Full Text Journal Articles by
Author David C Neujahr

Advertisement

Find full text journal articles






Lung transplantation: candidate selection and timing of transplant.

Purav Shah, David C Neujahr,

<h4>Purpose of review</h4>Over the past two decades, lung transplant has become the mainstay of treatment for several end-stage lung diseases. As the field continues to evolve, the criteria for referral and listing have also changed. The last update to these guidelines was in 2014 and several studies since then have ... Read more >>

Curr Opin Organ Transplant (Current opinion in organ transplantation)
[2021, 26(3):302-308]

Cited: 0 times

View full text PDF listing >>



Will the Donor Lungs Fit? Just Grab a Ruler.

David C Neujahr,

Transplantation (Transplantation)
[2021, 105(2):282-283]

Cited: 0 times

View full text PDF listing >>



Advertisement

Delayed Recognition of Community Transmission of COVID-19 Resulting in Healthcare Worker Infections.

Raymund B Dantes, Tait T Jones, David C Neujahr,

We describe a case of delayed COVID-19 diagnosis due to unrecognized community transmission in Atlanta, Georgia in mid-February 2020. This case resulted in transmission of COVID-19 to three of the four healthcare workers present during a diagnostic bronchoscopy procedure where only procedural masks were worn. ... Read more >>

Infect Control Hosp Epidemiol (Infection control and hospital epidemiology)
[2020, :1-6]

Cited: 1 time

View full text PDF listing >>



Transmission of Eastern Equine Encephalitis Virus From an Organ Donor to 3 Transplant Recipients.

Stephanie M Pouch, Shalika B Katugaha, Wun-Ju Shieh, Pallavi Annambhotla, William L Walker, Sridhar V Basavaraju, Jefferson Jones, Thanhthao Huynh, Sarah Reagan-Steiner, Julu Bhatnagar, Kacie Grimm, Susan L Stramer, Julie Gabel, G Marshall Lyon, Aneesh K Mehta, Prem Kandiah, David C Neujahr, Jeffrey Javidfar, Ram M Subramanian, Samir M Parekh, Palak Shah, Lauren Cooper, Mitchell A Psotka, Rachel Radcliffe, Carl Williams, Sherif R Zaki, J Erin Staples, Marc Fischer, Amanda J Panella, Robert S Lanciotti, Janeen J Laven, Olga Kosoy, Ingrid B Rabe, Carolyn V Gould, ,

<h4>Background</h4>In fall 2017, 3 solid organ transplant (SOT) recipients from a common donor developed encephalitis within 1 week of transplantation, prompting suspicion of transplant-transmitted infection. Eastern equine encephalitis virus (EEEV) infection was identified during testing of endomyocardial tissue from the heart recipient.<h4>Methods</h4>We reviewed medical records of the organ donor and ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2019, 69(3):450-458]

Cited: 1 time

View full text PDF listing >>



Low-dose cadmium potentiates lung inflammatory response to 2009 pandemic H1N1 influenza virus in mice.

Joshua D Chandler, Xin Hu, Eun-Ju Ko, Soojin Park, Jolyn Fernandes, Young-Tae Lee, Michael L Orr, Li Hao, M Ryan Smith, David C Neujahr, Karan Uppal, Sang-Moo Kang, Dean P Jones, Young-Mi Go,

Cadmium (Cd) is a toxic, pro-inflammatory metal ubiquitous in the diet that accumulates in body organs due to inefficient elimination. Responses to influenza virus infection are variable, particularly severity of pneumonia. We used a murine model of chronic low-dose oral exposure to Cd to test if increased lung tissue Cd ... Read more >>

Environ Int (Environment international)
[2019, 127:720-729]

Cited: 5 times

View full text PDF listing >>



Quantifying Frailty in Post-Lung Transplant Patients-Can We Predict Who Will Need Readmission?

David C Neujahr,

Transplantation (Transplantation)
[2018, 102(5):723-724]

Cited: 0 times

View full text PDF listing >>



Selenium supplementation prevents metabolic and transcriptomic responses to cadmium in mouse lung.

Xin Hu, Joshua D Chandler, Jolyn Fernandes, Michael L Orr, Li Hao, Karan Uppal, David C Neujahr, Dean P Jones, Young-Mi Go,

<b>Background:</b>The protective effect of selenium (Se) on cadmium (Cd) toxicity is well documented, but underlying mechanisms are unclear.<br><br><b>Methods:</b>Male mice fed standard diet were given Cd (CdCl<sub>2</sub>, 18 μmol/L) in drinking water with or without Se (Na<sub>2</sub>SeO<sub>4,</sub> 20 μmol/L) for 16 weeks. Lungs were analyzed for Cd concentration, transcriptomics and metabolomics. Data were analyzed ... Read more >>

Biochim Biophys Acta Gen Subj (Biochimica et biophysica acta. General subjects)
[2018, 1862(11):2417-2426]

Cited: 6 times

View full text PDF listing >>



Lung Retransplantation: Practical and Ethical Considerations Raised by the Hannover Protocol.

David C Neujahr,

Transplantation (Transplantation)
[2018, 102(3):355-356]

Cited: 2 times

View full text PDF listing >>



Two common human CLDN5 alleles encode different open reading frames but produce one protein isoform.

Ronald M Cornely, Barbara Schlingmann, Whitney S Shepherd, Joshua D Chandler, David C Neujahr, Michael Koval,

Claudins provide tight junction barrier selectivity. The human CLDN5 gene contains a high-frequency single-nucleotide polymorphism (rs885985), where the G allele codes for glutamine (Q) and the A allele codes for an amber stop codon. Thus, these different CLDN5 alleles define nested open reading frames (ORFs) encoding claudin-5 proteins that are ... Read more >>

Ann N Y Acad Sci (Annals of the New York Academy of Sciences)
[2017, 1397(1):119-129]

Cited: 0 times

View full text PDF listing >>



Nuclear Thioredoxin-1 Overexpression Attenuates Alcohol-Mediated Nrf2 Signaling and Lung Fibrosis.

Viranuj Sueblinvong, Stephen T Mills, David C Neujahr, Young-Mi Go, Dean P Jones, David M Guidot,

<h4>Background</h4>Alcohol abuse, which impairs antioxidant defenses and promotes acute lung injury, increases Nrf2 nuclear translocation but nevertheless inhibits its activation of the antioxidant response element (ARE). Thioredoxin-1 (Trx1) is required for optimal Nrf2 binding and activation of the ARE, and we hypothesized that its inhibition contributes to impaired Nrf2-ARE signaling ... Read more >>

Alcohol Clin Exp Res (Alcoholism, clinical and experimental research)
[2016, 40(9):1846-1856]

Cited: 6 times

View full text PDF listing >>



Low-dose oral cadmium increases airway reactivity and lung neuronal gene expression in mice.

Joshua D Chandler, Cherry Wongtrakool, Sophia A Banton, Shuzhao Li, Michael L Orr, Dana Boyd Barr, David C Neujahr, Roy L Sutliff, Young-Mi Go, Dean P Jones,

Inhalation of cadmium (Cd) is associated with lung diseases, but less is known concerning pulmonary effects of Cd found in the diet. Cd has a decades-long half-life in humans and significant bioaccumulation occurs with chronic dietary intake. We exposed mice to low-dose CdCl2 (10 mg/L in drinking water) for 20 weeks, which ... Read more >>

Physiol Rep (Physiological reports)
[2016, 4(13):]

Cited: 7 times

View full text PDF listing >>



Recurrent and metastatic squamous cell carcinoma in lung transplant recipient on voriconazole: Lessons learned.

Shali Zhang, David C Neujahr, Fiona O Zwald,

JAAD Case Rep (JAAD case reports)
[2015, 1(6):S12-5]

Cited: 1 time

View full text PDF listing >>



Lung Microvessicles May Hold Clues to Lung Transplant Failure.

David C Neujahr,

Transplantation (Transplantation)
[2015, 99(11):2243-2244]

Cited: 0 times

View full text PDF listing >>



Intragraft regulatory T cells and lung transplant outcomes--we are still at square one.

David C Neujahr,

Clin Transplant (Clinical transplantation)
[2015, 29(3):177-178]

Cited: 2 times

View full text PDF listing >>



TGFβ1 mediates alcohol-induced Nrf2 suppression in lung fibroblasts.

Viranuj Sueblinvong, Victor Tseng, Tierra Smith, Ramin Saghafi, Stephen T Mills, David C Neujahr, David M Guidot,

<h4>Background</h4>Chronic alcohol ingestion induces the expression of transforming growth factor beta-1(TGFβ1), inhibits nuclear factor (erythroid-derived 2)-like 2 (Nrf2)-mediated activation of the antioxidant response element (ARE), depletes alveolar glutathione pools, and potentiates acute lung injury. In this study, we examined the mechanistic relationship between TGFβ1 and Nrf2-ARE signaling in the experimental ... Read more >>

Alcohol Clin Exp Res (Alcoholism, clinical and experimental research)
[2014, 38(11):2731-2742]

Cited: 14 times

View full text PDF listing >>



Aging promotes pro-fibrotic matrix production and increases fibrocyte recruitment during acute lung injury.

Viranuj Sueblinvong, Wendy A Neveu, David C Neujahr, Stephen T Mills, Mauricio Rojas, Jesse Roman, David M Guidot,

Fibrotic lung diseases increase with age. Previously we determined that senescence increases tissue expression of fibronectin EDA (Fn-EDA) and decreases fibroblast expression of Thy-1, and that fibrocytes contribute to fibrosis following bleomycin-induced lung injury in mice. In this study we hypothesized that fibroblasts lacking Thy-1 expression produce an extracellular matrix ... Read more >>

Adv Biosci Biotechnol (Advances in bioscience and biotechnology (Print))
[2014, 5(1):19-30]

Cited: 20 times

View full text PDF listing >>



Predisposition for disrepair in the aged lung.

Viranuj Sueblinvong, David C Neujahr, S Todd Mills, Susanne Roser-Page, Jeffrey D Ritzenthaler, David Guidot, Mauricio Rojas, Jesse Roman,

<h4>Introduction</h4>Idiopathic pulmonary fibrosis (IPF) is a devastating progressive lung disease with an average survival of only 3 to 5 years. The mechanisms underlying the initiation and progression of IPF are poorly understood, and treatments available have only modest effect on disease progression. Interestingly, the incidence of IPF is approximately 60 ... Read more >>

Am J Med Sci (The American journal of the medical sciences)
[2012, 344(1):41-51]

Cited: 58 times

View full text PDF listing >>



Bilateral lung transplantation offers better long-term survival, compared with single-lung transplantation, for younger patients with idiopathic pulmonary fibrosis.

Seth D Force, Pat Kilgo, David C Neujahr, Andres Pelaez, Allan Pickens, Felix G Fernandez, Daniel L Miller, Clint Lawrence,

<h4>Background</h4>Single-lung transplantation (SLT) and bilateral lung transplantation (BLT) are both good options for patients with end-stage lung disease secondary to idiopathic pulmonary fibrosis. It is, however, unclear whether BLT offers any survival advantage over SLT. The purpose of our study was to evaluate a large group of patients to determine ... Read more >>

Ann Thorac Surg (The Annals of thoracic surgery)
[2011, 91(1):244-249]

Cited: 23 times

View full text PDF listing >>



Regulatory T cells in lung transplantation--an emerging concept.

David C Neujahr, Christian P Larsen,

Lung transplantation represents an option for patients with a variety of end-stage lung diseases. While surgical advances have led to improvements in short-term survival, long-term survival is limited by chronic rejection termed bronchiolitis obliterans syndrome (BOS). A growing body of work is devoted to determining why some patients develop BOS. ... Read more >>

Semin Immunopathol (Seminars in immunopathology)
[2011, 33(2):117-127]

Cited: 14 times

View full text PDF listing >>



Dynamics of human regulatory T cells in lung lavages of lung transplant recipients.

David C Neujahr, Adriana C Cardona, Onome Ulukpo, Mark Rigby, Andres Pelaez, Allan Ramirez, Anthony A Gal, Seth D Force, E Clinton Lawrence, Allan D Kirk, Christian P Larsen,

<h4>Background</h4>Despite advances in the field of lung transplantation, the median survival after lung transplant remains below 5 years. Early rejection is a risk factor for the development of chronic rejection. In animal models of transplant tolerance, regulatory T cells (Tregs) can prevent the establishment of rejection.<h4>Methods</h4>This study was designed to ... Read more >>

Transplantation (Transplantation)
[2009, 88(4):521-527]

Cited: 18 times

View full text PDF listing >>



Surgical correction of gastroesophageal reflux in lung transplant patients is associated with decreased effector CD8 cells in lung lavages: a case series.

David C Neujahr, Aminu Mohammed, Onome Ulukpo, Seth D Force, Allan M Ramirez, Andres Pelaez, E Clinton Lawrence, Christian P Larsen, Allan D Kirk,

<h4>Background</h4>Lung transplantation is associated with a high incidence of gastroesophageal reflux disease (GERD). The presence of GERD is considered a risk factor for the subsequent development of obliterative bronchiolitis (OB), and surgical correction of GERD by gastric fundoplication (GF) may be associated with increased freedom from OB. The mechanisms underlying ... Read more >>

Chest (Chest)
[2010, 138(4):937-943]

Cited: 8 times

View full text PDF listing >>



Gastroesophageal reflux disease and graft failure after lung transplantation.

Aminu Mohammed, David C Neujahr,

In spite of advances in lung transplantation, the median survival after lung transplant remains less than 5 years, an outcome that is significantly worse than other solid organ transplants. Efforts to understand the unique hurdles faced in lung transplant have revealed gastroesophageal reflux disease (GERD) as a risk factor for ... Read more >>

Transplant Rev (Orlando) (Transplantation reviews (Orlando, Fla.))
[2010, 24(2):99-103]

Cited: 6 times

View full text PDF listing >>



Effect of bone marrow-derived mesenchymal stem cells on endotoxin-induced oxidation of plasma cysteine and glutathione in mice.

Smita S Iyer, Edilson Torres-Gonzalez, David C Neujahr, Mike Kwon, Kenneth L Brigham, Dean P Jones, Ana L Mora, Mauricio Rojas,

Bone marrow-derived mesenchymal stem cells (BMDMSC) are emerging as a therapeutic modality in various inflammatory disease states, including acute lung injury (ALI). A hallmark of inflammation, and a consistent observation in patients with ALI, is a perturbation in the systemic redox environment. However, little is known about the effects of ... Read more >>

Stem Cells Int (Stem cells international)
[2010, 2010:868076]

Cited: 20 times

View full text PDF listing >>



Efficacy of oral ribavirin in lung transplant patients with respiratory syncytial virus lower respiratory tract infection.

Andres Pelaez, G Marshall Lyon, Seth D Force, Allan M Ramirez, David C Neujahr, Marianne Foster, Priyumvada M Naik, Anthony A Gal, Patrick O Mitchell, E Clinton Lawrence,

<h4>Background</h4>Respiratory syncytial virus (RSV) can cause severe lower respiratory tract infection (LRI) and is a risk factor for the development of bronchiolitis obliterans syndrome (BOS) after lung transplantation (LTx). Currently, the most widely used therapy for RSV is inhaled ribavirin. However, this therapy is costly and cumbersome. We investigated the ... Read more >>

J Heart Lung Transplant (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation)
[2009, 28(1):67-71]

Cited: 56 times

View full text PDF listing >>



Dapsone-induced hemolytic anemia in lung allograft recipients.

Priyumvada M Naik, G Marshall Lyon, Allan Ramirez, E Clinton Lawrence, David C Neujahr, Seth Force, Andres Pelaez,

<h4>Background</h4>Lung transplant (LT) recipients often receive dapsone for Pneumocystis jirovecii pneumonia (PCP) prophylaxis. However, the prevalence of dapsone-induced hematologic toxicity in LT recipients is unknown. We report a high prevalence of hemolytic anemia (HA) associated with dapsone use in LT patients when compared with other patients described in the literature ... Read more >>

J Heart Lung Transplant (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation)
[2008, 27(11):1198-1202]

Cited: 11 times

View full text PDF listing >>



Advertisement

Disclaimer
0.9996 s