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Author Daniele Martinelli

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Clinical and Electrophysiological Outcome Measures of Patients With Post-Infectious Neurological Syndromes Related to COVID-19 Treated With Intensive Neurorehabilitation.

Micol Avenali, Daniele Martinelli, Massimiliano Todisco, Isabella Canavero, Francesca Valentino, Giuseppe Micieli, Enrico Alfonsi, Cristina Tassorelli, Giuseppe Cosentino,

<b>Background:</b> The clinical spectrum of coronavirus disease 2019 (COVID-19), due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, may be quite wide, including neurological symptoms. Among them, para-infectious or post-infectious neurological syndromes (PINS), caused by an inflammatory response against the central and/or peripheral nervous system, have been reported. The ... Read more >>

Front Neurol (Frontiers in neurology)
[2021, 12:643713]

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Performance Analysis of Tunnel Boring Machines for Rock Excavation

Marilena Cardu, Ettore Catanzaro, Angelo Farinetti, Daniele Martinelli, Carmine Todaro,

The study takes into account different classes of tunnel boring machines (TBMs), with the aim of identifying correlation models which are meant to estimate, at a preliminary design phase, the construction time of a tunnel and to evaluate the mechanical and operational parameters of the TBMs, starting from the knowledge ... Read more >>

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Thalamocortical Connectivity in Experimentally-Induced Migraine Attacks: A Pilot Study.

Daniele Martinelli, Gloria Castellazzi, Roberto De Icco, Ana Bacila, Marta Allena, Arianna Faggioli, Grazia Sances, Anna Pichiecchio, David Borsook, Claudia A M Gandini Wheeler-Kingshott, Cristina Tassorelli,

In this study we used nitroglycerin (NTG)-induced migraine attacks as a translational human disease model. Static and dynamic functional connectivity (FC) analyses were applied to study the associated functional brain changes. A spontaneous migraine-like attack was induced in five episodic migraine (EM) patients using a NTG challenge. Four task-free functional ... Read more >>

Brain Sci (Brain sciences)
[2021, 11(2):]

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Migraine neuroscience: from experimental models to target therapy.

Rosaria Greco, Chiara Demartini, Roberto De Icco, Daniele Martinelli, Alessia Putortì, Cristina Tassorelli,

Migraine sciences have witnessed tremendous advances in recent years. Pre-clinical and clinical experimental models have contributed significantly to provide useful insights into the brain structures that mediate migraine attacks. These models have contributed to elucidate the role of neurotransmission pathways and to identify the role of important molecules within the ... Read more >>

Neurol Sci (Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology)
[2020, 41(Suppl 2):351-361]

Cited: 1 time

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Frontal and Cerebellar Atrophy Supports FTSD-ALS Clinical Continuum.

Beatrice Pizzarotti, Fulvia Palesi, Paolo Vitali, Gloria Castellazzi, Nicoletta Anzalone, Elena Alvisi, Daniele Martinelli, Sara Bernini, Matteo Cotta Ramusino, Mauro Ceroni, Giuseppe Micieli, Elena Sinforiani, Egidio D'Angelo, Alfredo Costa, Claudia A M Gandini Wheeler-Kingshott,

<h4>Background</h4>Frontotemporal Spectrum Disorder (FTSD) and Amyotrophic Lateral Sclerosis (ALS) are neurodegenerative diseases often considered as a continuum from clinical, epidemiologic, and genetic perspectives. We used localized brain volume alterations to evaluate common and specific features of FTSD, FTSD-ALS, and ALS patients to further understand this clinical continuum.<h4>Methods</h4>We used voxel-based morphometry ... Read more >>

Front Aging Neurosci (Frontiers in aging neuroscience)
[2020, 12:593526]

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Guidelines of the International Headache Society for controlled trials of preventive treatment of migraine attacks in episodic migraine in adults.

Hans-Christoph Diener, Cristina Tassorelli, David W Dodick, Stephan D Silberstein, Richard B Lipton, Messoud Ashina, Werner J Becker, Michel D Ferrari, Peter J Goadsby, Patricia Pozo-Rosich, Shuu-Jiun Wang, Timothy T Houle, Thomas C van den Hoek, Daniele Martinelli, Gisela M Terwindt, ,

Clinical trials are a key component of the evidence base for the treatment of headache disorders. In 1991, the International Headache Society Clinical Trials Standing Committee developed and published the first edition of the <i>Guidelines for Controlled Trials of Drugs in Migraine</i>. Advances in drugs, devices, and biologicals, as well ... Read more >>

Cephalalgia (Cephalalgia : an international journal of headache)
[2020, 40(10):1026-1044]

Cited: 2 times

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Neurophysiological and biomolecular effects of erenumab in chronic migraine: An open label study.

Roberto De Icco, Giuseppe Fiamingo, Rosaria Greco, Sara Bottiroli, Chiara Demartini, Anna Maria Zanaboni, Marta Allena, Elena Guaschino, Daniele Martinelli, Alessia Putortì, Valentina Grillo, Grazia Sances, Cristina Tassorelli,

<h4>Introduction</h4>Anti-calcitonin gene-related peptide antibodies proved effective in the preventive treatment of chronic migraine. In this open label study, we aim to assess the effects of erenumab administration on neurophysiological and biomolecular profiles in a representative cohort of chronic migraine patients.<h4>Methods</h4>Forty patients with a history of chronic migraine for at least ... Read more >>

Cephalalgia (Cephalalgia : an international journal of headache)
[2020, 40(12):1336-1345]

Cited: 1 time

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A Machine Learning Approach for the Differential Diagnosis of Alzheimer and Vascular Dementia Fed by MRI Selected Features.

Gloria Castellazzi, Maria Giovanna Cuzzoni, Matteo Cotta Ramusino, Daniele Martinelli, Federica Denaro, Antonio Ricciardi, Paolo Vitali, Nicoletta Anzalone, Sara Bernini, Fulvia Palesi, Elena Sinforiani, Alfredo Costa, Giuseppe Micieli, Egidio D'Angelo, Giovanni Magenes, Claudia A M Gandini Wheeler-Kingshott,

Among dementia-like diseases, Alzheimer disease (AD) and vascular dementia (VD) are two of the most frequent. AD and VD may share multiple neurological symptoms that may lead to controversial diagnoses when using conventional clinical and MRI criteria. Therefore, other approaches are needed to overcome this issue. Machine learning (ML) combined ... Read more >>

Front Neuroinform (Frontiers in neuroinformatics)
[2020, 14:25]

Cited: 2 times

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Chronic migraine and Botulinum Toxin Type A: Where do paths cross?

Daniele Martinelli, Sebastiano Arceri, Livio Tronconi, Cristina Tassorelli,

Migraine is a highly prevalent and disabling disorder accounted among the primary headaches. It is the expression of a complex, and not yet fully understood, pathophysiology involving the sensitization of peripheral and central nociceptive pathways. In this review we succinctly illustrate the molecular, anatomical, and functional abnormalities underlying the migraine ... Read more >>

Toxicon (Toxicon : official journal of the International Society on Toxinology)
[2020, 178:69-76]

Cited: 0 times

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Frontal and cerebellar atrophy supports FTSD-ALS clinical continuum

Beatrice Pizzarotti, Fulvia Palesi, Paolo Vitali, Gloria Castellazzi, Nicoletta Anzalone, Elena Alvisi, Daniele Martinelli, Sara Bernini, Matteo Cotta Ramusino, Mauro Ceroni, Giuseppe Micieli, Elena Sinforiani, Egidio D’Angelo, Alfredo Costa, Claudia AM Gandini Wheeler-Kingshott,

<h4>Background</h4> Frontotemporal Spectrum Disorder (FTSD) and Amyotrophic Lateral Sclerosis (ALS) are neurodegenerative diseases often considered as a continuum from clinical, epidemiologic and genetic perspectives. We used localized brain volume alterations to evaluate common and specific features of FTSD, FTSD-ALS and ALS patients to further understand this clinical continuum. <h4>Methods</h4> We ... Read more >>

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Limitations in daily activities and general perception of quality of life: Long term follow-up in patients with anti-myelin-glycoprotein antibody polyneuropathy.

Marta Campagnolo, Marta Ruiz, Yuri M Falzone, Mario Ermani, Mariangela Bianco, Daniele Martinelli, Federica Cerri, Angelo Quattrini, Alessandro Salvalaggio, Francesca Castellani, Giancarlo Comi, Fabio Giannini, Eduardo Nobile-Orazio, Raffaella Fazio, Nilo Riva, Chiara Briani,

In this study, we assessed the modifications over time of daily activities and quality of life (QoL) in 32 subjects with anti-myelin-glycoprotein (MAG) antibody neuropathy. A widespread panel including clinical scores and patient-reported questionnaires, in compliance of the terms by the International Classification of Functioning, Disability, and Health (ICF) of ... Read more >>

J Peripher Nerv Syst (Journal of the peripheral nervous system : JPNS)
[2019, 24(3):276-282]

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Adherence to the 2008 IHS guidelines for controlled trials of drugs for the preventive treatment of chronic migraine in adults.

Marie Deen, Daniele Martinelli, Judith Pijpers, Hans-Christoph Diener, Stephen Silberstein, Michel D Ferrari, Messoud Ashina, Cristina Tassorelli, Hsiangkuo Yuan,

<h4>Introduction</h4>Since the definition of chronic migraine as a new disease entity in 2004, numerous clinical trials have examined the efficacy of preventive treatments in chronic migraine. Our aim was to assess the adherence of these trials to the Guidelines of the International Headache Society published in 2008.<h4>Methods</h4>We searched PubMed for ... Read more >>

Cephalalgia (Cephalalgia : an international journal of headache)
[2019, 39(8):1058-1066]

Cited: 0 times

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Safety and efficacy of nabiximols on spasticity symptoms in patients with motor neuron disease (CANALS): a multicentre, double-blind, randomised, placebo-controlled, phase 2 trial.

Nilo Riva, Gabriele Mora, Gianni Sorarù, Christian Lunetta, Ottavia E Ferraro, Yuri Falzone, Letizia Leocani, Raffaella Fazio, Mauro Comola, Giancarlo Comi, ,

BACKGROUND:Spasticity is a major determinant of disability and decline in quality of life in patients with motor neuron disease. Cannabinoids have been approved for symptomatic treatment of spasticity in multiple sclerosis. We investigated whether cannabinoids might also reduce spasticity in patients with motor neuron disease. METHODS:We did an investigator-initiated, randomised, ... Read more >>

Lancet Neurol (The Lancet. Neurology)
[2019, 18(2):155-164]

Cited: 8 times

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Functioning and quality of life in patients with neuropathy associated with anti-MAG antibodies.

Yuri M Falzone, Marta Campagnolo, Mariangela Bianco, Patrizia Dacci, Daniele Martinelli, Marta Ruiz, Silvia Bocci, Federica Cerri, Angelo Quattrini, Giancarlo Comi, Luana Benedetti, Fabio Giannini, Giuseppe Lauria, Eduardo Nobile-Orazio, Chiara Briani, Raffaella Fazio, Nilo Riva,

Although anti-myelin-associated glycoprotein (MAG) antibody neuropathy is reported as a slowly progressive disease, it can lead to significant disability and impairment of health-related quality of life (HR-QoL) and social participation. The aim of this cross-sectional study was to evaluate the functioning and HR-QoL determinants in 67 patients with anti-MAG neuropathy ... Read more >>

J Neurol (Journal of neurology)
[2018, 265(12):2927-2933]

Cited: 1 time

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Consistent effects of non-invasive vagus nerve stimulation (nVNS) for the acute treatment of migraine: additional findings from the randomized, sham-controlled, double-blind PRESTO trial.

Paolo Martelletti, Piero Barbanti, Licia Grazzi, Giulia Pierangeli, Innocenzo Rainero, Pierangelo Geppetti, Anna Ambrosini, Paola Sarchielli, Cristina Tassorelli, Eric Liebler, Marina de Tommaso, ,

<h4>Background</h4>Non-invasive vagus nerve stimulation (nVNS) has been shown to be practical, safe, and well tolerated for treating primary headache disorders. The recent multicenter, randomized, double-blind, sham-controlled PRESTO trial provided Class I evidence that for patients with episodic migraine, nVNS significantly increases the probability of having mild pain or being pain-free ... Read more >>

J Headache Pain (The journal of headache and pain)
[2018, 19(1):101]

Cited: 5 times

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Practical and clinical utility of non-invasive vagus nerve stimulation (nVNS) for the acute treatment of migraine: a post hoc analysis of the randomized, sham-controlled, double-blind PRESTO trial.

Licia Grazzi, Cristina Tassorelli, Marina de Tommaso, Giulia Pierangeli, Paolo Martelletti, Innocenzo Rainero, Pierangelo Geppetti, Anna Ambrosini, Paola Sarchielli, Eric Liebler, Piero Barbanti, ,

<h4>Background</h4>The PRESTO study of non-invasive vagus nerve stimulation (nVNS; gammaCore®) featured key primary and secondary end points recommended by the International Headache Society to provide Class I evidence that for patients with an episodic migraine, nVNS significantly increases the probability of having mild pain or being pain-free 2 h post stimulation. ... Read more >>

J Headache Pain (The journal of headache and pain)
[2018, 19(1):98]

Cited: 6 times

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Noninvasive vagus nerve stimulation as acute therapy for migraine: The randomized PRESTO study.

Cristina Tassorelli, Licia Grazzi, Marina de Tommaso, Giulia Pierangeli, Paolo Martelletti, Innocenzo Rainero, Stefanie Dorlas, Pierangelo Geppetti, Anna Ambrosini, Paola Sarchielli, Eric Liebler, Piero Barbanti, ,

OBJECTIVE:To evaluate the efficacy, safety, and tolerability of noninvasive vagus nerve stimulation (nVNS; gammaCore; electroCore, LLC, Basking Ridge, NJ) for the acute treatment of migraine in a multicenter, double-blind, randomized, sham-controlled trial. METHODS:A total of 248 participants with episodic migraine with/without aura were randomized to receive nVNS or sham within ... Read more >>

Neurology (Neurology)
[2018, 91(4):e364-e373]

Cited: 32 times

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Peripheral vagal nerve stimulation modulates the nociceptive withdrawal reflex in healthy subjects: A randomized, cross-over, sham-controlled study.

Roberto De Icco, Daniele Martinelli, Vito Bitetto, Mauro Fresia, Eric Liebler, Giorgio Sandrini, Cristina Tassorelli,

Introduction The mechanism of action of non-invasive vagal nerve stimulation in the treatment of migraine is elusive. We studied its effect in a human model of pain, the nociceptive withdrawal reflex. Methods We enrolled 10 healthy subjects who underwent active non-invasive vagal nerve stimulation and sham treatment in a randomized, ... Read more >>

Cephalalgia (Cephalalgia : an international journal of headache)
[2018, 38(10):1658-1664]

Cited: 5 times

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Botulinum toxin for chronic migraine: Clinical trials and technical aspects.

Cristina Tassorelli, Grazia Sances, Micol Avenali, Roberto De Icco, Daniele Martinelli, Vito Bitetto, Giuseppe Nappi, Giorgio Sandrini,

OnabotulinumtoxinA has been approved for the prophylaxis of chronic migraine following the demonstration of efficacy in two large controlled trials. Data collected from pragmatic studies in the real-life setting have contributed important additional information useful for the management of this group of extremely disabled and challenging patients. The main findings ... Read more >>

Toxicon (Toxicon : official journal of the International Society on Toxinology)
[2018, 147:111-115]

Cited: 1 time

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MRI signatures of the frontotemporal lobar degeneration continuum.

Federica Agosta, Sebastiano Galantucci, Giuseppe Magnani, Alessandra Marcone, Daniele Martinelli, Maria Antonietta Volontè, Nilo Riva, Sandro Iannaccone, Pilar M Ferraro, Francesca Caso, Adriano Chiò, Giancarlo Comi, Andrea Falini, Massimo Filippi,

<h4>Objective</h4>To identify overlapping and unique grey (GM) and white matter (WM) signatures within the frontotemporal lobar degeneration (FTLD) continuum, and discriminate likely FTLD-TAU and FTLD-TDP patients using structural and diffusion tensor (DT) magnetic resonance imaging (MRI).<h4>Methods</h4>T1-weighted and DT MRI were collected from 121 subjects: 35 motor neuron disease (MND), 14 ... Read more >>

Hum Brain Mapp (Human brain mapping)
[2015, 36(7):2602-2614]

Cited: 17 times

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