).<h4>Research design</h4>A fluid percussion injury (FPI) or a sham-injury was administered to wild type (WT) or tau knockout (Tau-/-) mice. Mice were assigned to a one-week or twelve-week recovery period before behavioral testing and ... Read more >>

Brain Inj (Brain injury)
[2020, 34(1):131-139]

Cited: 3 times

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Archaeological assessment reveals Earth's early transformation through land use.

Lucas Stephens, Dorian Fuller, Nicole Boivin, Torben Rick, Nicolas Gauthier, Andrea Kay, Ben Marwick, Chelsey Geralda Armstrong, C Michael Barton, Tim Denham, Kristina Douglass, Jonathan Driver, Lisa Janz, Patrick Roberts, J Daniel Rogers, Heather Thakar, Mark Altaweel, Amber L Johnson, Maria Marta Sampietro Vattuone, Mark Aldenderfer, Sonia Archila, Gilberto Artioli, Martin T Bale, Timothy Beach, Ferran Borrell, Todd Braje, Philip I Buckland, Nayeli Guadalupe Jiménez Cano, José M Capriles, Agustín Diez Castillo, Çiler Çilingiroğlu, Michelle Negus Cleary, James Conolly, Peter R Coutros, R Alan Covey, Mauro Cremaschi, Alison Crowther, Lindsay Der, Savino di Lernia, John F Doershuk, William E Doolittle, Kevin J Edwards, Jon M Erlandson, Damian Evans, Andrew Fairbairn, Patrick Faulkner, Gary Feinman, Ricardo Fernandes, Scott M Fitzpatrick, Ralph Fyfe, Elena Garcea, Steve Goldstein, Reed Charles Goodman, Jade Dalpoim Guedes, Jason Herrmann, Peter Hiscock, Peter Hommel, K Ann Horsburgh, Carrie Hritz, John W Ives, Aripekka Junno, Jennifer G Kahn, Brett Kaufman, Catherine Kearns, Tristram R Kidder, François Lanoë, Dan Lawrence, Gyoung-Ah Lee, Maureece J Levin, Henrik B Lindskoug, José Antonio López-Sáez, Scott Macrae, Rob Marchant, John M Marston, Sarah McClure, Mark D McCoy, Alicia Ventresca Miller, Michael Morrison, Giedre Motuzaite Matuzeviciute, Johannes Müller, Ayushi Nayak, Sofwan Noerwidi, Tanya M Peres, Christian E Peterson, Lucas Proctor, Asa R Randall, Steve Renette, Gwen Robbins Schug, Krysta Ryzewski, Rakesh Saini, Vivian Scheinsohn, Peter Schmidt, Pauline Sebillaud, Oula Seitsonen, Ian A Simpson, Arkadiusz Sołtysiak, Robert J Speakman, Robert N Spengler, Martina L Steffen, Michael J Storozum, Keir M Strickland, Jessica Thompson, T L Thurston, Sean Ulm, M Cemre Ustunkaya, Martin H Welker, Catherine West, Patrick Ryan Williams, David K Wright, Nathan Wright, Muhammad Zahir, Andrea Zerboni, Ella Beaudoin, Santiago Munevar Garcia, Jeremy Powell, Alexa Thornton, Jed O Kaplan, Marie-José Gaillard, Kees Klein Goldewijk, Erle Ellis,

Environmentally transformative human use of land accelerated with the emergence of agriculture, but the extent, trajectory, and implications of these early changes are not well understood. An empirical global assessment of land use from 10,000 years before the present (yr B.P.) to 1850 CE reveals a planet largely transformed by ... Read more >>

Science (Science (New York, N.Y.))
[2019, 365(6456):897-902]

Cited: 23 times

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Aged rats have an altered immune response and worse outcomes after traumatic brain injury.

Mujun Sun, Rhys D Brady, Pablo M Casillas-Espinosa, David K Wright, Bridgette D Semple, Hyun Ah Kim, Richelle Mychasiuk, Christopher G Sobey, Terence J O'Brien, Antony Vinh, Stuart J McDonald, Sandy R Shultz,

Initial studies suggest that increased age is associated with worse outcomes after traumatic brain injury (TBI), though the pathophysiological mechanisms responsible for this remain unclear. Immunosenescence (i.e., dysregulation of the immune system due to aging) may play a significant role in influencing TBI outcomes. This study therefore examined neurological outcomes ... Read more >>

Brain Behav Immun (Brain, behavior, and immunity)
[2019, 80:536-550]

Cited: 4 times

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A Scoping Review to Map Empirical Evidence Regarding Key Domains and Questions in the Clinical Pathway of Delirium in Palliative Care.

Peter G Lawlor, Nicole A Rutkowski, Alistair R MacDonald, Mohammed T Ansari, Lindsey Sikora, Franco Momoli, Salmaan Kanji, David K Wright, Erin Rosenberg, Annmarie Hosie, Jose L Pereira, David Meagher, Jill Rice, John Scott, Shirley H Bush,

CONTEXT:Based on the clinical care pathway of delirium in palliative care (PC), a published analytic framework (AF) formulated research questions in key domains and recommended a scoping review to identify evidence gaps. OBJECTIVES:To produce a literature map for key domains of the published AF: screening, prognosis and diagnosis, management, and ... Read more >>

J Pain Symptom Manage (Journal of pain and symptom management)
[2019, 57(3):661-681.e12]

Cited: 2 times

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Stand dynamics 11 years after retention harvest in a lodgepole pine forest

Justin S Crotteau, Christopher R Keyes, Sharon M Hood, Andrew J Larson, Elaine Kennedy Sutherland, David K Wright, Joel M Egan,

Structurally diverse forests provide resilience to an array of disturbances and are a mainstay of multiple-resource management. Silviculture based on natural disturbance can increase structural heterogeneity while providing other ecological and economic benefits. One useful silvicultural tool for promoting structural heterogeneity is retention harvesting, whereby a portion of forest stands ... Read more >>

For Ecol Manage (Forest ecology and management)
[2018, 427:169-181]

Cited: 0 times

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Elimination of vesicular zinc alters the behavioural and neuroanatomical effects of social defeat stress in mice.

Brendan B McAllister, David K Wright, Ryan C Wortman, Sandy R Shultz, Richard H Dyck,

Chronic stress can have deleterious effects on mental health, increasing the risk of developing depression or anxiety. But not all individuals are equally affected by stress; some are susceptible while others are more resilient. Understanding the mechanisms that lead to these differing outcomes has been a focus of considerable research. ... Read more >>

Neurobiol Stress (Neurobiology of stress)
[2018, 9:199-213]

Cited: 2 times

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Diffusion MRI abnormalities in adolescent rats given repeated mild traumatic brain injury.

Ryan C Wortman, Alicia Meconi, Katie J Neale, Rhys D Brady, Stuart J McDonald, Brian R Christie, David K Wright, Sandy R Shultz,

<h4>Objective</h4>Mild traumatic brain injury (mTBI) is a serious health concern in the adolescent population. Repeated mTBI may result in more pronounced deficits, and has been associated with long-term neurological consequences including neurodegeneration. As such, there is a critical need for the development of objective mTBI biomarkers to help guide medical ... Read more >>

Ann Clin Transl Neurol (Annals of clinical and translational neurology)
[2018, 5(12):1588-1598]

Cited: 4 times

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