Full Text Journal Articles by
Author David A Holdsworth

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Abnormal whole-body energy metabolism in iron-deficient humans despite preserved skeletal muscle oxidative phosphorylation.

Matthew C Frise, David A Holdsworth, Andrew W Johnson, Yu Jin Chung, M Kate Curtis, Pete J Cox, Kieran Clarke, Damian J Tyler, David J Roberts, Peter J Ratcliffe, Keith L Dorrington, Peter A Robbins,

Iron deficiency impairs skeletal muscle metabolism. The underlying mechanisms are incompletely characterised, but animal and human experiments suggest the involvement of signalling pathways co-dependent upon oxygen and iron availability, including the pathway associated with hypoxia-inducible factor (HIF). We performed a prospective, case-control, clinical physiology study to explore the effects of ... Read more >>

Sci Rep (Scientific reports)
[2022, 12(1):998]

Cited: 0 times

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Dysautonomia following COVID-19 is not associated with subjective limitations or symptoms but is associated with objective functional limitations.

Peter Ladlow, Oliver O'Sullivan, Andrew Houston, Robert Barker-Davies, Samantha May, Daniel Mills, Dominic Dewson, Rebecca Chamley, Jon Naylor, Joseph Mulae, Alexander N Bennett, Edward D Nicol, David A Holdsworth,

<h4>Background</h4>Individuals who contract coronavirus disease 2019 (COVID-19) can suffer with persistent and debilitating symptoms long after the initial acute illness. Heart rate (HR) profiles determined during cardiopulmonary exercise testing (CPET) and delivered as part of a post-COVID recovery service may provide insight into the presence and impact of dysautonomia on ... Read more >>

Heart Rhythm (Heart rhythm)
[2021, :]

Cited: 1 time

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The European Association of Preventive Cardiology Aviation and Occupational Cardiology Task Force.

Edward D Nicol, David A Holdsworth, Martin Halle, Constantinos H Davos,

Eur Heart J (European heart journal)
[2021, 42(21):2030-2033]

Cited: 0 times

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Iron bioavailability and cardiopulmonary function during ascent to very high altitude.

David A Holdsworth, Matthew C Frise, Josh Bakker-Dyos, Christopher Boos, Keith L Dorrington, David Woods, Adrian Mellor, Peter A Robbins,

Eur Respir J (The European respiratory journal)
[2020, 56(3):]

Cited: 1 time

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Echocardiographic changes following active heat acclimation.

Iain T Parsons, Daniel Snape, John O'Hara, David A Holdsworth, Michael J Stacey, Nick Gall, Phil Chowienczyk, Barney Wainwright, David R Woods,

Heat adaption through acclimatisation or acclimation improves cardiovascular stability by maintaining cardiac output due to compensatory increases in stroke volume. The main aim of this study was to assess whether 2D transthoracic echocardiography (TTE) could be used to confirm differences in resting echocardiographic parameters, before and after active heat acclimation ... Read more >>

J Therm Biol (Journal of thermal biology)
[2020, 93:102705]

Cited: 1 time

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An Introduction to Occupational Cardiology.

Rebecca R Chamley, David A Holdsworth, Joanna L D'arcy, Edward D Nicol,

Eur Heart J (European heart journal)
[2019, 40(29):2389-2392]

Cited: 0 times

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ECG interpretation.

Rebecca R Chamley, David A Holdsworth, Kim Rajappan, Edward D Nicol,

Eur Heart J (European heart journal)
[2019, 40(32):2663-2666]

Cited: 1 time

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Occupational Cardiology: The need for a 21st century sub-specialty?

Edward D Nicol, Joanna L D'Arcy, Maj Thomas Syburra, David A Holdsworth,

Eur Heart J (European heart journal)
[2019, 40(48):3878-3881]

Cited: 0 times

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The importance of exercise testing in occupational cardiovascular assessment for high-hazard professions.

David A Holdsworth, Rebecca R Chamley, Oliver J Rider, Edward D Nicol,

Eur Heart J (European heart journal)
[2019, 40(37):3078-3080]

Cited: 0 times

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The assessment of asymptomatic inherited QT prolongation for high-hazard occupations.

Norbert Guettler, Kim Rajappan, David A Holdsworth, Edward D Nicol,

Eur Heart J (European heart journal)
[2019, 40(33):2750-2753]

Cited: 0 times

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Assessment of clinical and occupational cardiovascular risk.

David A Holdsworth, Leanne J Eveson, Olivier Manen, Edward D Nicol,

Eur Heart J (European heart journal)
[2019, 40(29):2392-2395]

Cited: 0 times

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Smartphone-Enabled Heart Rate Variability and Acute Mountain Sickness.

Adrian Mellor, Josh Bakker-Dyos, John OʼHara, David Richard Woods, David A Holdsworth, Christopher J Boos,

<h4>Introduction</h4>The autonomic system and sympathetic activation appears integral in the pathogenesis of acute mountain sickness (AMS) at high altitude (HA), yet a link between heart rate variability (HRV) and AMS has not been convincingly shown. In this study we investigated the utility of the smartphone-derived HRV score to predict and ... Read more >>

Clin J Sport Med (Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine)
[2018, 28(1):76-81]

Cited: 2 times

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A Ketone Ester Drink Increases Postexercise Muscle Glycogen Synthesis in Humans.

David A Holdsworth, Peter J Cox, Tom Kirk, Huw Stradling, Samuel G Impey, Kieran Clarke,

<h4>Introduction</h4>Physical endurance can be limited by muscle glycogen stores, in that glycogen depletion markedly reduces external work. During carbohydrate restriction, the liver synthesizes the ketone bodies, D-β-hydroxybutyrate, and acetoacetate from fatty acids. In animals and in the presence of glucose, D-β-hydroxybutyrate promotes insulin secretion and increases glycogen synthesis. Here we ... Read more >>

Med Sci Sports Exerc (Medicine and science in sports and exercise)
[2017, 49(9):1789-1795]

Cited: 17 times

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Assessment of Cardiac Arrhythmias at Extreme High Altitude Using an Implantable Cardiac Monitor: REVEAL HA Study (REVEAL High Altitude).

Christopher John Boos, David A Holdsworth, David Richard Woods, John O'Hara, Naomi Brooks, Lee Macconnachie, Josh Bakker-Dyos, John Paisey, Adrian Mellor,

Circulation (Circulation)
[2017, 135(8):812-814]

Cited: 8 times

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A comparison of substrate oxidation during prolonged exercise in men at terrestrial altitude and normobaric normoxia following the coingestion of 13C glucose and 13C fructose.

John P O'Hara, David R Woods, Adrian Mellor, Christopher Boos, Liam Gallagher, Costas Tsakirides, Nicola C Arjomandkhah, David A Holdsworth, Carlton B Cooke, Douglas J Morrison, Thomas Preston, Roderick Fgj King,

This study compared the effects of coingesting glucose and fructose on exogenous and endogenous substrate oxidation during prolonged exercise at altitude and sea level, in men. Seven male British military personnel completed two bouts of cycling at the same relative workload (55% W<sub>max</sub>) for 120 min on acute exposure to altitude ... Read more >>

Physiol Rep (Physiological reports)
[2017, 5(1):]

Cited: 5 times

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Using CMR to improve the diagnostic accuracy of the ECG for the detection of left ventricular hypertrophy; production of a simple adjustment for body mass index

Oliver Rider, Sacha C Bull, Richard M Nethononda, Ntobeko A Ntusi, Vanessa M Ferreira, Cameron Holloway, David A Holdsworth, Masliza Mahmod, Jennifer J Rayner, Rajarshi Banerjee, Saul G Myerson, Stefan Neubauer, Hugh Watkins,

J Cardiovasc Magn Reson (Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance)
[2016, 18(Suppl 1):]

Cited: 0 times

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Cardiac biomarkers and high altitude pulmonary edema.

Christopher J Boos, David A Holdsworth, David R Woods, Kevin Green, Jon Naylor, Adrian Mellor,

Int J Cardiol (International journal of cardiology)
[2013, 167(3):e65-6]

Cited: 6 times

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