Full Text Journal Articles by
Author Danny Yakoub

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Comprehensive tumor profiling reveals unique molecular differences between peritoneal metastases and primary colorectal adenocarcinoma.

Matthew K Stein, Forrest W Williard, Joanne Xiu, Miriam W Tsao, Michael G Martin, Benjamin W Deschner, Paxton V Dickson, Evan S Glazer, Danny Yakoub, David Shibata, Axel F Grothey, Philip A Philip, Jimmy J Hwang, Anthony F Shields, John L Marshall, W Michael Korn, Heinz-Josef Lenz, Jeremiah L Deneve,

BACKGROUND AND OBJECTIVES:Peritoneal metastases (PM) from primary colorectal cancer (pCRC) are associated with poor outcomes; however, molecular differences are not well defined. METHODS:We compared unpaired tumor profiles of patients with pCRC and PM from Caris Life Sciences. Testing included next-generation sequencing of 592 genes, microsatellite instability (MSI) and tumor mutational ... Read more >>

J Surg Oncol (Journal of surgical oncology)
[2020, 121(8):1320-1328]

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Surgical Management of the Axilla in Patients with Occult Breast Cancer (cT0 N+) After Neoadjuvant Chemotherapy.

Brianna L Cohen, Amber L Collier, Kristin N Kelly, Neha Goel, Susan B Kesmodel, Danny Yakoub, Mecker Moller, Eli Avisar, Dido Franceschi, Francis I Macedo,

BACKGROUND:Occult breast cancer (OBC) is a rare clinical entity. Current surgical management includes axillary lymphadenectomy (ALND) with or without mastectomy. We sought to investigate the role of sentinel lymph node biopsy (SLNB) in patients with OBC treated with neoadjuvant chemotherapy (NAC). METHODS:Patients with clinical T0N+ breast cancer were selected from ... Read more >>

Ann. Surg. Oncol. (Annals of surgical oncology)
[2020, 27(6):1830-1841]

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Restaging Patients with Rectal Cancer Following Neoadjuvant Chemoradiation: A Systematic Review.

Leah E Hendrick, Renee L Levesque, Nathan M Hinkle, Justin J Monroe, Evan S Glazer, Jeremiah L Deneve, Danny Yakoub, David Shibata, Paxton V Dickson,

BACKGROUND:In the USA, most patients with clinical stage II/III rectal cancer receive neoadjuvant chemoradiation (chemo/XRT) over 5-6 weeks followed by a 6-10-week break before proctectomy. As chemotherapy is delivered at radio-sensitizing doses, there is essentially a 3-month window during which potential systemic disease is untreated. Evidence regarding the utility of restaging ... Read more >>

World J Surg (World journal of surgery)
[2020, 44(3):973-979]

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Minimally Invasive Surgery is Associated with an Increased Risk of Postoperative Venous Thromboembolism After Distal Pancreatectomy.

Brent A Willobee, Austin R Dosch, Casey J Allen, Francisco I Macedo, Tyler S Bartholomew, Omar Picado, Alex A Gaidarski, Vikas Dudeja, Danny Yakoub, Nipun B Merchant,

BACKGROUND:Venous thromboembolism (VTE) is a major cause of morbidity and mortality following distal pancreatectomy (DP). However, the influence of operative technique on VTE risk after DP is unknown. OBJECTIVE:The purpose of this study was to examine the association between the MIS technique versus the open technique and the development of ... Read more >>

Ann. Surg. Oncol. (Annals of surgical oncology)
[2020, 27(7):2498-2505]

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The impact of race and socioeconomic status on the presentation, management and outcomes for gastric cancer patients: Analysis from a metropolitan area in the southeast United States.

Miriam W Tsao, Olivia M Delozier, Zachary E Stiles, Louis J Magnotti, Stephen W Behrman, Jeremiah L Deneve, Evan S Glazer, David Shibata, Danny Yakoub, Paxton V Dickson,

BACKGROUND:Socioeconomic disparities in gastric cancer have been associated with differences in care and inferior outcomes. We evaluated the presentation, treatment, and survival for patients with gastric cancer (GC) in a metropolitan setting with a large African American population. METHODS:Retrospective cohort analysis of patients with GC (2003-2018) across a multi-hospital system ... Read more >>

J Surg Oncol (Journal of surgical oncology)
[2020, 121(3):494-502]

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Utility of Radiation After Neoadjuvant Chemotherapy for Surgically Resectable Esophageal Cancer.

Francis I Macedo, Jose Wilson Mesquita-Neto, Kristin N Kelly, Basem Azab, Danny Yakoub, Nipun B Merchant, Alan S Livingstone, Dido Franceschi,

INTRODUCTION:Neoadjuvant chemotherapy (NAC) ± radiation (NRT) is the "gold standard" approach for locally advanced esophageal cancer (EC). However, the benefits of RT on overall survival (OS) in patients with resectable EC undergoing neoadjuvant therapy followed by esophagectomy remain controversial. METHODS:The National Cancer Data Base was queried for patients with nonmetastatic EC between ... Read more >>

Ann. Surg. Oncol. (Annals of surgical oncology)
[2020, 27(3):662-670]

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Cardiac physiology in post myocardial infarction patients: the effect of cardiac rehabilitation programs-a systematic review and update meta-analysis.

Irene Kirolos, Danny Yakoub, Fiorella Pendola, Omar Picado, Aghapy Kirolos, Yehoshua C Levine, Sunil Jha, Rajesh Kabra, Brandon Cave, Rami N Khouzam,

Cardiac rehabilitation program (CRP) is a recognized non-pharmacological modality to decrease mortality after acute myocardial infarction (AMI) events. We aimed to evaluate the effect of CRP on the cardiac physiology in patients post myocardial infarction (MI). Online database search of PubMed, MEDLINE, EMBASE, SCOPUS, COCHRANE, and GOOGLE SCHOLAR were performed ... Read more >>

Ann Transl Med (Annals of translational medicine)
[2019, 7(17):416]

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Does Neoadjuvant Chemotherapy Change the Role of Regional Lymphadenectomy in Pancreatic Cancer Survival?

Francis Igor Macedo, Omar Picado, Peter J Hosein, Vikas Dudeja, Dido Franceschi, Jose Wilson Mesquita-Neto, Danny Yakoub, Nipun B Merchant,

OBJECTIVES:The objective of this study was to evaluate the role of lymph node (LN) dissection and staging in outcomes of patients with pancreatic adenocarcinoma (PDAC) who underwent neoadjuvant chemotherapy (NAC). METHODS:National Cancer Database was queried for patients with stages I to III PDAC diagnosed between 2004 and 2014. Overall survival ... Read more >>

Pancreas (Pancreas)
[2019, 48(6):823-831]

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Optimal radiation dosing in concurrent neoadjuvant chemoradiation for resectable esophageal cancer: a meta-analysis.

Steven Engel, Adam Awerbuch, Deukwoo Kwon, Omar Picado, Raphael Yechieli, Danny Yakoub, Lorraine Portelance,

Background:This is the first meta-analysis to study optimal radiation dose in the setting of concurrent neoadjuvant chemoradiotherapy (cnCRT) for esophageal cancer (EC). We sought to compare outcomes between high dose radiotherapy (HDRT) [>48.85 Gy biologically effective dose (BED)] group and low dose radiotherapy (LDRT) (≤48.85 Gy BED) for patients with ... Read more >>

J Gastrointest Oncol (Journal of gastrointestinal oncology)
[2019, 10(3):391-399]

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Hepatocellular carcinoma: resection with adjuvant hepatic artery infusion therapy vs resection alone. A systematic review and meta-analysis.

Alexandra Moran, Lorena Flor Ramos, Omar Picado, Fiorella Pendola, Danny Sleeman, Vikas Dudeja, Nipun Merchant, Danny Yakoub,

Hepatocellular carcinoma (HCC) has a recurrence rate of up to 70% in 5 years after resection, detrimentally lowering survival. The role of adjuvant therapy remains controversial; therefore, the aim of this study was to evaluate the disease-free and overall survival of patients with HCC, not candidates for transplantation, undergoing resection ... Read more >>

J Surg Oncol (Journal of surgical oncology)
[2019, 119(4):455-463]

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A large national comparative study of clinicopathological features and long-term survivals between esophageal gastrointestinal stromal tumor and leiomyosarcoma.

Basem Azab, Francisco Igor Macedo, Samuel H Cass, Caroline Ripat, Syed S Razi, Omar Picado, Dido Franceschi, Alan S Livingstone, Danny Yakoub,

BACKGROUND:Esophageal gastrointestinal stromal tumors (E-GIST) and leiomyosarcoma (E-LMS) are rare tumors. Previous studies are limited to small number of patients. We sought to study these two tumors using a large national database. METHODS:The National Cancer Data Base 2004-2014 was queried for patients with E-GIST and E-LMS. The primary outcome was ... Read more >>

Am. J. Surg. (American journal of surgery)
[2019, 218(2):323-328]

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The Role of Completion Lymphadenectomy in Positive Regional Lymph Nodes in Melanoma: A Meta-analysis.

Francisco Igor Macedo, Rachel A Fayne, Basem Azab, Danny Yakoub, Mecker G Möller,

BACKGROUND:The optimal management of melanoma with positive sentinel lymph node (SLN) remains unclear. Completion lymph node dissection (CLND) only yields additional positive non-SLN in 20% of cases and its benefits on survival remains debatable. METHODS:An online database search of Medline was performed; key bibliographies were reviewed. Studies comparing outcomes after ... Read more >>

J. Surg. Res. (The Journal of surgical research)
[2019, 236:83-91]

Cited: 1 time

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Long-term Quality of Life and Gastrointestinal Functional Outcomes After Pancreaticoduodenectomy.

Casey J Allen, Danny Yakoub, Francisco Igor Macedo, Austin R Dosch, Jessica Brosch, Vikas Dudeja, Ronda Ayala, Nipun B Merchant,

OBJECTIVE:To perform a comprehensive assessment of long-term quality of life (QOL) and gastrointestinal (GI) function in patients following pancreaticoduodenectomy (PD). SUMMARY OF BACKGROUND DATA:Survival after PD has greatly improved and thus has resulted in a larger population of survivors, yet long-term QOL and GI function after PD is largely unknown. ... Read more >>

Ann. Surg. (Annals of surgery)
[2018, 268(4):657-664]

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Does Surgical Margin Impact Recurrence in Noninvasive Intraductal Papillary Mucinous Neoplasms?: A Multi-institutional Study.

Vikrom K Dhar, Nipun B Merchant, Sameer H Patel, Michael J Edwards, Koffi Wima, Joseph Imbus, Daniel E Abbott, Sharon M Weber, Raphael Louie, Hong J Kim, Robert C G Martin, Charles R Scoggins, David J Bentrem, Michael T LeCompte, Kamran Idrees, Alexandra G Lopez-Aguiar, Shishir K Maithel, David A Kooby, Daniel A Franco, Danny Yakoub, Syed A Ahmad,

OBJECTIVE:The relevance of margin positivity on recurrence after resection of intraductal papillary mucinous neoplasms (IPMNs) is poorly defined and represents one reason controversy remains regarding optimal surveillance recommendations. METHODS:Patients undergoing surgery for noninvasive IPMN at 8 academic medical centers from the Central Pancreas Consortium were analyzed. A positive margin was ... Read more >>

Ann. Surg. (Annals of surgery)
[2018, 268(3):469-478]

Cited: 2 times

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Impact of Chemoradiation-to-Surgery Interval on Pathological Complete Response and Short- and Long-Term Overall Survival in Esophageal Cancer Patients.

Basem Azab, Julia R Amundson, Omar Picado, Caroline Ripat, Francisco Igor Macedo, Dido Franceschi, Alan S Livingstone, Danny Yakoub,

BACKGROUND:The impact of the neoadjuvant chemoradiation-to-surgery (CRT-S) interval in patients with esophageal cancer is not clear. We aimed to determine the relationship between CRT-S interval and pathological complete response rate (pCR) and overall survival (OS). METHODS:National Cancer Data Base patients with CRT followed by surgery were studied. CRT-S interval was ... Read more >>

Ann. Surg. Oncol. (Annals of surgical oncology)
[2019, 26(3):861-868]

Cited: 1 time

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The Role of Surgical Resection for Stage IV Gastric Cancer With Synchronous Hepatic Metastasis.

Omar Picado, Levi Dygert, Francisco Igor Macedo, Dido Franceschi, Danny Sleeman, Alan S Livingstone, Nipun Merchant, Danny Yakoub,

BACKGROUND:With improved responses to chemotherapy and targeted treatments, the role of surgery in metastatic gastric cancer (MGC) to the liver needs to be revisited. We sought to examine whether surgical resection is associated with improvement of long-term survival. METHODS:The National Cancer Database was queried for MGC to the liver (2010-2014). ... Read more >>

J. Surg. Res. (The Journal of surgical research)
[2018, 232:422-429]

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Giant symptomatic gastric lipoma: A case report and literature review.

Julia R Amundson, David Straus, Basem Azab, Sandy Liu, Monica T Garcia Buitrago, Danny Yakoub,

INTRODUCTION:Lipomas are uncommon tumors of the gastrointestinal tract; gastric lipomas account for <1% of all gastric tumors encountered (Nickloes and Sutphin [1]). Giant gastric lipomas, defined as ≥10 cm, are exceedingly rare with only 6 cases reported since 1980 (Cappell et al., Termos et al., Singh et al., Ramaraj et al., ... Read more >>

Int J Surg Case Rep (International journal of surgery case reports)
[2018, 51:313-317]

Cited: 1 time

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Myoepithelial carcinoma or epithelioid sarcoma - A rare diagnosis with poor prognosis. A case report and review of literature.

Kristina Khazeni, Hannah LaBove, Breelyn Wilky, Andrew E Rosenberg, Elizabeth Paulus, Harvey Chim, Joseph M Pearson, Danny Yakoub,

Myoepithelial carcinoma and proximal-type epithelioid sarcoma of the vulva are two rare malignancies with known aggressive behavior. In addition to a similar clinical course, these two disease entities also have significant histologic and pathologic overlap. Given the rarity of these malignancies, there is limited literature on the appropriate treatment regimen. ... Read more >>

Int J Surg Case Rep (International journal of surgery case reports)
[2018, 49:239-243]

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Extent of regional lymph node surgery and impact on outcomes in patients with early-stage breast cancer and limited axillary disease undergoing mastectomy.

Omar Picado, Kristina Khazeni, Casey Allen, Danny Yakoub, Eli Avisar, Susan B Kesmodel,

PURPOSE:Management of the axilla in patients with early-stage breast cancer (ESBC) has evolved. Recent trials support less extensive axillary surgery in patients undergoing mastectomy. We examine factors affecting regional lymph node (RLN) surgery and outcomes in patients with ESBC undergoing mastectomy. METHODS:Women with clinical T1/2 N0 M0 invasive BC who ... Read more >>

Breast Cancer Res. Treat. (Breast cancer research and treatment)
[2018, 171(2):461-469]

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Erratum to: Unresectable Hepatocellular Carcinoma: Radioembolization Versus Chemoembolization: A Systematic Review and Meta-analysis.

Laila Lobo, Danny Yakoub, Omar Picado, Caroline Ripat, Fiorella Pendola, Rishika Sharma, Rana ElTawil, Deukwoo Kwon, Shree Venkat, Loraine Portelance, Raphael Yechieli,

Cardiovasc Intervent Radiol (Cardiovascular and interventional radiology)
[2017, 40(9):1487]

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The Impact of Surgeon Volume on Outcomes After Pancreaticoduodenectomy: a Meta-analysis.

Francisco Igor B Macedo, Prakash Jayanthi, Mia Mowzoon, Danny Yakoub, Vikas Dudeja, Nipun Merchant,

Despite significant improvement in operative mortality rates following pancreaticoduodenectomy (PD), morbidity remains high. Outcomes following PD may be improved in high-volume centers and with high-volume surgeons. We sought to evaluate the association between surgeon experience and postoperative outcomes after PD.An online database search of MEDLINE and EMBASE was performed; key ... Read more >>

J. Gastrointest. Surg. (Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract)
[2017, 21(10):1723-1731]

Cited: 2 times

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Esophagectomy for cancer in octogenarians: should we do it?

Elizabeth Paulus, Caroline Ripat, Vadim Koshenkov, Angela T Prescott, Kiran Sethi, Heather Stuart, Gregory Tiesi, Alan S Livingstone, Danny Yakoub,

Inconsistent data exists regarding esophagectomy outcomes in octogenarians undergoing transhiatal esophagectomy for esophageal cancer.A retrospective review was performed for esophagectomy cancer patients between 2000 and 2012 at our tertiary referral center. Outcome data for octogenarians was compared to younger patients aged 20 to 79 years. A case-matched group of patients younger ... Read more >>

Langenbecks Arch Surg (Langenbeck's archives of surgery)
[2017, 402(3):539-545]

Cited: 2 times

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Pancreatic Neuroendocrine Tumors (panNETs): Analysis of Overall Survival of Nonsurgical Management Versus Surgical Resection.

Paige Finkelstein, Rishika Sharma, Omar Picado, Rahul Gadde, Heather Stuart, Caroline Ripat, Alan S Livingstone, Danny Sleeman, Nipun Merchant, Danny Yakoub,

Outcomes of patients with pancreatic neuroendocrine tumors (panNETs) undergoing surgical or nonsurgical management and outcomes of enucleation versus standard resection were compared.MEDLINE, EMBASE, PubMed, Scopus, and Cochrane were queried (2000 to present). All studies comparing patients undergoing surgical versus nonsurgical treatments, or enucleation versus standard resection, were included. Pooled risk ... Read more >>

J. Gastrointest. Surg. (Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract)
[2017, 21(5):855-866]

Cited: 4 times

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Distal pancreatectomy for benign and low grade malignant tumors: Short-term postoperative outcomes of spleen preservation-A systematic review and update meta-analysis.

Fiorella Pendola, Rahul Gadde, Caroline Ripat, Rishika Sharma, Omar Picado, Laila Lobo, Danny Sleeman, Alan S Livingstone, Nipun Merchant, Danny Yakoub,

The value of spleen preservation with distal pancreatectomy (DP) for benign and low grade malignant tumors remains unclear. The aim of this study was to evaluate the short-term postoperative clinical outcomes in patients undergoing DP with splenectomy (DPS) or spleen preservation (SPDP).Online database search was performed (2000 to present); key ... Read more >>

J Surg Oncol (Journal of surgical oncology)
[2017, 115(2):137-143]

Cited: 1 time

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Extracorporeal membrane oxygenation for repair of tracheal injury during transhiatal esophagectomy.

Lilibeth Fermin, Sarah Arnold, Lorena Nunez, Danny Yakoub,

Extracorporeal Membrane Oxygenation (ECMO) for repair of tracheal injury during transhiatal esophagectomy Tracheal injury is a rare but potentially fatal complication of esophagectomies requiring prompt recognition and treatment. We describe a case of tracheal injury recognized in the operative period of an open transhiatal esophagectomy for squamous cell carcinoma of ... Read more >>

Ann Card Anaesth (Annals of cardiac anaesthesia)
[2017, 20(Supplement):S67-S69]

Cited: 2 times

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