Full Text Journal Articles by
Author David B Guthrie

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Patients with psychiatric disease: implications for anesthesiologists.

David B Guthrie, Deborah C Richman,

<h4>Purpose of review</h4>Psychiatric illness is common in patients presenting for surgery. Overall health and surgical outcomes are adversely affected by the presence of psychiatric comorbidities.<h4>Recent findings</h4>As new treatment modalities become available, their perioperative implications need to be evaluated. These implications include drug-drug interactions, hemodynamic effects, bleeding risk, and factors affecting ... Read more >>

Curr Opin Anaesthesiol (Current opinion in anaesthesiology)
[2021, 34(3):345-351]

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Retrospective Comparison of Intramuscular Admixtures of Ketamine and Dexmedetomidine Versus Ketamine and Midazolam for Preoperative Sedation.

David B Guthrie, Martin R Boorin, Andrew R Sisti, Ralph H Epstein, Jamie L Romeiser, David K Lam, Tong J Gan, Elliott Bennett-Guerrero,

Precooperative children and patients with intellectual disabilities often require intramuscular (IM) sedation prior to the induction of general anesthesia (GA). Ketamine is an effective preinduction sedative but can produce significant adverse side effects. Dexmedetomidine, a sedative with sympatholytic and analgesic properties, may provide advantages when used in combination with ketamine. ... Read more >>

Anesth Prog (Anesthesia progress)
[2021, 68(1):3-9]

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Tracheopulmonary Complications of a Malpositioned Nasogastric Tube.

David B Guthrie, James P Pezzollo, David K Lam, Ralph H Epstein,

Tracheopulmonary complications following placement of a nasogastric (NG) feeding tube are uncommon but can cause significant morbidity and mortality. In this case report, an 83-year-old woman of American Society of Anesthesiologists class IV with underlying pulmonary disease required placement of an NG feeding tube after surgical treatment of primary squamous ... Read more >>

Anesth Prog (Anesthesia progress)
[2020, 67(3):151-157]

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The prophylactic and therapeutic activity of a broadly active ribonucleoside analog in a murine model of intranasal venezuelan equine encephalitis virus infection.

George R Painter, Richard A Bowen, Gregory R Bluemling, John DeBergh, Vindhya Edpuganti, Prabhakar R Gruddanti, David B Guthrie, Michael Hager, Damien L Kuiper, Mark A Lockwood, Deborah G Mitchell, Michael G Natchus, Zachary M Sticher, Alexander A Kolykhalov,

The New World alphaviruses Venezuelan, Eastern, and Western equine encephalitis viruses (VEEV, EEEV and WEEV, respectively) commonly cause a febrile disease that can progress to meningoencephalitis, resulting in significant morbidity and mortality. To address the need for a therapeutic agent for the treatment of Alphavirus infections, we identified and pursued ... Read more >>

Antiviral Res (Antiviral research)
[2019, 171:104597]

Cited: 6 times

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Development of a novel progesterone analog in the treatment of traumatic brain injury.

Iqbal Sayeed, Bushra Wali, David B Guthrie, Manohar T Saindane, Michael G Natchus, Dennis C Liotta, Donald G Stein,

Although systemic progesterone (PROG) treatment has been shown to be neuroprotective by many laboratories and in multiple animal models of brain injury including traumatic brain injury (TBI), PROG's poor aqueous solubility limits its potential for use as a therapeutic agent. The problem of solubility presents challenges for an acute intervention ... Read more >>

Neuropharmacology (Neuropharmacology)
[2019, 145(Pt B):292-298]

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Evaluating the neurotherapeutic potential of a water-soluble progesterone analog after traumatic brain injury in rats.

Bushra Wali, Iqbal Sayeed, David B Guthrie, Michael G Natchus, Nefize Turan, Dennis C Liotta, Donald G Stein,

The poor aqueous solubility of progesterone (PROG) limits its potential use as a therapeutic agent. We designed and tested EIDD-1723, a novel water-soluble analog of PROG with >100-fold higher solubility than that of native PROG, as candidate for development as a field-ready treatment for traumatic brain injury (TBI). The pharmacokinetic ... Read more >>

Neuropharmacology (Neuropharmacology)
[2016, 109:148-158]

Cited: 5 times

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Water-soluble progesterone analogues are effective, injectable treatments in animal models of traumatic brain injury.

David B Guthrie, Donald G Stein, Dennis C Liotta, Mark A Lockwood, Iqbal Sayeed, Fahim Atif, Richard F Arrendale, G Prabhakar Reddy, Taylor J Evers, Jose R Marengo, Randy B Howard, Deborah G Culver, Michael G Natchus,

After more than 30 years of research and 30 failed clinical trials with as many different treatments, progesterone is the first agent to demonstrate robust clinical efficacy as a treatment for traumatic brain injuries. It is currently being investigated in two, independent phase III clinical trials in hospital settings; however, ... Read more >>

ACS Med Chem Lett (ACS medicinal chemistry letters)
[2012, 3(5):362-366]

Cited: 3 times

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Memory of axial chirality in aryl radical phosphanylations.

Achim Bruch, Andrea Ambrosius, Roland Fröhlich, Armido Studer, David B Guthrie, Hanmo Zhang, Dennis P Curran,

The rate constant for phosphanylation of an aryl radical with trimethylstannyl diphenylphosphane (Me(3)SnPPh(2)) has been measured as k(phos) approximately 9 x 10(8) M(-1) s(-1). Aryl radicals derived from several axially chiral o-haloanilides are trapped by Me(3)SnPPh(2) with complete retention of axial chirality as shown by oxidation of the phosphanes to ... Read more >>

J Am Chem Soc (Journal of the American Chemical Society)
[2010, 132(33):11452-11454]

Cited: 17 times

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Synthesis of highly enantioenriched 3,4-dihydroquinolin-2-ones by 6-exo-trig radical cyclizations of axially chiral alpha-halo-ortho-alkenyl anilides.

David B Guthrie, Steven J Geib, Dennis P Curran,

Radical cyclizations (Bu(3)SnH, Et(3)B/air, rt) of racemic alpha-halo-ortho-alkenyl anilides provide 3,4-dihydroquinolin-2-ones in high yield. Cyclizations of enantioenriched precursors occur in similarly high yields and with transfer of axial chirality to the new stereocenter of the products with exceptionally high fidelity (often >95%). Single and tandem cyclizations of alpha-halo-ortho-alkenyl anilides bearing ... Read more >>

J Am Chem Soc (Journal of the American Chemical Society)
[2009, 131(42):15492-15500]

Cited: 11 times

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Radical and Heck cyclizations of diastereomeric o-haloanilide atropisomers.

David B Guthrie, Steven J Geib, Dennis P Curran,

The outcomes of radical cyclizations and Heck reactions of N-(cyclohex-2-enyl)-N-(2-iodophenyl)acetamides depend critically on the configurations of the chiral axis and the stereocenter. In substrates without an ortho-methyl group, the diastereomeric precursors interconvert slowly at ambient temperatures. Cyclization of enriched mixtures of diastereomers provided similar yields of acetyl tetrahydrocarbazoles or dihydrocarbazoles, ... Read more >>

J Am Chem Soc (Journal of the American Chemical Society)
[2011, 133(1):115-122]

Cited: 9 times

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Bond rotation dynamics of N-cycloalkenyl-N-benzyl alpha-haloacetamide derivatives.

David B Guthrie, Krishnan Damodaran, Dennis P Curran, Paul Wilson, Andrew J Clark,

Barriers to rotation of the N-alkenyl bond in a series of N-cycloalkenyl-N-benzyl alpha-haloacetamide derivatives have been measured by variable-temperature NMR experiments. The barriers range from 10 to 18 kcal/mol, depending on ring size and on substituents on the cycloalkene and the amide. The observed trends aid in the design of ... Read more >>

J Org Chem (The Journal of organic chemistry)
[2009, 74(11):4262-4266]

Cited: 0 times

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Asymmetric radical and anionic cyclizations of axially chiral carbamates.

David B Guthrie, Dennis P Curran,

Standard Boc, Alloc, and Cbz derivatives of N-2,4-dimethyl-6-iodophenyl-N-allyl anilines are axially chiral and can be readily resolved into atropisomers whose racemization barriers exceed 30 kcal/mol. The resolved axially chiral carbamates undergo radical and anionic cyclizations with high levels of chirality transfer from the N-Ar axis to the new stereocenter in ... Read more >>

Org Lett (Organic letters)
[2009, 11(1):249-251]

Cited: 9 times

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How do analogous alpha-chloroenamides and alpha-iodoenamides give different product distributions in 5-endo radical cyclizations?

Dennis P Curran, David B Guthrie, Steven J Geib,

5-Endo cyclizations of N-alkenyl carbamoylmethyl radicals provide gamma-lactam radicals, which in turn evolve to reduced or non-reduced (alkene) products depending on reagents and reaction conditions. Several groups have made surprising observations that chlorides are better radical precursors than iodides in such cyclizations. Here is described a detailed study of tin ... Read more >>

J Am Chem Soc (Journal of the American Chemical Society)
[2008, 130(26):8437-8445]

Cited: 9 times

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