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Association between convalescent plasma treatment and mortality in COVID-19: a collaborative systematic review and meta-analysis of randomized clinical trials.

Cathrine Axfors, Perrine Janiaud, Andreas M Schmitt, Janneke Van't Hooft, Emily R Smith, Noah A Haber, Akin Abayomi, Manal Abduljalil, Abdulkarim Abdulrahman, Yeny Acosta-Ampudia, Manuela Aguilar-Guisado, Farah Al-Beidh, Marissa M Alejandria, Rachelle N Alfonso, Mohammad Ali, Manaf AlQahtani, Alaa AlZamrooni, Juan-Manuel Anaya, Mark Angelo C Ang, Ismael F Aomar, Luis E Argumanis, Alexander Averyanov, Vladimir P Baklaushev, Olga Balionis, Thomas Benfield, Scott Berry, Nadia Birocco, Lynn B Bonifacio, Asha C Bowen, Abbie Bown, Carlos Cabello-Gutierrez, Bernardo Camacho, Adrian Camacho-Ortiz, Sally Campbell-Lee, Damon H Cao, Ana Cardesa, Jose M Carnate, German Jr J Castillo, Rossana Cavallo, Fazle R Chowdhury, Forhad U H Chowdhury, Giovannino Ciccone, Antonella Cingolani, Fresthel Monica M Climacosa, Veerle Compernolle, Carlo Francisco N Cortez, Abel Costa Neto, Sergio D'Antico, James Daly, Franca Danielle, Joshua S Davis, Francesco Giuseppe De Rosa, Justin T Denholm, Claudia M Denkinger, Daniel Desmecht, Juan C Díaz-Coronado, Juan A Díaz Ponce-Medrano, Anne-Françoise Donneau, Teresita E Dumagay, Susanna Dunachie, Cecile C Dungog, Olufemi Erinoso, Ivy Mae S Escasa, Lise J Estcourt, Amy Evans, Agnes L M Evasan, Christian J Fareli, Veronica Fernandez-Sanchez, Claudia Galassi, Juan E Gallo, Patricia J Garcia, Patricia L Garcia, Jesus A Garcia, Mutien Garigliany, Elvira Garza-Gonzalez, Deonne Thaddeus V Gauiran, Paula A Gaviria García, Jose-Antonio Giron-Gonzalez, David Gómez-Almaguer, Anthony C Gordon, André Gothot, Jeser Santiago Grass Guaqueta, Cameron Green, David Grimaldi, Naomi E Hammond, Heli Harvala, Francisco M Heralde, Jesica Herrick, Alisa M Higgins, Thomas E Hills, Jennifer Hines, Karin Holm, Ashraful Hoque, Eric Hoste, Jose M Ignacio, Alexander V Ivanov, Maike Janssen, Jeffrey H Jennings, Vivekanand Jha, Ruby Anne N King, Jens Kjeldsen-Kragh, Paul Klenerman, Aditya Kotecha, Fiorella Krapp, Luciana Labanca, Emma Laing, Mona Landin-Olsson, Pierre-François Laterre, Lyn-Li Lim, Jodor Lim, Oskar Ljungquist, Jorge M Llaca-Díaz, Concepción López-Robles, Salvador López-Cárdenas, Ileana Lopez-Plaza, Josephine Anne C Lucero, Maria Lundgren, Juan Macías, Sandy C Maganito, Anna Flor G Malundo, Rubén D Manrique, Paola M Manzini, Miguel Marcos, Ignacio Marquez, Francisco Javier Martínez-Marcos, Ana M Mata, Colin J McArthur, Zoe K McQuilten, Bryan J McVerry, David K Menon, Geert Meyfroidt, Ma Angelina L Mirasol, Benoît Misset, James S Molton, Alric V Mondragon, Diana M Monsalve, Parastoo Moradi Choghakabodi, Susan C Morpeth, Paul R Mouncey, Michel Moutschen, Carsten Müller-Tidow, Erin Murphy, Tome Najdovski, Alistair D Nichol, Henrik Nielsen, Richard M Novak, Matthew V N O'Sullivan, Julian Olalla, Akin Osibogun, Bodunrin Osikomaiya, Salvador Oyonarte, Juan M Pardo-Oviedo, Mahesh C Patel, David L Paterson, Carlos A Peña-Perez, Angel A Perez-Calatayud, Eduardo Pérez-Alba, Anastasia Perkina, Naomi Perry, Mandana Pouladzadeh, Inmaculada Poyato, David J Price, Anne Kristine H Quero, Md M Rahman, Md S Rahman, Mayur Ramesh, Carolina Ramírez-Santana, Magnus Rasmussen, Megan A Rees, Eduardo Rego, Jason A Roberts, David J Roberts, Yhojan Rodríguez, Jesús Rodríguez-Baño, Benjamin A Rogers, Manuel Rojas, Alberto Romero, Kathryn M Rowan, Fabio Saccona, Mehdi Safdarian, Maria Clariza M Santos, Joe Sasadeusz, Gitana Scozzari, Manu Shankar-Hari, Gorav Sharma, Thomas Snelling, Alonso Soto, Pedrito Y Tagayuna, Amy Tang, Geneva Tatem, Luciana Teofili, Steven Y C Tong, Alexis F Turgeon, Januario D Veloso, Balasubramanian Venkatesh, Yanet Ventura-Enriquez, Steve A Webb, Lothar Wiese, Christian Wikén, Erica M Wood, Gaukhar M Yusubalieva, Kai Zacharowski, Ryan Zarychanski, Nina Khanna, David Moher, Steven N Goodman, John P A Ioannidis, Lars G Hemkens,

<h4>Background</h4>Convalescent plasma has been widely used to treat COVID-19 and is under investigation in numerous randomized clinical trials, but results are publicly available only for a small number of trials. The objective of this study was to assess the benefits of convalescent plasma treatment compared to placebo or no treatment ... Read more >>

BMC Infect Dis (BMC infectious diseases)
[2021, 21(1):1170]

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A Precuneal Causal Loop Mediates External and Internal Information Integration in the Human Brain.

Dian Lyu, Ioannis Pappas, David K Menon, Emmanuel A Stamatakis,

Human brains interpret external stimuli based on internal representations. One untested hypothesis is that the default-mode network (DMN), widely considered responsible for internally oriented cognition, can decode external information. Here, we posit that the unique structural and functional fingerprint of the precuneus (PCu) supports a prominent role for the posterior ... Read more >>

J Neurosci (The Journal of neuroscience : the official journal of the Society for Neuroscience)
[2021, :]

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Effect of Convalescent Plasma on Organ Support-Free Days in Critically Ill Patients With COVID-19: A Randomized Clinical Trial.

, Lise J Estcourt, Alexis F Turgeon, Zoe K McQuilten, Bryan J McVerry, Farah Al-Beidh, Djillali Annane, Yaseen M Arabi, Donald M Arnold, Abigail Beane, Philippe Bégin, Wilma van Bentum-Puijk, Lindsay R Berry, Zahra Bhimani, Janet E Birchall, Marc J M Bonten, Charlotte A Bradbury, Frank M Brunkhorst, Meredith Buxton, Jeannie L Callum, Michaël Chassé, Allen C Cheng, Matthew E Cove, James Daly, Lennie Derde, Michelle A Detry, Menno De Jong, Amy Evans, Dean A Fergusson, Matthew Fish, Mark Fitzgerald, Claire Foley, Herman Goossens, Anthony C Gordon, Iain B Gosbell, Cameron Green, Rashan Haniffa, Heli Harvala, Alisa M Higgins, Thomas E Hills, Veronica C Hoad, Christopher Horvat, David T Huang, Cara L Hudson, Nao Ichihara, Emma Laing, Abigail A Lamikanra, François Lamontagne, Patrick R Lawler, Kelsey Linstrum, Edward Litton, Elizabeth Lorenzi, Sheila MacLennan, John Marshall, Daniel F McAuley, John F McDyer, Anna McGlothlin, Shay McGuinness, Gail Miflin, Stephanie Montgomery, Paul R Mouncey, Srinivas Murthy, Alistair Nichol, Rachael Parke, Jane C Parker, Nicole Priddee, Damian F J Purcell, Luis F Reyes, Peter Richardson, Nancy Robitaille, Kathryn M Rowan, Jennifer Rynne, Hiroki Saito, Marlene Santos, Christina T Saunders, Ary Serpa Neto, Christopher W Seymour, Jon A Silversides, Alan A Tinmouth, Darrell J Triulzi, Anne M Turner, Frank van de Veerdonk, Timothy S Walsh, Erica M Wood, Scott Berry, Roger J Lewis, David K Menon, Colin McArthur, Ryan Zarychanski, Derek C Angus, Steve A Webb, David J Roberts, Manu Shankar-Hari,

<h4>Importance</h4>The evidence for benefit of convalescent plasma for critically ill patients with COVID-19 is inconclusive.<h4>Objective</h4>To determine whether convalescent plasma would improve outcomes for critically ill adults with COVID-19.<h4>Design, setting, and participants</h4>The ongoing Randomized, Embedded, Multifactorial, Adaptive Platform Trial for Community-Acquired Pneumonia (REMAP-CAP) enrolled and randomized 4763 adults with suspected or ... Read more >>

JAMA (JAMA)
[2021, 326(17):1690-1702]

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Role of hyperpolarization-activated cyclic nucleotide-gated ion channels in neuropathic pain: a proof-of-concept study of ivabradine in patients with chronic peripheral neuropathic pain.

Shannon A Bernard Healey, Ingrid Scholtes, Mark Abrahams, Peter A McNaughton, David K Menon, Michael C Lee,

<h4>Introduction</h4>Hyperpolarization-activated cyclic nucleotide-gated (HCN) ion channels mediate repetitive action potential firing in the heart and nervous system. The HCN2 isoform is expressed in nociceptors, and preclinical studies suggest a critical role in neuropathic pain. Ivabradine is a nonselective HCN blocker currently available for prescription for cardiac indications. Mouse data suggest ... Read more >>

Pain Rep (Pain reports)
[2021, 6(4):e967]

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Reliability of multi-modal MRI-derived brain phenotypes for multi-site assessment of neuropsychiatric complications of SARS-CoV-2 infection

Eugene Duff, Fernando Zelaya, Fidel Alfaro Almagro, Karla Miller, Naomi Martin, Thomas Nichols, Bernd Taschler, Ludovica Griffanti, Christoph Arthofer, Chaoyue Wang, Richard A.I. Bethlehem, Klaus Eickel, Matthias Günther, David Menon, Guy Williams, Bethany Facer, Greta Wood, David Lythgoe, Flavio Dell’Acqua, Steven CR Williams, Gavin Houston, Simon Keller, Gerome Breen, Benedict Michael, Peter Jezzard, Stephen Smith, Edward Bullmore,

<h4>Background</h4> Magnetic resonance imaging (MRI) of the brain could be a key diagnostic and research tool for understanding the neuropsychiatric complications of COVID-19. For maximum impact, multi-modal MRI protocols will be needed to measure the effects of SARS-CoV2 infection on the brain by diverse potentially pathogenic mechanisms, and with high ... Read more >>

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Modeling Brain-Heart Crosstalk Information in Patients with Traumatic Brain Injury.

Giovanna Maria Dimitri, Erta Beqiri, Michal M Placek, Marek Czosnyka, Nino Stocchetti, Ari Ercole, Peter Smielewski, Pietro Lió, ,

<h4>Background</h4>Traumatic brain injury (TBI) is an extremely heterogeneous and complex pathology that requires the integration of different physiological measurements for the optimal understanding and clinical management of patients. Information derived from intracranial pressure (ICP) monitoring can be coupled with information obtained from heart rate (HR) monitoring to assess the interplay ... Read more >>

Neurocrit Care (Neurocritical care)
[2021, :]

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Focally administered succinate improves cerebral metabolism in traumatic brain injury patients with mitochondrial dysfunction.

Abdelhakim Khellaf, Nuria Marco Garcia, Tamara Tajsic, Aftab Alam, Matthew G Stovell, Monica J Killen, Duncan J Howe, Mathew R Guilfoyle, Ibrahim Jalloh, Ivan Timofeev, Michael P Murphy, T Adrian Carpenter, David K Menon, Ari Ercole, Peter J Hutchinson, Keri Lh Carpenter, Eric P Thelin, Adel Helmy,

Following traumatic brain injury (TBI), raised cerebral lactate/pyruvate ratio (LPR) reflects impaired energy metabolism. Raised LPR correlates with poor outcome and mortality following TBI. We prospectively recruited patients with TBI requiring neurocritical care and multimodal monitoring, and utilised a tiered management protocol targeting LPR. We identified patients with persistent raised ... Read more >>

J Cereb Blood Flow Metab (Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism)
[2021, :271678X211042112]

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Virological Characterization of Critically Ill Patients With COVID-19 in the United Kingdom: Interactions of Viral Load, Antibody Status, and B.1.1.7 Infection.

Jeremy Ratcliff, Dung Nguyen, Matthew Fish, Jennifer Rynne, Aislinn Jennings, Sarah Williams, Farah Al-Beidh, David Bonsall, Amy Evans, Tanya Golubchik, Anthony C Gordon, Abigail Lamikanra, Pat Tsang, Nick A Ciccone, Ullrich Leuscher, Wendy Slack, Emma Laing, Paul R Mouncey, Sheba Ziyenge, Marta Oliveira, Rutger Ploeg, Kathryn M Rowan, Manu Shankar-Hari, David J Roberts, David K Menon, Lise Estcourt, Peter Simmonds, Heli Harvala, ,

<h4>Background</h4>Convalescent plasma containing neutralizing antibody to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is under investigation for coronavirus disease 2019 (COVID-19) treatment. We report diverse virological characteristics of UK intensive care patients enrolled in the Immunoglobulin Domain of the REMAP-CAP randomized controlled trial that potentially influence treatment outcomes.<h4>Methods</h4>SARS-CoV-2 RNA in ... Read more >>

J Infect Dis (The Journal of infectious diseases)
[2021, 224(4):595-605]

Cited: 9 times

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Spectrum, risk factors and outcomes of neurological and psychiatric complications of COVID-19: a UK-wide cross-sectional surveillance study.

Amy L Ross Russell, Marc Hardwick, Athavan Jeyanantham, Laura M White, Saumitro Deb, Girvan Burnside, Harriet M Joy, Craig J Smith, Thomas A Pollak, Timothy R Nicholson, Nicholas W S Davies, Hadi Manji, Ava Easton, Stephen Ray, Michael S Zandi, Jonathan P Coles, David K Menon, Aravinthan Varatharaj, Beth McCausland, Mark A Ellul, Naomi Thomas, Gerome Breen, Stephen Keddie, Michael P Lunn, John P S Burn, Graziella Quattrocchi, Luke Dixon, Claire M Rice, George Pengas, Rustam Al-Shahi Salman, Alan Carson, Eileen M Joyce, Martin R Turner, Laura A Benjamin, Tom Solomon, Rachel Kneen, Sarah Pett, Rhys H Thomas, Benedict D Michael, Ian Galea,

SARS-CoV-2 is associated with new-onset neurological and psychiatric conditions. Detailed clinical data, including factors associated with recovery, are lacking, hampering prediction modelling and targeted therapeutic interventions. In a UK-wide cross-sectional surveillance study of adult hospitalized patients during the first COVID-19 wave, with multi-professional input from general and sub-specialty neurologists, psychiatrists, ... Read more >>

Brain Commun (Brain communications)
[2021, 3(3):fcab168]

Cited: 3 times

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Persistent SARS-CoV-2 infection: the urgent need for access to treatment and trials.

Ed Moran, Tim Cook, Anna L Goodman, Ravindra K Gupta, Stephen Jolles, David K Menon, David J Roberts, Sinisa Savic, Manu Shankar-Hari, Michael Brown, David M Lowe,

Lancet Infect Dis (The Lancet. Infectious diseases)
[2021, 21(10):1345-1347]

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Targeting Autoregulation-Guided Cerebral Perfusion Pressure after Traumatic Brain Injury (COGiTATE): A Feasibility Randomized Controlled Clinical Trial.

Jeanette Tas, Erta Beqiri, Ruud C van Kaam, Marek Czosnyka, Joseph Donnelly, Roel H Haeren, Iwan C C van der Horst, Peter J Hutchinson, Sander M J van Kuijk, Analisa L Liberti, David K Menon, Cornelia W E Hoedemaekers, Bart Depreitere, Peter Smielewski, Geert Meyfroidt, Ari Ercole, Marcel J H Aries,

Managing traumatic brain injury (TBI) patients with a cerebral perfusion pressure (CPP) near to the cerebral autoregulation (CA)-guided "optimal" CPP (CPPopt) value is associated with improved outcome and might be useful to individualize care, but has never been prospectively evaluated. This study evaluated the feasibility and safety of CA-guided CPP ... Read more >>

J Neurotrauma (Journal of neurotrauma)
[2021, 38(20):2790-2800]

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Delta band activity contributes to the identification of command following in disorder of consciousness.

Gonzalo Rivera-Lillo, Emmanuel A Stamatakis, Tristan A Bekinschtein, David K Menon, Srivas Chennu,

The overt or covert ability to follow commands in patients with disorders of consciousness is considered a sign of awareness and has recently been defined as cortically mediated behaviour. Despite its clinical relevance, the brain signatures of the perceptual processing supporting command following have been elusive. This multimodal study investigates ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):16267]

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Imputation strategies for missing baseline neurological assessment covariates after traumatic brain injury: A CENTER-TBI study.

Ari Ercole, Abhishek Dixit, David W Nelson, Shubhayu Bhattacharyay, Frederick A Zeiler, Daan Nieboer, Omar Bouamra, David K Menon, Andrew I R Maas, Simone A Dijkland, Hester F Lingsma, Lindsay Wilson, Fiona Lecky, Ewout W Steyerberg, ,

Statistical models for outcome prediction are central to traumatic brain injury research and critical to baseline risk adjustment. Glasgow coma score (GCS) and pupil reactivity are crucial covariates in all such models but may be measured at multiple time points between the time of injury and hospital and are subject ... Read more >>

PLoS One (PloS one)
[2021, 16(8):e0253425]

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Occurrence and timing of withdrawal of life-sustaining measures in traumatic brain injury patients: a CENTER-TBI study.

Ernest van Veen, Mathieu van der Jagt, Giuseppe Citerio, Nino Stocchetti, Diederik Gommers, Alex Burdorf, David K Menon, Andrew I R Maas, Erwin J O Kompanje, Hester F Lingsma, ,

<h4>Background</h4>In patients with severe brain injury, withdrawal of life-sustaining measures (WLSM) is common in intensive care units (ICU). WLSM constitutes a dilemma: instituting WLSM too early could result in death despite the possibility of an acceptable functional outcome, whereas delaying WLSM could unnecessarily burden patients, families, clinicians, and hospital resources. ... Read more >>

Intensive Care Med (Intensive care medicine)
[2021, 47(10):1115-1129]

Cited: 0 times

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A Precision Medicine Framework for Classifying Patients with Disorders of Consciousness: Advanced Classification of Consciousness Endotypes (ACCESS).

Daniel Kondziella, David K Menon, Raimund Helbok, Lionel Naccache, Marwan H Othman, Verena Rass, Benjamin Rohaut, Michael N Diringer, Robert D Stevens, ,

<h4>Background</h4>Consciousness in patients with brain injury is traditionally assessed based on semiological evaluation at the bedside. This classification is limited because of low granularity, ill-defined and rigid nomenclatures incompatible with the highly fluctuating nature of consciousness, failure to identify specific brain states like cognitive motor dissociation, and neglect for underlying ... Read more >>

Neurocrit Care (Neurocritical care)
[2021, 35(Suppl 1):27-36]

Cited: 2 times

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Brain Temperature Influences Intracranial Pressure and Cerebral Perfusion Pressure After Traumatic Brain Injury: A CENTER-TBI Study.

Tatiana Birg, Fabrizio Ortolano, Eveline J A Wiegers, Peter Smielewski, Yan Savchenko, Bogdan A Ianosi, Raimund Helbok, Sandra Rossi, Marco Carbonara, Tommaso Zoerle, Nino Stocchetti, ,

<h4>Background</h4>After traumatic brain injury (TBI), fever is frequent. Brain temperature (BT), which is directly linked to body temperature, may influence brain physiology. Increased body and/or BT may cause secondary brain damage, with deleterious effects on intracranial pressure (ICP), cerebral perfusion pressure (CPP), and outcome.<h4>Methods</h4>Collaborative European NeuroTrauma Effectiveness Research in Traumatic ... Read more >>

Neurocrit Care (Neurocritical care)
[2021, :]

Cited: 0 times

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Management of arterial partial pressure of carbon dioxide in the first week after traumatic brain injury: results from the CENTER-TBI study.

Giuseppe Citerio, Chiara Robba, Paola Rebora, Matteo Petrosino, Eleonora Rossi, Letterio Malgeri, Nino Stocchetti, Stefania Galimberti, David K Menon, ,

<h4>Purpose</h4>To describe the management of arterial partial pressure of carbon dioxide (PaCO<sub>2</sub>) in severe traumatic brain-injured (TBI) patients, and the optimal target of PaCO<sub>2</sub> in patients with high intracranial pressure (ICP).<h4>Methods</h4>Secondary analysis of CENTER-TBI, a multicentre, prospective, observational, cohort study. The primary aim was to describe current practice in PaCO<sub>2</sub> ... Read more >>

Intensive Care Med (Intensive care medicine)
[2021, 47(9):961-973]

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Brain Hypoxia Is Associated With Neuroglial Injury in Humans Post-Cardiac Arrest.

Ryan L Hoiland, Philip N Ainslie, Cheryl L Wellington, Jennifer Cooper, Sophie Stukas, Sonny Thiara, Denise Foster, Nicholas A Fergusson, Edward M Conway, David K Menon, Peter Gooderham, Veronica Hirsch-Reinshagen, Donald E Griesdale, Mypinder S Sekhon,

[Figure: see text]. ... Read more >>

Circ Res (Circulation research)
[2021, 129(5):583-597]

Cited: 1 time

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Metabolic derangements are associated with impaired glucose delivery following traumatic brain injury.

Jeroen Hermanides, Young T Hong, Monica Trivedi, Joanne Outtrim, Franklin Aigbirhio, Peter J Nestor, Matthew Guilfoyle, Stefan Winzeck, Virginia F J Newcombe, Tilak Das, Marta M Correia, Keri L H Carpenter, Peter J A Hutchinson, Arun K Gupta, Tim D Fryer, John D Pickard, David K Menon, Jonathan P Coles,

Metabolic derangements following traumatic brain injury are poorly characterised. In this single-centre observational cohort study we combined 18F-FDG and multi-tracer oxygen-15 PET to comprehensively characterise the extent and spatial pattern of metabolic derangements. Twenty-six patients requiring sedation and ventilation with intracranial pressure monitoring following head injury within a Neurosciences Critical ... Read more >>

Brain (Brain : a journal of neurology)
[2021, :]

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Dopaminergic brainstem disconnection is common to pharmacological and pathological consciousness perturbation.

Lennart R B Spindler, Andrea I Luppi, Ram M Adapa, Michael M Craig, Peter Coppola, Alexander R D Peattie, Anne E Manktelow, Paola Finoia, Barbara J Sahakian, Guy B Williams, Judith Allanson, John D Pickard, David K Menon, Emmanuel A Stamatakis,

Clinical research into consciousness has long focused on cortical macroscopic networks and their disruption in pathological or pharmacological consciousness perturbation. Despite demonstrating diagnostic utility in disorders of consciousness (DoC) and monitoring anesthetic depth, these cortico-centric approaches have been unable to characterize which neurochemical systems may underpin consciousness alterations. Instead, preclinical ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2021, 118(30):]

Cited: 2 times

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Finding a Place for Candidate Gene Studies in a Genome-Wide Association Study World.

David K Menon, Jonathan Rosand,

JAMA Netw Open (JAMA network open)
[2021, 4(7):e2118594]

Cited: 0 times

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The future of acute and emergency care.

Virginia Newcombe, Timothy Coats, Paul Dark, Anthony Gordon, Steve Harris, Danny F McAuley, David K Menon, Susanna Price, Zudin Puthucheary, Mervyn Singer,

Improved outcomes for acutely unwell patients are predicated on early identification of deterioration, accelerating the time to accurate diagnosis of the underlying condition, selection and titration of treatments that target biological phenotypes, and personalised endpoints to achieve optimal benefit yet minimise iatrogenic harm. Technological developments entering routine clinical practice over ... Read more >>

Future Healthc J (Future healthcare journal)
[2021, 8(2):e230-e236]

Cited: 0 times

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Complex Autoantibody Responses Occur following Moderate to Severe Traumatic Brain Injury.

Edward J Needham, Oda Stoevesandt, Eric P Thelin, Henrik Zetterberg, Elisa R Zanier, Faiez Al Nimer, Nicholas J Ashton, Joanne G Outtrim, Virginia F J Newcombe, Hani S Mousa, Joel Simrén, Kaj Blennow, Zhihui Yang, Peter J Hutchinson, Fredrik Piehl, Adel E Helmy, Mike J Taussig, Kevin K W Wang, Joanne L Jones, David K Menon, Alasdair J Coles,

Most of the variation in outcome following severe traumatic brain injury (TBI) remains unexplained by currently recognized prognostic factors. Neuroinflammation may account for some of this difference. We hypothesized that TBI generated variable autoantibody responses between individuals that would contribute to outcome. We developed a custom protein microarray to detect ... Read more >>

J Immunol (Journal of immunology (Baltimore, Md. : 1950))
[2021, :]

Cited: 1 time

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Preserved fractal character of structural brain networks is associated with covert consciousness after severe brain injury.

Andrea I Luppi, Michael M Craig, Peter Coppola, Alexander R D Peattie, Paola Finoia, Guy B Williams, Judith Allanson, John D Pickard, David K Menon, Emmanuel A Stamatakis,

Self-similarity is ubiquitous throughout natural phenomena, including the human brain. Recent evidence indicates that fractal dimension of functional brain networks, a measure of self-similarity, is diminished in patients diagnosed with disorders of consciousness arising from severe brain injury. Here, we set out to investigate whether loss of self-similarity is observed ... Read more >>

Neuroimage Clin (NeuroImage. Clinical)
[2021, 30:102682]

Cited: 1 time

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Global Incidence of Neurological Manifestations Among Patients Hospitalized With COVID-19-A Report for the GCS-NeuroCOVID Consortium and the ENERGY Consortium.

Sherry H-Y Chou, Ettore Beghi, Raimund Helbok, Elena Moro, Joshua Sampson, Valeria Altamirano, Shraddha Mainali, Claudio Bassetti, Jose I Suarez, Molly McNett, ,

<h4>Importance</h4>The COVID-19 pandemic continues to affect millions of people globally, with increasing reports of neurological manifestations but limited data on their incidence and associations with outcome.<h4>Objective</h4>To determine the neurological phenotypes, incidence, and outcomes among adults hospitalized with COVID-19.<h4>Design, setting, and participants</h4>This cohort study included patients with clinically diagnosed or laboratory-confirmed ... Read more >>

JAMA Netw Open (JAMA network open)
[2021, 4(5):e2112131]

Cited: 13 times

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