Full Text Journal Articles by
Author Darryl P Leong

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Editorial Comment.

Filipe Cirne, Darryl P Leong,

J Urol (The Journal of urology)
[2021, :101097JU000000000000178501]

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Psychological morbidity associated with prostate cancer: Rates and predictors of depression in the RADICAL PC study.

Gagan Fervaha, Jason P Izard, Dean A Tripp, Nazanin Aghel, Bobby Shayegan, Laurence Klotz, Tamim Niazi, Vincent Fradet, Daniel Taussky, Luke T Lavallée, Robert J Hamilton, Ian Brown, Joseph Chin, Darin Gopaul, Philippe D Violette, Margot K Davis, Sarah Karampatos, Jehonathan H Pinthus, Darryl P Leong, D Robert Siemens, ,

<h4>Introduction</h4>Across all cancer sites and stages, prostate cancer has one of the greatest median five-year survival rates, highlighting the important focus on survivorship issues following diagnosis and treatment. In the current study, we sought to evaluate the prevalence and predictors of depression in a large, multicenter, contemporary, prospectively collected sample ... Read more >>

Can Urol Assoc J (Canadian Urological Association journal = Journal de l'Association des urologues du Canada)
[2021, 15(6):181-186]

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Cardiovascular consequences of discontinuing low-dose rivaroxaban in people with chronic coronary or peripheral artery disease.

Gilles R Dagenais, Leanne Dyal, Jacqueline J Bosch, Darryl P Leong, Victor Aboyans, Scott D Berkowitz, Deepak L Bhatt, Stuart J Connolly, Keith A A Fox, Eva Muehlhofer, Jeffrey L Probstfield, Petr Widimsky, Bernhard R Winkelmann, Salim Yusuf, John W Eikelboom,

<h4>Objective</h4>In patients with chronic coronary or peripheral artery disease enrolled in the Cardiovascular Outcomes for People Using Anticoagulation Strategies trial, randomised antithrombotic treatments were stopped after a median follow-up of 23 months because of benefits of the combination of rivaroxaban 2.5 mg two times per day and aspirin 100 mg once daily ... Read more >>

Heart (Heart (British Cardiac Society))
[2021, :]

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COVID-19 Vaccination Prioritization Based on Cardiovascular Risk Factors and Number-Needed-to-Vaccinate to Prevent Death.

Darryl P Leong, Amitava Banerjee, Salim Yusuf,

The supply limitations of COVID-19 vaccines have led to the need to prioritize vaccine distribution. Obesity, diabetes and hypertension have been associated with an increased risk of severe COVID-19 infection. Approximately half as many individuals with a cardiovascular risk factor need to be vaccinated against COVID-19 to prevent related death ... Read more >>

Can J Cardiol (The Canadian journal of cardiology)
[2021, :]

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The prediction of Metabolic Syndrome alterations is improved by combining waist circumference and handgrip strength measurements compared to either alone.

Jose P Lopez-Lopez, Daniel D Cohen, Daniela Ney-Salazar, Daniel Martinez, Johanna Otero, Diego Gomez-Arbelaez, Paul A Camacho, Gregorio Sanchez-Vallejo, Edgar Arcos, Claudia Narvaez, Henry Garcia, Maritza Perez, Dora I Molina, Carlos Cure, Aristides Sotomayor, Álvaro Rico, Eric Hernandez-Triana, Myriam Duran, Fresia Cotes, Darryl P Leong, Sumathy Rangarajan, Salim Yusuf, Patricio Lopez-Jaramillo,

<h4>Background</h4>Adiposity is a major component of the metabolic syndrome (MetS), low muscle strength has also been identified as a risk factor for MetS and for cardiovascular disease. We describe the prevalence of MetS and evaluate the relationship between muscle strength, anthropometric measures of adiposity, and associations with the cluster of ... Read more >>

Cardiovasc Diabetol (Cardiovascular diabetology)
[2021, 20(1):68]

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Impact of social isolation on mortality and morbidity in 20 high-income, middle-income and low-income countries in five continents.

Ryo Naito, Darryl P Leong, Shrikant Ishver Bangdiwala, Martin McKee, S V Subramanian, Sumathy Rangarajan, Shofiqul Islam, Alvaro Avezum, Karen E Yeates, Scott A Lear, Rajeev Gupta, Afzalhussein Yusufali, Antonio L Dans, Andrzej Szuba, Khalid F Alhabib, Manmeet Kaur, Omar Rahman, Pamela Seron, Rafael Diaz, Thandi Puoane, Weida Liu, Yibing Zhu, Yundong Sheng, Patricio Lopez-Jaramillo, Jephat Chifamba, Ismail Rosnah, Kubilay Karsidag, Roya Kelishadi, Annika Rosengren, Rasha Khatib, Leela Itty Amma K R, Syed Iqbal Azam, Koon Teo, Salim Yusuf,

<h4>Objective</h4>To examine the association between social isolation and mortality and incident diseases in middle-aged adults in urban and rural communities from high-income, middle-income and low-income countries.<h4>Design</h4>Population-based prospective observational study.<h4>Setting</h4>Urban and rural communities in 20 high income, middle income and low income.<h4>Participants</h4>119 894 community-dwelling middle-aged adults.<h4>Main outcome measures</h4>Associations of social isolation with ... Read more >>

BMJ Glob Health (BMJ global health)
[2021, 6(3):]

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THE CARDIOVASCULAR EFFECTS OF GNRH ANTAGONISTS IN MEN WITH PROSTATE CANCER.

Filipe Cirne, Nazanin Aghel, Jo-Anne Petropoulos, Laurence Klotz, Daniel J Lenihan, Fred Saad, Jehonathan Pinthus, Darryl P Leong,

<h4>Aims</h4>The aim of this study was to determine whether gonadotropin-releasing hormone (GnRH) antagonists (an emerging class of drugs to suppress testosterone synthesis in the treatment of prostate cancer) cause less adverse cardiovascular events than the more commonly use GnRH agonists.<h4>Methods and results</h4>We conducted a systematic review to identify all randomised, ... Read more >>

Eur Heart J Cardiovasc Pharmacother (European heart journal. Cardiovascular pharmacotherapy)
[2021, :]

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The Indirect Consequences of the Response to the COVID-19 Pandemic.

Darryl P Leong, John W Eikelboom, Salim Yusuf,

J Am Coll Cardiol (Journal of the American College of Cardiology)
[2021, 77(2):186-188]

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Frailty to predict unplanned hospitalization, stroke, bleeding, and death in atrial fibrillation.

Rebecca Gugganig, Stefanie Aeschbacher, Darryl P Leong, Pascal Meyre, Steffen Blum, Michael Coslovsky, Jürg H Beer, Giorgio Moschovitis, Dominic Müller, Daniela Anker, Nicolas Rodondi, Samuel Stempfel, Christian Mueller, Christine Meyer-Zürn, Michael Kühne, David Conen, Stefan Osswald, ,

<h4>Aims</h4>Atrial fibrillation (AF) and frailty are common, and the prevalence is expected to rise further. We aimed to investigate the prevalence of frailty and the ability of a frailty index (FI) to predict unplanned hospitalizations, stroke, bleeding, and death in patients with AF.<h4>Methods and results</h4>Patients with known AF were enrolled ... Read more >>

Eur Heart J Qual Care Clin Outcomes (European heart journal. Quality of care & clinical outcomes)
[2021, 7(1):42-51]

Cited: 2 times

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The association of grip strength with cardiovascular diseases and all-cause mortality in people with hypertension: Findings from the Prospective Urban Rural Epidemiology China Study.

Weida Liu, Darryl P Leong, Bo Hu, Lap AhTse, Sumathy Rangarajan, Yang Wang, Chuangshi Wang, Fanghong Lu, Yindong Li, Salim Yusuf, Lisheng Liu, Wei Li,

<h4>Background</h4>Both hypertension and grip strength (GS) are predictors of mortality and cardiovascular disease (CVD), but whether these risk factors interact to affect CVD and all-cause mortality is unknown. This study sought to investigate the associations of GS with the risk of major CVD incidence, CVD mortality, and all-cause mortality in ... Read more >>

J Sport Health Sci (Journal of sport and health science)
[2020, :]

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Is It Only Takotsubo Syndrome? Cardiac MRI and a Case of Delayed ST-Elevation.

Anthony R Sandre, Darryl P Leong, David Landry, Leslie J Martin,

Takotsubo syndrome is a well described clinical phenomenon that often mimics acute coronary syndrome. We present an atypical case of Takotsubo syndrome, characterized by delayed troponin elevation and electrocardiogram changes suggestive of acute coronary syndrome, but a normal coronary angiogram. We describe the integration of cardiac magnetic resonance imaging to ... Read more >>

CJC Open (CJC open)
[2020, 2(6):722-725]

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Accelerated surgery versus standard care in hip fracture (HIP ATTACK): an international, randomised, controlled trial.

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<h4>Background</h4>Observational studies have suggested that accelerated surgery is associated with improved outcomes in patients with a hip fracture. The HIP ATTACK trial assessed whether accelerated surgery could reduce mortality and major complications.<h4>Methods</h4>HIP ATTACK was an international, randomised, controlled trial done at 69 hospitals in 17 countries. Patients with a hip ... Read more >>

Lancet (Lancet (London, England))
[2020, 395(10225):698-708]

Cited: 19 times

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Accumulation of Deficits as a Key Risk Factor for Cardiovascular Morbidity and Mortality: A Pooled Analysis of 154 000 Individuals.

Mohammed A M Farooqi, Hertzel Gerstein, Salim Yusuf, Darryl P Leong,

Background Frailty is associated with higher mortality in individuals at high cardiovascular disease (CVD) risk. We hypothesize that frailty is a more important prognostic factor than CVD risk factors and aim to determine the prognostic value of a cumulative deficit frailty index in patients with or at high risk for ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2020, 9(3):e014686]

Cited: 8 times

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Cardiovascular Risk in Men with Prostate Cancer: Insights from the RADICAL PC Study.

Darryl P Leong, Vincent Fradet, Bobby Shayegan, Emmanuelle Duceppe, Robert Siemens, Tamim Niazi, Laurence Klotz, Ian Brown, Joseph Chin, Luke Lavallee, Negareh Mousavi, Patrick Luke, Himu Lukka, Darin Gopaul, Philippe Violette, Rob J Hamilton, Margot K Davis, Sarah Karampatos, Rajibul Mian, Guila Delouya, Yves Fradet, Som Mukherjee, David Conen, Annabel Chen-Tournoux, Christopher Johnson, Amal Bessissow, George Dresser, Adnan Kazi Hameed, Husam Abdel-Qadir, Alp Sener, Raveen Pal, P J Devereaux, Jehonathan Pinthus,

PURPOSE:We describe the cardiovascular risk profile in a representative cohort of patients with prostate cancer treated with or without androgen deprivation therapy. MATERIALS AND METHODS:We prospectively characterized in detail 2,492 consecutive men (mean age 68 years) with prostate cancer (newly diagnosed or with a plan to prescribe androgen deprivation therapy ... Read more >>

J Urol (The Journal of urology)
[2020, 203(6):1109-1116]

Cited: 4 times

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Variations in common diseases, hospital admissions, and deaths in middle-aged adults in 21 countries from five continents (PURE): a prospective cohort study.

Gilles R Dagenais, Darryl P Leong, Sumathy Rangarajan, Fernando Lanas, Patricio Lopez-Jaramillo, Rajeev Gupta, Rafael Diaz, Alvaro Avezum, Gustavo B F Oliveira, Andreas Wielgosz, Shameena R Parambath, Prem Mony, Khalid F Alhabib, Ahmet Temizhan, Noorhassim Ismail, Jephat Chifamba, Karen Yeates, Rasha Khatib, Omar Rahman, Katarzyna Zatonska, Khawar Kazmi, Li Wei, Jun Zhu, Annika Rosengren, K Vijayakumar, Manmeet Kaur, Viswanathan Mohan, AfzalHussein Yusufali, Roya Kelishadi, Koon K Teo, Philip Joseph, Salim Yusuf,

BACKGROUND:To our knowledge, no previous study has prospectively documented the incidence of common diseases and related mortality in high-income countries (HICs), middle-income countries (MICs), and low-income countries (LICs) with standardised approaches. Such information is key to developing global and context-specific health strategies. In our analysis of the Prospective Urban Rural ... Read more >>

Lancet (Lancet (London, England))
[2020, 395(10226):785-794]

Cited: 63 times

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Major Bleeding in Patients With Coronary or Peripheral Artery Disease Treated With Rivaroxaban Plus Aspirin.

John W Eikelboom, Jacqueline J Bosch, Stuart J Connolly, Olga Shestakovska, Gilles R Dagenais, Robert G Hart, Darryl P Leong, Martin O'Donnell, Keith A A Fox, Deepak L Bhatt, John A Cairns, Christoph Tasto, Scott D Berkowitz, Nancy Cook Bruns, Eva Muehlhofer, Rafael Diaz, Aldo P Maggioni, Salim Yusuf,

<h4>Background</h4>In patients with coronary or peripheral artery disease, the combination of rivaroxaban 2.5 mg twice daily and aspirin 100 mg once daily compared with aspirin 100 mg once daily reduced major adverse cardiovascular events and mortality and increased bleeding.<h4>Objectives</h4>This study sought to explore the effects of the combination of rivaroxaban and aspirin compared ... Read more >>

J Am Coll Cardiol (Journal of the American College of Cardiology)
[2019, 74(12):1519-1528]

Cited: 3 times

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From ACE Inhibitors/ARBs to ARNIs in Coronary Artery Disease and Heart Failure (Part 2/5).

Darryl P Leong, John J V McMurray, Philip G Joseph, Salim Yusuf,

The pharmacological inhibition of the renin-angiotensin-aldosterone system as a therapeutic strategy is one of the most significant advances in the treatment and prevention of cardiovascular disease in heart failure with reduced ejection fraction and in coronary artery disease. Recently, the addition of neprilysin inhibition to angiotensin receptor blockade has been ... Read more >>

J Am Coll Cardiol (Journal of the American College of Cardiology)
[2019, 74(5):683-698]

Cited: 4 times

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Adjuvant Trastuzumab Therapy: Can We Balance Efficacy and Safety?

Carly C Barron, Nidhi Kumar Tyagi, Muhammad Mustafa Alhussein, Som D Mukherjee, Peter M Ellis, Sukhbinder Dhesy-Thind, Darryl P Leong,

Trastuzumab is an effective treatment for HER2-positive breast cancer. Current guidelines recommend withholding trastuzumab in patients experiencing a significant asymptomatic decline in left ventricular function. In this commentary, we discuss the survival benefits afforded by trastuzumab juxtaposed against the risk of trastuzumab-mediated cardiotoxicity. It is not known whether the net ... Read more >>

Oncologist (The oncologist)
[2019, 24(11):1405-1409]

Cited: 1 time

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Predictive Values of Anthropometric Measurements for Cardiometabolic Risk Factors and Cardiovascular Diseases Among 44 048 Chinese.

Jia Liu, Lap Ah Tse, Zhiguang Liu, Sumathy Rangarajan, Bo Hu, Lu Yin, Darryl P Leong, Wei Li, ,

Background The predictive value of adiposity indices and the newly developed index for cardiometabolic risk factors and cardiovascular diseases (CVDs) remains unclear in the Chinese population. This study aimed to compare the predictive value of A Body Shape Index with other 5 conventional obesity-related anthropometric indices (body mass index, waist ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2019, 8(16):e010870]

Cited: 9 times

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The Evolution of β-Blockers in Coronary Artery Disease and Heart Failure (Part 1/5).

Philip Joseph, Karl Swedberg, Darryl P Leong, Salim Yusuf,

As new treatments continue to improve clinical outcomes in coronary artery disease (CAD) and heart failure, it is necessary to characterize the appropriate use of β-adrenergic receptor blockers (β-blockers) in the contemporary management of these conditions. This review examines the current evidence supporting β-blocker use in heart failure with preserved ... Read more >>

J Am Coll Cardiol (Journal of the American College of Cardiology)
[2019, 74(5):672-682]

Cited: 3 times

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A post-hoc subgroup analysis assessing acute cardiac biomarker profiles in female cancer patients during adjuvant therapy.

Katharine Mackett, Sukhbinder Dhesy-Thind, Elysia K Donovan, Som Mukherjee, Anand Swaminath, Darryl P Leong, Sachi Voruganti, Jonathan Sussman, James Wright, Gordon Okawara, Graham Fraser, Stephen Sagar, Louise Bordeleau, Peter M Ellis, Hal Hirte, Peter A Kavsak,

Clin Chim Acta (Clinica chimica acta; international journal of clinical chemistry)
[2019, 495:355-357]

Cited: 0 times

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Are the cardiac effects of alcohol good, bad, or neither?

Darryl P Leong,

Eur Heart J (European heart journal)
[2019, 40(9):712-714]

Cited: 1 time

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Long term prognostic importance of late gadolinium enhancement in first-presentation non-ischaemic dilated cardiomyopathy.

Karthigesh Sree Raman, Gaetano Nucifora, Darryl P Leong, Christian Marx, Ranjit Shah, Richard J Woodman, Payman Molaee, Masoumeh Gh Shirazi, Andrew D McGavigan, Carmine G De Pasquale, Joseph B Selvanayagam,

BACKGROUND:Presence of myocardial fibrosis in well-established non-ischaemic dilated cardiomyopathy (NIDCM) is associated with adverse clinical outcomes. However, the impact of myocardial fibrosis at first presentation in NIDCM, and its long-term association with left ventricular (LV) dysfunction, heart failure (HF) and ventricular arrhythmia (VA) remains unclear. We investigated whether the presence ... Read more >>

Int J Cardiol (International journal of cardiology)
[2019, 280:124-129]

Cited: 3 times

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Depression and prostate cancer: A focused review for the clinician.

Gagan Fervaha, Jason P Izard, Dean A Tripp, Selina Rajan, Darryl P Leong, D Robert Siemens,

Prostate cancer is the most common malignancy among men. Given its prevalence and relatively low mortality rates, several biopsychosocial survivorship issues have garnered recent attention. This article reviews the literature on the association between depression and prostate cancer, emphasizing key practice points relevant for clinicians. Depression is prevalent among men ... Read more >>

Urol Oncol (Urologic oncology)
[2019, 37(4):282-288]

Cited: 8 times

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Statin therapy in the treatment of active cancer: A systematic review and meta-analysis of randomized controlled trials.

Mohammed A M Farooqi, Nikita Malhotra, Som D Mukherjee, Stephanie Sanger, Sukhbinder K Dhesy-Thind, Peter Ellis, Darryl P Leong,

BACKGROUND:Preclinical evidence suggests statins may have anti-tumor properties. Large observational studies are also consistent with improved survival and cancer-specific outcomes among cancer patients on statins. We sought to evaluate the randomized controlled trials of statins in addition to usual anti-cancer therapy. METHODS:A systematic search of MEDLINE, Embase, CINAHL, Cochrane Library, ... Read more >>

PLoS One (PloS one)
[2018, 13(12):e0209486]

Cited: 9 times

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