Full Text Journal Articles by
Author David Borsook

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Rhythmic Change of Cortical Hemodynamic Signals Associated with Ongoing Nociception in Awake and Anesthetized Individuals: An Exploratory Functional Near Infrared Spectroscopy Study.

Ke Peng, Keerthana Deepti Karunakaran, Arielle Lee, Andrea Gomez-Morad, Robert Labadie, Arielle Mizrahi-Arnaud, Delany Berry, Barry Kussman, David Zurakowski, Lyle Micheli, Lino Becerra, David Borsook,

<h4>Background</h4>Patients undergoing surgical procedures are vulnerable to repetitive evoked or ongoing nociceptive barrage. Using functional near infrared spectroscopy, the authors aimed to evaluate the cortical hemodynamic signal power changes during ongoing nociception in healthy awake volunteers and in surgical patients under general anesthesia. The authors hypothesized that ongoing nociception to ... Read more >>

Anesthesiology (Anesthesiology)
[2021, 135(5):877-892]

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DTI and MTR Measures of Nerve Fiber Integrity in Pediatric Patients With Ankle Injury.

Scott A Holmes, Anastasia Karapanagou, Steven J Staffa, David Zurakowski, Ronald Borra, Laura E Simons, Christine Sieberg, Alyssa Lebel, David Borsook,

Acute peripheral nerve injury can lead to chronic neuropathic pain. Having a standardized, non-invasive method to evaluate pathological changes in a nerve following nerve injury would help with diagnostic and therapeutic assessments or interventions. The accurate evaluation of nerve fiber integrity after injury may provide insight into the extent of ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2021, 9:656843]

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Targeting the stress response in pediatric pain: current evidence for psychosocial intervention and avenues for future investigation.

Sarah Nelson, David Borsook, Michelle Bosquet Enlow,

Nonpharmacological treatments for chronic pain in youth have been identified as first-line treatments over and above medication. Therapies such as cognitive-behavioral therapy and mindfulness-based stress reduction have shown good efficacy in reducing the psychological correlates (eg, anxiety, depression, and stress) and social or behavioral sequelae (eg, limited physical activity and ... Read more >>

Pain Rep (Pain reports)
[2021, 6(3):e953]

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Migraine: interactions between brain's trait and state.

Edina Szabo, Stephen Green, Keerthana Deepti Karunakaran, Christine B Sieberg, Igor Elman, Rami Burstein, David Borsook,

It is well established that migraine is a multifactorial disorder. A deep understanding of migraine should be based upon both the underlying traits and the current states affected by different physiological, psychological, and environmental factors. At this point, there is no framework fully meeting these criteria. Here, we describe a ... Read more >>

CNS Spectr (CNS spectrums)
[2021, :1-9]

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A lateralized model of the pain-depression dyad.

Anne Margarette S Maallo, Eric A Moulton, Christine B Sieberg, Donald B Giddon, David Borsook, Scott A Holmes,

Chronic pain and depression are two frequently co-occurring and debilitating conditions. Even though the former is treated as a physical affliction, and the latter as a mental illness, both disorders closely share neural substrates. Here, we review the association of pain with depression, especially when symptoms are lateralized on either ... Read more >>

Neurosci Biobehav Rev (Neuroscience and biobehavioral reviews)
[2021, 127:876-883]

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Neuropathic corneal pain and dry eye: a continuum of nociception.

Gabriela Dieckmann, David Borsook, Eric Moulton,

Throughout the body, damage to peripheral nerves normally involved in nociception may produce a constellation of symptoms-including irritation, itchiness and pain. The neurobiological processes involved in corneal symptoms of dry eye (DE) and neuropathic corneal pain (NCP) have not been clearly considered in terms of nociceptive processing. The conventional underlying ... Read more >>

Br J Ophthalmol (The British journal of ophthalmology)
[2021, :]

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Left to themselves: Time to target chronic pain in childhood rare diseases.

Christine B Sieberg, Alyssa Lebel, Erin Silliman, Scott Holmes, David Borsook, Igor Elman,

<h4>Background</h4>Chronic pain is prevalent among patients with rare diseases (RDs). However, little is understood about how biopsychosocial mechanisms may be integrated in the unique set of clinical features and therapeutic challenges inherent in their pain conditions.<h4>Methods</h4>This review presents examples of major categories of RDs with particular pain conditions. In addition, ... Read more >>

Neurosci Biobehav Rev (Neuroscience and biobehavioral reviews)
[2021, 126:276-288]

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Altered Brain Network Connectivity Underlies Persistent Post-Traumatic Headache following Mild Traumatic Brain Injury in Youth.

Jordan Lemme, Scott Holmes, Diana Sibai, Joud Mari, Laura E Simons, Rami Burstein, David Zurakowski, Alyssa Lebel, Michael O'Brien, Jaymin Upadhyay, David Borsook,

Post-traumatic headaches (PTHs) are associated with mild traumatic brain injuries (mTBI) and may predict the persistence of concussion symptoms. Altered brain networks implicated in brain injury and the affective components of headache-related pain may underlie the resolution of PTH. This is a hypothesis-generating investigation to evaluate the extent to which ... Read more >>

J Neurotrauma (Journal of neurotrauma)
[2021, 38(12):1632-1641]

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Pain stickiness in pediatric complex regional pain syndrome: A role for the nucleus accumbens.

Andrew M Youssef, Ke Peng, Pearl Kijoo Kim, Alyssa Lebel, Navil F Sethna, Corey Kronman, David Zurakowski, David Borsook, Laura E Simons,

Some individuals with chronic pain experience improvement in their pain with treatment, whereas others do not. The neurobiological reason is unclear, but an understanding of brain structure and functional patterns may provide insights into pain's responsivity to treatment. In this investigation, we used magnetic resonance imaging (MRI) techniques to determine ... Read more >>

Neurobiol Pain (Neurobiology of pain (Cambridge, Mass.))
[2021, 9:100062]

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Thalamocortical Connectivity in Experimentally-Induced Migraine Attacks: A Pilot Study.

Daniele Martinelli, Gloria Castellazzi, Roberto De Icco, Ana Bacila, Marta Allena, Arianna Faggioli, Grazia Sances, Anna Pichiecchio, David Borsook, Claudia A M Gandini Wheeler-Kingshott, Cristina Tassorelli,

In this study we used nitroglycerin (NTG)-induced migraine attacks as a translational human disease model. Static and dynamic functional connectivity (FC) analyses were applied to study the associated functional brain changes. A spontaneous migraine-like attack was induced in five episodic migraine (EM) patients using a NTG challenge. Four task-free functional ... Read more >>

Brain Sci (Brain sciences)
[2021, 11(2):]

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Mechanisms Underlying Unconscious Processing and Their Alterations in Post-traumatic Stress Disorder: Neuroimaging of Zero Monetary Outcomes Contextually Framed as "No Losses" vs. "No Gains".

Igor Elman, Jaymin Upadhyay, Steven Lowen, Keerthana Karunakaran, Mark Albanese, David Borsook,

Although unconscious processing is a key element of mental operation, its neural correlates have not been established. Also, clinical observations suggest that unconscious processing may be involved in the pathophysiology of post-traumatic stress disorder (PTSD), but the neurobiological mechanisms underlying such impairments remain unknown. The purpose of the present study ... Read more >>

Front Neurosci (Frontiers in neuroscience)
[2020, 14:604867]

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Dissecting Salience Network Responsivity to Evoked Nociception and Pain: Model Free Analyses

Lino Becerra, David Borsook,

Dissecting the responses of brain changes to acute nociceptive stimuli includes understanding networks that dynamically interact to produce the experience of pain. Among these networks the salience, default, sensory, and cognitive/central executive networks are known to interact in monitoring external stimuli, assigning salience and diverting activity from self-reflection (default mode) ... Read more >>

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Ictal and interictal brain activation in episodic migraine: Neural basis for extent of allodynia.

Nasim Maleki, Edina Szabo, Lino Becerra, Eric Moulton, Steven J Scrivani, Rami Burstein, David Borsook,

In some patients, migraine attacks are associated with symptoms of allodynia which can be localized (cephalic) or generalized (extracephalic). Using functional neuroimaging and cutaneous thermal stimulation, we aimed to investigate the differences in brain activation of patients with episodic migraine (n = 19) based on their allodynic status defined by ... Read more >>

PLoS One (PloS one)
[2021, 16(1):e0244320]

Cited: 2 times

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NIRS measures in pain and analgesia: Fundamentals, features, and function.

Keerthana Deepti Karunakaran, Ke Peng, Delany Berry, Stephen Green, Robert Labadie, Barry Kussman, David Borsook,

Current pain assessment techniques based only on clinical evaluation and self-reports are not objective and may lead to inadequate treatment. Having a functional biomarker will add to the clinical fidelity, diagnosis, and perhaps improve treatment efficacy in patients. While many approaches have been deployed in pain biomarker discovery, functional near-infrared ... Read more >>

Neurosci Biobehav Rev (Neuroscience and biobehavioral reviews)
[2021, 120:335-353]

Cited: 2 times

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Commentary: Novel Use of Offset Analgesia to Assess Adolescents and Adults with Treatment Resistant Endometriosis-Associated Pain.

Claire E Lunde, Edina Szabo, Scott A Holmes, David Borsook, Christine B Sieberg,

<h4>Background and objective</h4>Endometriosis, affecting approximately 176 million adults and adolescents worldwide, is a debilitating condition in which uterine tissue grows outside the uterus. The condition costs the US economy approximately $78 billion annually in pain-related disability. By understanding the neural underpinnings of endometriosis-associated pain (EAP) and risk factors for chronification, ... Read more >>

J Pain Res (Journal of pain research)
[2020, 13:2775-2782]

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The cornucopia of central disinhibition pain - An evaluation of past and novel concepts.

Julia Forstenpointner, Delany Berry, Ralf Baron, David Borsook,

Central disinhibition (CD), as applied to pain, decreases thresholds of endogenous systems. This provokes onset of spontaneous or evoked pain in an individual beyond the ability of the nervous system to inhibit pain resulting from a disease or tissue damage. The original CD concept as proposed by Craig entails a ... Read more >>

Neurobiol Dis (Neurobiology of disease)
[2020, 145:105041]

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Discovery and validation of biomarkers to aid the development of safe and effective pain therapeutics: challenges and opportunities.

Karen D Davis, Nima Aghaeepour, Andrew H Ahn, Martin S Angst, David Borsook, Ashley Brenton, Michael E Burczynski, Christopher Crean, Robert Edwards, Brice Gaudilliere, Georgene W Hergenroeder, Michael J Iadarola, Smriti Iyengar, Yunyun Jiang, Jiang-Ti Kong, Sean Mackey, Carl Y Saab, Christine N Sang, Joachim Scholz, Marta Segerdahl, Irene Tracey, Christin Veasley, Jing Wang, Tor D Wager, Ajay D Wasan, Mary Ann Pelleymounter,

Pain medication plays an important role in the treatment of acute and chronic pain conditions, but some drugs, opioids in particular, have been overprescribed or prescribed without adequate safeguards, leading to an alarming rise in medication-related overdose deaths. The NIH Helping to End Addiction Long-term (HEAL) Initiative is a trans-agency ... Read more >>

Nat Rev Neurol (Nature reviews. Neurology)
[2020, 16(7):381-400]

Cited: 18 times

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Author Correction: Metabolic and Addiction Indices in Patients on Opioid Agonist Medication-Assisted Treatment: A Comparison of Buprenorphine and Methadone.

Igor Elman, Margaret Howard, Jacob T Borodovsky, David Mysels, David Rott, David Borsook, Mark Albanese,

An amendment to this paper has been published and can be accessed via a link at the top of the paper. ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):7680]

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Secondary effects on brain physiology caused by focused ultrasound-mediated disruption of the blood-brain barrier.

Nick Todd, Cleide Angolano, Christiane Ferran, Anna Devor, David Borsook, Nathan McDannold,

Focused ultrasound (FUS) combined with microbubbles is a non-invasive method for targeted, reversible disruption of the blood-brain barrier (FUS-BBB opening). This approach holds great promise for improving delivery of therapeutics to the brain. In order to achieve this clinically important goal, the approach necessarily breaks a protective barrier, temporarily, which ... Read more >>

J Control Release (Journal of controlled release : official journal of the Controlled Release Society)
[2020, 324:450-459]

Cited: 5 times

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Stressful experiences in youth: "Set-up" for diminished resilience to chronic pain.

Sarah Nelson, Maureen Burns, Bruce McEwen, David Borsook,

Chronic pain in youth is common, with prevalence rates in some reports exceeding 50%. Given the plasticity of brain systems in youth and their general level of activity, the underlying processes relating to the evolution of chronic pain may be different from that observed in adults. One aspect that affects ... Read more >>

Brain Behav Immun Health (Brain, behavior, & immunity - health)
[2020, 5:100095]

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Metabolic and Addiction Indices in Patients on Opioid Agonist Medication-Assisted Treatment: A Comparison of Buprenorphine and Methadone.

Igor Elman, Margaret Howard, Jacob T Borodovsky, David Mysels, David Rott, David Borsook, Mark Albanese,

Metabolic hormones stabilize brain reward and motivational circuits, whereas excessive opioid consumption counteracts this effect and may impair metabolic function. Here we addressed the role of metabolic processes in the course of the agonist medication-assisted treatment for opioid use disorder (OUD) with buprenorphine or methadone. Plasma lipids, hemoglobin A1C, body ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):5617]

Cited: 1 time

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Brain signatures of threat-safety discrimination in adolescent chronic pain.

Lauren C Heathcote, Inge Timmers, Corey A Kronman, Farah Mahmud, J Maya Hernandez, Jason Bentley, Andrew M Youssef, Daniel S Pine, David Borsook, Laura E Simons,

Approximately 1.7 million youth suffer from debilitating chronic pain in the US alone, conferring risk of continued pain in adulthood. Aberrations in threat-safety (T-S) discrimination are proposed to contribute to pain chronicity in adults and youth by interacting with pain-related distress. Yet, few studies have examined the neural circuitry underlying ... Read more >>

Pain (Pain)
[2020, 161(3):630-640]

Cited: 5 times

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Implications of the putamen in pain and motor deficits in complex regional pain syndrome.

Monica Azqueta-Gavaldon, Andrew M Youssef, Claudia Storz, Jordan Lemme, Heike Schulte-Göcking, Lino Becerra, Shahnaz C Azad, Anselm Reiners, Birgit Ertl-Wagner, David Borsook, Jaymin Upadhyay, Eduard Kraft,

Complex regional pain syndrome (CRPS) develops after-limb injury, with persistent pain and deficits in movement frequently co-occurring. The striatum is critical for mediating multiple mechanisms that are often aberrant in CRPS, which includes sensory and pain processing, motor function, and goal-directed behaviors associated with movement. Yet, much remains unknown with ... Read more >>

Pain (Pain)
[2020, 161(3):595-608]

Cited: 2 times

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Clinical features and sex differences in pediatric post-traumatic headache: A retrospective chart review at a Boston area concussion clinic.

Haley McEvoy, David Borsook, Scott A Holmes,

<h4>Background</h4>Often concussion/mTBI triggers a chronic headache syndrome called persistent post-traumatic headache (P-PTH) that can last from months to years post-injury, and produce significant disruption of childhood education, social interaction and development. Although prevalent and highly disabling, P-PTH is underrepresented in headache and pain research and lacks clear definition and pathophysiology. ... Read more >>

Cephalalgia (Cephalalgia : an international journal of headache)
[2020, 40(7):701-711]

Cited: 1 time

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Enhancing Choice and Outcomes for Therapeutic Trials in Chronic Pain: N-of-1 + Imaging (+ i).

David Borsook, Jaymin Upadhyay, Richard Hargreaves, Tor Wager,

The attrition of novel analgesic drugs in the clinic can be attributed in the main to two factors: failure of preclinical research findings translating into human pain conditions, and a drop-off of efficacy between proof-of-concept (i.e., Phase II trials) and pivotal, confirmatory (Phase III trials) testing. In order to enhance ... Read more >>

Trends Pharmacol Sci (Trends in pharmacological sciences)
[2020, 41(2):85-98]

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