Full Text Journal Articles by
Author David A Jones

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The Aspergillus nidulans IQGAP orthologue SepG is required for constriction of the contractile actomyosin ring.

Terry W Hill, Kristen E Wendt, David A Jones, McLean H Williamson, Uchenna J Ugwu, Lauren B Rowland, Loretta Jackson-Hayes,

In this research we report that the sepG1 mutation in Aspergillus nidulans resides in gene AN9463, which is predicted to encode an IQGAP orthologue. The genetic lesion is predicted to result in a G-to-R substitution at residue 1637 of the 1737-residue protein in a highly conserved region of the RasGAP-C-terminal ... Read more >>

Fungal Genet Biol (Fungal genetics and biology : FG & B)
[2020, 144:103439]

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Are Force Enhancement after Stretch and Muscle Fatigue Due to Effects of Elevated Inorganic Phosphate and Low Calcium on Cross Bridge Kinetics?

Hans Degens, David A Jones,

Background and Objectives: Muscle fatigue is characterised by (1) loss of force, (2) decreased maximal shortening velocity and (3) a greater resistance to stretch that could be due to reduced intracellular Ca2+ and increased Pi, which alter cross bridge kinetics. Materials and Methods: To investigate this, we used (1) 2,3-butanedione ... Read more >>

Medicina (Kaunas) (Medicina (Kaunas, Lithuania))
[2020, 56(5):]

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Low frequency fatigue and changes in muscle fascicle length following eccentric exercise of the knee extensors.

Pornpimol Muanjai, Mantas Mickevicius, Audrius Sniečkus, Saulė Sipavičienė, Danguole Satkunskiene, Sigitas Kamandulis, David A Jones,

NEW FINDING:What is the central question of this study? Does low frequency muscle fatigue indicate a failure of excitation-contraction coupling after eccentric exercise, or is it simply due to a change in muscle length? What is the main finding and its importance? The low to high frequency muscle fatigue ratio ... Read more >>

Exp. Physiol. (Experimental physiology)
[2020, 105(3):502-510]

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Flax rust infection transcriptomics reveals a transcriptional profile that may be indicative for rust Avr genes.

Wenjie Wu, Adnane Nemri, Leila M Blackman, Ann-Maree Catanzariti, Jana Sperschneider, Gregory J Lawrence, Peter N Dodds, David A Jones, Adrienne R Hardham,

Secreted effectors of fungal pathogens are essential elements for disease development. However, lack of sequence conservation among identified effectors has long been a problem for predicting effector complements in fungi. Here we have explored the expression characteristics of avirulence (Avr) genes and candidate effectors of the flax rust fungus, Melampsora ... Read more >>

PLoS One (PloS one)
[2019, 14(12):e0226106]

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Concurrent cisplatin or cetuximab with radiotherapy for HPV-positive oropharyngeal cancer: Medical resource use, costs, and quality-adjusted survival from the De-ESCALaTE HPV trial.

David A Jones, Pankaj Mistry, Matthew Dalby, Tessa Fulton-Lieuw, Anthony H Kong, Janet Dunn, Hisham M Mehanna, Alastair M Gray,

BACKGROUND:The De-ESCALaTE HPV trial confirmed the dominance of cisplatin over cetuximab for tumour control in patients with human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC). Here, we present the analysis of health-related quality of life (HRQoL), resource use, and health care costs in the trial, as well as complete 2-year ... Read more >>

Eur. J. Cancer (European journal of cancer (Oxford, England : 1990))
[2020, 124:178-185]

Cited: 1 time

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A systematic review of health economic evaluations of proton beam therapy for adult cancer: Appraising methodology and quality.

David A Jones, Joel Smith, Xue W Mei, Maria A Hawkins, Tim Maughan, Frank van den Heuvel, Thomas Mee, Karen Kirkby, Norman Kirkby, Alastair Gray,

Background and purpose:With high treatment costs and limited capacity, decisions on which adult patients to treat with proton beam therapy (PBT) must be based on the relative value compared to the current standard of care. Cost-utility analyses (CUAs) are the gold-standard method for doing this. We aimed to appraise the ... Read more >>

Clin Transl Radiat Oncol (Clinical and translational radiation oncology)
[2020, 20:19-26]

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The contribution of low-frequency fatigue to the loss of quadriceps contractile function following repeated drop jumps.

Sigitas Kamandulis, Pornpimol Muanjai, Albertas Skurvydas, Marius Brazaitis, Audrius Sniečkus, Tomas Venckūnas, Vytautas Streckis, Dalia Mickeviciene, David A Jones,

NEW FINDINGS:What is the central question of this study? Why do some subjects recover slowly following a bout of eccentric exercise and why is recovery faster following a repeated bout? What is the main finding and its importance? The results are consistent with two major causes of the reduction of ... Read more >>

Exp. Physiol. (Experimental physiology)
[2019, 104(11):1701-1710]

Cited: 1 time

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Cholinesterase Inhibitory Arisugacins L-Q from a Penicillium sp. Isolate Obtained through a Citizen Science Initiative and Their Activities in a Phenotype-Based Zebrafish Assay.

Wentao Dai, Imelda T Sandoval, Shengxin Cai, Kaylee A Smith, Richard Glenn C Delacruz, Kevin A Boyd, Jessica J Mills, David A Jones, Robert H Cichewicz,

Phenotype-based screening of a fungal extract library yielded an active sample from a Penicillium sp. isolate that impaired zebrafish motility. Bioassay-guided purification led to the identification of 14 meroterpenoids including six new metabolites, arisugacins L-Q (4, 5, 8, and 12-14), seven known arisugacins (1-3, 6, 7, 9, and 10), and ... Read more >>

J. Nat. Prod. (Journal of natural products)
[2019, 82(9):2627-2637]

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Five-year longitudinal changes in thigh muscle mass of septuagenarian men and women assessed with DXA and MRI.

James Cameron, Jamie S McPhee, David A Jones, Hans Degens,

Magnetic resonance imaging (MRI) and dual-energy X-ray absorptiometry (DXA) were used to assess changes in thigh lean mass in septuagenarian men and women during a 5-year longitudinal study. Twenty-four older individuals participated in the study (10 men: 71.6 ± 4.1 years; 14 women: 71.3 ± 3.2 years at baseline). Thigh MRI and whole-body DXA scans were ... Read more >>

Aging Clin Exp Res (Aging clinical and experimental research)
[2020, 32(4):617-624]

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Combined Resistance and Stretching Exercise Training Benefits Stair Descent Biomechanics in Older Adults.

James P Gavin, Neil D Reeves, David A Jones, Mike Roys, John G Buckley, Vasilios Baltzopoulos, Constantinos N Maganaris,

Introduction:Stair descent is a physically demanding activity of daily life and common risk for falls. Age-related deteriorations in ankle joint capacities make stair descent particularly challenging for older adults in built environments, where larger rise steps are encountered. Exercise training may allow older adults to safely cope with the high ... Read more >>

(Frontiers in physiology)
[2019, 10:873]

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Functional characterization of CNOT3 variants identified in familial adenomatous polyposis adenomas.

Richard Glenn C Delacruz, Imelda T Sandoval, Kyle Chang, Braden N Miller, Laura Reyes-Uribe, Ester Borras, Patrick M Lynch, Melissa W Taggart, Ernest T Hawk, Eduardo Vilar, David A Jones,

Germline mutations in the tumor suppressor Adenomatous Polyposis Coli (APC) define Familial Adenomatous Polyposis (FAP), the genetic predisposition to developing adenomatous polyps. Recent sequencing of FAP adenomas have challenged established dogma that APC mutations alone represent the adenoma mutational landscape because recurrent somatic mutations in non-WNT pathway genes were also ... Read more >>

Oncotarget (Oncotarget)
[2019, 10(39):3939-3951]

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The effects of slow loaded breathing training on exercise blood pressure in isolated systolic hypertension.

Chulee Ubolsakka-Jones, Phailin Tongdee, David A Jones,

OBJECTIVES:Slow loaded breathing training has been shown to reduce resting blood pressure (BP) in isolated systolic hypertension (ISH), but it is not known whether this also reduces their exaggerated BP responses to exercise. METHODS:The study was a randomized controlled trial with block allocation stratified by sex. Twenty ISH patients (68 ± 5 yrs, ... Read more >>

Physiother Res Int (Physiotherapy research international : the journal for researchers and clinicians in physical therapy)
[2019, 24(4):e1785]

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Slow torque recovery after eccentric exercise and the repeated bout effect; the role of primary and secondary muscle damage.

Pornpimol Muanjai, Mantas Mickevičius, Audrius Sniečkus, Danguole Satkunskiene, Sigitas Kamandulis, David A Jones,

OBJECTIVES:To determine the role of primary and secondary damage in the variation between people of maximum voluntary contraction (MVC) torque recovery following eccentric exercise and the faster recovery following a repeated bout of exercise. METHODS:Twenty-one healthy, active but untrained young female subjects undertook eccentric exercise of the elbow flexors and ... Read more >>

J Musculoskelet Neuronal Interact (Journal of musculoskeletal & neuronal interactions)
[2019, 19(2):207-214]

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Frailty phenotype and frailty index are associated with distinct neuromuscular electrophysiological characteristics in men.

Agnieszka Swiecicka, Mathew Piasecki, Daniel W Stashuk, Alex Ireland, David A Jones, Martin K Rutter, Jamie S McPhee,

NEW FINDINGS:What is the central question of this study? Human frailty is characterized by accumulated health complaints, including medical conditions, low physical and psychological function and social components. It is currently unknown whether the condition is associated with neuromuscular changes detectable by electrophysiology obtained from voluntary and involuntary muscle contractions. ... Read more >>

Exp Physiol (Experimental physiology)
[2019, 104(8):1154-1161]

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Toxic effects of a methanolic coal dust extract on fish early life stage.

Angélica Guerrero-Castilla, Jesús Olivero-Verbel, Imelda T Sandoval, David A Jones,

Coal dust is a contaminant that impacts the terrestrial and aquatic environment with a complex mixture of chemicals, including PAHs and metals. This study aims to evaluate the toxic effect of a methanolic coal dust extract on a fish early life stage by analyzing phenotypic alterations, transcriptome changes, and mortality ... Read more >>

Chemosphere (Chemosphere)
[2019, 227:100-108]

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The relationship between stiffness and pain following unaccustomed eccentric exercise: the effects of gentle stretch and repeated bout.

Pornpimol Muanjai, Mantas Mickevicius, Sigitas Kamandulis, Audrius Snieckus, David A Jones,

PURPOSE:To determine how muscle stiffness and pain which develop after eccentric exercise are affected by gentle stretching and repeated exercise. METHODS:Twenty-one healthy female participants undertook eccentric exercise of the elbow flexors and changes in resting elbow flexion angle (REFA; a measure of muscle stiffness), pain on stretch scale, pain elicited ... Read more >>

Eur. J. Appl. Physiol. (European journal of applied physiology)
[2019, 119(5):1183-1194]

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The immediate effects of breathing with oscillated inspiratory and expiratory airflows on secretion clearance in intubated patients with cervical spinal cord injury.

Sujittra Kluayhomthong, Chulee Ubolsakka-Jones, Pornanan Domthong, Wipa Reechaipichitkul, David A Jones,

STUDY DESIGN:A prospective, randomized crossover trial. OBJECTIVES:To evaluate the efficacy of the combination of incentive spirometry with oscillation (OIS) and positive expiratory pressure with oscillation (OPEP) to promote secretion clearance in intubated patients with cervical spinal cord injury. SETTING:Spinal cord unit, tertiary care hospital, North East Thailand. METHODS:Thirteen intubated patients ... Read more >>

Spinal Cord (Spinal cord)
[2019, 57(4):308-316]

Cited: 1 time

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Structural and functional insights into the modulation of the activity of a flax cytokinin oxidase by flax rust effector AvrL567-A.

Li Wan, Markus Koeck, Simon J Williams, Anthony R Ashton, Gregory J Lawrence, Hitoshi Sakakibara, Mikiko Kojima, Christine Böttcher, Daniel J Ericsson, Adrienne R Hardham, David A Jones, Jeffrey G Ellis, Bostjan Kobe, Peter N Dodds,

During infection, plant pathogens secrete effector proteins to facilitate colonization. In comparison with our knowledge of bacterial effectors, the current understanding of how fungal effectors function is limited. In this study, we show that the effector AvrL567-A from the flax rust fungus Melampsora lini interacts with a flax cytosolic cytokinin ... Read more >>

Mol. Plant Pathol. (Molecular plant pathology)
[2019, 20(2):211-222]

Cited: 2 times

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Evidence for horizontal gene transfer and separation of effector recognition from effector function revealed by analysis of effector genes shared between cape gooseberry- and tomato-infecting formae speciales of Fusarium oxysporum.

Jaime Simbaqueba, Ann-Maree Catanzariti, Carolina González, David A Jones,

RNA sequencing (RNAseq) reads from cape gooseberry plants (Physalis peruviana) infected with Fusarium oxysporumf. sp. physali (Foph) were mapped against the lineage-specific transcriptome of Fusarium oxysporumf. sp. lycopersici (Fol) to look for putative effector genes. Homologues of Fol SIX1(designated SIX1a and SIX1b), SIX7, SIX10, SIX12, SIX15 and Ave1were identified. The ... Read more >>

Mol. Plant Pathol. (Molecular plant pathology)
[2018, 19(10):2302-2318]

Cited: 3 times

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Positive expiratory pressure breathing speeds recovery of postexercise dyspnea in chronic obstructive pulmonary disease.

Chulee Ubolsakka-Jones, Khajonsak Pongpanit, Watchara Boonsawat, David A Jones,

OBJECTIVES:Faster recovery of postexertional dyspnea might enable chronic obstructive pulmonary disease (COPD) patients to undertake more physical activity. The purpose of this study was to determine whether breathing with a positive expiratory load to reduce dynamic hyperinflation (DH) would hasten recovery. METHODS:Thirteen male COPD patients (59 ± 7 years; Global Initiative for Obstructive ... Read more >>

Physiother Res Int (Physiotherapy research international : the journal for researchers and clinicians in physical therapy)
[2019, 24(1):e1750]

Cited: 1 time

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The Contributions of Fiber Atrophy, Fiber Loss, In Situ Specific Force, and Voluntary Activation to Weakness in Sarcopenia.

Jamie S McPhee, James Cameron, Thomas Maden-Wilkinson, Mathew Piasecki, Moi Hoon Yap, David A Jones, Hans Degens,

The contributions of fiber atrophy, fiber loss, in situ specific force, and voluntary activation to weakness in sarcopenia remain unclear. To investigate, 40 older (20 women; age 72 ± 4 years) and 31 younger adults (15 women, age 22 ± 3 years) completed measurements. The knee extensor maximal voluntary torque ... Read more >>

J Gerontol A Biol Sci Med Sci (The journals of gerontology. Series A, Biological sciences and medical sciences)
[2018, 73(10):1287-1294]

Cited: 8 times

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Design and Function of a New Conical Positive Expiratory Pressure Device to Be Used During Exercise.

Chatchai Phimphasak, Chulee Ubolsakka-Jones, David A Jones,

BACKGROUND:A flow-dependent conical positive expiratory pressure (PEP) resistor incorporated into a oronasal mask was developed, which might reduce dyspnea and dynamic hyperinflation and increase exercise endurance for patients with COPD. We reported here the flow-pressure relationships and the safety and suitability of the device when used by healthy young and ... Read more >>

Respir Care (Respiratory care)
[2018, 63(8):966-980]

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Comparison of breathing patterns, pressure, volume, and flow characteristics of three breathing techniques to encourage lung inflation in healthy older people.

Chulee Ubolsakka-Jones, Wiraporn Tasangkar, David A Jones,

Background: It is important to encourage lung inflation to prevent postsurgical pulmonary complications and we compared three breathing techniques that place different emphasis on inspiratory flow and breath-holding. Methods: Fourteen healthy older people (69 ± 3.6 yrs) used diaphragmatic breathing (DB), Triflo II (TF), and a water pressure threshold device (BreatheMAX; BM) in ... Read more >>

Physiother Theory Pract (Physiotherapy theory and practice)
[2019, 35(12):1283-1291]

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Active BRAF-V600E is the key player in generation of a sessile serrated polyp-specific DNA methylation profile.

Somaye Dehghanizadeh, Vahid Khoddami, Timothy L Mosbruger, Sue S Hammoud, Kornelia Edes, Therese S Berry, Michelle Done, Wade S Samowitz, James A DiSario, Daniel G Luba, Randall W Burt, David A Jones,

Sessile serrated polyps (SSPs) have emerged as important precursors for a large number of sporadic colorectal cancers. They are difficult to detect during colonoscopy due to their flat shape and the excessive amounts of secreted mucin that cover the polyps. The underlying genetic and epigenetic basis for the emergence of ... Read more >>

PLoS One (PloS one)
[2018, 13(3):e0192499]

Cited: 3 times

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Slow loaded breathing training improves blood pressure, lung capacity and arm exercise endurance for older people with treated and stable isolated systolic hypertension.

Chulee Ublosakka-Jones, Phailin Tongdee, Orathai Pachirat, David A Jones,

BACKGROUND:Hypertension and reduced lung function are important features of aging. Slow loaded breathing training reduces resting blood pressure and the question is whether this can also improve lung function. METHODS:Thirty-two people (67 ± 5 years, 16 male) with controlled isolated systolic hypertension undertook an eight weeks randomised controlled training trial with an inspiratory ... Read more >>

Exp. Gerontol. (Experimental gerontology)
[2018, 108:48-53]

Cited: 1 time

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