Full Text Journal Articles by
Author David Durantel

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Two-dimensional-cultures of primary human hepatocytes allow efficient HBV infection: Old tricks still work!

Julie Lucifora, Maud Michelet, Michel Rivoire, Ulrike Protzer, David Durantel, Fabien Zoulim,

J. Hepatol. (Journal of hepatology)
[2020, 73(2):449-451]

Cited: 0 times

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Nucleic Acid Polymers are Effective in Targeting Hepatitis B Surface Antigen, but More Trials Are Needed.

David Durantel, Tarik Asselah,

Gastroenterology (Gastroenterology)
[2020, 158(8):2051-2054]

Cited: 0 times

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A dual role for hepatocyte-intrinsic canonical NF-κB signaling in virus control.

Sukumar Namineni, Tracy O'Connor, Suzanne Faure-Dupuy, Pål Johansen, Tobias Riedl, Kaijing Liu, Haifeng Xu, Indrabahadur Singh, Prashant Shinde, Fanghui Li, Aleksandra Pandyra, Piyush Sharma, Marc Ringelhan, Andreas Muschaweckh, Katharina Borst, Patrick Blank, Sandra Lampl, Katharina Neuhaus, David Durantel, Rayan Farhat, Achim Weber, Daniela Lenggenhager, Thomas M Kündig, Peter Staeheli, Ulrike Protzer, Dirk Wohlleber, Bernhard Holzmann, Marco Binder, Kai Breuhahn, Lisa Mareike Assmus, Jacob Nattermann, Zeinab Abdullah, Maude Rolland, Emmanuel Dejardin, Philipp A Lang, Karl S Lang, Michael Karin, Julie Lucifora, Ulrich Kalinke, Percy A Knolle, Mathias Heikenwalder,

BACKGROUND & AIMS:Hepatic innate immune control of viral infections has largely been attributed to Kupffer cells, the liver-resident macrophages. However, hepatocytes, the parenchymal cells of the liver, also possess potent immunological functions in addition to their known metabolic functions. Owing to their abundance in the liver and known immunological functions, ... Read more >>

J. Hepatol. (Journal of hepatology)
[2020, 72(5):960-975]

Cited: 1 time

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Corrigendum to "Toll-like receptor 3 downregulation is an escape mechanism from apoptosis during hepatocarcinogenesis" [J Hepatol 71 (2019) 763-772].

Marc Bonnin, Nadim Fares, Barbara Testoni, Yann Estornes, Kathrin Weber, Béatrice Vanbervliet, Lydie Lefrançois, Amandine Garcia, Alain Kfoury, Floriane Pez, Isabelle Coste, Pierre Saintigny, Alain Viari, Kévin Lang, Baptiste Guey, Virginie Petrilli, Valérie Hervieu, Brigitte Bancel, Birke Bartosch, David Durantel, Toufic Renno, Philippe Merle, Serge Lebecque,

J. Hepatol. (Journal of hepatology)
[2020, 72(3):594]

Cited: 0 times

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Toll-like receptor 3 downregulation is an escape mechanism from apoptosis during hepatocarcinogenesis.

Marc Bonnin, Nadim Fares, Barbara Testoni, Yann Estornes, Kathrin Weber, Béatrice Vanbervliet, Lydie Lefrançois, Amandine Garcia, Alain Kfoury, Floriane Pez, Isabelle Coste, Pierre Saintigny, Alain Viari, Kévin Lang, Baptiste Guey, Valérie Hervieu, Brigitte Bancel, Birke Bartoch, David Durantel, Toufic Renno, Philippe Merle, Serge Lebecque,

BACKGROUND & AIMS:Low levels of toll-like receptor 3 (TLR3) in patients with hepatocellular carcinoma (HCC) are associated with poor prognosis, primarily owing to the loss of inflammatory signaling and subsequent lack of immune cell recruitment to the liver. Herein, we explore the role of TLR3-triggered apoptosis in HCC cells. METHODS:Quantitative ... Read more >>

J. Hepatol. (Journal of hepatology)
[2019, 71(4):763-772]

Cited: 1 time

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Who Defends the Stem Cell's Citadel?

Hélène Strick-Marchand, David Durantel,

Recently in Cell, Wu et al. (2018) demonstrated that intrinsic expression of a subset of interferon stimulated genes confers resistance to viral infections in stem cells both in vitro and in vivo, while differentiated cells lose this intrinsic gatekeeper expression pattern in favor of inducible interferon responses. ... Read more >>

Cell Stem Cell (Cell stem cell)
[2018, 22(3):287-289]

Cited: 0 times

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[A new immune competent mouse model for the study of hepatitis D virus infection].

Dulce Alfaiate, David Durantel,

Med Sci (Paris) (Medecine sciences : M/S)
[2017, 33(6-7):570-573]

Cited: 0 times

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Ribavirin restores IFNα responsiveness in HCV-infected livers by epigenetic remodelling at interferon stimulated genes.

Barbara Testoni, David Durantel, Fanny Lebossé, Judith Fresquet, François Helle, Francesco Negro, Maria Francesca Donato, Massimo Levrero, Fabien Zoulim,

Caveats in the understanding of ribavirin (RBV) mechanisms of action has somehow prevented the development of better analogues able to further improve its therapeutic contribution in interferon (IFN)-based and direct antiviral agent-based regimens for chronic HCV or other indications. Here, we describe a new mechanism by which RBV modulates IFN-stimulated ... Read more >>

Gut (Gut)
[2016, 65(4):672-682]

Cited: 4 times

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An immortalized human liver endothelial sinusoidal cell line for the study of the pathobiology of the liver endothelium.

Romain Parent, David Durantel, Thomas Lahlali, Aurélie Sallé, Marie-Laure Plissonnier, Daniel DaCosta, Gaëtan Lesca, Fabien Zoulim, Marie-Jeanne Marion, Birke Bartosch,

BACKGROUND: The endothelium lines blood and lymph vessels and protects underlying tissues against external agents such as viruses, bacteria and parasites. Yet, microbes and particularly viruses have developed sophisticated ways to bypass the endothelium in order to gain access to inner organs. De novo infection of the liver parenchyma by ... Read more >>

Biochem. Biophys. Res. Commun. (Biochemical and biophysical research communications)
[2014, 450(1):7-12]

Cited: 12 times

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Mechanism of action of ribavirin in anti-HCV regimens: new insights for an age-old question?

Barbara Testoni, Massimo Levrero, David Durantel,

Gut (Gut)
[2014, 63(1):3-4]

Cited: 5 times

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Lymphotoxin signaling is initiated by the viral polymerase in HCV-linked tumorigenesis.

Yannick Simonin, Serena Vegna, Leila Akkari, Damien Grégoire, Etienne Antoine, Jacques Piette, Nicolas Floc'h, Patrice Lassus, Guann-Yi Yu, Arielle R Rosenberg, Michael Karin, David Durantel, Urszula Hibner,

Exposure to hepatitis C virus (HCV) typically results in chronic infection that leads to progressive liver disease ranging from mild inflammation to severe fibrosis and cirrhosis as well as primary liver cancer. HCV triggers innate immune signaling within the infected hepatocyte, a first step in mounting of the adaptive response ... Read more >>

PLoS Pathog. (PLoS pathogens)
[2013, 9(3):e1003234]

Cited: 12 times

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Advances in the development of nucleoside and nucleotide analogues for cancer and viral diseases.

Lars Petter Jordheim, David Durantel, Fabien Zoulim, Charles Dumontet,

Nucleoside analogues have been in clinical use for almost 50 years and have become cornerstones of treatment for patients with cancer or viral infections. The approval of several additional drugs over the past decade demonstrates that this family still possesses strong potential. Here, we review new nucleoside analogues and associated ... Read more >>

Nat Rev Drug Discov (Nature reviews. Drug discovery)
[2013, 12(6):447-464]

Cited: 240 times

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Hepatitis C virus fails to activate NF-kappaB signaling in plasmacytoid dendritic cells.

Ruzena Stranska, Jonathan Florentin, Clélia Dental, Besma Aouar, Francoise Gondois-Rey, David Durantel, Thomas F Baumert, Jacques A Nunes, Daniel Olive, Ivan Hirsch,

Retrovirology (Retrovirology)
[2012, 9(Suppl 1):O5-O5]

Cited: 0 times

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Inhibition of hepatitis C virus replication by semi-synthetic derivatives of glycopeptide antibiotics.

Susan Obeid, Svetlana S Printsevskaya, Eugenia N Olsufyeva, Kai Dallmeier, David Durantel, Fabien Zoulim, Maria N Preobrazhenskaya, Johan Neyts, Jan Paeshuyse,

OBJECTIVES:Some semi-synthetic derivatives of glycopeptide antibiotics have been shown to exert in vitro antiviral activity against HIV and coronaviruses. Here we report and characterize the in vitro anti-hepatitis C virus (HCV) activity of several semi-synthetic derivatives of teicoplanin aglycone. METHODS:Anti-HCV activity was analysed in: (i) three different subgenomic HCV replicon ... Read more >>

J. Antimicrob. Chemother. (The Journal of antimicrobial chemotherapy)
[2011, 66(6):1287-1294]

Cited: 8 times

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Innate response to hepatitis B virus infection: observations challenging the concept of a stealth virus.

David Durantel, Fabien Zoulim,

Hepatology (Hepatology (Baltimore, Md.))
[2009, 50(6):1692-1695]

Cited: 17 times

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HCV research 20 years after discovery: a summary of the 16th international symposium on hepatitis C virus and related viruses.

Jean-Michel Pawlotsky, Laurence Cocquerel, David Durantel, Dimitri Lavillette, Hervé Lerat, Eve-Isabelle Pécheur, Stephen J Polyak, Norbert Tautz, Robert Thimme,

Gastroenterology (Gastroenterology)
[2010, 138(1):6-12.e1-2]

Cited: 3 times

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Celgosivir, an alpha-glucosidase I inhibitor for the potential treatment of HCV infection.

David Durantel,

Celgosivir, in development by MIGENIX Inc for the treatment of HCV infection, is an oral prodrug of the natural product castanospermine that inhibits alpha-glucosidase I, an enzyme that plays a critical role in viral maturation by initiating the processing of the N-linked oligosaccharides of viral envelope glycoproteins. Celgosivir is well ... Read more >>

Curr Opin Investig Drugs (Current opinion in investigational drugs (London, England : 2000))
[2009, 10(8):860-870]

Cited: 36 times

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Statins potentiate the in vitro anti-hepatitis C virus activity of selective hepatitis C virus inhibitors and delay or prevent resistance development.

Leen Delang, Jan Paeshuyse, Inge Vliegen, Pieter Leyssen, Susan Obeid, David Durantel, Fabien Zoulim, Anne Op de Beeck, Johan Neyts,

Statins are 3-hydroxyl-3-methylglutaryl coenzyme A (HMG CoA) reductase inhibitors used for the treatment of hypercholesterolemia. It was recently reported that statins inhibit in vitro hepatitis C virus (HCV) RNA replication. We here report that, of five statins studied, mevastatin and simvastatin exhibit the strongest in vitro anti-HCV activity, lovastatin and ... Read more >>

Hepatology (Hepatology (Baltimore, Md.))
[2009, 50(1):6-16]

Cited: 69 times

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Short peptide nucleic acids (PNA) inhibit hepatitis C virus internal ribosome entry site (IRES) dependent translation in vitro.

Christine Alotte, Amaury Martin, Sergio A Caldarelli, Audrey Di Giorgio, Roger Condom, Fabien Zoulim, David Durantel, Olivier Hantz,

The internal ribosome entry site (IRES) of hepatitis C virus (HCV) which governs the initiation of protein synthesis from viral RNA represents an ideal target for antisense approaches. Using an original bicistronic plasmid, we first established that sequence and translational activity of HCV IRESs cloned from six patients, whether responders ... Read more >>

Antiviral Res. (Antiviral research)
[2008, 80(3):280-287]

Cited: 11 times

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Characterization of the double-stranded RNA responses in human liver progenitor cells.

Magali Maire, Romain Parent, Anne-Laure Morand, Christine Alotte, Christian Trépo, David Durantel, Marie-Anne Petit,

Human HepaRG cells are liver progenitors which possess hepatocyte-like functionality. We investigated the effects of double-stranded (ds) RNA on interferon (IFN)-beta and chemokine (CK) expression in these cells. By microarray and ELISA, we showed strong induction of CXCL10 and interleulin (IL)-8 besides IFN-beta and other CK ligands. RNA interference directed ... Read more >>

Biochem. Biophys. Res. Commun. (Biochemical and biophysical research communications)
[2008, 368(3):556-562]

Cited: 12 times

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Learning from HIV: how will drug resistance influence treatment strategies against hepatitis C?

David Durantel, Fabien Zoulim,

J HIV Ther (Journal of HIV therapy)
[2007, 12(4):88-91]

Cited: 0 times

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Glucosidase inhibitors as antiviral agents for hepatitis B and C.

David Durantel, Christine Alotte, Fabien Zoulim,

HBV and HCV infections are a major public health concern. New antiviral drugs are urgently needed with improved efficacy. Compounds that specifically target viral enzymes are the most attractive in terms of drug development and are therefore the most studied. However, antiviral strategies based entirely on this class of compounds ... Read more >>

Curr Opin Investig Drugs (Current opinion in investigational drugs (London, England : 2000))
[2007, 8(2):125-129]

Cited: 25 times

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Going towards more relevant cell culture models to study the in vitro replication of serum-derived hepatitis C virus and virus/host cell interactions?

David Durantel, Fabien Zoulim,

J. Hepatol. (Journal of hepatology)
[2007, 46(1):1-5]

Cited: 9 times

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Novel alpha interferon (IFN-alpha) variant with improved inhibitory activity against hepatitis C virus genotype 1 replication compared to IFN-alpha2b therapy in a subgenomic replicon system.

Vanessa Escuret, Amaury Martin, David Durantel, Romain Parent, Olivier Hantz, Christian Trépo, Thierry Menguy, Emmanuel Bottius, Jerome Dardy, Jean Maral, Jean Louis Escary, Fabien Zoulim,

Hepatitis C virus (HCV) treatment is based on the association of pegylated alpha interferon (IFN-alpha) and ribavirin. To improve the level of sustained virological response to treatment, especially in patients infected with HCV genotype 1, new IFNs with improved efficacy and toxicity profiles may be developed. In this report, we ... Read more >>

Antimicrob. Agents Chemother. (Antimicrobial agents and chemotherapy)
[2006, 50(12):3984-3991]

Cited: 6 times

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Synthesis of 5-haloethynyl- and 5-(1,2-dihalo)vinyluracil nucleosides: antiviral activity and cellular toxicity.

Vanessa Escuret, Vincent Aucagne, Nicolas Joubert, David Durantel, Kimberly L Rapp, Raymond F Schinazi, Fabien Zoulim, Luigi A Agrofoglio,

In this article, we report the synthesis of hitherto unknown 5-haloethynyl and 5-(1,2-dihalo)vinyluracil nucleosides in the 2'-deoxy, 3'-deoxy- and ribosyl series, and we discuss their in vitro anti-HIV and anti-HCV activities and cellular toxicitites. As a result, on the basis of their selectivity index (SI) obtained with the HCV replicon ... Read more >>

Bioorg. Med. Chem. (Bioorganic & medicinal chemistry)
[2005, 13(21):6015-6024]

Cited: 4 times

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