Full Text Journal Articles by
Author Daniel B Kim Shapiro

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A randomized controlled trial of nitrate supplementation in well-trained middle and older-aged adults.

Michael J Berry, Gary D Miller, Daniel B Kim-Shapiro, Macie S Fletcher, Caleb G Jones, Zachary D Gauthier, Summer L Collins, Swati Basu, Timothy M Heinrich,

PURPOSE:Nitrate (NO3-), through its conversion to nitrite (NO2-) and nitric oxide, has been shown to increase exercise tolerance in healthy younger adults and older diseased patients. Nitrate's effect in well-trained middle to older-aged adults has not been studied. Therefore, the purpose of this investigation was to examine the effects of ... Read more >>

PLoS ONE (PloS one)
[2020, 15(6):e0235047]

Cited: 0 times

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Carbonic anhydrase II does not regulate nitrite-dependent nitric oxide formation and vasodilation.

Ling Wang, Courtney E Sparacino-Watkins, Jun Wang, Nadeem Wajih, Paul Varano, Qinzi Xu, Eric Cecco, Jesús Tejero, Manoocher Soleimani, Daniel B Kim-Shapiro, Mark T Gladwin,

BACKGROUND AND PURPOSE:Although it has been reported that bovine carbonic anhydrase CAII is capable of generating NO from nitrite, the function and mechanism of CAII in nitrite-dependent NO formation and vascular responses remain controversial. We tested the hypothesis that CAII catalyses NO formation from nitrite and contributes to nitrite-dependent inhibition ... Read more >>

Br. J. Pharmacol. (British journal of pharmacology)
[2020, 177(4):898-911]

Cited: 0 times

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Response by Lundberg et al to Letter Regarding Article, "Hemoglobin β93 Cysteine Is Not Required for Export of Nitric Oxide Bioactivity From the Red Blood Cell".

Jon O Lundberg, Pedro Cabrales, Amy G Tsai, Rakesh P Patel, Daniel B Kim-Shapiro,

Circulation (Circulation)
[2019, 140(19):e760-e761]

Cited: 0 times

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Haptoglobin therapy has differential effects depending on severity of canine septic shock and cell-free hemoglobin level.

Kenneth E Remy, Irene Cortés-Puch, Junfeng Sun, Jing Feng, Juan J Lertora, Thomas Risoleo, Julia Katz, Swati Basu, Xiaohua Liu, Andreas Perlegas, Daniel B Kim-Shapiro, Harvey G Klein, Charles Natanson, Steven B Solomon,

BACKGROUND:During sepsis, higher plasma cell-free hemoglobin (CFH) levels portend worse outcomes. In sepsis models, plasma proteins that bind CFH improve survival. In our canine antibiotic-treated Staphylococcus aureus pneumonia model, with and without red blood cell (RBC) exchange transfusion, commercial human haptoglobin (Hp) concentrates bound and compartmentalized CFH intravascularly, increased CFH ... Read more >>

Transfusion (Transfusion)
[2019, 59(12):3628-3638]

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Hemoglobin β93 Cysteine Is Not Required for Export of Nitric Oxide Bioactivity From the Red Blood Cell.

Chiao-Wang Sun, Jiangning Yang, Andrei L Kleschyov, Zhengbing Zhuge, Mattias Carlström, John Pernow, Nadeem Wajih, T Scott Isbell, Joo-Yeun Oh, Pedro Cabrales, Amy G Tsai, Tim Townes, Daniel B Kim-Shapiro, Rakesh P Patel, Jon O Lundberg,

BACKGROUND:Nitrosation of a conserved cysteine residue at position 93 in the hemoglobin β chain (β93C) to form S-nitroso (SNO) hemoglobin (Hb) is claimed to be essential for export of nitric oxide (NO) bioactivity by the red blood cell (RBC) to mediate hypoxic vasodilation and cardioprotection. METHODS:To test this hypothesis, we ... Read more >>

Circulation (Circulation)
[2019, 139(23):2654-2663]

Cited: 3 times

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Impact of different standard red blood cell storage temperatures on human and canine RBC hemolysis and chromium survival.

Kevin P Blaine, Irene Cortés-Puch, Junfeng Sun, Dong Wang, Steven B Solomon, Jing Feng, Mark T Gladwin, Daniel B Kim-Shapiro, Swati Basu, Andreas Perlegas, Kamille West, Harvey G Klein, Charles Natanson,

BACKGROUND:Storage temperature is a critical factor for maintaining red-blood cell (RBC) viability, especially during prolonged cold storage. The target range of 1 to 6°C was established decades ago and may no longer be optimal for current blood-banking practices. STUDY DESIGN AND METHODS:Human and canine RBCs were collected under standard conditions ... Read more >>

Transfusion (Transfusion)
[2019, 59(1):347-358]

Cited: 0 times

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Effects of acute dietary nitrate supplementation on aortic blood pressures and pulse wave characteristics in post-menopausal women.

Danielle Jin-Kwang Kim, Carly A Roe, Yasina B Somani, David J Moore, Megan A Barrett, Michael Flanagan, Daniel B Kim-Shapiro, Swati Basu, Matthew D Muller, David N Proctor,

PURPOSE:Consumption of nitrate-rich beetroot juice can lower blood pressure in peripheral as well as central arteries and may exert additional hemodynamic benefits (e.g. reduced aortic wave reflections). The specific influence of nitrate supplementation on arterial pressures and aortic wave properties in postmenopausal women, a group that experiences accelerated increases in ... Read more >>

Nitric Oxide (Nitric oxide : biology and chemistry)
[2019, 85:10-16]

Cited: 0 times

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Nitrite and nitrate chemical biology and signalling.

Anthony W DeMartino, Daniel B Kim-Shapiro, Rakesh P Patel, Mark T Gladwin,

Inorganic nitrate (NO3 - ), nitrite (NO2 - ) and NO are nitrogenous species with a diverse and interconnected chemical biology. The formation of NO from nitrate and nitrite via a reductive 'nitrate-nitrite-NO' pathway and resulting in vasodilation is now an established complementary route to traditional NOS-derived vasodilation. Nitrate, found ... Read more >>

Br. J. Pharmacol. (British journal of pharmacology)
[2019, 176(2):228-245]

Cited: 4 times

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Haptoglobin improves shock, lung injury, and survival in canine pneumonia.

Kenneth E Remy, Irene Cortés-Puch, Steven B Solomon, Junfeng Sun, Benjamin M Pockros, Jing Feng, Juan J Lertora, Roy R Hantgan, Xiaohua Liu, Andreas Perlegas, H Shaw Warren, Mark T Gladwin, Daniel B Kim-Shapiro, Harvey G Klein, Charles Natanson,

During the last half-century, numerous antiinflammatory agents were tested in dozens of clinical trials and have proven ineffective for treating septic shock. The observation in multiple studies that cell-free hemoglobin (CFH) levels are elevated during clinical sepsis and that the degree of increase correlates with higher mortality suggests an alternative ... Read more >>

JCI Insight (JCI insight)
[2018, 3(18):]

Cited: 2 times

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Erythrocytic bioactivation of nitrite and its potentiation by far-red light.

Nadeem Wajih, Swati Basu, Kamil B Ucer, Fernando Rigal, Aryatara Shakya, Elaheh Rahbar, Vidula Vachharajani, Martin Guthold, Mark T Gladwin, Lane M Smith, Daniel B Kim-Shapiro,

BACKGROUND:Nitrite is reduced by heme-proteins and molybdenum-containing enzymes to form the important signaling molecule nitric oxide (NO), mediating NO signaling. Substantial evidence suggests that deoxygenated hemoglobin within red blood cells (RBCs) is the main erythrocytic protein responsible for mediating nitrite-dependent NO signaling. In other work, infrared and far red light ... Read more >>

Redox Biol (Redox Biology)
[2019, 20:442-450]

Cited: 0 times

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Nitric oxide pathology and therapeutics in sickle cell disease.

Daniel B Kim-Shapiro, Mark T Gladwin,

Sickle cell disease is caused by a mutant form of hemoglobin that polymerizes under hypoxic conditions which leads to red blood cell (RBC) distortion, calcium-influx mediated RBC dehydration, increased RBC adhesivity, reduced RBC deformability, increased RBC fragility, and hemolysis. These impairments in RBC structure and function result in multifaceted downstream ... Read more >>

Clin. Hemorheol. Microcirc. (Clinical hemorheology and microcirculation)
[2018, 68(2-3):223-237]

Cited: 4 times

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Beet Root Juice: An Ergogenic Aid for Exercise and the Aging Brain.

Meredith Petrie, W Jack Rejeski, Swati Basu, Paul J Laurienti, Anthony P Marsh, James L Norris, Daniel B Kim-Shapiro, Jonathan H Burdette,

Exercise has positive neuroplastic effects on the aging brain. It has also been shown that ingestion of beet root juice (BRJ) increases blood flow to the brain and enhances exercise performance. Here, we examined whether there are synergistic effects of BRJ and exercise on neuroplasticity in the aging brain.Peak metabolic ... Read more >>

J. Gerontol. A Biol. Sci. Med. Sci. (The journals of gerontology. Series A, Biological sciences and medical sciences)
[2017, 72(9):1284-1289]

Cited: 1 time

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Conjugated Linoleic Acid Modulates Clinical Responses to Oral Nitrite and Nitrate.

Kara S Hughan, Stacy Gelhaus Wendell, Meghan Delmastro-Greenwood, Nicole Helbling, Catherine Corey, Landon Bellavia, Gopal Potti, George Grimes, Bret Goodpaster, Daniel B Kim-Shapiro, Sruti Shiva, Bruce A Freeman, Mark T Gladwin,

Dietary NO3- (nitrate) and NO2- (nitrite) support ˙NO (nitric oxide) generation and downstream vascular signaling responses. These nitrogen oxides also generate secondary nitrosating and nitrating species that react with low molecular weight thiols, heme centers, proteins, and unsaturated fatty acids. To explore the kinetics of NO3-and NO2-metabolism and the impact ... Read more >>

Hypertension (Hypertension (Dallas, Tex. : 1979))
[2017, 70(3):634-644]

Cited: 5 times

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Parenteral irons versus transfused red blood cells for treatment of anemia during canine experimental bacterial pneumonia.

Dante A Suffredini, Wanying Xu, Junfeng Sun, Jesús Barea-Mendoza, Steven B Solomon, Samuel L Brashears, Andreas Perlegas, Daniel B Kim-Shapiro, Harvey G Klein, Charles Natanson, Irene Cortés-Puch,

BACKGROUND:No studies have been performed comparing intravenous (IV) iron with transfused red blood cells (RBCs) for treating anemia during infection. In a previous report, transfused older RBCs increased free iron release and mortality in infected animals when compared to fresher cells. We hypothesized that treating anemia during infection with transfused ... Read more >>

Transfusion (Transfusion)
[2017, 57(10):2338-2347]

Cited: 6 times

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Exposure of fibrinogen and thrombin to nitric oxide donor ProliNONOate affects fibrin clot properties.

Christine C Helms, Shannon Kapadia, Anne C Gilmore, Zhexi Lu, Swati Basu, Daniel B Kim-Shapiro,

: Fibrin fibers form the structural backbone of blood clots. The structural properties of fibrin clots are highly dependent on formation kinetics. Environmental factors such as protein concentration, pH, salt, and protein modification, to name a few, can affect fiber kinetics through altered fibrinopeptide release, monomer association, and/or lateral aggregation. ... Read more >>

Blood Coagul. Fibrinolysis (Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis)
[2017, 28(5):356-364]

Cited: 2 times

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Potential therapeutic action of nitrite in sickle cell disease.

Nadeem Wajih, Swati Basu, Anuj Jailwala, Hee Won Kim, David Ostrowski, Andreas Perlegas, Crystal A Bolden, Nancy L Buechler, Mark T Gladwin, David L Caudell, Elaheh Rahbar, Martha A Alexander-Miller, Vidula Vachharajani, Daniel B Kim-Shapiro,

Sickle cell disease is caused by a mutant form of hemoglobin that polymerizes under hypoxic conditions, increasing rigidity, fragility, calcium influx-mediated dehydration, and adhesivity of red blood cells. Increased red cell fragility results in hemolysis, which reduces nitric oxide (NO) bioavailability, and induces platelet activation and inflammation leading to adhesion ... Read more >>

Redox Biol (Redox Biology)
[2017, 12:1026-1039]

Cited: 8 times

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Effects of supervised exercise and dietary nitrate in older adults with controlled hypertension and/or heart failure with preserved ejection fraction.

Hossam A Shaltout, Joel Eggebeen, Anthony P Marsh, Peter H Brubaker, Paul J Laurienti, Jonathan H Burdette, Swati Basu, Ashley Morgan, Patricia C Dos Santos, James L Norris, Timothy M Morgan, Gary D Miller, W Jack Rejeski, Amret T Hawfield, Debra I Diz, J Thomas Becton, Daniel B Kim-Shapiro, Dalane W Kitzman,

Aerobic exercise training is an effective therapy to improve peak aerobic power (peak VO2) in individuals with hypertension (HTN, AHA/ACC class A) and heart failure patients with preserved ejection fraction (HFpEF). High nitrate containing beetroot juice (BRJ) also improves sub-maximal endurance and decreases blood pressure in both HTN and HFpEF. ... Read more >>

Nitric Oxide (Nitric oxide : biology and chemistry)
[2017, 69:78-90]

Cited: 12 times

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Recent insights into nitrite signaling processes in blood.

Christine C Helms, Xiaohua Liu, Daniel B Kim-Shapiro,

Nitrite was once thought to be inert in human physiology. However, research over the past few decades has established a link between nitrite and the production of nitric oxide (NO) that is potentiated under hypoxic and acidic conditions. Under this new role nitrite acts as a storage pool for bioavailable ... Read more >>

Biol. Chem. (Biological chemistry)
[2017, 398(3):319-329]

Cited: 4 times

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Five-coordinate H64Q neuroglobin as a ligand-trap antidote for carbon monoxide poisoning.

Ivan Azarov, Ling Wang, Jason J Rose, Qinzi Xu, Xueyin N Huang, Andrea Belanger, Ying Wang, Lanping Guo, Chen Liu, Kamil B Ucer, Charles F McTiernan, Christopher P O'Donnell, Sruti Shiva, Jesús Tejero, Daniel B Kim-Shapiro, Mark T Gladwin,

Carbon monoxide (CO) is a leading cause of poisoning deaths worldwide, with no available antidotal therapy. We introduce a potential treatment paradigm for CO poisoning, based on near-irreversible binding of CO by an engineered human neuroglobin (Ngb). Ngb is a six-coordinate hemoprotein, with the heme iron coordinated by two histidine ... Read more >>

Sci Transl Med (Science translational medicine)
[2016, 8(368):368ra173]

Cited: 13 times

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Stored blood: how old is too old?

Janet S Lee, Daniel B Kim-Shapiro,

Transfusion of rbc is a routine, often lifesaving procedure that depends on a stored supply of blood. In the US, 42 days is the maximum duration allowed for rbc storage; however, several lines of evidence indicate that patients that receive blood at the upper end of this storage limit are ... Read more >>

J. Clin. Invest. (The Journal of clinical investigation)
[2017, 127(1):100-102]

Cited: 2 times

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Dietary Nitrate and the Epidemiology of Cardiovascular Disease: Report From a National Heart, Lung, and Blood Institute Workshop.

Amrita Ahluwalia, Mark Gladwin, Gary D Coleman, Norman Hord, George Howard, Daniel B Kim-Shapiro, Martin Lajous, Filip J Larsen, David J Lefer, Leslie A McClure, Bernard T Nolan, Ryszard Pluta, Alan Schechter, Chia-Yih Wang, Mary H Ward, Jane L Harman,

J Am Heart Assoc (Journal of the American Heart Association)
[2016, 5(7):]

Cited: 17 times

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Reactions between nitrosopersulfide and heme proteins.

Crystal Bolden, S Bruce King, Daniel B Kim-Shapiro,

When nitrosothiols react with excess hydrogen sulfide, H2S, they form several intermediates including nitrosopersulfide (SSNO-). The stability and importance of this species has been debated. While some data suggest SSNO- can be a relatively stable source of NO activity, others suggest that the species degrades too quickly. We find the ... Read more >>

Free Radic. Biol. Med. (Free radical biology & medicine)
[2016, 99:418-425]

Cited: 7 times

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Sickle Cell Trait Increases Red Blood Cell Storage Hemolysis and Post-Transfusion Clearance in Mice.

David O Osei-Hwedieh, Tamir Kanias, Claudette St Croix, Morgan Jessup, Zeyu Xiong, Derek Sinchar, Jonathan Franks, Qinzi Xu, Enrico M Novelli, Jonas T Sertorio, Karin Potoka, Robert J Binder, Swati Basu, Andrea M Belanger, Daniel B Kim-Shapiro, Darrell Triulzi, Janet S Lee, Mark T Gladwin,

Transfusion of blood at the limits of approved storage time is associated with lower red blood cell (RBC) post-transfusion recovery and hemolysis, which increases plasma cell-free hemoglobin and iron, proposed to induce endothelial dysfunction and impair host defense. There is noted variability among donors in the intrinsic rate of storage ... Read more >>

EBioMedicine (EBioMedicine)
[2016, 11:239-248]

Cited: 11 times

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Globin X is a six-coordinate globin that reduces nitrite to nitric oxide in fish red blood cells.

Paola Corti, Jianmin Xue, Jesús Tejero, Nadeem Wajih, Ming Sun, Donna B Stolz, Michael Tsang, Daniel B Kim-Shapiro, Mark T Gladwin,

The discovery of novel globins in diverse organisms has stimulated intense interest in their evolved function, beyond oxygen binding. Globin X (GbX) is a protein found in fish, amphibians, and reptiles that diverged from a common ancestor of mammalian hemoglobins and myoglobins. Like mammalian neuroglobin, GbX was first designated as ... Read more >>

Proc. Natl. Acad. Sci. U.S.A. (Proceedings of the National Academy of Sciences of the United States of America)
[2016, 113(30):8538-8543]

Cited: 13 times

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Rainbow of hemolysis associated with acquired thrombotic thrombocytopenic purpura.

Jay S Raval, Marshall A Mazepa, Daniel B Kim-Shapiro, Swati Basu, Raj S Kasthuri, Herbert C Whinna, Yara A Park,

J Clin Apher (Journal of clinical apheresis)
[2017, 32(4):274-275]

Cited: 0 times

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