Full Text Journal Articles by
Author Daniel Matemo

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Urine Biomarker Assessment of Infant Adherence to Isoniazid Prophylaxis.

Sylvia M LaCourse, Daniel Leon, Nuttada Panpradist, Barbra A Richardson, Elizabeth Maleche-Obimbo, Jerphason Mecha, Daniel Matemo, Jaclyn N Escudero, John Kinuthia, Barry Lutz, Grace John-Stewart,

We assessed adherence in an infant tuberculosis prevention trial in Kenya with a urine isoniazid metabolite-detecting dipstick. Ninety-seven infants had 155 assays performed; 77 (49.7%) were found to be positive despite caregiver-reported adherence. Positive assays were associated with maternal secondary education, HIV suppression and no reported missed doses in past ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2021, 40(1):e43-e45]

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Recent Diagnosis, Lower Rates of HIV Disclosure, and High Technology Access in Pregnant Adolescent Girls and Young Women Living With HIV: A Descriptive Study.

Wenwen Jiang, Lusi Osborn, Alison L Drake, Jennifer A Unger, Daniel Matemo, John Kinuthia, Grace John-Stewart, Keshet Ronen,

J Assoc Nurses AIDS Care (The Journal of the Association of Nurses in AIDS Care : JANAC)
[2020, :]

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Elevation of cervical C-X-C motif chemokine ligand 10 levels is associated with HIV-1 acquisition in pregnant and postpartum women.

Michelle C Sabo, Dara A Lehman, Jillian C Pintye, Bingjie Wang, Alison L Drake, John Kinuthia, Lusi Osborn, Daniel Matemo, Barbra A Richardson, Julie Overbaugh, Grace John-Stewart, Susan M Graham,

<h4>Objective</h4>To evaluate the relationship between cervical cytokine/chemokine concentrations and HIV-1 acquisition in peripartum Kenyan women.<h4>Design</h4>Nested case-control study.<h4>Methods</h4>Women participating in a prospective study of peripartum HIV acquisition in Kenya (the Mama Salama Study), were tested for HIV-1 at 1-3 month intervals during pregnancy and through 9 months postpartum. Cases positive for ... Read more >>

AIDS (AIDS (London, England))
[2020, 34(12):1725-1733]

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An Interactive Text Messaging Intervention to Improve Adherence to Option B+ Prevention of Mother-to-Child HIV Transmission in Kenya: Cost Analysis.

Yilin Chen, Keshet Ronen, Daniel Matemo, Jennifer A Unger, John Kinuthia, Grace John-Stewart, Carol Levin,

<h4>Background</h4>Mobile health (mHealth) approaches offer potentially affordable ways to support the care of HIV-infected patients in overstretched health care systems. However, only few studies have analyzed the costs associated with mHealth solutions for HIV care.<h4>Objective</h4>The aim of this study was to estimate the total incremental costs and incremental cost per ... Read more >>

JMIR Mhealth Uhealth (JMIR mHealth and uHealth)
[2020, 8(10):e18351]

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Brief Report: High Programmatic Isoniazid Preventive Therapy (IPT) Use in Pregnancy Among HIV-Infected Women.

Sylvia M LaCourse, Anjuli D Wagner, Lisa M Cranmer, Audrey Copeland, Elizabeth Maleche-Obimbo, Barbra A Richardson, Daniel Matemo, John Kinuthia, Grace John-Stewart,

<h4>Background</h4>The World Health Organization recommends isoniazid preventive therapy (IPT) for people living with HIV (PLHIV) to prevent tuberculosis (TB), including pregnant women. Recent trial results suggest increased adverse pregnancy outcomes associated with IPT during pregnancy. Data are limited regarding programmatic IPT use in pregnant PLHIV.<h4>Methods</h4>We assessed previous programmatic IPT during ... Read more >>

J Acquir Immune Defic Syndr (Journal of acquired immune deficiency syndromes (1999))
[2019, 82(1):41-45]

Cited: 2 times

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A randomized controlled trial of isoniazid to prevent Mycobacterium tuberculosis infection in Kenyan HIV-exposed uninfected infants.

Sylvia M LaCourse, Barbra A Richardson, John Kinuthia, A J Warr, Elizabeth Maleche-Obimbo, Daniel Matemo, Lisa M Cranmer, Jerphason Mecha, Jaclyn N Escudero, Thomas R Hawn, Grace John-Stewart,

<h4>Background</h4>HIV-exposed uninfected (HEU) infants in endemic settings are at high risk of tuberculosis (TB). For infants, progression from primary M. tuberculosis infection to TB disease can be rapid. We assessed whether isoniazid (INH) prevents primary Mtb infection.<h4>Methods</h4>We conducted a randomized non-blinded controlled trial enrolling HEU infants 6 weeks of age ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2020, :]

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Influenza-Induced Interferon Lambda Response Is Associated With Longer Time to Delivery Among Pregnant Kenyan Women.

Christof Seiler, Nicholas L Bayless, Rosemary Vergara, Jillian Pintye, John Kinuthia, Lusi Osborn, Daniel Matemo, Barbra A Richardson, Grace John-Stewart, Susan Holmes, Catherine A Blish,

Specific causes of preterm birth remain unclear. Several recent studies have suggested that immune changes during pregnancy are associated with the timing of delivery, yet few studies have been performed in low-income country settings where the rates of preterm birth are the highest. We conducted a retrospective nested case-control evaluation ... Read more >>

Front Immunol (Frontiers in immunology)
[2020, 11:452]

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Infant TB Infection Prevention Study (iTIPS): a randomised trial protocol evaluating isoniazid to prevent M. tuberculosis infection in HIV-exposed uninfected children.

Sylvia M LaCourse, Barbra A Richardson, John Kinuthia, A J Warr, Elizabeth Maleche-Obimbo, Daniel Matemo, Lisa M Cranmer, Jaclyn N Escudero, Thomas R Hawn, Grace C John-Stewart,

INTRODUCTION:HIV-exposed uninfected (HEU) infants in tuberculosis (TB) endemic settings are at high risk of Mycobacterium tuberculosis (Mtb) infection and TB disease, even in the absence of known Mtb exposure. Because infancy is a time of rapid progression from primary infection to active TB disease, it is important to define when ... Read more >>

BMJ Open (BMJ open)
[2020, 10(1):e034308]

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Utilizing perspectives from HIV-infected women, male partners and healthcare providers to design family planning SMS in Kenya: a qualitative study.

Karren Lewis, Elizabeth K Harrington, Daniel Matemo, Alison L Drake, Keshet Ronen, Gabrielle O'Malley, John Kinuthia, Grace John-Stewart, Jennifer A Unger,

BACKGROUND:Short message service (SMS) presents an opportunity to expand the reach of care and improve reproductive health outcomes. SMS could increase family planning (FP) use through education, support and demand generation. The purpose of this analysis is to determine the perspectives of potential FP users to inform design of SMS. ... Read more >>

BMC Health Serv Res (BMC health services research)
[2019, 19(1):870]

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1344. Interferon Gamma Release Assay (IGRA) Responses in HIV-Infected and -Uninfected Women in Pregnancy.

Samantha Kaplan, Daniel Matemo, Jerphason O Mecha, John Kinuthia, Grace John-Stewart, Sylvia LaCourse,

AbstractBackgroundPregnancy and HIV-associated immunologic changes may affect latent TB infection (LTBI) interferon-gamma release assay (IGRA) QuantiFERON TB Gold Plus (QFT-Plus) diagnostic performance.MethodsIn this ongoing study, HIV-infected and -uninfected women 20–34 weeks gestation without TB in the past year are enrolled from antenatal clinics in western Kenya and tested with QFT-Plus. ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2019, 6(Suppl 2):S486-S487]

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Acceptability, feasibility and utility of a Mobile health family planning decision aid for postpartum women in Kenya.

Rubee Dev, Nancy F Woods, Jennifer A Unger, John Kinuthia, Daniel Matemo, Shiza Farid, Emily R Begnel, Pamela Kohler, Alison L Drake,

<h4>Background</h4>Unmet need for contraception is high during the postpartum period, increasing the risk of unintended subsequent pregnancy. We developed a client facing mobile phone-based family planning (FP) decision aid and assessed acceptability, feasibility, and utility of the tool among health care providers and postpartum women.<h4>Methods</h4>Semi-structured in-depth interviews (IDIs) were conducted ... Read more >>

Reprod Health (Reproductive health)
[2019, 16(1):97]

Cited: 1 time

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Associations between vaginal bacteria implicated in HIV acquisition risk and proinflammatory cytokines and chemokines.

Michelle C Sabo, Dara A Lehman, Bingjie Wang, Barbra A Richardson, Sujatha Srinivasan, Lusi Osborn, Daniel Matemo, John Kinuthia, Tina L Fiedler, Matthew M Munch, Alison L Drake, David N Fredricks, Julie Overbaugh, Grace John-Stewart, R Scott McClelland, Susan M Graham,

<h4>Objectives</h4>Recent studies have identified vaginal bacterial taxa associated with increased HIV risk. A possible mechanism to explain these results is that individual taxa differentially promote cervicovaginal inflammation. This study aimed to explore relationships between concentrations of bacteria previously linked to HIV acquisition and vaginal concentrations of proinflammatory cytokines and chemokines.<h4>Methods</h4>In ... Read more >>

Sex Transm Infect (Sexually transmitted infections)
[2020, 96(1):3-9]

Cited: 1 time

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An mHealth SMS intervention on Postpartum Contraceptive Use Among Women and Couples in Kenya: A Randomized Controlled Trial.

Elizabeth K Harrington, Alison L Drake, Daniel Matemo, Keshet Ronen, Alfred O Osoti, Grace John-Stewart, John Kinuthia, Jennifer A Unger,

<i>Objectives.</i> To assess the effect of 2-way short message service (SMS) with a nurse on postpartum contraceptive use among individual women and couples. <i>Methods.</i> From 2016 to 2017, we conducted a randomized controlled trial at 2 public hospitals in western Kenya. We assigned eligible pregnant women to receive 2-way SMS ... Read more >>

Am J Public Health (American journal of public health)
[2019, 109(6):934-941]

Cited: 2 times

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Engaging men in an mHealth approach to support postpartum family planning among couples in Kenya: a qualitative study.

Elizabeth K Harrington, Erin E McCoy, Alison L Drake, Daniel Matemo, Grace John-Stewart, John Kinuthia, Jennifer A Unger,

<h4>Background</h4>Involving male partners in family planning (FP) education and counseling may improve FP utilization and help meet couples' reproductive health needs in the postpartum period. We aimed to explore Kenyan men's and women's perspectives on an interactive short message service (SMS) approach to support postpartum FP decision-making, and inform intervention ... Read more >>

Reprod Health (Reproductive health)
[2019, 16(1):17]

Cited: 3 times

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Sexually transmitted infections during pregnancy and subsequent risk of stillbirth and infant mortality in Kenya: a prospective study.

Alex J Warr, Jillian Pintye, John Kinuthia, Alison L Drake, Jennifer A Unger, R Scott McClelland, Daniel Matemo, Lusi Osborn, Grace John-Stewart,

<h4>Objectives</h4>We evaluated the relationship of sexually transmitted infections (STIs) and genital infections during pregnancy and subsequent risk for infant mortality and stillbirth.<h4>Methods</h4>This was a nested longitudinal analysis using data from a study of peripartum HIV acquisition in Kenya. In the parent study, HIV-uninfected women were enrolled during pregnancy and followed ... Read more >>

Sex Transm Infect (Sexually transmitted infections)
[2019, 95(1):60-66]

Cited: 2 times

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You Will Know That Despite Being HIV Positive You Are Not Alone: Qualitative Study to Inform Content of a Text Messaging Intervention to Improve Prevention of Mother-to-Child HIV Transmission.

Jade Fairbanks, Kristin Beima-Sofie, Pamela Akinyi, Daniel Matemo, Jennifer A Unger, John Kinuthia, Gabrielle O'Malley, Alison L Drake, Grace John-Stewart, Keshet Ronen,

<h4>Background</h4>Prevention of mother-to-child HIV transmission (PMTCT) relies on long-term adherence to antiretroviral therapy (ART). Mobile health approaches, such as text messaging (short message service, SMS), may improve adherence in some clinical contexts, but it is unclear what SMS content is desired to improve PMTCT-ART adherence.<h4>Objective</h4>We aimed to explore the SMS ... Read more >>

JMIR Mhealth Uhealth (JMIR mHealth and uHealth)
[2018, 6(7):e10671]

Cited: 3 times

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HIV-Uninfected Kenyan Adolescent and Young Women Share Perspectives on Using Pre-Exposure Prophylaxis During Pregnancy.

Jillian Pintye, Kristin M Beima-Sofie, Pamela A Makabong'O, Anne Njoroge, Susan Brown Trinidad, Renee A Heffron, Jared M Baeten, Connie Celum, Daniel Matemo, John Kinuthia, Maureen C Kelley, Grace C John-Stewart,

To optimize scale-up of pre-exposure prophylaxis (PrEP) for pregnant women at risk of HIV in high HIV burden settings, implementation strategies must be developed that account for perceptions of PrEP in this unique population. Semistructured focus group discussions were conducted with 68 HIV-uninfected Kenyan pregnant and postpartum women without prior ... Read more >>

AIDS Patient Care STDS (AIDS patient care and STDs)
[2018, 32(12):538-544]

Cited: 11 times

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Motherhood increases support for family planning among Kenyan adolescents.

Julia Velonjara, Bonnie Crouthamel, Gabrielle O'Malley, Mona Wiggins, Daniel Matemo, Grace John-Stewart, Jennifer A Unger, John Kinuthia, Alison L Drake,

OBJECTIVE:Adolescent fertility rates are high in Kenya, and increase the risks of unintended repeat pregnancies and maternal and infant morbidity and mortality. Our objective was to examine knowledge, practices, and influences surrounding contraceptive access and use among Kenyan postpartum adolescents. STUDY DESIGN:We conducted a mixed methods study (surveys and focus ... Read more >>

Sex Reprod Healthc (Sexual & reproductive healthcare : official journal of the Swedish Association of Midwives)
[2018, 16:124-131]

Cited: 2 times

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SMS messaging to improve ART adherence: perspectives of pregnant HIV-infected women in Kenya on HIV-related message content.

Keshet Ronen, Jennifer A Unger, Alison L Drake, Trevor Perrier, Pamela Akinyi, Lusi Osborn, Daniel Matemo, Gabrielle O'Malley, John Kinuthia, Grace John-Stewart,

There is growing evidence that mobile health (mHealth) approaches including short messaging service (SMS) can improve antiretroviral therapy (ART) adherence, but consensus is lacking regarding communication of HIV-related information. Most interventions to date have delivered SMS that do not overtly refer to HIV or ART in order to avoid risk ... Read more >>

AIDS Care (AIDS care)
[2018, 30(4):500-505]

Cited: 12 times

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HIV acquisition during pregnancy and postpartum is associated with genital infections and partnership characteristics.

John Kinuthia, Alison L Drake, Daniel Matemo, Barbra A Richardson, Clement Zeh, Lusi Osborn, Julie Overbaugh, R Scott McClelland, Grace John-Stewart,

<h4>Objective</h4>The objective of this study is to determine the risk and cofactors for HIV acquisition during pregnancy and postpartum.<h4>Design</h4>A prospective cohort study<h4>Methods</h4>: Pregnant women in western Kenya were enrolled if HIV seronegative at that visit or within 3 months. Serial HIV nucleic acid amplification tests (NAATs) were conducted at 1 ... Read more >>

AIDS (AIDS (London, England))
[2015, 29(15):2025-2033]

Cited: 34 times

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Establishment of reference intervals during normal pregnancy through six months postpartum in western Kenya.

Collins Odhiambo, Collins Odhiambo, Paul Omolo, Boaz Oyaro, John Williamson, John Kinuthia, Daniel Matemo, Alison Drake, Grace John-Stewart, Clement Zeh,

<h4>Background</h4>Pregnancy is associated with changes in hematological and biochemistry values, yet there are no African reference intervals for clinical management of pregnant women. We sought to 1) develop laboratory reference intervals during pregnancy and up to 24 weeks postpartum and 2) determine the proportion of women in a previous clinical ... Read more >>

PLoS One (PloS one)
[2017, 12(4):e0175546]

Cited: 0 times

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Sexual Behavior and Vaginal Practices During Pregnancy and Postpartum: Implications for HIV Prevention Strategies.

John Kinuthia, Barbra A Richardson, Alison L Drake, Daniel Matemo, Jennifer A Unger, Raymond S McClelland, Grace John-Stewart,

<h4>Background</h4>Understanding sexual behaviors and vaginal practices of pregnant and breastfeeding women in sub-Saharan Africa is critical to inform HIV prevention strategies during these periods.<h4>Methods</h4>HIV-uninfected women presenting for antenatal care in western Kenya were enrolled and followed through 36 weeks postpartum. Sexual behavior and vaginal practices were ascertained by structured questionnaires. ... Read more >>

J Acquir Immune Defic Syndr (Journal of acquired immune deficiency syndromes (1999))
[2017, 74(2):142-149]

Cited: 11 times

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Evaluation of mHealth strategies to optimize adherence and efficacy of Option B+ prevention of mother-to-child HIV transmission: Rationale, design and methods of a 3-armed randomized controlled trial.

Alison L Drake, Jennifer A Unger, Keshet Ronen, Daniel Matemo, Trevor Perrier, Brian DeRenzi, Barbra A Richardson, John Kinuthia, Grace John-Stewart,

<h4>Background</h4>Lifelong antiretroviral therapy (ART) (Option B+) is recommended for all HIV-infected pregnant/postpartum women, but high adherence is required to maximize HIV prevention potential and maintain maternal health. Mobile health (mHealth) interventions may provide treatment adherence support for women during, and beyond, the pregnancy and postpartum periods.<h4>Methods and design</h4>We are conducting ... Read more >>

Contemp Clin Trials (Contemporary clinical trials)
[2017, 57:44-50]

Cited: 11 times

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Effect of Pregnancy on Interferon Gamma Release Assay and Tuberculin Skin Test Detection of Latent TB Infection Among HIV-Infected Women in a High Burden Setting.

Sylvia M LaCourse, Lisa M Cranmer, Daniel Matemo, John Kinuthia, Barbra A Richardson, David J Horne, Grace John-Stewart,

<h4>Background</h4>Peripartum immunologic changes may affect latent tuberculosis infection (LTBI) diagnostic performance among HIV-infected women.<h4>Methods</h4>HIV-infected women were serially tested with tuberculin skin test (TST) and interferon gamma release assay [QuantiFERON TB Gold In-tube (QFT)] in pregnancy and 6 weeks postpartum in Kenya. Prevalence, sensitivity and agreement, and correlates of QFT/TST positivity ... Read more >>

J Acquir Immune Defic Syndr (Journal of acquired immune deficiency syndromes (1999))
[2017, 75(1):128-136]

Cited: 3 times

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A Risk Assessment Tool for Identifying Pregnant and Postpartum Women Who May Benefit From Preexposure Prophylaxis.

Jillian Pintye, Alison L Drake, John Kinuthia, Jennifer A Unger, Daniel Matemo, Renee A Heffron, Ruanne V Barnabas, Pamela Kohler, R Scott McClelland, Grace John-Stewart,

<h4>Background</h4>A human immunodeficiency virus (HIV) risk assessment tool for pregnant women could identify women who would most benefit from preexposure prophylaxis (PrEP) while minimizing unnecessary PrEP exposure.<h4>Methods</h4>Data from a prospective study of incident HIV among pregnant/postpartum women in Kenya were randomly divided into derivation (n = 654) and validation (n ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2017, 64(6):751-758]

Cited: 18 times

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