Full Text Journal Articles by
Author David C A Gaboriau

Advertisement

Find full text journal articles








A machine learning approach to define antimalarial drug action from heterogeneous cell-based screens.

George W Ashdown, Michelle Dimon, Minjie Fan, Fernando Sánchez-Román Terán, Kathrin Witmer, David C A Gaboriau, Zan Armstrong, D Michael Ando, Jake Baum,

Drug resistance threatens the effective prevention and treatment of an ever-increasing range of human infections. This highlights an urgent need for new and improved drugs with novel mechanisms of action to avoid cross-resistance. Current cell-based drug screens are, however, restricted to binary live/dead readouts with no provision for mechanism of ... Read more >>

Sci Adv (Science advances)
[2020, 6(39):]

Cited: 0 times

View full text PDF listing >>



The acid injury and repair (AIR) model: A novel ex-vivo tool to understand lung repair.

Sally Yunsun Kim, Róisín Mongey, Peizhu Wang, Stephen Rothery, David C A Gaboriau, Matthew Hind, Mark Griffiths, Charlotte H Dean,

Research into mechanisms underlying lung injury and subsequent repair responses is currently of paramount importance. There is a paucity of models that bridge the gap between in vitro and in vivo research. Such intermediate models are critical for researchers to decipher the mechanisms that drive repair and to test potential ... Read more >>

Biomaterials (Biomaterials)
[2021, 267:120480]

Cited: 0 times

View full text PDF listing >>



Advertisement

Effect of the CXCR4 antagonist plerixafor on endogenous neutrophil dynamics in the bone marrow, lung and spleen.

Janesh Pillay, Nicola Tregay, Goda Juzenaite, Leo M Carlin, Chiara Pirillo, David C A Gaboriau, Neda Farahi, Charlotte Summers, Cristina Lo Celso, Edwin R Chilvers, Sara Rankin, Katia De Filippo,

Treatment with the CXCR4 antagonist, plerixafor (AMD3100), has been proposed for clinical use in patients with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome and in pulmonary fibrosis. However, there is controversy with respect to the impact of plerixafor on neutrophil dynamics in the lung, which may affect its safety profile. ... Read more >>

J Leukoc Biol (Journal of leukocyte biology)
[2020, 107(6):1175-1185]

Cited: 0 times

View full text PDF listing >>



Chemical biology tools for probing transcytosis at the blood-brain barrier.

Rhiannon Beard, David C A Gaboriau, Antony D Gee, Edward W Tate,

Absorptive- and receptor-mediated transcytosis (AMT/RMT) are widely studied strategies to deliver therapeutics across the blood-brain barrier (BBB). However, an improved understanding of the mechanism surrounding trafficking is required that could promote delivery. Accordingly, we designed a flexible platform that merged AMT and RMT motifs on a single scaffold to probe ... Read more >>

Chem Sci (Chemical science)
[2019, 10(46):10772-10778]

Cited: 0 times

View full text PDF listing >>



Leader β-cells coordinate Ca2+ dynamics across pancreatic islets in vivo.

Victoria Salem, Luis Delgadillo Silva, Kinga Suba, Eleni Georgiadou, S Neda Mousavy Gharavy, Nadeem Akhtar, Aldara Martin-Alonso, David C A Gaboriau, Stephen M Rothery, Theodoros Stylianides, Gaelle Carrat, Timothy J Pullen, Sumeet Pal Singh, David J Hodson, Isabelle Leclerc, A M James Shapiro, Piero Marchetti, Linford J B Briant, Walter Distaso, Nikolay Ninov, Guy A Rutter,

Pancreatic β-cells form highly connected networks within isolated islets. Whether this behaviour pertains to the situation in vivo, after innervation and during continuous perfusion with blood, is unclear. In the present study, we used the recombinant Ca<sup>2+</sup> sensor GCaMP6 to assess glucose-regulated connectivity in living zebrafish Danio rerio, and in ... Read more >>

Nat Metab (Nature metabolism)
[2019, 1(6):615-629]

Cited: 4 times

View full text PDF listing >>



Live imaging of alveologenesis in precision-cut lung slices reveals dynamic epithelial cell behaviour.

Khondoker M Akram, Laura L Yates, Róisín Mongey, Stephen Rothery, David C A Gaboriau, Jeremy Sanderson, Matthew Hind, Mark Griffiths, Charlotte H Dean,

Damage to alveoli, the gas-exchanging region of the lungs, is a component of many chronic and acute lung diseases. In addition, insufficient generation of alveoli results in bronchopulmonary dysplasia, a disease of prematurity. Therefore visualising the process of alveolar development (alveologenesis) is critical for our understanding of lung homeostasis and ... Read more >>

Nat Commun (Nature communications)
[2019, 10(1):1178]

Cited: 2 times

View full text PDF listing >>



Rationally-engineered reproductive barriers using CRISPR & CRISPRa: an evaluation of the synthetic species concept in Drosophila melanogaster.

Andrew J Waters, Paolo Capriotti, David C A Gaboriau, Philippos Aris Papathanos, Nikolai Windbichler,

The ability to erect rationally-engineered reproductive barriers in animal or plant species promises to enable a number of biotechnological applications such as the creation of genetic firewalls, the containment of gene drives or novel population replacement and suppression strategies for genetic control. However, to date no experimental data exist that ... Read more >>

Sci Rep (Scientific reports)
[2018, 8(1):13125]

Cited: 2 times

View full text PDF listing >>



Protein stability versus function: effects of destabilizing missense mutations on BRCA1 DNA repair activity.

David C A Gaboriau, Pamela J E Rowling, Ciaran G Morrison, Laura S Itzhaki,

Mutations in breast cancer susceptibility gene BRCA1 (breast cancer early-onset 1) are associated with increased risk of developing breast and ovarian cancers. BRCA1 is a large protein of 1863 residues with two small structured domains at its termini: a RING domain at the N-terminus and a BRCT (BRCA1 C-terminus domain) ... Read more >>

Biochem J (The Biochemical journal)
[2015, 466(3):613-624]

Cited: 6 times

View full text PDF listing >>





Advertisement

Disclaimer
0.8395 s