Full Text Journal Articles by
Author David A Brown

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Effects of the Positive Threshold and Data Analysis on Human MOG Antibody Detection by Live Flow Cytometry.

Fiona Tea, Deepti Pilli, Sudarshini Ramanathan, Joseph A Lopez, Vera Merheb, Fiona X Z Lee, Alicia Zou, Ganesha Liyanage, Chelsea B Bassett, Selina Thomsen, Stephen W Reddel, Michael H Barnett, David A Brown, Russell C Dale, Fabienne Brilot, ,

Human autoantibodies targeting myelin oligodendrocyte glycoprotein (MOG Ab) have become a useful clinical biomarker for the diagnosis of a spectrum of inflammatory demyelinating disorders. Live cell-based assays that detect MOG Ab against conformational MOG are currently the gold standard. Flow cytometry, in which serum binding to MOG-expressing cells and control ... Read more >>

Front Immunol (Frontiers in immunology)
[2020, 11:119]

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Safety of drug use in patients with a primary mitochondrial disease: An international Delphi-based consensus.

Maaike C De Vries, David A Brown, Mitchell E Allen, Laurence Bindoff, Gráinne S Gorman, Amel Karaa, Nandaki Keshavan, Costanza Lamperti, Robert McFarland, Yi Shiau Ng, Mar O'Callaghan, Robert D S Pitceathly, Shamima Rahman, Frans G M Russel, Kristin N Varhaug, Tom J J Schirris, Michelangelo Mancuso,

Clinical guidance is often sought when prescribing drugs for patients with primary mitochondrial disease. Theoretical considerations concerning drug safety in patients with mitochondrial disease may lead to unnecessary withholding of a drug in a situation of clinical need. The aim of this study was to develop consensus on safe medication ... Read more >>

J. Inherit. Metab. Dis. (Journal of inherited metabolic disease)
[2020, :]

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Neurons, Receptors, and Channels.

David A Brown,

Here, I recount some adventures that I and my colleagues have had over some 60 years since 1957 studying the effects of drugs and neurotransmitters on neuronal excitability and ion channel function, largely, but not exclusively, using sympathetic neurons as test objects. Studies include effects of centrally active drugs on ... Read more >>

Annu. Rev. Pharmacol. Toxicol. (Annual review of pharmacology and toxicology)
[2020, 60:9-30]

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Bioenergetics underlying single-cell migration on aligned nanofiber scaffolds.

Abinash Padhi, Alexander H Thomson, Justin B Perry, Grace N Davis, Ryan P McMillan, Sandra Loesgen, Elizabeth N Kaweesa, Rakesh Kapania, Amrinder S Nain, David A Brown,

Cell migration is centrally involved in a myriad of physiological processes, including morphogenesis, wound healing, tissue repair, and metastatic growth. The bioenergetics that underlie migratory behavior are not fully understood, in part because of variations in cell culture media and utilization of experimental cell culture systems that do not model ... Read more >>

Am. J. Physiol., Cell Physiol. (American journal of physiology. Cell physiology)
[2020, 318(3):C476-C485]

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Demonstration of spiral wave front sonar for active localization.

Benjamin R Dzikowicz, James F Tressler, David A Brown,

Spiral wave front sonar is a non-imaging, active sonar technique for remote target localization. It operates by transmitting a reference signal and a spiral signal whose phase varies by 2π over the transducer's azimuthal plane. Range is given by time-of-flight, and azimuthal aspect by computing the phase difference between reference ... Read more >>

J. Acoust. Soc. Am. (The Journal of the Acoustical Society of America)
[2019, 146(6):4821]

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Autoimmune psychosis: an international consensus on an approach to the diagnosis and management of psychosis of suspected autoimmune origin.

Thomas A Pollak, Belinda R Lennox, Sabine Müller, Michael E Benros, Harald Prüss, Ludger Tebartz van Elst, Hans Klein, Johann Steiner, Thomas Frodl, Bernhard Bogerts, Li Tian, Laurent Groc, Alkomiet Hasan, Bernhard T Baune, Dominique Endres, Ebrahim Haroon, Robert Yolken, Francesco Benedetti, Angelos Halaris, Jeffrey H Meyer, Hans Stassen, Marion Leboyer, Dietmar Fuchs, Markus Otto, David A Brown, Angela Vincent, Souhel Najjar, Karl Bechter,

There is increasing recognition in the neurological and psychiatric literature of patients with so-called isolated psychotic presentations (ie, with no, or minimal, neurological features) who have tested positive for neuronal autoantibodies (principally N-methyl-D-aspartate receptor antibodies) and who have responded to immunotherapies. Although these individuals are sometimes described as having atypical, ... Read more >>

Lancet Psychiatry (The lancet. Psychiatry)
[2020, 7(1):93-108]

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Fore-aft resistance applied at the center of mass using a novel robotic interface proportionately increases propulsive force generation in healthy nonimpaired individuals walking at a constant speed.

Avantika Naidu, Sarah A Graham, David A Brown,

BACKGROUND:Past studies have utilized external interfaces like resistive bands and motor-generated pulling systems to increase limb propulsion during walking on a motorized treadmill. However, assessing changes in limb propulsion against increasing resistance demands during self-controlled walking has not been undertaken. PURPOSE:We assessed limb propulsion against increasing fore-aft loading demands by ... Read more >>

J Neuroeng Rehabil (Journal of neuroengineering and rehabilitation)
[2019, 16(1):111]

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Characterization of the human myelin oligodendrocyte glycoprotein antibody response in demyelination.

Fiona Tea, Joseph A Lopez, Sudarshini Ramanathan, Vera Merheb, Fiona X Z Lee, Alicia Zou, Deepti Pilli, Ellis Patrick, Anneke van der Walt, Mastura Monif, Esther M Tantsis, Eppie M Yiu, Steve Vucic, Andrew P D Henderson, Anthony Fok, Clare L Fraser, Jeanette Lechner-Scott, Stephen W Reddel, Simon Broadley, Michael H Barnett, David A Brown, Jan D Lunemann, Russell C Dale, Fabienne Brilot, ,

Over recent years, human autoantibodies targeting myelin oligodendrocyte glycoprotein (MOG Ab) have been associated with monophasic and relapsing central nervous system demyelination involving the optic nerves, spinal cord, and brain. While the clinical relevance of MOG Ab detection is becoming increasingly clear as therapeutic and prognostic differences from multiple sclerosis ... Read more >>

Acta Neuropathol Commun (Acta neuropathologica communications)
[2019, 7(1):145]

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Cardioprotective effects of idebenone do not involve ROS scavenging: Evidence for mitochondrial complex I bypass in ischemia/reperfusion injury.

Justin B Perry, Grace N Davis, Mitchell E Allen, Marina Makrecka-Kuka, Maija Dambrova, Robert W Grange, Saame Raza Shaikh, David A Brown,

Novel therapeutic strategies to treat mitochondrial deficiencies in acute coronary syndromes are needed. Complex I of the mitochondrial electron transport system is damaged following ischemia/reperfusion (I/R) injury. This disruption contributes to aberrant electron transport, diminished bioenergetics, an altered redox environment, and mitochondrial damage involved in tissue injury. In this study, ... Read more >>

J. Mol. Cell. Cardiol. (Journal of molecular and cellular cardiology)
[2019, 135:160-171]

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MIC-1/GDF15 Overexpression Is Associated with Increased Functional Recovery in Traumatic Spinal Cord Injury.

Masoud Hassanpour Golakani, Mohammad G Mohammad, Hui Li, Joanne Gamble, Samuel N Breit, Marc J Ruitenberg, David A Brown,

Spinal cord injury (SCI) has devastating consequences, with limited therapeutic options; therefore, improving its functional outcome is a major goal. The outcome of SCI is contributed to by neuroinflammation, which may be a target for improved recovery and quality of life after injury. Macrophage inhibitory cytokine-1/growth differentiation factor 15 (MIC-1/GDF15) ... Read more >>

J. Neurotrauma (Journal of neurotrauma)
[2019, 36(24):3410-3421]

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Dynamic stability during increased walking speeds is related to balance confidence of older adults: a pilot study.

Jutaluk Kongsuk, David A Brown, Christopher P Hurt,

BACKGROUND:Some older individuals walk slower, which may be due to decreases in mechanical stability at faster speeds or due to psychological factors like balance confidence. RESEARCH QUESTION:What is the relationship between progressively increasing walking speeds on dynamic stability in older and younger adults and how does this relationship interact with ... Read more >>

Gait Posture (Gait & posture)
[2019, 73:86-92]

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GDF15 mediates adiposity resistance through actions on GFRAL neurons in the hindbrain AP/NTS.

Vicky Wang-Wei Tsai, Hong Ping Zhang, Rakesh Manandhar, Peter Schofield, Daniel Christ, Ka Ki Michelle Lee-Ng, Hélène Lebhar, Christopher Peter Marquis, Yasmin Husaini, David A Brown, Samuel N Breit,

BACKGROUND:Elevated circulating levels of the divergent transforming growth factor-beta (TGFb) family cytokine, growth differentiation factor 15 (GDF15), acting through its CNS receptor, glial-derived neurotrophic factor receptor alpha-like (GFRAL), can cause anorexia and weight loss leading to anorexia/cachexia syndrome of cancer and other diseases. Preclinical studies suggest that administration of drugs ... Read more >>

Int J Obes (Lond) (International journal of obesity (2005))
[2019, 43(12):2370-2380]

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Computational Analysis of the Mature Unilateral Cleft Lip Nasal Deformity on Nasal Patency.

Dennis O Frank-Ito, David J Carpenter, Tracy Cheng, Yash J Avashia, David A Brown, Adam Glener, Alexander Allori, Jeffrey R Marcus,

Background:Nasal airway obstruction (NAO) due to nasal anatomic deformities is known to be more common among cleft patients than the general population, yet information is lacking regarding severity and variability of cleft-associated nasal obstruction relative to other conditions causing NAO. This preliminary study compares differences in NAO experienced by unilateral ... Read more >>

Plast Reconstr Surg Glob Open (Plastic and reconstructive surgery. Global open)
[2019, 7(5):e2244]

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The skin transcriptome in hidradenitis suppurativa uncovers an antimicrobial and sweat gland gene signature which has distinct overlap with wounded skin.

Margaret Coates, Paula Mariottoni, David L Corcoran, Hélène Fradin Kirshner, Tarannum Jaleel, David A Brown, Stephen R Brooks, John Murray, Maria I Morasso, Amanda S MacLeod,

Hidradenitis suppurativa (HS) is a debilitating chronic inflammatory skin disease resulting in non-healing wounds affecting body areas of high hair follicle and sweat gland density. The pathogenesis of HS is not well understood but appears to involve dysbiosis-driven aberrant activation of the innate immune system leading to excessive inflammation. Marked ... Read more >>

PLoS ONE (PloS one)
[2019, 14(5):e0216249]

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Evidence from genome wide association studies implicates reduced control of Epstein-Barr virus infection in multiple sclerosis susceptibility.

Ali Afrasiabi, Grant P Parnell, Nicole Fewings, Stephen D Schibeci, Monica A Basuki, Ramya Chandramohan, Yuan Zhou, Bruce Taylor, David A Brown, Sanjay Swaminathan, Fiona C McKay, Graeme J Stewart, David R Booth,

BACKGROUND:Genome wide association studies have identified > 200 susceptibility loci accounting for much of the heritability of multiple sclerosis (MS). Epstein-Barr virus (EBV), a memory B cell tropic virus, has been identified as necessary but not sufficient for development of MS. The molecular and immunological basis for this has not been ... Read more >>

Genome Med (Genome medicine)
[2019, 11(1):26]

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The subthreshold-active KV7 current regulates neurotransmission by limiting spike-induced Ca2+ influx in hippocampal mossy fiber synaptic terminals.

Katiuscia Martinello, Elisabetta Giacalone, Michele Migliore, David A Brown, Mala M Shah,

Little is known about the properties and function of ion channels that affect synaptic terminal-resting properties. One particular subthreshold-active ion channel, the Kv7 potassium channel, is highly localized to axons, but its role in regulating synaptic terminal intrinsic excitability and release is largely unexplored. Using electrophysiological recordings together with computational ... Read more >>

Commun Biol (Communications biology)
[2019, 2:145]

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The role of cardiolipin concentration and acyl chain composition on mitochondrial inner membrane molecular organization and function.

Edward Ross Pennington, Katsuhiko Funai, David A Brown, Saame Raza Shaikh,

Cardiolipin (CL) is a key phospholipid of the mitochondria. A loss of CL content and remodeling of CL's acyl chains is observed in several pathologies. Strong shifts in CL concentration and acyl chain composition would presumably disrupt mitochondrial inner membrane biophysical organization. However, it remains unclear in the literature as ... Read more >>

Biochim Biophys Acta Mol Cell Biol Lipids (Biochimica et biophysica acta. Molecular and cell biology of lipids)
[2019, 1864(7):1039-1052]

Cited: 3 times

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Perioperative Treatment with a Prolyl Hydroxylase Inhibitor Reduces Necrosis in a Rat Ischemic Skin Flap Model.

Amanda R Sergesketter, Roger W Cason, Mohamed M Ibrahim, Whitney O Lane, David T Lubkin, Scott T Hollenbeck, David A Brown,

BACKGROUND:The hypoxia-inducible factor (HIF) pathway, regulated by prolyl hydroxylase, is central to tissue adaptation to ischemia. The authors tested whether the prolyl hydroxylase inhibitor dimethyloxalylglycine reduces skin flap necrosis. METHODS:Dorsal skin flaps were raised on hairless rats, with dimethyloxalylglycine delivered intraperitoneally and/or topically for 7 days before and after surgery. ... Read more >>

Plast. Reconstr. Surg. (Plastic and reconstructive surgery)
[2019, 143(4):769e-779e]

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Multimodal Characterization of the Mature Septal Deformity and Airspace Associated with Unilateral Cleft Lip and Palate.

Jeffrey R Marcus, David A Brown, David Carpenter, Adam Glener, Alexander Allori, Dennis Frank-Ito,

BACKGROUND:The nasal deformity that accompanies cleft conditions is often acknowledged as the most difficult obstacle to restoring facial balance in affected children. Despite considerable progress in the treatment of cleft lip and palate, the outcomes of cleft septorhinoplasty have proven variable and difficult to predict, possibly because of incomplete understanding ... Read more >>

Plast. Reconstr. Surg. (Plastic and reconstructive surgery)
[2019, 143(3):865-873]

Cited: 1 time

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Acetylcholine and cholinergic receptors.

David A Brown,

This review provides a distillate of the advances in knowledge about the neurotransmitter functions of acetylcholine over the 50-year period between 1967 and 2017, together with incremental information about the cognate nicotinic and muscarinic acetylcholine receptors, and some brief comments on possible advances in the near future. The text is ... Read more >>

Brain Neurosci Adv (Brain and neuroscience advances)
[2019, 3:2398212818820506]

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The latitude-dependent autoimmune disease risk genes ZMIZ1 and IRF8 regulate mononuclear phagocytic cell differentiation in response to vitamin D.

Grant P Parnell, Stephen D Schibeci, Nicole L Fewings, Ali Afrasiabi, Samantha P L Law, Shanuka Samaranayake, Jing Hui Kh'ng, Yee Hsu Fong, David A Brown, Christopher Liddle, Graeme J Stewart, David R Booth,

Epidemiological, molecular and genetic studies have indicated that high serum vitamin D levels are associated with lower risk of several autoimmune diseases. The vitamin D receptor (VDR) binding sites in monocytes and dendritic cells (DCs) are more common in risk genes for diseases with latitude dependence than in risk genes ... Read more >>

Hum. Mol. Genet. (Human molecular genetics)
[2019, 28(2):269-278]

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Novel Surrogate Markers of CNS Inflammation in CSF in the Diagnosis of Autoimmune Encephalitis.

Jocelyn X Jiang, Nicole Fewings, Suat Dervish, Alessandro F Fois, Stephen R Duma, Matthew Silsby, Sushil Bandodkar, Sudarshini Ramanathan, Andrew Bleasel, Bryne John, David A Brown, Ming-Wei Lin,

Background: Autoimmune encephalitis (AE) is an important cause of refractory epilepsy, rapidly progressive cognitive decline, and unexplained movement disorders in adults. Whilst there is identification of an increasing number of associated autoantibodies, patients remain with a high clinical probability of autoimmune encephalitis but no associated characterized autoantibody. These patients represent ... Read more >>

Front Neurol (Frontiers in Neurology)
[2019, 10:1390]

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Targeting the divergent TGFβ superfamily cytokine MIC-1/GDF15 for therapy of anorexia/cachexia syndromes.

Vicky Wang-Wei Tsai, David A Brown, Samuel N Breit,

PURPOSE OF REVIEW:To review recent finding on MIC-1/GDF15 and re-evaluate it as a potential target for the therapy of anorexia/cachexia syndromes. RECENT FINDINGS:MIC-1/GDF15 consistently induces anorexia/cachexia in animal models. Its actions on brainstem feeding centers leads to anorexia, inducing prolonged undernutrition and consequent loss of both lean and fat mass. ... Read more >>

Curr Opin Support Palliat Care (Current opinion in supportive and palliative care)
[2018, 12(4):404-409]

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Walking and balance outcomes for stroke survivors: a randomized clinical trial comparing body-weight-supported treadmill training with versus without challenging mobility skills.

Sarah A Graham, Elliot J Roth, David A Brown,

BACKGROUND:Treadmill training, with or without body-weight support (BWSTT), typically involves high step count, faster walking speed, and higher heart-rate intensity than overground walking training. The addition of challenging mobility skill practice may offer increased opportunities to improve walking and balance skills. Here we compare walking and balance outcomes of chronic ... Read more >>

J Neuroeng Rehabil (Journal of neuroengineering and rehabilitation)
[2018, 15(1):92]

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The MIC-1/GDF15-GFRAL Pathway in Energy Homeostasis: Implications for Obesity, Cachexia, and Other Associated Diseases.

Vicky W W Tsai, Yasmin Husaini, Amanda Sainsbury, David A Brown, Samuel N Breit,

MIC-1/GDF15 is a stress response cytokine and a distant member of the transforming growth factor beta (TGFb) superfamily, with no close relatives. It acts via a recently identified receptor called glial-derived neurotrophic factor (GDNF) receptor alpha-like (GFRAL), which is a distant orphan member of the GDNF receptor family that signals ... Read more >>

Cell Metab. (Cell metabolism)
[2018, 28(3):353-368]

Cited: 5 times

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