Full Text Journal Articles by
Author David Guenat

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DNA demethylation agent 5azadC downregulates HPV16 E6 expression in cervical cancer cell lines independently of TBX2 expression.

Jerome Perrard, Adrien Morel, Koceila Meznad, Philippe Paget-Bailly, Veronique Dalstein, David Guenat, Celine Mourareau, Christine Clavel, Sylvie Fauconnet, Aurelie Baguet, Christiane Mougin, Jean-Luc Pretet,

HPV16 is the most carcinogenic human papillomavirus and causes >50% of cervical cancers, the majority of anal cancers and 30% of oropharyngeal squamous cell carcinomas. HPV carcinogenesis relies on the continuous expression of the two main viral oncoproteins E6 and E7 that target >150 cellular proteins. Among them, epigenetic modifiers, ... Read more >>

Oncol Lett (Oncology letters)
[2020, 19(1):1074-1081]

Cited: 0 times

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Clinical Validity of HPV Circulating Tumor DNA in Advanced Anal Carcinoma: An Ancillary Study to the Epitopes-HPV02 Trial.

Alice Bernard-Tessier, Emmanuelle Jeannot, David Guenat, Alice Debernardi, Marc Michel, Charlotte Proudhon, Anne Vincent-Salomon, Ivan Bièche, Jean-Yves Pierga, Bruno Buecher, Aurélia Meurisse, Éric François, Romain Cohen, Marine Jary, Véronique Vendrely, Emmanuelle Samalin, Farid El Hajbi, Nabil Baba-Hamed, Christophe Borg, François-Clément Bidard, Stefano Kim,

PURPOSE:Human papillomavirus (HPV) is found in 90% of squamous cell carcinomas of the anal canal (SCCA). We investigated the clinical validity of HPV circulating tumor DNA (ctDNA) detection in patients enrolled in the Epitopes-HPV02 trial that demonstrated the efficacy of docetaxel, cisplatin, and 5-FU as first-line chemotherapy in advanced SCCA. ... Read more >>

Clin Cancer Res (Clinical cancer research : an official journal of the American Association for Cancer Research)
[2019, 25(7):2109-2115]

Cited: 3 times

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Personalized identification of tumor-associated immunogenic neoepitopes in hepatocellular carcinoma in complete remission after sorafenib treatment.

Sindy Vrecko, David Guenat, Patricia Mercier-Letondal, Hugues Faucheu, Magalie Dosset, Bernard Royer, Jeanne Galaine, Romain Boidot, Stefano Kim, Marine Jary, Olivier Adotévi, Christophe Borg, Yann Godet,

Sorafenib, a multi-targeted kinase inhibitor, is the current standard systemic treatment for advanced hepatocellular carcinoma. Sorafenib has anti-angiogenic and anti-proliferative properties and is also known to favor anti-tumor T cell responses by reducing the population of immunosuppressive cells such as Treg and MDSC. Anti-tumor immune responses, especially mediated by CD4+ ... Read more >>

Oncotarget (Oncotarget)
[2018, 9(83):35394-35407]

Cited: 2 times

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Development and interlaboratory agreement of real-time PCR for HPV16 quantification in liquid-based cervical samples.

David Guenat, Véronique Dalstein, Frédéric Mauny, Maëlle Saunier, Jenny Briolat, Christine Clavel, Didier Riethmuller, Christiane Mougin, Jean-Luc Prétet,

High risk HPV infection is the necessary cause for the development of precancerous and cancerous lesions of the cervix. Among HPV, HPV16 represents the most carcinogenic type. Since the determination of HPV16 DNA load could be clinically useful, we assessed quantitative real-time PCR targeting E6HPV16 and albumin genes on two ... Read more >>

Papillomavirus Res (Papillomavirus research (Amsterdam, Netherlands))
[2018, 6:27-32]

Cited: 0 times

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Awareness of cervical cancer among women attending an HIV treatment centre: a cross-sectional study from Morocco.

Essaada Belglaiaa, Tiatou Souho, Latifa Badaoui, Michel Segondy, Jean-Luc Prétet, David Guenat, Christiane Mougin,

OBJECTIVE:To explore awareness about cervical cancer among Moroccan women attending an HIV treatment centre in Laâyoune city, Morocco. DESIGN:A cross-sectional study was conducted from April to June 2017 using a knowledge test regarding cervical cancer, its risk factors and its prevention. SETTING:HIV treatment centre at the Hospital of Moulay Hassan ... Read more >>

BMJ Open (BMJ open)
[2018, 8(8):e020343]

Cited: 1 time

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A dualistic model of primary anal canal adenocarcinoma with distinct cellular origins, etiologies, inflammatory microenvironments and mutational signatures: implications for personalised medicine.

Michael Herfs, Patrick Roncarati, Benjamin Koopmansch, Olivier Peulen, Diane Bruyere, Alizee Lebeau, Elodie Hendrick, Pascale Hubert, Aurelie Poncin, William Penny, Nathalie Piazzon, Franck Monnien, David Guenat, Christiane Mougin, Jean-Luc Prétet, Lucine Vuitton, Karin Segers, Frederic Lambert, Vincent Bours, Laurence de Leval, Severine Valmary-Degano, Charles M Quick, Christopher P Crum, Philippe Delvenne,

BACKGROUND:Primary adenocarcinoma of the anal canal is a rare and aggressive gastrointestinal disease with unclear pathogenesis. Because of its rarity, no clear clinical practice guideline has been defined and a targeted therapeutic armamentarium has yet to be developed. The present article aimed at addressing this information gap by in-depth characterising ... Read more >>

Br J Cancer (British journal of cancer)
[2018, 118(10):1302-1312]

Cited: 3 times

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5azadC treatment upregulates miR-375 level and represses HPV16 E6 expression.

Adrien Morel, Aurélie Baguet, Jérôme Perrard, Caroline Demeret, Elise Jacquin, David Guenat, Christiane Mougin, Jean-Luc Prétet,

High-risk human papillomaviruses are the etiological agents of cervical cancer and HPV16 is the most oncogenic genotype. Immortalization and transformation of infected cells requires the overexpression of the two viral oncoproteins E6 and E7 following HPV DNA integration into the host cell genome. Integration often leads to the loss of ... Read more >>

Oncotarget (Oncotarget)
[2017, 8(28):46163-46176]

Cited: 5 times

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DNA damage response defect in Williams-Beuren syndrome.

David Guenat, Giuseppe Merla, Eric Deconinck, Christophe Borg, Pierre-Simon Rohrlich,

Williams-Beuren syndrome (WBS, no. OMIM 194050) is a rare multisystem genetic disorder caused by a microdeletion on chromosome 7q11.23 and characterized by cardiovascular malformations, mental retardation, and a specific facial dysmorphism. Recently, we reported that a series of non‑Hodgkin's lymphoma occurs in children with WBS and thus hypothesized that a predisposition to ... Read more >>

Int. J. Mol. Med. (International journal of molecular medicine)
[2017, 39(3):622-628]

Cited: 2 times

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Somatic mutational spectrum analysis in a prospective series of 104 gastrointestinal stromal tumors.

David Guenat, Olivier Deroo, Sandrine Magnin, Loïc Chaigneau, Franck Monnien, Christophe Borg, Christiane Mougin, Jean-François Emile, Jean-Luc Prétet,

Gastrointestinal stromal tumors (GISTs) are mesenchymal tumors distinguished by driver mutations in proto-oncogenes KIT or PDGFRA in 85-90% of cases. These mutations have been linked to the response to imatinib, a multikinase inhibitor, and have independent prognostic impact. Here, we describe the prospective study of the molecular characteristics of 104 GISTs ... Read more >>

Oncol. Rep. (Oncology reports)
[2017, 37(3):1671-1681]

Cited: 0 times

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Validation of Novaprep(®) HQ+ liquid-based cytology medium for high-risk human papillomavirus detection by hc2.

David Guenat, Sophie Launay, Didier Riethmuller, Christiane Mougin, Jean-Luc Prétet,

BACKGROUND:Preanalytical conditions determine the reliability and validity of bioassays. Therefore, the analytic performances of biological tests need to be determined when preanalytical steps differ from those recommended by the manufacturer. The objective of the study was to assess the analytic performance of the hc2 test for the detection of high-risk ... Read more >>

(Infectious agents and cancer)
[2016, 11:41]

Cited: 1 time

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[Analysis of MGMT methylation with the therascreen(®) MGMT Pyro(®) Kit (Qiagen). A method verification].

Alexandra Luquain, Sandrine Magnin, David Guenat, Jean-Luc Prétet, Gabriel Viennet, Séverine Valmary-Degano, Christiane Mougin,

Promoter methylation of the MGMT gene, encoding the enzyme O6-methylguanine-ubiquitous methyltransferase, is a theranostic good prognosis marker of glioblastomas treated with alkylating chemotherapy (temozolomide, Temodal(®)). Among the methylation analysis techniques, pyrosequencing is a reproducible and sensitive quantitative method. As part of the accreditation of the hospital platform of molecular genetics ... Read more >>

Ann. Biol. Clin. (Paris) (Annales de biologie clinique)
[2015, 73(6):665-670]

Cited: 1 time

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High prevalence of abnormal cervical smears in a hospital cohort of French women beyond the upper age limit screening program.

Alexandra Luquain, Essaada Belglaiaa, David Guenat, Sindy Vrecko, Didier Riethmuller, Séverine Valmary-Degano, Isabelle Bedgedjian, Said Chouham, Jean-Luc Prétet, Christiane Mougin,

To determine the prevalence of cytological abnormalities and high risk Human PapillomaVirus (hrHPV) in cervical smears from French women aged over 65 years who attended the referent Gynecology Clinic of the Besançon University Hospital.Between 2002 and 2012, 796 French women aged 66-99 years were cotested for cytology and hrHPV by ... Read more >>

Prev Med (Preventive medicine)
[2015, 81:157-162]

Cited: 1 time

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Nouveaux biomarqueurs viraux des lésions du col de l'utérus associées aux papillomavirus humains.

Élise Jacquin, David Guenat, Didier Riethmuller, Christiane Mougin, Jean-Luc Prétet,

High-risk human Papillomaviruses (HR-HPV) - the most carcinogenic infectious agents - are responsible for the development of cervical cancer. The knowledge of HPV infection natural history and viral carcinogenesis led to the investigation of viral biomarkers (genotype, viral load, integration, E6/E7 mRNA expression, viral DNA methylation) from clinical samples representative of the evolution ... Read more >>

Virologie (Montrouge) (Virologie (Montrouge, France))
[2014, 18(4):211-228]

Cited: 0 times

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Constitutional and somatic deletions of the Williams-Beuren syndrome critical region in non-Hodgkin lymphoma.

David Guenat, Samuel Quentin, Carmelo Rizzari, Catarina Lundin, Tiziana Coliva, Patrick Edery, Helen Fryssira, Laurent Bermont, Christophe Ferrand, Jean Soulier, Christophe Borg, Pierre-Simon Rohrlich,

Here, we report and investigate the genomic alterations of two novel cases of Non-Hodgkin Lymphoma (NHL) in children with Williams-Beuren syndrome (WBS), a multisystem disorder caused by 7q11.23 hemizygous deletion. Additionally, we report the case of a child with NHL and a somatic 7q11.23 deletion. Although the WBS critical region ... Read more >>

J Hematol Oncol (Journal of hematology & oncology)
[2014, 7:82]

Cited: 4 times

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New HPV16 viral biomarkers to understand the progression of cervical lesions towards cancer.

Jean-Luc Prétet, David Guenat, Didier Riethmuller, Christiane Mougin,

Indian J. Med. Res. (The Indian journal of medical research)
[2014, 139(4):487-489]

Cited: 1 time

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