Full Text Journal Articles by
Author Daniela Ferreira

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Mushroom small RNAs as potential anticancer agents: a closer look at Cantharellus cibarius proapoptotic and antiproliferative effects in colon cancer cells.

Marta K Lemieszek, Patrícia S Marques, Miguel Ribeiro, Daniela Ferreira, Guilhermina Marques, Raquel Chaves, Piotr Pożarowski, Fernando M Nunes, Wojciech Rzeski,

Screening aimed at the evaluation of the presence of small RNAs with anticancer properties in three mushrooms species, besides Boletus edulis, namely Boletus spretus (current name Baorangia emilei), Boletus pinophilus and Cantharellus cibarius, was conducted. All mushrooms yielded an ethanol insoluble and water soluble small RNA fraction purified from co-extracted ... Read more >>

Food Funct (Food & function)
[2019, 10(5):2739-2751]

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Invasive mechanical ventilation and biomarkers as predictors of bronchopulmonary dysplasia in preterm infants.

Camila Piqui Nascimento, Larissa Prado Maia, Patrícia Terra Alves, Aline Teodoro de Paula, Jair Pereira Cunha Junior, Vânia Olivetti Steffen Abdallah, Daniela Marques de Lima Mota Ferreira, Luiz Ricardo Goulart, Vivian Mara Gonçalves de Oliveira Azevedo,

OBJECTIVES:To evaluate the impact of invasive mechanical ventilation associated with two serum inflammatory cytokines and clinical indicators, on the second day of life, as predictors of bronchopulmonary dysplasia in very low birth weight preterm infants. It was hypothesized that the use of invasive mechanical ventilation in the first hours of ... Read more >>

J Pediatr (Rio J) (Jornal de pediatria)
[2020, :]

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Experimental human pneumococcal colonisation in older adults is feasible and safe, not immunogenic

Hugh Adler, Esther German, Elena Mitsi, Elissavet Nikolaou, Sherin Pojar, Caz Hales, Rachel Robinson, Victoria Connor, Helen Hill, Angel Hyder-Wright, Lepa Lazarova, Catherine Lowe, Emma Smith, India Wheeler, Seher Zaidi, Simon Jochems, Dessi Loukov, Jesus Reine, Carla Solorzano-Gonzalez, Polly deGorguettedArgoeuves, Tessa Jones, David Goldblatt, Tao Chen, Stephen Aston, Neil French, Andrea Collins, Stephen Gordon, Jamie Rylance, Daniela Ferreira,

Rationale: Pneumococcal colonisation is key to the pathogenesis of invasive disease, but is also immunogenic in young adults, protecting against re-colonisation. Colonisation is rarely detected in older adults, despite high rates of pneumococcal disease. Objectives: To establish experimental human pneumococcal colonisation in healthy adults aged 50-84 years, to measure the ... Read more >>

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Isolate differences in colonization efficiency during experimental human pneumococcal challenge

Sherin Pojar, Alan Basset, Jenna Gritzfeld, Elissavet Nikolaou, Saskia van Selm, Marc Eleveld, Rebecca Gladstone, Carla Solórzano, Ankur Dalia, Esther German, Elena Mitsi, Victoria Connor, Angela Hyder-Wright, Helen Hill, Caz Hales, Tao Chen, Andrew Camilli, Andrea Collins, Jamie Rylance, Stephen Bentley, Simon Jochems, Marien de Jonge, Jeffrey Weiser, David Cleary, Stuart Clarke, Richard Malley, Stephen Gordon, Daniela Ferreira,

Colonization efficiency varies considerably between Streptococcus pneumoniae (pneumococcus) strains. The microbial characteristics that influence those differences are still largely unknown. Here, we compare rates and kinetics of colonization of four pneumococcal strains upon experimental human pneumococcal challenge. Healthy adults were intranasally challenged with one of four pneumococcal strains (serotype/clonal name: ... Read more >>

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Application of a Bundle in the Prevention of Peri-Intraventricular Hemorrhage in Preterm Newborns.

Daniela Monteiro Ferreira, Ana Lívia Araújo Girão, Ana Valeska Siebra E Silva, Edna Maria Camelo Chaves, Paulo César de Almeida, Vanessa Sousa Freire, Rhanna Emanuela Fontenele Lima de Carvalho,

The purpose of this study was to evaluate the impact of implementing a care bundle for preventing peri-intraventricular hemorrhage (PIVH) in preterm newborns. A longitudinal, quantitative, quasi-experimental study was conducted with preterm newborns from a neonatal unit. The study was divided into 2 stages: the first consisted of a retrospective ... Read more >>

J Perinat Neonatal Nurs (The Journal of perinatal & neonatal nursing)
[2020, 34(2):E5-E11]

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Upper respiratory tract colonization with Streptococcus pneumoniae in adults.

Adriano Arguedas, Krzysztof Trzciński, Katherine L O'Brien, Daniela M Ferreira, Anne L Wyllie, Daniel Weinberger, Leon Danon, Stephen I Pelton, Chiara Azzari, Laura L Hammitt, Raquel Sá-Leão, Maria-Cristina C Brandileone, Samir Saha, Jose Suaya, Raul Isturiz, Luis Jodar, Bradford D Gessner,

INTRODUCTION:Most of the current evidence regarding pneumococcal upper respiratory colonization in adults suggests that despite high disease burden, carriage prevalence is low. Contemporary studies on adult pneumococcal colonization have largely followed the pediatric approach by which samples are obtained mostly from the nasopharynx and bacterial detection is evaluated by routine ... Read more >>

Expert Rev Vaccines (Expert review of vaccines)
[2020, 19(4):353-366]

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The whole blood phagocytosis assay: a clinically relevant test of neutrophil function and dysfunction in community-acquired pneumonia

Jesús Reiné, Jamie Rylance, Daniela Ferreira, Shaun Pennington, Ingeborg Dorothea Welters, Robert Parker, Ben Morton,

Abstract OBJECTIVE: To refine and validate a neutrophil function assay with clinical relevance for patients with community-acquired pneumonia (CAP). Design: Two phase cross-sectional study to standardise and refine the assay in blood from healthy volunteers and test neutrophil phagocytic function in hospital patients with CAP. Participants : Phase one: Healthy ... Read more >>

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Pneumococcal colonisation is an asymptomatic event in healthy adults using an experimental human colonisation model.

Ashleigh Trimble, Victoria Connor, Ryan E Robinson, Daniella McLenaghan, Carole A Hancock, Duolao Wang, Stephen B Gordon, Daniela M Ferreira, Angela D Wright, Andrea M Collins,

INTRODUCTION:Pneumococcal colonisation is regarded as a pre-requisite for developing pneumococcal disease. In children previous studies have reported pneumococcal colonisation to be a symptomatic event and described a relationship between symptom severity/frequency and colonisation density. The evidence for this in adults is lacking in the literature. This study uses the experimental ... Read more >>

PLoS ONE (PloS one)
[2020, 15(3):e0229558]

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Nasal Pneumococcal Density Is Associated with Microaspiration and Heightened Human Alveolar Macrophage Responsiveness to Bacterial Pathogens.

Elena Mitsi, Beatriz Carniel, Jesús Reiné, Jamie Rylance, Seher Zaidi, Alessandra Soares-Schanoski, Victoria Connor, Andrea M Collins, Andreas Schlitzer, Elissavet Nikolaou, Carla Solórzano, Sherin Pojar, Helen Hill, Angela D Hyder-Wright, Kondwani C Jambo, Marco R Oggioni, Megan De Ste Croix, Stephen B Gordon, Simon P Jochems, Daniela M Ferreira,

Rationale: Pneumococcal pneumonia remains a global health problem. Colonization of the nasopharynx with Streptococcus pneumoniae (Spn), although a prerequisite of infection, is the main source of exposure and immunological boosting in children and adults. However, our knowledge of how nasal colonization impacts on the lung cells, especially on the predominant ... Read more >>

Am. J. Respir. Crit. Care Med. (American journal of respiratory and critical care medicine)
[2020, 201(3):335-347]

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Pneumococcal colonization impairs nasal and lung mucosal immune responses to Live Attenuated Influenza Vaccination in adults

Beatriz Carniel, Fernando Marcon, Jamie Rylance, Seher Zaidi, Jesus Reine, Edessa Negera, Elissavet Nikolaou, Sherin Pojar, Carla Solorzano, Andrea Collins, Victoria Connor, Debby Bogaert, Stephen Gordon, Helder Nakaya, Daniela Ferreira, Simon Jochems, Elena Mitsi,

Influenza virus infections affect millions of people annually. Current available vaccines provide varying rates of protection. There is a knowledge gap on how the nasal microbiota, particularly established pneumococcal colonization, shapes the response to influenza vaccination. In this study, we inoculated healthy adults with live S. pneumoniae and vaccinated them ... Read more >>

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State-of-the-art in the pneumococcal field: Proceedings of the 11th International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD-11).

Brenda Anna Kwambana-Adams, E Kim Mulholland, Catherine Satzke, ,

The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) is the premier global scientific symposium dedicated to the exchange, advancement and dissemination of the latest research on the pneumococcus, one of the world's deadliest bacterial pathogens. Since the first ISPPD was held in 1998, substantial progress has been made to ... Read more >>

Pneumonia (Nathan) (Pneumonia (Nathan Qld.))
[2020, 12:2]

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Symptoms associated with influenza vaccination and experimental human pneumococcal colonisation of the nasopharynx.

Caz Hales, Simon P Jochems, Rachel Robinson, Carla Solórzano, Beatriz Carniel, Sherin Pojar, Jesús Reiné, Esther L German, Elissavet Nikolaou, Elena Mitsi, Angela D Hyder-Wright, Helen Hill, Hugh Adler, Victoria Connor, Seher Zaidi, Catherine Lowe, Xiaojing Fan, Duolao Wang, Stephen B Gordon, Jamie Rylance, Daniela M Ferreira,

BACKGROUND:Nasopharyngeal colonisation by S. pneumoniae is a prerequisite for invasive pneumococcal infections. Influenza co-infection leads to increased susceptibility to secondary pneumonia and mortality during influenza epidemics. Increased bacterial load and impaired immune responses to pneumococcus caused by influenza play a role in this increased susceptibility. Using an Experimental Human Challenge ... Read more >>

Vaccine (Vaccine)
[2020, 38(10):2298-2306]

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Antiproliferative Activities of Diimine-Based Mixed Ligand Copper(II) Complexes.

Nazanin Kordestani, Hadi Amiri Rudbari, Alexandra R Fernandes, Luís R Raposo, Pedro V Baptista, Daniela Ferreira, Giuseppe Bruno, Giovanni Bella, Rosario Scopelliti, Jason D Braun, David E Herbert, Olivier Blacque,

A series of Cu(diimine)(X-sal)(NO3) complexes, where the diimine is either 2,2'-bipyridine (bpy) or 1,10-phenanthroline (phen) and X-sal is a monoanionic halogenated salicylaldehyde (X = Cl, Br, I, or H), have been synthesized and characterized by elemental analysis and X-ray crystallography. Penta-coordinate geometries copper(II) were observed for all cases. The influence ... Read more >>

ACS Comb Sci (ACS combinatorial science)
[2020, 22(2):89-99]

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Affective responses to different prescriptions of high-intensity interval exercise in hypertensive patients.

Ozeas L Lins-Filho, Raphael M Ritti-Dias, Tony M Santos, Jessica F Silva, Giselly F Leite, Luana S Gusmão, Daniela K Ferreira,

BACKGROUND:Studies have indicated that high-intensity interval training (HIIT) promotes similar acute reductions on blood pressure (BP) when compared to continuous moderate aerobic exercise. However, it has been associated with lower affective responses to exercise. Therefore, strategies to improve affective responses to exercise are needed. The purpose of this study was ... Read more >>

J Sports Med Phys Fitness (The Journal of sports medicine and physical fitness)
[2020, 60(2):308-313]

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Decoding the Role of Satellite DNA in Genome Architecture and Plasticity-An Evolutionary and Clinical Affair.

Sandra Louzada, Mariana Lopes, Daniela Ferreira, Filomena Adega, Ana Escudeiro, Margarida Gama-Carvalho, Raquel Chaves,

Repetitive DNA is a major organizational component of eukaryotic genomes, being intrinsically related with their architecture and evolution. Tandemly repeated satellite DNAs (satDNAs) can be found clustered in specific heterochromatin-rich chromosomal regions, building vital structures like functional centromeres and also dispersed within euchromatin. Interestingly, despite their association to critical chromosomal ... Read more >>

Genes (Basel) (Genes)
[2020, 11(1):]

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New Comparative Cytogenetic Data on Three Genera of Armored Catfishes of Ancistrini (Loricariidae: Hypostominae).

Sandra Mariotto, Liano Centofante, Paulo C Venere, Daniela C Ferreira, Roberto F Artoni,

The karyotypes and other chromosomal markers of 4 catfish species, namely Lasiancistrus schomburgkii, Lasiancistrus sp., Araichthysloro, and Megalancistrus sp., members of a taxonomically complex and speciose tribe of catfishes Ancistrini, Hypostominae, were examined using conventional (Giemsa staining, Ag-NOR, and C-banding) and molecular cytogenetic protocols (FISH) and DNA barcoding. In L. ... Read more >>

Cytogenet. Genome Res. (Cytogenetic and genome research)
[2019, 159(4):208-214]

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Minimally Invasive Nasal Sampling in Children Offers Accurate Pneumococcal Colonization Detection.

Elissavet Nikolaou, Annie Blizard, Sherin Pojar, Elena Mitsi, Esther L German, Jesús Reiné, Helen Hill, Paul S McNamara, Andrea M Collins, Daniela M Ferreira, Simon P Jochems,

Nasopharyngeal colonization of potential respiratory pathogens such as Streptococcus pneumoniae is the major source of transmission and precursor of invasive disease. Swabbing deeply the nasopharynx, which is currently recommended by World Health Organization, provides accurate pneumococcal detection but is unpleasant. We showed that nasal lining fluid filter strips offer equal ... Read more >>

Pediatr. Infect. Dis. J. (The Pediatric infectious disease journal)
[2019, 38(11):1147-1149]

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Tuning the matrix metalloproteinase-1 degradability of peptide amphiphile nanofibers through supramolecular engineering.

Yejiao Shi, Daniela S Ferreira, Jayati Banerjee, Andrew R Pickford, Helena S Azevedo,

Matrix metalloproteinases (MMPs) are a family of endopeptidases capable of degrading extracellular matrix (ECM) components. They are known to play crucial roles during the ECM turnover in both physiological and pathological processes. As such, their activities are utilized as biological stimuli to engineer MMP-responsive peptide-based biomaterials such as self-assembled peptide ... Read more >>

Biomater Sci (Biomaterials science)
[2019, 7(12):5132-5142]

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Gene expression association study in feline mammary carcinomas.

Daniela Ferreira, Bárbara Martins, Maria Soares, Jorge Correia, Filomena Adega, Fernando Ferreira, Raquel Chaves,

Works on cancer-related genes expression using feline mammary carcinomas (FMCs) are scarce but crucial, not only to validate these tumours as models for human breast cancer studies but also to improve small animal practice. Here, the expression of the cancer-related genes TP53, CCND1, FUS, YBX1, PTBP1, c-MYC and PKM2 was ... Read more >>

PLoS ONE (PloS one)
[2019, 14(8):e0221776]

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DNA Barcoding Reveals High Levels of Divergence among Mitochondrial Lineages of Brycon (Characiformes, Bryconidae).

Pábila S S Arruda, Daniela C Ferreira, Claudio Oliveira, Paulo C Venere,

Brycon is an important group of Neotropical fish and the principal genus of the family Bryconidae, with 44 valid species that are found in some Central American rivers and practically all the major hydrographic basins of South America. These fish are medium to large in size, migratory, omnivorous, important seed ... Read more >>

Genes (Basel) (Genes)
[2019, 10(9):]

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Innate and adaptive nasal mucosal immune responses following experimental human pneumococcal colonization.

Simon P Jochems, Karin de Ruiter, Carla Solórzano, Astrid Voskamp, Elena Mitsi, Elissavet Nikolaou, Beatriz F Carniel, Sherin Pojar, Esther L German, Jesús Reiné, Alessandra Soares-Schanoski, Helen Hill, Rachel Robinson, Angela D Hyder-Wright, Caroline M Weight, Pascal F Durrenberger, Robert S Heyderman, Stephen B Gordon, Hermelijn H Smits, Britta C Urban, Jamie Rylance, Andrea M Collins, Mark D Wilkie, Lepa Lazarova, Samuel C Leong, Maria Yazdanbakhsh, Daniela M Ferreira,

Streptococcus pneumoniae (Spn) is a common cause of respiratory infection, but also frequently colonizes the nasopharynx in the absence of disease. We used mass cytometry to study immune cells from nasal biopsy samples collected following experimental human pneumococcal challenge in order to identify immunological mechanisms of control of Spn colonization. ... Read more >>

J. Clin. Invest. (The Journal of clinical investigation)
[2019, 130:4523-4538]

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FA-SAT ncRNA interacts with PKM2 protein: depletion of this complex induces a switch from cell proliferation to apoptosis.

Daniela Ferreira, Ana Escudeiro, Filomena Adega, Sandra I Anjo, Bruno Manadas, Raquel Chaves,

FA-SAT is a highly conserved satellite DNA sequence transcribed in many Bilateria species. To disclose the cellular and functional profile of FA-SAT non-coding RNAs, a comprehensive experimental approach, including the transcripts location in the cell and in the cell cycle, the identification of its putative protein interactors, and silencing/ectopic expression ... Read more >>

Cell. Mol. Life Sci. (Cellular and molecular life sciences : CMLS)
[2020, 77(7):1371-1386]

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Association between insulin resistance and haematological parameters: A cohort study from adolescence to adulthood.

Daniela Ferreira, Milton Severo, Joana Araújo, Henrique Barros, João T Guimarães, Elisabete Ramos,

BACKGROUND:The aim of this study was to quantify the relationship between insulin resistance and haematological parameters from adolescence to adulthood. METHODS:Participants from the EPITeen cohort were evaluated at 13, 17, and 21 years, through standardized procedures. A fasting blood sample was obtained, and insulin resistance was evaluated by the homeostatic model ... Read more >>

Diabetes Metab. Res. Rev. (Diabetes/metabolism research and reviews)
[2019, 35(8):e3194]

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Vitamin D deficiency is a potential risk factor for lipid Amphotericin B nephrotoxicity.

Daniela Ferreira, Ana Carolina de Bragança, Rildo Aparecido Volpini, Maria Heloisa Massola Shimizu, Pedro Henrique França Gois, Adriana Castello Costa Girardi, Antonio Carlos Seguro, Daniele Canale,

Invasive fungal infections (IFI) is a worldwide serious health problem and Amphotericin B (AmB) has been considered the drug of choice for IFI treatment. Despite its efficacy, clinical use of AmB has been associated with renal toxicity. Some lines of evidence have shown that an extemporaneous lipid emulsion preparation of ... Read more >>

PLoS Negl Trop Dis (PLoS neglected tropical diseases)
[2019, 13(7):e0007567]

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Microinvasion by Streptococcus pneumoniae induces epithelial innate immunity during colonisation at the human mucosal surface.

Caroline M Weight, Cristina Venturini, Sherin Pojar, Simon P Jochems, Jesús Reiné, Elissavet Nikolaou, Carla Solórzano, Mahdad Noursadeghi, Jeremy S Brown, Daniela M Ferreira, Robert S Heyderman,

Control of Streptococcus pneumoniae colonisation at human mucosal surfaces is critical to reducing the burden of pneumonia and invasive pneumococcal disease, interrupting transmission, and achieving herd protection. Here, we use an experimental human pneumococcal carriage model (EHPC) to show that S. pneumoniae colonisation is associated with epithelial surface adherence, micro-colony ... Read more >>

Nat Commun (Nature communications)
[2019, 10(1):3060]

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