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Author Daniel Q Huang

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Cost-effectiveness of HCC surveillance among HCV patients after sustained virological response with direct-acting antivirals.

Daniel Q Huang, Mindie H Nguyen,

Liver Int (Liver international : official journal of the International Association for the Study of the Liver)
[2021, :]

Cited: 0 times

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Letter: hepatocellular carcinoma risk in patients with non-selective beta blockers.

Daniel Q Huang, Mindie H Nguyen,

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2021, 54(8):1093-1094]

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Substantial gaps in evaluation and treatment of patients with hepatitis B in the US.

Qing Ye, Leslie Y Kam, Yee Hui Yeo, Nolan Dang, Daniel Q Huang, Ramsey Cheung, Mindie H Nguyen,

<h4>Background & aims</h4>The occurrence of HBV-associated liver complications is reduced by antiviral therapy. However, prior studies using local institutional cohorts have suggested that evaluation and treatment are suboptimal. We aimed to determine the proportion of patients with chronic HBV infection who received adequate evaluation, were treatment eligible, and received antiviral ... Read more >>

J Hepatol (Journal of hepatology)
[2021, :]

Cited: 0 times

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Letter to the Editor: Hepatocellular Carcinoma Surveillance in Cirrhosis Patients: Is the Real-World Situation Even Worse Than Reported?

Daniel Q Huang, Yee Hui Yeo, Mindie H Nguyen,

Hepatology (Hepatology (Baltimore, Md.))
[2021, 74(3):1714-1715]

Cited: 0 times

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A network meta-analysis of direct oral anticoagulants for portal vein thrombosis in cirrhosis.

Cheng Han Ng, Darren Jun Hao Tan, Kameswara Rishi Yeshayahu Nistala, Nicholas Syn, Jieling Xiao, Eunice Xiang Xuan Tan, Felicia Zuying Woo, Nicholas W S Chew, Daniel Q Huang, Yock Young Dan, Arun J Sanyal, Mark D Muthiah,

<h4>Background</h4>Current guidelines have limited consensus on the approach to portal venous thrombosis (PVT) in cirrhotic patients. While there is rising interest in direct oral anticoagulants (DOACs) use for PVT, current evidence is limited by small sample size and lack of comparisons to traditional anticoagulants. Thus, a network meta-analysis was conducted ... Read more >>

Hepatol Int (Hepatology international)
[2021, 15(5):1196-1206]

Cited: 0 times

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Effect of cell microenvironment on the drug sensitivity of hepatocellular cancer cells.

Bhaskar Bhattacharya, Daniel Q Huang, Sarah Hong Hui Low, Gim Hwa Tan, Min Ji Han, Sanamerjit Singh, Benny Tang, Sheng Chun Chang, Joey Sze Yun Lim, Mohd Feroz Mohd Omar, Yock Young Dan, Richie Soong,

The native hepatocellular cancer (HCC) microenvironment is characterized by more hypoxic, hypoglycemic, and acidic conditions than those used in standard cell culture. This study aimed to investigate whether HCC cells cultured in more native conditions have an altered phenotype and drug sensitivity compared to those cultured in standard conditions. Six ... Read more >>

Oncotarget (Oncotarget)
[2021, 12(7):674-685]

Cited: 1 time

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Treatment and Renal Outcomes Up to 96 Weeks After Tenofovir Alafenamide Switch From Tenofovir Disoproxil Fumarate in Routine Practice.

Hidenori Toyoda, Jennifer Leong, Charles Landis, Masanori Atsukawa, Tsunamasa Watanabe, Daniel Q Huang, Joanne Liu, Sabrina Xin Zi Quek, Toru Ishikawa, Taeang Arai, Keisuke Yokohama, Makoto Chuma, Koichi Takaguchi, Haruki Uojima, Tomonori Senoo, Hansen Dang, Mayumi Maeda, Joseph Hoang, Richard H Le, Satoshi Yasuda, Khin N Thin, Sally Tran, Nicholas Chien, Linda Henry, Akira Asai, Shinya Fukunishi, Ramsey Cheung, Seng Gee Lim, Huy N Trinh, Mindie H Nguyen,

<h4>Background and aims</h4>Real-world data for treatment effectiveness and renal outcomes in chronic hepatitis B (CHB) patients who were switched to the new and safer prodrug tenofovir alafenamide (TAF) from tenofovir disoproxil fumarate (TDF) are limited. Therefore, we aimed to evaluate treatment and renal outcomes of this population.<h4>Approach and results</h4>We analyzed ... Read more >>

Hepatology (Hepatology (Baltimore, Md.))
[2021, 74(2):656-666]

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Novel albumin, bilirubin and platelet criteria for the exclusion of high-risk varices in compensated advanced chronic liver disease: A validation study.

Yu Jun Wong, Guan Sen Kew, Poh Seng Tan, Zhaojin Chen, Martin Putera, Wenjun Alexander Yip, Tiing Leong Ang, Kwong Ming Fock, Guan Huei Lee, John Hsiang, Daniel Q Huang, Andrew Kwek, Mark D Muthiah, Rahul Kumar, Malcolm Tan, Jessica Tan, Prem Harichander Thurairajah, Eng Kiong Teo, Bee Choo Tai, Seng Gee Lim,

<h4>Background and aims</h4>Availability of transient elastography (TE) limits the application of Baveno-VI criteria. In a derivation study, the ABP criteria (Albumin >40 g/l, Bilirubin <22 μmol/l and Platelet >114,000/μl) had been shown to perform well in identifying compensated advanced chronic liver disease (cACLD) patients without high-risk varices (HRV). We aim to externally ... Read more >>

Clin Res Hepatol Gastroenterol (Clinics and research in hepatology and gastroenterology)
[2021, 45(6):101598]

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Neutrophil-to-Lymphocyte Ratio Predicts Development of Immune-Related Adverse Events and Outcomes from Immune Checkpoint Blockade: A Case-Control Study.

Pei Yi Lee, Kellynn Qi Xuan Oen, Grace Rui Si Lim, Juanda Leo Hartono, Mark Muthiah, Daniel Q Huang, Felicia Su Wei Teo, Andrew Yunkai Li, Anselm Mak, Nisha Suyien Chandran, Chris Lixian Tan, Peiling Yang, E Shyong Tai, Kay Wei Ping Ng, Joy Vijayan, Yee Cheun Chan, Li Ling Tan, Martin Beng-Huat Lee, Horng Ruey Chua, Wei Zhen Hong, Eng Soo Yap, Dawn K Lim, Yew Sen Yuen, Yiong Huak Chan, Folefac Aminkeng, Alvin Seng Cheong Wong, Yiqing Huang, Sen Hee Tay,

The utility of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) utility in predicting immune-related adverse events (irAEs) and survival have not been well studied in the context of treatment with immune checkpoint inhibitors (ICIs). We performed a case-control study of cancer patients who received at least one dose of ICI ... Read more >>

Cancers (Basel) (Cancers)
[2021, 13(6):]

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Treatment eligibility in hepatitis B: a call for better linkage to optimal care.

Daniel Q Huang, Mindie H Nguyen,

Lancet Gastroenterol Hepatol (The lancet. Gastroenterology & hepatology)
[2021, 6(3):160]

Cited: 0 times

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Natural History and Hepatocellular Carcinoma Risk in Untreated Chronic Hepatitis B Patients With Indeterminate Phase.

Daniel Q Huang, Xiaohe Li, Michael H Le, An K Le, Yee Hui Yeo, Huy N Trinh, Jian Zhang, Jiayi Li, Christopher Wong, Clifford Wong, Ramsey C Cheung, Hwai-I Yang, Mindie H Nguyen,

<h4>Background & aims</h4>Many patients with chronic hepatitis B (CHB) may not conform to any of the defined phases and hence are classified as indeterminate. We aimed to characterize the baseline prevalence of indeterminate patients and their natural history, phase transition, and hepatocellular carcinoma (HCC) risk.<h4>Methods</h4>This was a retrospective cohort study ... Read more >>

Clin Gastroenterol Hepatol (Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association)
[2021, :]

Cited: 0 times

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Defining Age-Related Thresholds for ALT and the Risk of Confounders.

Daniel Q Huang, Mindie H Nguyen,

Clin Gastroenterol Hepatol (Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association)
[2021, :]

Cited: 0 times

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Global epidemiology of NAFLD-related HCC: trends, predictions, risk factors and prevention.

Daniel Q Huang, Hashem B El-Serag, Rohit Loomba,

One quarter of the global population is estimated to have nonalcoholic fatty liver disease (NAFLD). The incidence of nonalcoholic steatohepatitis (NASH) is projected to increase by up to 56% in the next 10 years. NAFLD is already the fastest growing cause of hepatocellular carcinoma (HCC) in the USA, France and ... Read more >>

Nat Rev Gastroenterol Hepatol (Nature reviews. Gastroenterology & hepatology)
[2021, 18(4):223-238]

Cited: 18 times

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Extraction of intra-biliary hepatocellular carcinoma by endoscopic retrograde cholangiopancreatography.

Chieh Sian Koo, Khek Yu Ho, Yin Huei Pang, Daniel Q Huang,

<h4>Background</h4>Hepatocellular carcinoma with biliary ductal invasion is rare and associated with a significantly lower survival rate.<h4>Case presentation</h4>We present an unusual case of a patient with hepatocellular carcinoma and biliary invasion, who had his diagnosis confirmed by histological analysis from tissue extracted by endoscopic retrograde cholangiopancreatography. An 87-year-old male presented with ... Read more >>

BMC Gastroenterol (BMC gastroenterology)
[2020, 20(1):408]

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Effects of Cirrhosis and Diagnosis Scenario in Metabolic-Associated Fatty Liver Disease-Related Hepatocellular Carcinoma.

Vincent L Chen, Ming-Lun Yeh, Ju Dong Yang, Jennifer Leong, Daniel Q Huang, Hidenori Toyoda, Yao-Li Chen, Jennifer Guy, Mayumi Maeda, Pei-Chien Tsai, Chung-Feng Huang, Satoshi Yasuda, An K Le, Hansen Dang, Nasra H Giama, Hamdi A Ali, Ning Zhang, Xiaozhong Wang, Dae Won Jun, Cheng-Hao Tseng, Yao-Chun Hsu, Jee-Fu Huang, Chia-Yen Dai, Wan-Long Chuang, Qiang Zhu, Yock Young Dan, Myron Schwartz, Lewis R Roberts, Ming-Lung Yu, Mindie H Nguyen,

Metabolic-associated fatty liver disease (MAFLD) is a major cause of liver-related complications, including hepatocellular carcinoma (HCC). While MAFLD-related HCC is known to occur in the absence of cirrhosis, our understanding of MAFLD-related HCC in this setting is limited. Here, we characterize MAFLD-related HCC and the impact of cirrhosis and screening ... Read more >>

Hepatol Commun (Hepatology communications)
[2021, 5(1):122-132]

Cited: 0 times

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Epidemiology of COVID-19: A systematic review and meta-analysis of clinical characteristics, risk factors, and outcomes.

Jie Li, Daniel Q Huang, Biyao Zou, Hongli Yang, Wan Zi Hui, Fajuan Rui, Natasha Tang Sook Yee, Chuanli Liu, Sanjna Nilesh Nerurkar, Justin Chua Ying Kai, Margaret Li Peng Teng, Xiaohe Li, Hua Zeng, John A Borghi, Linda Henry, Ramsey Cheung, Mindie H Nguyen,

Coronavirus disease 2019 (COVID-19) has become a pandemic, but its reported characteristics and outcomes vary greatly amongst studies. We determined pooled estimates for clinical characteristics and outcomes in COVID-19 patients including subgroups by disease severity (based on World Health Organization Interim Guidance Report or Infectious Disease Society of America/American Thoracic ... Read more >>

J Med Virol (Journal of medical virology)
[2021, 93(3):1449-1458]

Cited: 64 times

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Radiofrequency ablation versus repeat resection for recurrent hepatocellular carcinoma (≤ 5 cm) after initial curative resection.

Yuemin Feng, Hao Wu, Daniel Q Huang, Chenghui Xu, Hang Zheng, Mayumi Maeda, Xinya Zhao, Le Wang, Feng Xiao, Huanran Lv, Tiantian Liu, Jianni Qi, Jie Li, Ning Zhong, Chuanxi Wang, Hong Feng, Bo Liang, Wanhua Ren, Chengyong Qin, Mindie H Nguyen, Qiang Zhu,

<h4>Objectives</h4>Recurrence rate is up to 70% at 5 years for hepatocellular carcinoma (HCC) after initial resection, but the management of recurrent HCC remains unclear. To compare the efficacy and safety of radiofrequency ablation (RFA) and repeat resection as the first-line treatment in recurrent HCC.<h4>Methods</h4>This multicenter retrospective study analyzed 290 patients ... Read more >>

Eur Radiol (European radiology)
[2020, 30(11):6357-6368]

Cited: 3 times

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Global prevalence, incidence, and outcomes of non-obese or lean non-alcoholic fatty liver disease: a systematic review and meta-analysis.

Qing Ye, Biyao Zou, Yee Hui Yeo, Jie Li, Daniel Q Huang, Yuankai Wu, Hongli Yang, Chuanli Liu, Leslie Y Kam, Xiang Xuan Eunice Tan, Nicholas Chien, Sam Trinh, Linda Henry, Christopher Donald Stave, Tetsuya Hosaka, Ramsey C Cheung, Mindie H Nguyen,

BACKGROUND:Although non-alcoholic fatty liver disease (NAFLD) is commonly associated with obesity, it is increasingly being identified in non-obese individuals. We aimed to characterise the prevalence, incidence, and long-term outcomes of non-obese or lean NAFLD at a global level. METHODS:For this systematic review and meta-analysis, we searched PubMed, Embase, Scopus, and ... Read more >>

Lancet Gastroenterol Hepatol (The lancet. Gastroenterology & hepatology)
[2020, 5(8):739-752]

Cited: 36 times

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Hepatitis B: Who to treat? A critical review of international guidelines.

Daniel Q Huang, Seng Gee Lim,

Chronic hepatitis B remains a global problem, affecting more than 250 million individuals worldwide. Around one-fifth of infected individuals develop advanced fibrosis or hepatocellular carcinoma (HCC). The World Health Organization (WHO) guidelines as well as the 2016 American Association for the Study of Liver Diseases (AASLD) guidelines are based on ... Read more >>

Liver Int (Liver international : official journal of the International Association for the Study of the Liver)
[2020, 40 Suppl 1:5-14]

Cited: 2 times

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A Brilliant Blue Liver.

Shirley H Bong, Gwyneth S Soon, Daniel Q Huang,

Clin Gastroenterol Hepatol (Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association)
[2021, 19(5):e47]

Cited: 0 times

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Nucleoside analog monotherapy for prophylaxis in Hepatitis B liver transplant patients is safe and efficacious.

Mark D Muthiah, En Ying Tan, Sin Hui Melissa Chua, Daniel Q Y Huang, Glenn K Bonney, Alfred W C Kow, Seng Gee Lim, Yock Young Dan, Poh Seng Tan, Guan Huei Lee, Boon Leng Lim,

BACKGROUND:Combination therapy with HBIG and NAs has reduced HBV recurrence post LT. Despite its efficacy, costs of HBIG remain prohibitive. With high-potency NAs, HBIG's use has been questioned. We aim to evaluate the efficacy and safety of HBIG-free regimens in patients transplanted for HBV-related liver disease. METHODS:A review of LT ... Read more >>

Hepatol Int (Hepatology international)
[2020, 14(1):57-69]

Cited: 2 times

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A murine model demonstrating reversal of structural and functional correlates of cirrhosis with progenitor cell transplantation.

Mark D Muthiah, Daniel Q Huang, Lei Zhou, Nur Halisah Jumat, Mahesh Choolani, Jerry Kok Yen Chan, Aileen Wee, Seng Gee Lim, Yock-Young Dan,

Development of cell transplantation for treating liver cirrhosis hinges critically on the availability of animal models for studying human stem cell transplantation. We report an immune-permissive murine model of liver cirrhosis with full clinical correlates of decompensated liver disease, and allows testing efficacy of stem cell transplantation. Liver cirrhosis was ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):15446]

Cited: 2 times

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