Full Text Journal Articles by
Author Danny Jonigk

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The Diagnosis and Treatment of Pulmonary Fibrosis.

Michael Kreuter, Ulf Müller Ladner, Ulrich Costabel, Danny Jonigk, Claus Peter Heussel,

<h4>Background</h4>The different types of pulmonary fibrosis are a subgroup of the interstitial lung diseases (ILDs). They are associated with a chronic and often progressive course.<h4>Methods</h4>This review is based on pertinent publications retrieved by a selective search in the EMBASE and PubMed databases, with an emphasis on articles published from 2000 ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, 118(Forthcoming):]

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[Cooperative approach of pathology and neuropathology in the COVID-19 pandemic : German registry for COVID-19 autopsies (DeRegCOVID) and German network for autopsies in pandemics (DEFEAT PANDEMIcs)].

Saskia von Stillfried, Till Acker, Martin Aepfelbacher, Gustavo Baretton, Roman David Bülow, Karl-Friedrich Bürrig, Hans-Ulrich Holtherm, Danny Jonigk, Ruth Knüchel, Raphael W Majeed, Rainer Röhrig, Jan Wienströer, Peter Boor,

<h4>Background</h4>Autopsy is an important tool for understanding the pathogenesis of diseases, including COVID-19.<h4>Material and methods</h4>On 15 April 2020, together with the German Society of Pathology and the Federal Association of German Pathologists, the German Registry of COVID-19 Autopsies (DeRegCOVID) was launched ( www.DeRegCOVID.ukaachen.de ). Building on this, the German Network ... Read more >>

Pathologe (Der Pathologe)
[2021, :]

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S2K Guideline for Diagnosis of Idiopathic Pulmonary Fibrosis.

Jürgen Behr, Andreas Günther, Francesco Bonella, Julien Dinkel, Ludger Fink, Thomas Geiser, Klaus Geissler, Sven Gläser, Sabin Handzhiev, Danny Jonigk, Dirk Koschel, Michael Kreuter, Gabriela Leuschner, Philipp Markart, Antje Prasse, Nicolas Schönfeld, Jonas Christian Schupp, Helmut Sitter, Joachim Müller-Quernheim, Ulrich Costabel,

Idiopathic pulmonary fibrosis (IPF) is a severe and often fatal disease. Diagnosis of IPF requires considerable expertise and experience. Since the publication of the international IPF guideline in the year 2011 and the update 2018 several studies and technical advances have occurred, which made a new assessment of the diagnostic ... Read more >>

Respiration (Respiration; international review of thoracic diseases)
[2021, :1-34]

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[COVID-19: effects on the lungs and heart].

Maximilian Ackermann, Christopher Werlein, Florian Länger, Mark P Kühnel, Danny D Jonigk,

Viral respiratory diseases constitute the most common reasons for hospitalization with more than half of all acute illnesses worldwide. Progressive respiratory failure with pronounced diffuse alveolar damage has been identified as the primary cause of death in COVID-19. COVID-19 pneumonia shares common histopathological hallmarks with influenza (H1N1)-related ARDS, like diffuse ... Read more >>

Pathologe (Der Pathologe)
[2021, :]

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TGF-β1 increases permeability of ciliated airway epithelia via redistribution of claudin 3 from tight junction into cell nuclei.

Carolin Schilpp, Robin Lochbaum, Peter Braubach, Danny Jonigk, Manfred Frick, Paul Dietl, Oliver H Wittekindt,

TGF-β1 is a major mediator of airway tissue remodelling during atopic asthma and affects tight junctions (TJs) of airway epithelia. However, its impact on TJs of ciliated epithelia is sparsely investigated. Herein we elaborated effects of TGF-β1 on TJs of primary human bronchial epithelial cells. We demonstrate that TGF-β1 activates ... Read more >>

Pflugers Arch (Pflugers Archiv : European journal of physiology)
[2021, 473(2):287-311]

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Targeting Jak-Stat Signaling in Experimental Pulmonary Hypertension.

Dinesh Yerabolu, Astrid Weiss, Baktybek Kojonazarov, Mario Boehm, Beate Christiane Schlueter, Clemens Ruppert, Andreas Günther, Danny Jonigk, Friedrich Grimminger, Hossein-Ardeschir Ghofrani, Werner Seeger, Norbert Weissmann, Ralph Theo Schermuly,

In pulmonary arterial hypertension (PAH), progressive structural remodeling accounts for the pulmonary vasculopathy including the obliteration of the lung vasculature that causes an increase in vascular resistance and mean blood pressure in the pulmonary arteries ultimately leading to right heart failure-mediated death. Deciphering the molecular details of aberrant signaling of ... Read more >>

Am J Respir Cell Mol Biol (American journal of respiratory cell and molecular biology)
[2021, 64(1):100-114]

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[The updated S2k guideline for the diagnosis of idiopathic pulmonary fibrosis : Essential aspects for pathology].

Ludger Fink, Danny Jonigk,

Idiopathic pulmonary fibrosis (IPF) is a specific form of chronic progressive fibrosing nonreversible interstitial lung disease of largely unknown origin. In high-resolution computer tomography (HRCT) and histopathology it presents with a UIP pattern. To diagnose IPF, (i) an ILD of known origin must be excluded (e.g., hypersensitivity pneumonitis, lung involvement in autoimmune or ... Read more >>

Pathologe (Der Pathologe)
[2021, 42(1):40-47]

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[Interstitial lung disease in infancy and early childhood].

Florian Länger, Christopher Werlein, Bisharah Soudah, Nicolaus Schwerk, Danny Jonigk,

Diffuse interstitial lung disease of infancy (chILD) shows a spectrum of disease substantially different from that of adults. Established classification systems divide chILD into conditions that are more prevalent in infancy and conditions that occur at any age. The classification is based on a multidisciplinary approach including clinical, radiological, genetic, and histological ... Read more >>

Pathologe (Der Pathologe)
[2021, 42(1):25-34]

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[Fibrotic remodeling of the lung following lung and stem-cell transplantation].

Christopher Werlein, Max Ackermann, Thia Leandra Hoffmann, Florian Laenger, Danny Jonigk,

Transplantation of solid organs and hematopoietic stem cells represents an important therapeutic option for a variety of end-stage pulmonary diseases, aggressive hematopoietic neoplasms, or severe immunodeficiencies. Although the overall survival following transplantation has generally improved over recent decades, long-time survival of lung and stem-cell transplant recipients is still alarmingly low with ... Read more >>

Pathologe (Der Pathologe)
[2021, 42(1):17-24]

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IL-17A from innate and adaptive lymphocytes contributes to inflammation and damage in cystic fibrosis lung disease.

Matthias Hagner, Melanie Albrecht, Matteo Guerra, Peter Braubach, Olga Halle, Zhe Zhou-Suckow, Simone Butz, Danny Jonigk, Gesine Hansen, Carsten Schultz, Anna-Maria Dittrich, Marcus A Mall,

<h4>Background</h4>Elevated levels of IL-17A were detected in the airways of patients with cystic fibrosis (CF), but its cellular sources and role in the pathogenesis of CF lung disease remain poorly understood. The aim of this study was to determine the sources of IL-17A and its role in airway inflammation and ... Read more >>

Eur Respir J (The European respiratory journal)
[2020, :]

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Role of the COX2-PGE2 axis in S. pneumoniae induced exacerbation of experimental fibrosis.

Tina Bormann, Regina Maus, Jennifer Stolper, Danny Jonigk, Tobias Welte, Jack Gauldie, Martin Rj Kolb, Ulrich A Maus,

Idiopathic pulmonary fibrosis (IPF) is an interstitial lung disease (ILD) associated with high morbidity and mortality. Patients with ILD frequently develop an acute exacerbation of their disease, which may be triggered by viral and/or bacterial infections. Prostaglandin E<sub>2</sub> (PGE<sub>2</sub>) is an eicosanoid released in a cyclooxygenase-2 (COX2) dependent manner and ... Read more >>

Am J Physiol Lung Cell Mol Physiol (American journal of physiology. Lung cellular and molecular physiology)
[2020, :]

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Targeting bioenergetics is key to counteracting the drug-tolerant state of biofilm-grown bacteria.

Monique Donnert, Sarah Elsheikh, Alejandro Arce-Rodriguez, Vinay Pawar, Peter Braubach, Danny Jonigk, Axel Haverich, Siegfried Weiss, Mathias Müsken, Susanne Häussler,

Embedded in an extracellular matrix, biofilm-residing bacteria are protected from diverse physicochemical insults. In accordance, in the human host the general recalcitrance of biofilm-grown bacteria hinders successful eradication of chronic, biofilm-associated infections. In this study, we demonstrate that upon addition of promethazine, an FDA approved drug, antibiotic tolerance of in ... Read more >>

PLoS Pathog (PLoS pathogens)
[2020, 16(12):e1009126]

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Visualization of SARS-CoV-2 in the Lung. Reply.

Maximilian Ackermann, Steven J Mentzer, Danny Jonigk,

N Engl J Med (The New England journal of medicine)
[2020, 383(27):2689-2690]

Cited: 1 time

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T cell receptor repertoires within liver allografts are different to those in the peripheral blood.

Young-Seon Mederacke, Mikalai Nienen, Michael Jarek, Robert Geffers, Katharina Hupa-Breier, Nina Babel, Petra Reinke, Ingmar Mederacke, Florian Wolfgang Rudolf Vondran, Danny Jonigk, Heiner Wedemeyer, Elmar Jaeckel,

<h4>Background and aims</h4>T cells are the main mediators of allogeneic immune responses. Specific T cell clones can be tracked by their unique T cell receptor (TCR), but specificity and function remain elusive and have not been investigated in human liver biopsies thus far.<h4>Methods</h4>TCR repertoire analysis of CD4<sup>+</sup>, CD8<sup>+</sup> and regulatory ... Read more >>

J Hepatol (Journal of hepatology)
[2020, :]

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Distinct systemic cytokine networks in symptomatic and asymptomatic carotid stenosis.

Ricarda D Stauss, Gerrit M Grosse, Lavinia Neubert, Christine S Falk, Danny Jonigk, Mark P Kühnel, Maria M Gabriel, Ramona Schuppner, Ralf Lichtinghagen, Mathias Wilhelmi, Karin Weissenborn, Claudia Schrimpf,

Inflammatory processes are crucial in atherosclerosis and atherothrombosis. This study aimed to identify a cytokine-pattern that is associated with plaque-vulnerability or symptomatic state in comprehensively investigated patients with symptomatic (sCS) and asymptomatic carotid stenosis (aCS). Twenty-two patients with sCS and twenty-four patients with aCS undergoing carotid endarterectomy (CEA) were considered. ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):21963]

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Interventional stroke treatment - Is it also safe for arteries? Looking at thrombectomy wall damage through clot histology.

Frank Donnerstag, Friedrich Götz, Mete Dadak, Peter Raab, Enrico Calvino Iglesias, Christopher Werlein, Heinrich Lanfermann, Danny Jonigk,

<h4>Background and purpose</h4>The aim of this study was to investigate whether morphological evidence of intracranial vascular injury can be found in the occluding thrombi of patients with ischemic stroke.<h4>Methods</h4>From 2015 until 2018 specimens of thrombi from patients with large vessel occlusion treated either by stent-assisted aspiration thrombectomy (TE) or by ... Read more >>

Interv Neuroradiol (Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences)
[2020, :1591019920976673]

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Dual Function of iPSC-Derived Pericyte-Like Cells in Vascularization and Fibrosis-Related Cardiac Tissue Remodeling In Vitro.

Monika Szepes, Anna Melchert, Julia Dahlmann, Jan Hegermann, Christopher Werlein, Danny Jonigk, Axel Haverich, Ulrich Martin, Ruth Olmer, Ina Gruh,

Myocardial interstitial fibrosis (MIF) is characterized by excessive extracellular matrix (ECM) deposition, increased myocardial stiffness, functional weakening, and compensatory cardiomyocyte (CM) hypertrophy. Fibroblasts (Fbs) are considered the principal source of ECM, but the contribution of perivascular cells, including pericytes (PCs), has gained attention, since MIF develops primarily around small vessels. ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(23):]

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Molecular approach to the classification of chronic fibrosing lung disease-there and back again.

Stijn E Verleden, Peter Braubach, Mark Kuehnel, Nicolas Dickgreber, Emily Brouwer, Pauline Tittmann, Florian Laenger, Danny Jonigk,

Chronic diffuse parenchymal lung disease (DPLD) is an umbrella term for a very heterogeneous group of lung diseases. Over the last decades, clinical, radiological and histopathological criteria have been established to define and separate these entities. More recently the clinical utility of this approach has been challenged as a unifying ... Read more >>

Virchows Arch (Virchows Archiv : an international journal of pathology)
[2020, :]

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A multicenter prospective, randomized, placebo-controlled phase II/III trial for preemptive acute graft-versus-host disease therapy.

Eva M Weissinger, Jochen Metzger, Michael Schleuning, Christoph Schmid, Diethelm Messinger, Gernot Beutel, Eva-Maria Wagner-Drouet, Johannes Schetelig, Herrad Baurmann, Andreas Rank, Friedrich Stolzl, Kerstin Schäfer-Eckart, Karin Westphal, Wolfgang Bethge, S von Harsdorf, Donald W Bunjes, Daniela Heidenreich, Stefan Klein, Ernst Holler, Hans H Kreipe, Danny Jonigk, Irina Türüchanow, Julia Raad, Armin Papkalla, Heiko von der Leyen, Lothar Hambach, Iyas Hamwi, Steve Ehrlich, Jurgen Krauter, Michael Stadler, Arnold Ganser,

Acute graft-versus-host disease (aGvHD) contributes to about 50% of transplant-related mortality (non-relapse mortality) after allogeneic hematopoietic stem cell transplantation (HSCT). Here the predictive value of a urinary proteomic profile (aGvHD_MS17) was tested together with preemptive prednisolone therapy. Two-hundred and fifty-nine of 267 patients were eligible for analysis. Ninety-two patients were ... Read more >>

Leukemia (Leukemia)
[2020, :]

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Delayed non-myeloablative irradiation to induce long-term allograft acceptance in a large animal lung transplantation model.

Karolin S Hacker, Katharina Jansson, Jeanette Pichler, Jawad Salman, Murat Avsar, Thierry Siemeni, Ann-Kathrin Knöfel, Klaus Höffler, Jens Gottlieb, Jörg Frühauf, Martin Werner, Reza Poyanmehr, Danny Jonigk, Michael S Balzer, Marion Hewicker-Trautwein, Axel Haverich, Wiebke Sommer, Gregor Warnecke,

We previously induced long-term allograft acceptance in an allogeneic lung transplantation (LTx) model in miniature swine using perioperative non-myeloablative irradiation (IRR) combined with infusion of donor specific alloantigen. In order to improve clinical applicability, we delayed induction with irradiation in this study. Left sided single LTx was performed in minipigs. ... Read more >>

Transpl Immunol (Transplant immunology)
[2020, :101350]

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Recurrent HNSCC Harbor an Immunosuppressive Tumor Immune Microenvironment Suggesting Successful Tumor Immune Evasion.

Christian Watermann, Helen Pasternack, Christian Idel, Julika Ribbat-Idel, Johannes Brägelmann, Patrick Kuppler, Anne Offermann, Danny Jonigk, Mark Philipp Kühnel, Andreas Schröck, Eva Dreyer, Christian Rosero, Jacqueline Nathansen, Anna Dubrovska, Lars Tharun, Jutta Kirfel, Barbara Wollenberg, Sven Perner, Rosemarie Krupar,

<h4>Purpose</h4>Recurrent tumors (RT) of head and neck squamous cell carcinoma (HNSCC) occur in up to 60%, with poor therapeutic response and detrimental prognosis. We hypothesized that HNSCC RTs successfully evade antitumor immune response and aimed to reveal tumor immune microenvironment (TIME) changes of primary tumors (PT) and corresponding RTs.<h4>Experimental design</h4>Tumor-infiltrating ... Read more >>

Clin Cancer Res (Clinical cancer research : an official journal of the American Association for Cancer Research)
[2021, 27(2):632-644]

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Airway Basal Cells show a dedifferentiated KRT17highPhenotype and promote Fibrosis in Idiopathic Pulmonary Fibrosis

Benedikt Jaeger, Jonas Christian Schupp, Linda Plappert, Oliver Terwolbeck, Gian Kayser, Peggy Engelhard, Taylor Sterling Adams, Robert Zweigerdt, Henning Kempf, Stefan Lienenklaus, Wiebke Garrels, Irina Nazarenko, Danny Jonigk, Malgorzata Wygrecka, Denise Klatt, Axel Schambach, Naftali Kaminski, Antje Prasse,

<h4>ABSTRACT</h4> Idiopathic pulmonary fibrosis (IPF) is a fatal disease with limited treatment options. In this study we focus on the profibrotic properties of airway basal cells (ABC) obtained from patients with IPF (IPF-ABC). Single cell RNA sequencing of bronchial brushes revealed extensive reprogramming of IPF-ABC towards a KRT17 high PTEN ... Read more >>

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Recurrent Life-threatening Pneumonitis in a 37-Year-Old Woman.

Jan-Christopher Kamp, Danny D Jonigk, Jan B Hinrichs, Marius M Hoeper, Bernd Schönhofer, Diana Ernst, Tobias Welte, Hendrik Suhling,

<h4>Case presentation</h4>A 37-year-old previously healthy and athletic woman presented to the ED in October 2018 with acute-onset high fever, dyspnea, and productive cough. Chest radiograph showed bilateral infiltrates that correlated with multifocal ground glass opacities in a thoracic CT scan (Fig 1). The patient was severely hypoxemic and required intensive ... Read more >>

Chest (Chest)
[2020, 158(3):e127-e132]

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In vitro culture of aberrant basal-like cells from fibrotic lung tissue

Petra Khan, Julien Roux, Sabrina Blumer, Lei Fang, Spasenija Savic, Lars Knudsen, Danny Jonigk, Mark Kuehnel, Amiq Gazdhar, Thomas Geiser, Michael Tamm, Katrin Hostettler,

<h4>ABSTRACT</h4> <h4>Rationale</h4> In idiopathic pulmonary fibrosis (IPF) atypical epithelial cells are present in the alveolar compartment. Their origin and contribution to IPF pathogenesis is unknown. We recently cultured a distinct population of cells, which readily grew from fibrotic lung tissue, but only rarely from non-fibrotic tissue. Here we aimed to ... Read more >>

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Mechanical circulatory support in refractory cardiogenic shock due to influenza virus-related myocarditis.

Jan-Thorben Sieweke, Muharrem Akin, Sebastian Stetskamp, Christian Riehle, Danny Jonigk, Ulrike Flierl, Tobias J Pfeffer, Valentin Hirsch, Jochen Dutzmann, Marius M Hoeper, Christian Kühn, Johann Bauersachs, Andreas Schäfer,

<h4>Background</h4>There is scarce evidence for mechanical circulatory support (MCS) in patients with influenza-related myocarditis complicated by refractory cardiogenic shock (rCS). We sought to investigate the impact of MCS using combined veno-arterial extracorporeal membrane oxygenation (VA-ECMO) and micro-axial flow pumps (the ECMELLA concept) in influenza-related myocarditis complicated by rCS.<h4>Methods</h4>This is a ... Read more >>

Eur Respir J (The European respiratory journal)
[2020, 56(3):]

Cited: 1 time

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