Full Text Journal Articles by
Author Darby Oldenburg

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Deletion of Murine Gammaherpesvirus Gene M2 in Activation-Induced Cytidine Deaminase-Expressing B Cells Impairs Host Colonization and Viral Reactivation.

Shana M Owens, Darby G Oldenburg, Douglas W White, J Craig Forrest,

Gammaherpesviruses (GHVs) are DNA tumor viruses that establish lifelong, chronic infections in lymphocytes of humans and other mammals. GHV infections are associated with numerous cancers, especially in immunocompromised hosts. While it is known that GHVs utilize host germinal center (GC) B cell responses during latency establishment, an understanding of how ... Read more >>

J Virol (Journal of virology)
[2020, 95(1):]

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Detection of antibodies to decorin-binding protein A (DbpA) and DbpB after infection of dogs with Borrelia burgdorferi by tick challenge.

Darby G Oldenburg, Dean A Jobe, Steven D Lovrich, Rhonda L LaFleur, Douglas W White, Jennifer C Dant, Steven M Callister,

We characterized the antibody response to decorin-binding protein A (DbpA) or DbpB from immune serum samples collected from 27 dogs infected with <i>Borrelia burgdorferi</i> by <i>Ixodes scapularis</i> ticks. Immunoglobulin M (IgM) antibodies to DbpA or DbpB were rarely detected, but high levels of IgG antibodies to DbpA were detected in ... Read more >>

J Vet Diagn Invest (Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc)
[2020, 32(3):481-485]

Cited: 0 times

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Deletion of Murine Gammaherpesvirus Gene M2 in AID-Expressing B Cells Impairs Host Colonization and Viral Reactivation

Shana Owens, Darby Oldenburg, Douglas White, Craig Forrest,

<h4>ABSTRACT</h4> Gammaherpesviruses (GHVs) are DNA tumor viruses that establish life-long, chronic infections in lymphocytes of humans and other mammals. GHV infections are associated with numerous cancers, especially in immune compromised hosts. While it is known that GHVs utilize host germinal center (GC) B cell responses during latency establishment, an understanding ... Read more >>

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Correction: Viral FGARAT ORF75A promotes early events in lytic infection and gammaherpesvirus pathogenesis in mice.

Nick D Van Skike, Nana K Minkah, Chad H Hogan, Gary Wu, Peter T Benziger, Darby G Oldenburg, Mehmet Kara, Deborah M Kim-Holzapfel, Douglas W White, Scott A Tibbetts, Jarrod B French, Laurie T Krug,

[This corrects the article DOI: 10.1371/journal.ppat.1006843.]. ... Read more >>

PLoS Pathog (PLoS pathogens)
[2018, 14(9):e1007319]

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Recurrent strokes, central nervous system vasculitis, and acquired protein S deficiency secondary to varicella zoster in a child with AIDS.

Jake A Deviley, Darby Oldenburg, Laurence C Berg, William A Agger,

A child with vertical transmission of human immunodeficiency virus refractory to therapy developed zoster-induced protein S deficiency and recurrent strokes. Extensive carotid arteritis was found postmortem. The carotid tissue was positive for herpes varicella zoster by polymerase chain reaction, as were immunofixation stains of the arterial wall. ... Read more >>

J Neurovirol (Journal of neurovirology)
[2019, 25(1):137-140]

Cited: 1 time

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Glycogen debranching enzyme (AGL) is a novel regulator of non-small cell lung cancer growth.

Craig S Richmond, Darby Oldenburg, Garrett Dancik, David R Meier, Benjamin Weinhaus, Dan Theodorescu, Sunny Guin,

Glycogen debranching enzyme (AGL) and Glycogen phosphorylase (PYG) are responsible for glycogen breakdown. We have earlier shown that AGL is a regulator of bladder tumor growth. Here we investigate the role of AGL in non-small cell lung cancers (NSCLC). Short hairpin RNA (shRNA) driven knockdown of AGL resulted in increased ... Read more >>

Oncotarget (Oncotarget)
[2018, 9(24):16718-16730]

Cited: 1 time

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Host Tumor Suppressor p18INK4c Functions as a Potent Cell-Intrinsic Inhibitor of Murine Gammaherpesvirus 68 Reactivation and Pathogenesis.

Brian F Niemeyer, Lauren M Oko, Eva M Medina, Darby G Oldenburg, Douglas W White, Carlyne D Cool, Eric T Clambey, Linda F van Dyk,

Gammaherpesviruses are common viruses associated with lifelong infection and increased disease risk. Reactivation from latency aids the virus in maintaining infection throughout the life of the host and is responsible for a wide array of disease outcomes. Previously, we demonstrated that the virus-encoded cyclin (v-cyclin) of murine gammaherpesvirus 68 (γHV68) ... Read more >>

J Virol (Journal of virology)
[2018, 92(6):]

Cited: 3 times

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Unsupervised learning techniques reveal heterogeneity in memory CD8+ T cell differentiation following acute, chronic and latent viral infections.

Mingyong Liu, Erik S Barton, Ryan N Jennings, Darby G Oldenburg, Juliann M Whirry, Douglas W White, Jason M Grayson,

CD8<sup>+</sup> T lymphocytes are critical for the control of gammaherpesvirus latency. To determine how memory CD8<sup>+</sup> T cells generated during latency differ from those primed during acute or chronic viral infection, we adoptively transferred naive P14 CD8<sup>+</sup> T cells into uninfected recipients, and examined surface proteins, cytokines and transcription factors ... Read more >>

Virology (Virology)
[2017, 509:266-279]

Cited: 2 times

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Murine Gammaherpesvirus 68 Expressing Kaposi Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen (LANA) Reveals both Functional Conservation and Divergence in LANA Homologs.

Arundhati Gupta, Darby G Oldenburg, Eduardo Salinas, Douglas W White, J Craig Forrest,

Latency-associated nuclear antigen (LANA) is a multifunctional protein encoded by members of the <i>Rhadinovirus</i> genus of gammaherpesviruses. Studies using murine gammaherpesvirus 68 (MHV68) demonstrated that LANA is important for acute replication, latency establishment, and reactivation <i>in vivo</i> Despite structural similarities in their DNA-binding domains (DBDs), LANA homologs from Kaposi sarcoma-associated ... Read more >>

J Virol (Journal of virology)
[2017, 91(19):]

Cited: 6 times

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RTA Occupancy of the Origin of Lytic Replication during Murine Gammaherpesvirus 68 Reactivation from B Cell Latency.

Alexis L Santana, Darby G Oldenburg, Varvara Kirillov, Laraib Malik, Qiwen Dong, Roman Sinayev, Kenneth B Marcu, Douglas W White, Laurie T Krug,

RTA, the viral Replication and Transcription Activator, is essential for rhadinovirus lytic gene expression upon de novo infection and reactivation from latency. Lipopolysaccharide (LPS)/toll-like receptor (TLR)4 engagement enhances rhadinovirus reactivation. We developed two new systems to examine the interaction of RTA with host NF-kappaB (NF-κB) signaling during murine gammaherpesvirus 68 ... Read more >>

Pathogens (Pathogens (Basel, Switzerland))
[2017, 6(1):]

Cited: 3 times

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CD44 and RHAMM are essential for rapid growth of bladder cancer driven by loss of Glycogen Debranching Enzyme (AGL).

Darby Oldenburg, Yuanbin Ru, Benjamin Weinhaus, Steve Cash, Dan Theodorescu, Sunny Guin,

<h4>Background</h4>Loss of Amylo-alpha-1-6-glucosidase-4-alpha-glucanotransferase (AGL) drives rapid proliferation of bladder cancer cells by upregulating Hyaluronic acid(HA) Synthase (HAS2) mediated HA synthesis. However the role of HA receptors CD44 and Hyaluronan Mediated Motility Receptor (RHAMM) in regulating the growth of bladder cancer cells driven by loss of AGL has not been studied.<h4>Methods</h4>Western ... Read more >>

BMC Cancer (BMC cancer)
[2016, 16:713]

Cited: 11 times

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Borrelia miyamotoi Infection in Patients from Upper Midwestern United States, 2014-2015.

Dean A Jobe, Steven D Lovrich, Darby G Oldenburg, Todd J Kowalski, Steven M Callister,

We confirmed Borrelia miyamotoi infection in 7 patients who had contracted an illness while near La Crosse, Wisconsin, USA, an area where Ixodes scapularis ticks are endemic. B. miyamatoi infection should now be considered among differential diagnoses for patients from the midwestern United States who have signs and symptoms suggestive ... Read more >>

Emerg Infect Dis (Emerging infectious diseases)
[2016, 22(8):1471-1473]

Cited: 17 times

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Role of the Transporter-Like Sensor Kinase CbrA in Histidine Uptake and Signal Transduction.

Xue-Xian Zhang, Jonathan C Gauntlett, Darby G Oldenburg, Gregory M Cook, Paul B Rainey,

<h4>Unlabelled</h4>CbrA is an atypical sensor kinase found in Pseudomonas. The autokinase domain is connected to a putative transporter of the sodium/solute symporter family (SSSF). CbrA functions together with its cognate response regulator, CbrB, and plays an important role in nutrient acquisition, including regulation of hut genes for the utilization of ... Read more >>

J Bacteriol (Journal of bacteriology)
[2015, 197(17):2867-2878]

Cited: 15 times

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CD43 in the nucleus and cytoplasm of lung cancer is a potential therapeutic target.

Qiangwei Fu, Steven E Cash, Jeremiah J Andersen, Colin R Kennedy, Darby G Oldenburg, Valerie B Zander, Greta R Foley, Carl Simon Shelley,

CD43 is a transmembrane sialoglycoprotein. Normally the molecule is only produced by white blood cells where it regulates functions such as intercellular adhesion, intracellular signaling, apoptosis, migration and proliferation. Two CD43 antibodies were used to interrogate 66 cases of non-small cell lung cancer (NSCLC) and 24 cases of small cell ... Read more >>

Int J Cancer (International journal of cancer)
[2013, 132(8):1761-1770]

Cited: 15 times

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A gammaherpesvirus cooperates with interferon-alpha/beta-induced IRF2 to halt viral replication, control reactivation, and minimize host lethality.

Pratyusha Mandal, Bridgette E Krueger, Darby Oldenburg, Katherine A Andry, R Suzanne Beard, Douglas W White, Erik S Barton,

The gammaherpesviruses, including Epstein-Barr virus (EBV) and Kaposi's sarcoma-associated herpesvirus (KSHV), establish latency in memory B lymphocytes and promote lymphoproliferative disease in immunocompromised individuals. The precise immune mechanisms that prevent gammaherpesvirus reactivation and tumorigenesis are poorly defined. Murine gammaherpesvirus 68 (MHV68) is closely related to EBV and KSHV, and type ... Read more >>

PLoS Pathog (PLoS pathogens)
[2011, 7(11):e1002371]

Cited: 24 times

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