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Author David Baglietto Vargas

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Spatial coding defects of hippocampal neural ensemble calcium activities in the 3xTg-AD Alzheimer’s disease mouse model

Xiaoxiao Lin, Lujia Chen, David Baglietto-Vargas, Qiao Ye, Frank LaFerla, Douglas Nitz, Todd Holmes, Xiangmin Xu,

<h4>Background: </h4> Alzheimer’s disease (AD) causes progressive age-related defects in memory and cognitive function, and has emerged as a major health and socio-economic concern in the US and worldwide. To develop effective therapeutic treatments for AD, we need to better understand the neural mechanisms by which AD causes memory loss ... Read more >>

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Animal and Cellular Models of Alzheimer's Disease: Progress, Promise, and Future Approaches.

Laura Trujillo-Estrada, Elisabeth Sanchez-Mejias, Raquel Sanchez-Varo, Juan Antonio Garcia-Leon, Cristina Nuñez-Diaz, Jose Carlos Davila, Javier Vitorica, Frank M LaFerla, Ines Moreno-Gonzalez, Antonia Gutierrez, David Baglietto-Vargas,

Alzheimer's disease (AD) is an incurable neurodegenerative disease affecting over 45 million people worldwide. Transgenic mouse models have made remarkable contributions toward clarifying the pathophysiological mechanisms behind the clinical manifestations of AD. However, the limited ability of these in vivo models to accurately replicate the biology of the human disease ... Read more >>

Neuroscientist (The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry)
[2021, :10738584211001753]

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Systematic Phenotyping and Characterization of the 5xFAD mouse model of Alzheimer’s Disease

Stefania Forner, Shimako Kawauchi, Gabriela Balderrama-Gutierrez, Enikö Kramár, Dina Matheos, Jimmy Phan, Dominic Javonillo, Kristine Minh Tran, Edna Hingco, Celia da Cunha, Narges Rezaie, Joshua Andrei Alcantara, David Baglietto-Vargas, Camden Jansen, Jonathan Neumann, Marcelo Wood, Grant MacGregor, Ali Mortazavi, Andrea Tenner, Frank LaFerla, Kim Green,

Mouse models of human diseases are invaluable tools for studying pathogenic mechanisms and testing interventions and therapeutics. For disorders such as Alzheimer’s disease in which numerous models are being generated, a challenging first step is to identify the most appropriate model and age to effectively evaluate new therapeutic approaches. Here ... Read more >>

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Generation of a humanized Aβ expressing mouse demonstrating aspects of Alzheimer's disease-like pathology.

David Baglietto-Vargas, Stefania Forner, Lena Cai, Alessandra C Martini, Laura Trujillo-Estrada, Vivek Swarup, Marie Minh Thu Nguyen, Kelly Do Huynh, Dominic I Javonillo, Kristine Minh Tran, Jimmy Phan, Shan Jiang, Enikö A Kramár, Cristina Nuñez-Diaz, Gabriela Balderrama-Gutierrez, Franklin Garcia, Jessica Childs, Carlos J Rodriguez-Ortiz, Juan Antonio Garcia-Leon, Masashi Kitazawa, Mohammad Shahnawaz, Dina P Matheos, Xinyi Ma, Celia Da Cunha, Ken C Walls, Rahasson R Ager, Claudio Soto, Antonia Gutierrez, Ines Moreno-Gonzalez, Ali Mortazavi, Andrea J Tenner, Grant R MacGregor, Marcelo Wood, Kim N Green, Frank M LaFerla,

The majority of Alzheimer's disease (AD) cases are late-onset and occur sporadically, however most mouse models of the disease harbor pathogenic mutations, rendering them better representations of familial autosomal-dominant forms of the disease. Here, we generated knock-in mice that express wildtype human Aβ under control of the mouse App locus. ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):2421]

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Model organism development and evaluation for late-onset Alzheimer's disease: MODEL-AD.

Adrian L Oblak, Stefania Forner, Paul R Territo, Michael Sasner, Gregory W Carter, Gareth R Howell, Stacey J Sukoff-Rizzo, Benjamin A Logsdon, Lara M Mangravite, Ali Mortazavi, David Baglietto-Vargas, Kim N Green, Grant R MacGregor, Marcelo A Wood, Andrea J Tenner, Frank M LaFerla, Bruce T Lamb, , ,

Alzheimer's disease (AD) is a major cause of dementia, disability, and death in the elderly. Despite recent advances in our understanding of the basic biological mechanisms underlying AD, we do not know how to prevent it, nor do we have an approved disease-modifying intervention. Both are essential to slow or ... Read more >>

Alzheimers Dement (N Y) (Alzheimer's & dementia (New York, N. Y.))
[2020, 6(1):e12110]

Cited: 1 time

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Reply to Peng and Zhao: Loss of endocytic protein TOM1 in Alzheimer's disease.

Alessandra C Martini, David Baglietto-Vargas, Rodrigo Medeiros, Frank M LaFerla,

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2020, 117(8):3917-3919]

Cited: 0 times

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Editorial: Risk Factors for Alzheimer's Disease.

Ines Moreno-Gonzalez, Rodrigo Morales, David Baglietto-Vargas, Raquel Sanchez-Varo,

Front Aging Neurosci (Frontiers in aging neuroscience)
[2020, 12:124]

Cited: 1 time

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Astrocytes: From the Physiology to the Disease.

Laura Trujillo-Estrada, Angela Gomez-Arboledas, Stefânia Forner, Alessandra Cadete Martini, Antonia Gutierrez, David Baglietto-Vargas, Frank M LaFerla,

Astrocytes are key cells for adequate brain formation and regulation of cerebral blood flow as well as for the maintenance of neuronal metabolism, neurotransmitter synthesis and exocytosis, and synaptic transmission. Many of these functions are intrinsically related to neurodegeneration, allowing refocusing on the role of astrocytes in physiological and neurodegenerative ... Read more >>

Curr Alzheimer Res (Current Alzheimer research)
[2019, 16(8):675-698]

Cited: 3 times

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Tau underlies synaptic and cognitive deficits for type 1, but not type 2 diabetes mouse models.

Laura Trujillo-Estrada, Cassidy Nguyen, Celia da Cunha, Lena Cai, Stefania Forner, Alessandra C Martini, Rahasson R Ager, Gilberto Aleph Prieto, Carl W Cotman, David Baglietto-Vargas, Frank M LaFerla,

Diabetes mellitus (DM) is one of the most devastating diseases that currently affects the aging population. Recent evidence indicates that DM is a risk factor for many brain disorders, due to its direct effects on cognition. New findings have shown that the microtubule-associated protein tau is pathologically processed in DM; ... Read more >>

Aging Cell (Aging cell)
[2019, 18(3):e12919]

Cited: 4 times

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Impaired Spatial Reorientation in the 3xTg-AD Mouse Model of Alzheimer's Disease.

Alina C Stimmell, David Baglietto-Vargas, Shawn C Moseley, Valérie Lapointe, Lauren M Thompson, Frank M LaFerla, Bruce L McNaughton, Aaron A Wilber,

In early Alzheimer's disease (AD) spatial navigation is impaired; however, the precise cause of this impairment is unclear. Recent evidence suggests that getting lost is one of the first impairments to emerge in AD. It is possible that getting lost represents a failure to use distal cues to get oriented ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):1311]

Cited: 4 times

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Impaired AMPA signaling and cytoskeletal alterations induce early synaptic dysfunction in a mouse model of Alzheimer's disease.

David Baglietto-Vargas, Gilberto Aleph Prieto, Agenor Limon, Stefania Forner, Carlos J Rodriguez-Ortiz, Kenji Ikemura, Rahasson R Ager, Rodrigo Medeiros, Laura Trujillo-Estrada, Alessandra C Martini, Masashi Kitazawa, Jose C Davila, Carl W Cotman, Antonia Gutierrez, Frank M LaFerla,

Alzheimer's disease (AD) is a devastating neurodegenerative disorder that impairs memory and causes cognitive and psychiatric deficits. New evidences indicate that AD is conceptualized as a disease of synaptic failure, although the molecular and cellular mechanisms underlying these defects remain to be elucidated. Determining the timing and nature of the ... Read more >>

Aging Cell (Aging cell)
[2018, 17(4):e12791]

Cited: 20 times

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Early long-term administration of the CSF1R inhibitor PLX3397 ablates microglia and reduces accumulation of intraneuronal amyloid, neuritic plaque deposition and pre-fibrillar oligomers in 5XFAD mouse model of Alzheimer's disease.

Justyna Sosna, Stephan Philipp, Ricardo Albay, Jorge Mauricio Reyes-Ruiz, David Baglietto-Vargas, Frank M LaFerla, Charles G Glabe,

BACKGROUND:Besides the two main classical features of amyloid beta aggregation and tau-containing neurofibrillary tangle deposition, neuroinflammation plays an important yet unclear role in the pathophysiology of Alzheimer's disease (AD). Microglia are believed to be key mediators of neuroinflammation during AD and responsible for the regulation of brain homeostasis by balancing ... Read more >>

Mol Neurodegener (Molecular neurodegeneration)
[2018, 13(1):11]

Cited: 63 times

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Impaired Spatial Reorientation in the 3xTg-AD Mouse Model of Alzheimer’s Disease

Alina Stimmell, David Baglietto-Vargas, Shawn Moseley, Valérie Lapointe, Lauren Thompson, Frank LaFerla, Bruce McNaughton, Aaron Wilber,

In early Alzheimer’s disease (AD) spatial navigation is impaired; however, the precise cause of this impairment is unclear. Recent evidence suggests that getting lost in new surroundings is one of the first impairments to emerge in AD. It is possible that getting lost in new surroundings represents a failure to ... Read more >>

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Dual roles of Aβ in proliferative processes in an amyloidogenic model of Alzheimer's disease.

David Baglietto-Vargas, Elisabeth Sánchez-Mejias, Victoria Navarro, Sebastián Jimenez, Laura Trujillo-Estrada, Angela Gómez-Arboledas, Maria Sánchez-Mico, Raquel Sánchez-Varo, Marisa Vizuete, José Carlos Dávila, José Manuel García-Verdugo, Javier Vitorica, Antonia Gutierrez,

Alzheimer's disease is a major neurodegenerative disorder that leads to severe cognitive deficits in the elderly population. Over the past two decades, multiple studies have focused on elucidating the causative factors underlying memory defects in Alzheimer's patients. In this regard, new evidence linking Alzheimer's disease-related pathology and neuronal stem cells ... Read more >>

Sci Rep (Scientific reports)
[2017, 7(1):10085]

Cited: 11 times

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Past to Future: What Animal Models Have Taught Us About Alzheimer's Disease.

Alessandra C Martini, Stefania Forner, Laura Trujillo-Estrada, David Baglietto-Vargas, Frank M LaFerla,

Alzheimer's disease (AD) impairs memory and causes significant cognitive deficits. The disease course is prolonged, with a poor prognosis, and thus exacts an enormous economic and social burden. Over the past two decades, genetically engineered mouse models have proven indispensable for understanding AD pathogenesis, as well as for discovering new ... Read more >>

J Alzheimers Dis (Journal of Alzheimer's disease : JAD)
[2018, 64(s1):S365-S378]

Cited: 4 times

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Synaptic Impairment in Alzheimer's Disease: A Dysregulated Symphony.

Stefania Forner, David Baglietto-Vargas, Alessandra C Martini, Laura Trujillo-Estrada, Frank M LaFerla,

Alzheimer's disease (AD) is characterized by memory loss, cognitive decline, and devastating neurodegeneration, not only as a result of the extracellular accumulation of beta-amyloid peptide (Aβ) and intracellular accumulation of tau, but also as a consequence of the dysfunction and loss of synapses. Although significant advances have been made in ... Read more >>

Trends Neurosci (Trends in neurosciences)
[2017, 40(6):347-357]

Cited: 91 times

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Diabetes and Alzheimer's disease crosstalk.

David Baglietto-Vargas, Jessica Shi, Devin M Yaeger, Rahasson Ager, Frank M LaFerla,

Despite intensive research efforts over the past few decades, the mechanisms underlying the etiology of sporadic Alzheimer's disease (AD) remain unknown. This fact is of major concern because the number of patients affected by this medical condition is increasing exponentially and the existing treatments are only palliative in nature and ... Read more >>

Neurosci Biobehav Rev (Neuroscience and biobehavioral reviews)
[2016, 64:272-287]

Cited: 43 times

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Short-term modern life-like stress exacerbates Aβ-pathology and synapse loss in 3xTg-AD mice.

David Baglietto-Vargas, Yuncai Chen, Dongjin Suh, Rahasson R Ager, Carlos J Rodriguez-Ortiz, Rodrigo Medeiros, Kristoffer Myczek, Kim N Green, Tallie Z Baram, Frank M LaFerla,

Alzheimer's disease (AD) is a progressive neurological disorder that impairs memory and other cognitive functions in the elderly. The social and financial impacts of AD are overwhelming and are escalating exponentially as a result of population aging. Therefore, identifying AD-related risk factors and the development of more efficacious therapeutic approaches ... Read more >>

J Neurochem (Journal of neurochemistry)
[2015, 134(5):915-926]

Cited: 44 times

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Repeated cognitive stimulation alleviates memory impairments in an Alzheimer's disease mouse model.

Hilda Martinez-Coria, Stephen T Yeung, Rahasson R Ager, Carlos J Rodriguez-Ortiz, David Baglietto-Vargas, Frank M LaFerla,

Alzheimer's disease is a neurodegenerative disease associated with progressive memory and cognitive decline. Previous studies have identified the benefits of cognitive enrichment on reducing disease pathology. Additionally, epidemiological and clinical data suggest that repeated exercise, and cognitive and social enrichment, can improve and/or delay the cognitive deficiencies associated with aging ... Read more >>

Brain Res Bull (Brain research bulletin)
[2015, 117:10-15]

Cited: 6 times

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Restoration of lipoxin A4 signaling reduces Alzheimer's disease-like pathology in the 3xTg-AD mouse model.

Haley C Dunn, Rahasson R Ager, David Baglietto-Vargas, David Cheng, Masashi Kitazawa, David H Cribbs, Rodrigo Medeiros,

The initiation of an inflammatory response is critical to the survival of an organism. However, when inflammation fails to reach resolution, a chronic inflammatory state may occur, potentially leading to bystander tissue damage. Accumulating evidence suggests that chronic inflammation contributes to the progression of Alzheimer's disease (AD), and identifying mechanisms ... Read more >>

J Alzheimers Dis (Journal of Alzheimer's disease : JAD)
[2015, 43(3):893-903]

Cited: 31 times

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Genetic ablation of tau mitigates cognitive impairment induced by type 1 diabetes.

Serena Abbondante, David Baglietto-Vargas, Carlos J Rodriguez-Ortiz, Tatiana Estrada-Hernandez, Rodrigo Medeiros, Frank M Laferla,

Patients affected by diabetes show an increased risk of developing Alzheimer disease (AD). Similarly, patients with AD show impaired insulin function and glucose metabolism. However, the underlying molecular mechanisms connecting these two disorders are still not well understood. Herein, we investigated the microtubule-associated protein tau as a new link between ... Read more >>

Am J Pathol (The American journal of pathology)
[2014, 184(3):819-826]

Cited: 19 times

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Upregulation of miR-181 decreases c-Fos and SIRT-1 in the hippocampus of 3xTg-AD mice.

Carlos J Rodriguez-Ortiz, David Baglietto-Vargas, Hilda Martinez-Coria, Frank M LaFerla, Masashi Kitazawa,

MicroRNAs are a group of small RNAs that regulate diverse cellular processes including neuronal function. Recent studies have shown that dysregulation of specific microRNAs is critically involved in the development of Alzheimer's disease (AD). Most of these reports have focused on microRNAs implicated in alterations of amyloid-β and tau. However, ... Read more >>

J Alzheimers Dis (Journal of Alzheimer's disease : JAD)
[2014, 42(4):1229-1238]

Cited: 33 times

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Hippocampal adaptive response following extensive neuronal loss in an inducible transgenic mouse model.

Kristoffer Myczek, Stephen T Yeung, Nicholas Castello, David Baglietto-Vargas, Frank M LaFerla,

Neuronal loss is a common component of a variety of neurodegenerative disorders (including Alzheimer's, Parkinson's, and Huntington's disease) and brain traumas (stroke, epilepsy, and traumatic brain injury). One brain region that commonly exhibits neuronal loss in several neurodegenerative disorders is the hippocampus, an area of the brain critical for the ... Read more >>

PLoS One (PloS one)
[2014, 9(9):e106009]

Cited: 4 times

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In vivo modification of Abeta plaque toxicity as a novel neuroprotective lithium-mediated therapy for Alzheimer's disease pathology.

Laura Trujillo-Estrada, Sebastian Jimenez, Vanessa De Castro, Manuel Torres, David Baglietto-Vargas, Ines Moreno-Gonzalez, Victoria Navarro, Raquel Sanchez-Varo, Elisabeth Sanchez-Mejias, Jose Carlos Davila, Marisa Vizuete, Antonia Gutierrez, Javier Vitorica,

<h4>Background</h4>Alzheimer's disease (AD) is characterized by the abnormal accumulation of extracellular beta-amyloid (Abeta) plaques, intracellular hyperphosphorylated tau, progressive synaptic alterations, axonal dystrophies, neuronal loss and the deterioration of cognitive capabilities of patients. However, no effective disease-modifying treatment has been yet developed. In this work we have evaluated whether chronic lithium ... Read more >>

Acta Neuropathol Commun (Acta neuropathologica communications)
[2013, 1:73]

Cited: 12 times

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Endogenous murine tau promotes neurofibrillary tangles in 3xTg-AD mice without affecting cognition.

David Baglietto-Vargas, Masashi Kitazawa, Elaine J Le, Tatiana Estrada-Hernandez, Carlos J Rodriguez-Ortiz, Rodrigo Medeiros, Kim N Green, Frank M LaFerla,

Recent studies on tauopathy animal models suggest that the concomitant expression of the endogenous murine tau delays the pathological accumulation of human tau, and interferes with the disease progression. To elucidate the role of endogenous murine tau in a model with both plaques and tangles, we developed a novel transgenic ... Read more >>

Neurobiol Dis (Neurobiology of disease)
[2014, 62:407-415]

Cited: 12 times

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