Full Text Journal Articles by
Author Daniela Pohl

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Continuous EEG in a Pediatric Intensive Care Unit: Adherence to Monitoring Criteria and Barriers to Adequate Implementation.

Jamie Ghossein, Fuad Alnaji, Richard J Webster, Srinivas Bulusu, Daniela Pohl,

BACKGROUND:Subclinical seizures are common in critically ill children and are best detected by continuous EEG (cEEG) monitoring. Timely detection of seizures requires pediatric intensive care unit (PICU) physicians to identify patients at risk of seizures and request cEEG monitoring. A recent consensus statement from the American Clinical Neurophysiology Society (ACNS) ... Read more >>

Neurocrit Care (Neurocritical care)
[2020, :]

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Correction to: Long-Term Effect of Immediate Versus Delayed Fingolimod Treatment in Young Adult Patients with Relapsing-Remitting Multiple Sclerosis: Pooled Analysis from the FREEDOMS/FREEDOMSII Trials.

Angelo Ghezzi, Tanuja Chitnis, Annik K-Laflamme, Rolf Meinert, Dieter A Häring, Daniela Pohl,

Figures 1a, 1b and 3 were published incorrectly in the original version. The corrected images are given as follows. ... Read more >>

Neurol Ther (Neurology and therapy)
[2020, 9(1):193-195]

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Expanding the phenotypic and molecular spectrum of RNA polymerase III-related leukodystrophy.

Stefanie Perrier, Laurence Gauquelin, Catherine Fallet-Bianco, Megan K Dishop, Mackenzie A Michell-Robinson, Luan T Tran, Kether Guerrero, Lama Darbelli, Myriam Srour, Kevin Petrecca, Deborah L Renaud, Michael Saito, Seth Cohen, Steffen Leiz, Bader Alhaddad, Tobias B Haack, Ingrid Tejera-Martin, Fernando I Monton, Norberto Rodriguez-Espinosa, Daniela Pohl, Savithri Nageswaran, Annette Grefe, Emma Glamuzina, Geneviève Bernard,

Objective:To expand the phenotypic spectrum of severity of POLR3-related leukodystrophy and identify genotype-phenotype correlations through study of patients with extremely severe phenotypes. Methods:We performed an international cross-sectional study on patients with genetically proven POLR3-related leukodystrophy and atypical phenotypes to identify 6 children, 3 males and 3 females, with an extremely ... Read more >>

Neurol Genet (Neurology. Genetics)
[2020, 6(3):e425]

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4H leukodystrophy: Mild clinical phenotype and comorbidity with multiple sclerosis.

Stephanie M DeGasperis, Geneviève Bernard, Nicole I Wolf, Elka Miller, Daniela Pohl,

Neurol Genet (Neurology. Genetics)
[2020, 6(2):e409]

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Cannabis Treatment in Children with Epilepsy: Practices of Canadian Neurologists.

Stephanie M DeGasperis, Richard Webster, Daniela Pohl,

BACKGROUND:Medical cannabis has recently emerged as a treatment option for children with drug-resistant epilepsy. Despite the fact that many pediatric epilepsy patients across Canada are currently being treated with cannabis, little is known about the attitudes of neurologists toward cannabinoid treatment of children with epilepsy. METHODS:A 21-item online survey was ... Read more >>

Can J Neurol Sci (The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques)
[2020, 47(4):511-518]

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Physically active children with epilepsy have good objective sleep duration and efficiency despite subjective reports of fatigue and sleep problems.

Jeffrey Do, Richard J Webster, Patricia E Longmuir, Sara Ieradi, Deepti Reddy, Sharon Whiting, Daniela Pohl,

OBJECTIVE:The aim of this study was to longitudinally characterize in children with epilepsy the objective and subjective sleep quality and the relationship between increased physical activity and sleep as well as measures of psychosocial well-being. METHODS:Baseline physical activity and sleep were established in children with epilepsy over four weeks, prior ... Read more >>

Epilepsy Behav (Epilepsy & behavior : E&B)
[2020, 104(Pt A):106853]

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No improvement in quality of life in children with epilepsy treated with the low glycemic index diet.

Sama Boles, Richard J Webster, Sophie Parnel, Julie Murray, Erick Sell, Daniela Pohl,

BACKGROUND:Up to 30% of children with epilepsy show a poor therapeutic response to pharmacologic treatment. Ketogenic diets, including the less strict low glycemic index treatment (LGIT), may improve seizure control in pharmacoresistant epilepsy. However, little is known about the quality of life (QoL) in children on LGIT. To explore psychosocial ... Read more >>

Epilepsy Behav (Epilepsy & behavior : E&B)
[2020, 104(Pt A):106664]

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Benign spasms of infancy: a mimicker of infantile epileptic disorders.

Jamie Ghossein, Daniela Pohl,

Benign spasms of infancy (BSI), previously described as benign non-epileptic infantile spasms or benign myoclonus of early infancy, are non-epileptic movements manifesting during the first year of life and spontaneously resolving in the second year of life. BSI are characterized by spasms typically lasting 1-2 seconds, involving, to varying degrees, ... Read more >>

Epileptic Disord (Epileptic disorders : international epilepsy journal with videotape)
[2019, 21(6):585-589]

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Clinical trials of disease-modifying agents in pediatric MS: Opportunities, challenges, and recommendations from the IPMSSG.

Emmanuelle Waubant, Brenda Banwell, Evangeline Wassmer, Maria-Pia Sormani, Maria-Pia Amato, Rogier Hintzen, Lauren Krupp, Kevin Rostásy, Silvia Tenembaum, Tanuja Chitnis, ,

OBJECTIVE:The impetus for this consensus discussion was to recommend clinical trial designs that can deliver high-quality data for effective therapies for pediatric patients, in a reasonable timeframe, with a key focus on short- and long-term safety. METHODS:The International Pediatric Multiple Sclerosis Study Group convened a meeting of experts to review ... Read more >>

Neurology (Neurology)
[2019, 92(22):e2538-e2549]

Cited: 2 times

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18 Continuous EEG for the Detection of Non-Convulsive Seizures in the PICU: A Quality Improvement Project.

Jamie Ghossein, Fuad Alnaji, Daniela Pohl,

AbstractBackgroundPatients in the pediatric intensive care unit (PICU) are at risk for central nervous system insults, including seizures, potentially resulting in irreversible neurological damage if untreated. Seizures in critically ill patients are often clinically silent, impeding recognition and timely anticonvulsant treatment. Continuous electroencephalographic (cEEG) monitoring facilitates the detection of subclinical ... Read more >>

Paediatr Child Health (Paediatrics & Child Health)
[2019, 24(Suppl 2):e8-e8]

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Long-Term Effect of Immediate Versus Delayed Fingolimod Treatment in Young Adult Patients with Relapsing-Remitting Multiple Sclerosis: Pooled Analysis from the FREEDOMS/FREEDOMS II Trials.

Angelo Ghezzi, Tanuja Chitnis, Annik K-Laflamme, Rolf Meinert, Dieter A Häring, Daniela Pohl,

INTRODUCTION:Fingolimod has demonstrated clinical and MRI benefits versus placebo/interferon β-1a in young adults with multiple sclerosis (MS). Here we report the long-term effects of fingolimod 0.5 mg on clinical and MRI outcomes in young adults with MS aged ≤ 30 years followed up for up to 8 years (96 months). METHODS:This post hoc analysis of pooled ... Read more >>

Neurol Ther (Neurology and therapy)
[2019, 8(2):461-475]

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Infantile Idiopathic Intracranial Hypertension: A Case Study and Review of the Literature.

Sama Boles, Claudia Martinez-Rios, Daniel Tibussek, Daniela Pohl,

Idiopathic intracranial hypertension, or pseudotumor cerebri, is an increase in cerebrospinal fluid pressure of unknown etiology. It is mostly seen in adults, less frequently in adolescents, rarely in younger children. Only 5 infants meeting idiopathic intracranial hypertension criteria have been mentioned in the literature. We report a case of a ... Read more >>

J. Child Neurol. (Journal of child neurology)
[2019, 34(13):806-814]

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Continuous Electroencephalography Monitoring for Critically Ill Neonates: A Canadian Perspective.

Sarah Grace Buttle, Erick Sell, Richard Webster, Melanie Varin, Brigitte Lemyre, Cecil Hahn, Daniela Pohl,

BACKGROUND:Continuous EEG monitoring, in the form of amplitude-integrated (aEEG) or conventional EEG (cEEG), is used in the neonatal intensive care unit (NICU) to detect subclinical central nervous system pathologies, inform management, and prognosticate neurodevelopmental outcomes. To learn more about provider attitudes and current practices in Canada, we evaluated neurologist and ... Read more >>

Can J Neurol Sci (The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques)
[2019, 46(4):394-402]

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Can behavioral strategies increase physical activity and influence depressive symptoms and quality of life among children with epilepsy? Results of a randomized controlled trial.

Denver M Y Brown, Nadilein Mahlberg, Daniela Pohl, Brian W Timmons, Steven R Bray, David L Streiner, Mark A Ferro, Sabrina Hamer, Peter L Rosenbaum, Gabriel M Ronen,

PURPOSE:This study examined whether increasing physical activity (PA) through 6 months of behavioral counseling positively influenced depressive symptoms and quality of life (QoL) over 12 months among children with epilepsy (CWE). METHODS:A longitudinal multisite randomized controlled trial (RCT) was conducted with 8-14-year-old children with active epilepsy. Participants wore a pedometer to track ... Read more >>

Epilepsy Behav (Epilepsy & behavior : E&B)
[2019, 94:158-166]

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Combined Conventional and Amplitude-Integrated EEG Monitoring in Neonates: A Prospective Study.

Sarah Grace Buttle, Brigitte Lemyre, Erick Sell, Stephanie Redpath, Srinivas Bulusu, Richard J Webster, Daniela Pohl,

BACKGROUND/OBJECTIVE:Seizure monitoring via amplitude-integrated EEG is standard of care in many neonatal intensive care units; however, conventional EEG is the gold standard for seizure detection. We compared the diagnostic yield of amplitude-integrated EEG interpreted at the bedside, amplitude-integrated EEG interpreted by an expert, and conventional EEG. METHODS:Neonates requiring seizure monitoring ... Read more >>

J. Child Neurol. (Journal of child neurology)
[2019, 34(6):313-320]

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Neonatal Bicycling Movements Associated With a Basal Ganglia Stroke.

Monica D McKeown, Justin Graveline, Salini Thulasirajah, Daniela Pohl,

Mov Disord Clin Pract (Movement Disorders Clinical Practice)
[2019, 6(2):176-178]

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Relationship Between Physical Activity, Tic Severity and Quality of Life in Children with Tourette Syndrome.

Asif Doja, Ammar Bookwala, Daniela Pohl, Alessandra Rossi-Ricci, Nicholas Barrowman, Jason Chan, Patricia E Longmuir,

Objective:To examine the relationship between physical activity, tic severity and quality of life (QoL) in children and adolescents with persistent tic disorder and Tourette Syndrome. Method:Baseline data was examined from a larger randomized controlled trial (Clinicaltrials.gov NCT02153463). Physical activity was assessed via pedometers with daily step count recorded. Tic severity ... Read more >>

J Can Acad Child Adolesc Psychiatry (Journal of the Canadian Academy of Child and Adolescent Psychiatry = Journal de l'Academie canadienne de psychiatrie de l'enfant et de l'adolescent)
[2018, 27(4):222-227]

Cited: 2 times

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Oligoclonal bands increase the specificity of MRI criteria to predict multiple sclerosis in children with radiologically isolated syndrome.

Naila Makhani, Christine Lebrun, Aksel Siva, Sona Narula, Evangeline Wassmer, David Brassat, J Nicholas Brenton, Philippe Cabre, Clarisse Carra Dallière, Jérôme de Seze, Francoise Durand Dubief, Matilde Inglese, Megan Langille, Guillaume Mathey, Rinze F Neuteboom, Jean Pelletier, Daniela Pohl, Daniel S Reich, Juan Ignacio Rojas, Veronika Shabanova, Eugene D Shapiro, Robert T Stone, Silvia Tenembaum, Mar Tintoré, Ugur Uygunoglu, Wendy Vargas, Sunita Venkateswaren, Patrick Vermersch, Orhun Kantarci, Darin T Okuda, Daniel Pelletier, ,

Background:Steps towards the development of diagnostic criteria are needed for children with the radiologically isolated syndrome to identify children at risk of clinical demyelination. Objectives:To evaluate the 2005 and 2016 MAGNIMS magnetic resonance imaging criteria for dissemination in space for multiple sclerosis, both alone and with oligoclonal bands in cerebrospinal ... Read more >>

Mult Scler J Exp Transl Clin (Multiple sclerosis journal - experimental, translational and clinical)
[2019, 5(1):2055217319836664]

Cited: 1 time

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Higher screen time, lower muscular endurance, and decreased agility limit the physical literacy of children with epilepsy.

Daniela Pohl, Anastasia Alpous, Sabrina Hamer, Patricia E Longmuir,

OBJECTIVE:The objective of this study was to determine the physical literacy (the motivation, confidence, physical competence, and knowledge contributing to the capacity for physical activity) of children with epilepsy, as compared with that of their healthy peers. METHODS:Patients age 8-12 years with epilepsy, without any disabilities interfering with their ability to ... Read more >>

Epilepsy Behav (Epilepsy & behavior : E&B)
[2019, 90:260-265]

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Incidence and prevalence of MS in children: A population-based study in Ontario, Canada.

Ruth Ann Marrie, Julia O'Mahony, Colleen Maxwell, Vicki Ling, E Ann Yeh, Douglas L Arnold, Amit Bar-Or, Brenda Banwell, ,

OBJECTIVE:To validate a case definition of multiple sclerosis (MS) in the pediatric population using administrative (health claims) data, and to estimate the incidence and prevalence of MS in the pediatric population for Ontario, Canada. METHODS:We used population-based administrative data to identify persons aged ≤18 years with MS. We assessed the ... Read more >>

Neurology (Neurology)
[2018, 91(17):e1579-e1590]

Cited: 2 times

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Sensitivity, specificity, and reliability of the Get Active Questionnaire for identifying children with medically necessary special considerations for physical activity.

Patricia E Longmuir, Julia Jackson, Emily Ertel, Maala Bhatt, Asif Doja, Ciarán Duffy, Letizia Gardin, Roman Jurencak, Sherri Lynne Katz, Lillian Lai, Christine Lamontagne, Suzie Lee, Jane Lougheed, Anna McCormick, Hugh McMillan, Daniela Pohl, Johannes Roth, Carol Theoret-Douglas, Karen Watanabe Duffy, Derek Wong, Roger Zemek,

Physical activity is promoted for optimal health but may carry risks for children who require medically necessary activity restrictions. The sensitivity, specificity, and reliability of the Get Active Questionnaire (GAQ) for identifying children needing special considerations during physical activity was evaluated among parents of 207 children aged 3 to 14 ... Read more >>

Appl Physiol Nutr Metab (Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme)
[2019, 44(7):736-743]

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MRI of the first event in pediatric acquired demyelinating syndromes with antibodies to myelin oligodendrocyte glycoprotein.

Matthias Baumann, Astrid Grams, Tanja Djurdjevic, Eva-Maria Wendel, Christian Lechner, Bettina Behring, Astrid Blaschek, Katharina Diepold, Astrid Eisenkölbl, Joel Fluss, Michael Karenfort, Johannes Koch, Bahadir Konuşkan, Steffen Leiz, Andreas Merkenschlager, Daniela Pohl, Mareike Schimmel, Charlotte Thiels, Barbara Kornek, Kathrin Schanda, Markus Reindl, Kevin Rostásy,

Antibodies against the myelin oligodendrocyte glycoprotein (MOG-Ab) can be detected in various pediatric acquired demyelinating syndromes (ADS). Here, we analyze the spectrum of neuroradiologic findings in children with MOG-Ab and a first demyelinating event. The cerebral and spinal MRI of 69 children with different ADS was assessed in regard to ... Read more >>

J. Neurol. (Journal of neurology)
[2018, 265(4):845-855]

Cited: 9 times

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Relapse Rate and MRI Activity in Young Adult Patients With Multiple Sclerosis: A Post Hoc Analysis of Phase 3 Fingolimod Trials.

Jutta Gärtner, Tanuja Chitnis, Angelo Ghezzi, Daniela Pohl, Wolfgang Brück, Dieter Adrian Häring, Goeril Karlsson, Norman Putzki,

Disease activity differs in young patients with multiple sclerosis (MS) compared with the overall adult MS population.The objective of this paper is to evaluate the effect of fingolimod 0.5 mg on disease activity in young adults with MS from three randomized, double-blind Phase 3 trials.Annualized relapse rate (ARR), number of ... Read more >>

Mult Scler J Exp Transl Clin (Multiple sclerosis journal - experimental, translational and clinical)
[2018, 4(2):2055217318778610]

Cited: 6 times

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MRI and laboratory features and the performance of international criteria in the diagnosis of multiple sclerosis in children and adolescents: a prospective cohort study.

Giulia Fadda, Robert A Brown, Giulia Longoni, Denise A Castro, Julia O'Mahony, Leonard H Verhey, Helen M Branson, Patrick Waters, Amit Bar-Or, Ruth Ann Marrie, E Ann Yeh, Sridar Narayanan, Douglas L Arnold, Brenda Banwell, ,

BACKGROUND:MRI and laboratory features have been incorporated into international diagnostic criteria for multiple sclerosis. We assessed the pattern of MRI lesions and contributions of cerebrospinal fluid (CSF) and serum antibody findings that best identifies children with multiple sclerosis, and the applicability of international diagnostic criteria in the paediatric context. METHODS:In ... Read more >>

Lancet Child Adolesc Health (The Lancet. Child & adolescent health)
[2018, 2(3):191-204]

Cited: 6 times

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Health-Related Quality of Life for Patients With Genetically Determined Leukoencephalopathy.

Amytice Mirchi, Félixe Pelletier, Luan T Tran, Stephanie Keller, Nancy Braverman, Davide Tonduti, Adeline Vanderver, Amy Pizzino, Marie-Emmanuelle Dilenge, Chantal Poulin, Michael Shevell, Annette Majnemer, Guillaume Sébire, Myriam Srour, Bradley Osterman, Renée-Myriam Boucher, Michel Vanasse, Elsa Rossignol, John Mitchell, Sunita Venkateswaran, Daniela Pohl, Marcelo Kauffman, Raphael Schiffmann, Cyril Goizet, Sebastien Moutton, Federico Roncarolo, Geneviève Bernard,

BACKGROUND:We attempted to characterize the health-related quality of life in patients with genetically determined leukoencephalopathies as it relates to the severity of clinical features and the presence or absence of a precise molecular diagnosis. METHODS:Health-related quality of life was assessed using the Pediatric Quality of Life Inventory model (Pediatric Quality ... Read more >>

Pediatr. Neurol. (Pediatric Neurology)
[2018, 84:21-26]

Cited: 0 times

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