Full Text Journal Articles by
Author Dante Merlino

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Discordant Responses Between Primary Head and Neck Tumors and Nodal Metastases Treated With Neoadjuvant Nivolumab: Correlation of Radiographic and Pathologic Treatment Effect.

Dante J Merlino, Jennifer M Johnson, Madalina Tuluc, Stacey Gargano, Robert Stapp, Larry Harshyne, Benjamin E Leiby, Adam Flanders, Ralph Zinner, Rita Axelrod, Joseph Curry, David M Cognetti, Kyle Mannion, Young J Kim, Ulrich Rodeck, Athanassios Argiris, Adam J Luginbuhl,

PD-1 blockade represents a promising treatment in patients with head and neck squamous cell carcinoma (HNSCC). We analyzed results of a neoadjuvant randomized window-of-opportunity trial of nivolumab plus/minus tadalafil to investigate whether immunotherapy-mediated treatment effects vary by site of involvement (primary tumor, lymph nodes) and determine how radiographic tumor shrinkage ... Read more >>

Front Oncol (Frontiers in oncology)
[2020, 10:566315]

Cited: 3 times

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Therapeutic targeting of gastrointestinal cancer stem cells.

Jonathan Stem, John C Flickinger, Dante Merlino, Ellen M Caparosa, Adam E Snook, Scott A Waldman,

Gastrointestinal cancers remain a tremendous burden on society. Despite advances in therapy options, including chemotherapy and radiation, cancer mortality from recurrences and metastases occur frequently. Cancer stem cells (CSCs) drive disease recurrence and metastasis, as these cells are uniquely equipped to self-renew and evade therapy. Therefore, cancer eradication requires treatment ... Read more >>

Regen Med (Regenerative medicine)
[2019, 14(4):331-343]

Cited: 2 times

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Silencing the GUCA2A-GUCY2C tumor suppressor axis in CIN, serrated, and MSI colorectal neoplasia.

Babar Bashir, Dante J Merlino, Jeffrey A Rappaport, Esteban Gnass, Juan P Palazzo, Ying Feng, Eric R Fearon, Adam E Snook, Scott A Waldman,

Colorectal cancers (CRCs) initiate through distinct mutations, including in APC pathway components leading to tubular adenomas (TAs); in BRAF, with epigenetic silencing of CDX2, leading to serrated adenomas (SAs); and in the DNA mismatch repair machinery driving microsatellite instability (MSI). Transformation through the APC pathway involves loss of the hormone ... Read more >>

Hum Pathol (Human pathology)
[2019, 87:103-114]

Cited: 6 times

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Abstracts from the 8th International Conference on cGMP Generators, Effectors and Therapeutic Implications : Bamberg, Germany. 23-25 June, 2017.

BMC Pharmacol Toxicol (BMC pharmacology & toxicology)
[2017, 18(Suppl 1):64]

Cited: 0 times

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Intestinal Enteroids Model Guanylate Cyclase C-Dependent Secretion Induced by Heat-Stable Enterotoxins.

Amanda M Pattison, Erik S Blomain, Dante J Merlino, Fang Wang, Mary Ann S Crissey, Crystal L Kraft, Jeff A Rappaport, Adam E Snook, John P Lynch, Scott A Waldman,

Enterotoxigenic Escherichia coli (ETEC) causes ∼20% of the acute infectious diarrhea (AID) episodes worldwide, often by producing heat-stable enterotoxins (STs), which are peptides structurally homologous to paracrine hormones of the intestinal guanylate cyclase C (GUCY2C) receptor. While molecular mechanisms mediating ST-induced intestinal secretion have been defined, advancements in therapeutics have ... Read more >>

Infect Immun (Infection and immunity)
[2016, 84(10):3083-3091]

Cited: 13 times

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Guanylyl cyclase C signaling axis and colon cancer prevention.

Amanda M Pattison, Dante J Merlino, Erik S Blomain, Scott A Waldman,

Colorectal cancer (CRC) is a major cause of cancer-related mortality and morbidity worldwide. While improved treatments have enhanced overall patient outcome, disease burden encompassing quality of life, cost of care, and patient survival has seen little benefit. Consequently, additional advances in CRC treatments remain important, with an emphasis on preventative ... Read more >>

World J Gastroenterol (World journal of gastroenterology)
[2016, 22(36):8070-8077]

Cited: 17 times

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Guanylyl Cyclase C Hormone Axis at the Intersection of Obesity and Colorectal Cancer.

Erik S Blomain, Dante J Merlino, Amanda M Pattison, Adam E Snook, Scott A Waldman,

Obesity has emerged as a principal cause of mortality worldwide, reflecting comorbidities including cancer risk, particularly in colorectum. Although this relationship is established epidemiologically, molecular mechanisms linking colorectal cancer and obesity continue to be refined. Guanylyl cyclase C (GUCY2C), a membrane-bound guanylyl cyclase expressed in intestinal epithelial cells, binds the ... Read more >>

Mol Pharmacol (Molecular pharmacology)
[2016, 90(3):199-204]

Cited: 5 times

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GUCY2C lysosomotropic endocytosis delivers immunotoxin therapy to metastatic colorectal cancer.

Glen P Marszalowicz, Adam E Snook, Michael S Magee, Dante Merlino, Lisa D Berman-Booty, Scott A Waldman,

The emergence of targeted cancer therapy has been limited by the paucity of determinants which are tumor-specific and generally associated with disease, and have cell dynamics which effectively deploy cytotoxic payloads. Guanylyl cyclase C (GUCY2C) may be ideal for targeting because it is normally expressed only in insulated barrier compartments, ... Read more >>

Oncotarget (Oncotarget)
[2014, 5(19):9460-9471]

Cited: 15 times

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