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The Pulmonary Sequalae in Discharged Patients With COVID-19: A Short-term Observational Study

Dehan Liu, Wanshu Zhang, Feng Pan, Lin Li, Lian Yang, Jiazheng Wang, Dandan Zheng, Bo Liang,

Abstract Background: A cluster of patients with coronavirus disease 2019 (COVID-19) pneumonia were discharged from hospitals in Wuhan, China. We aimed to determine the cumulative percentage of complete radiological resolution at each time point, to explore the relevant affecting factors, and to describe the chest CT findings at different time ... Read more >>

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The pulmonary sequalae in discharged patients with COVID-19: a short-term observational study.

Dehan Liu, Wanshu Zhang, Feng Pan, Lin Li, Lian Yang, Dandan Zheng, Jiazheng Wang, Bo Liang,

BACKGROUND:A cluster of patients with coronavirus disease 2019 (COVID-19) pneumonia were discharged from hospitals in Wuhan, China. We aimed to determine the cumulative percentage of complete radiological resolution at each time point, to explore the relevant affecting factors, and to describe the chest CT findings at different time points after ... Read more >>

Respir. Res. (Respiratory research)
[2020, 21(1):125]

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Radiomics-Based Outcome Prediction for Pancreatic Cancer Following Stereotactic Body Radiotherapy.

Elsa Parr, Qian Du, Chi Zhang, Chi Lin, Ahsan Kamal, Josiah McAlister, Xiaoying Liang, Kyle Bavitz, Gerard Rux, Michael Hollingsworth, Michael Baine, Dandan Zheng,

(1) Background: Radiomics use high-throughput mining of medical imaging data to extract unique information and predict tumor behavior. Currently available clinical prediction models poorly predict treatment outcomes in pancreatic adenocarcinoma. Therefore, we used radiomic features of primary pancreatic tumors to develop outcome prediction models and compared them to traditional clinical ... Read more >>

Cancers (Basel) (Cancers)
[2020, 12(4):]

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The Pulmonary Sequalae in Discharged Patients With COVID-19:A Short-term Observational Study

Dehan Liu, Wanshu Zhang, Feng Pan, Lin Li, Lian Yang, Dandan Zheng, Jiazheng Wang, Bo Liang,

Abstract Background: A cluster of patients with coronavirus disease 2019 (COVID-19) pneumonia were discharged from hospitals in Wuhan, China. We aimed to determine the cumulative percentage of the complete radiological resolution at each time point, to explore the relevant affecting factors, and describe the chest CT findings through different timepoints ... Read more >>

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Learning transferable deep convolutional neural networks for the classification of bacterial virulence factors.

Dandan Zheng, Guansong Pang, Bo Liu, Lihong Chen, Jian Yang,

Identification of virulence factors (VFs) is critical to the elucidation of bacterial pathogenesis and prevention of related infectious diseases. Current computational methods for VF prediction focus on binary classification or involve only several class(es) of VFs with sufficient samples. However, thousands of VF classes are present in real-world scenarios, and ... Read more >>

Bioinformatics (Bioinformatics (Oxford, England))
[2020, :]

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Radiotherapy workflow and protection procedures during the Coronavirus Disease 2019 (COVID-19) outbreak: Experience of the Hubei Cancer Hospital in Wuhan, China.

Wei Wei, Dandan Zheng, Yu Lei, Shen Wu, Vivek Verma, Yongsheng Liu, Xueyan Wei, Jianping Bi, Desheng Hu, Guang Han,

The epidemic of Coronavirus Disease 2019 (COVID-19) first broke out in Wuhan in December 2019, and reached its peak in Wuhan in February 2020. It became a major public health challenge for China, and evolved into a global pandemic in March 2020. For radiation oncology departments, the COVID-19 pandemic presents ... Read more >>

Radiother Oncol (Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology)
[2020, 148:203-210]

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Minimum dose rate estimation for pulsed FLASH radiotherapy: A dimensional analysis.

Sumin Zhou, Dandan Zheng, Qiyong Fan, Ying Yan, Shuo Wang, Yu Lei, Abigail Besemer, Christina Zhou, Charles Enke,

PURPOSE/OBJECTIVES:To provide an order of magnitude estimate of the minimum dose rate ( Rmin ) required by pulsed ultra-high dose rate radiotherapy (FLASH RT) using dimensional analysis. MATERIALS/METHODS:In this study, we postulate that radiation-induced transient hypoxia inside normal tissue cells during FLASH RT results in better normal tissue sparing over ... Read more >>

Med Phys (Medical physics)
[2020, :]

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Correction to: The structure-activity relationship review of the main bioactive constituents of Morus genus plants.

Jiejing Yan, Jingya Ruan, Peijian Huang, Fan Sun, Dandan Zheng, Yi Zhang, Tao Wang,

The article The structure-activity relationship review of the main bioactive constituents of Morus genus plants, written by Jiejing Yan, Jingya Ruan, Peijian Huang, Fan Sun, Dandan Zheng, Yi Zhang and Tao Wang was originally published Online First without Open Access. ... Read more >>

J Nat Med (Journal of natural medicines)
[2020, 74(3):617]

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Pregnancy and Perinatal Outcomes of Women With Coronavirus Disease (COVID-19) Pneumonia: A Preliminary Analysis.

Dehan Liu, Lin Li, Xin Wu, Dandan Zheng, Jiazheng Wang, Lian Yang, Chuansheng Zheng,

OBJECTIVE. The purpose of this study was to describe the clinical manifestations and CT features of coronavirus disease (COVID-19) pneumonia in 15 pregnant women and to provide some initial evidence that can be used for guiding treatment of pregnant women with COVID-19 pneumonia. MATERIALS AND METHODS. We reviewed the clinical ... Read more >>

AJR Am J Roentgenol (AJR. American journal of roentgenology)
[2020, :1-6]

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Comparison of Model-Free and Model-Based Dynamic Contrast-Enhanced Magnetic Resonance Imaging Pharmacokinetic Parameters for Predicting Breast Cancers' Response to Neoadjuvant Chemotherapy.

Guangjie Lv, Yiming Zhou, Dandan Zheng, Jiayin Gao, Zhujin Xu, Lei Jiang,

OBJECTIVE:To prospectively compare the performance of model-based and model-free dynamic contrast-enhanced (DCE) pharmacokinetic parameters in monitoring breast cancers' early response to neoadjuvant chemotherapy (NACT). METHODS:Sixty patients, with 61 pathology-proven breast cancers, were examined using DCE magnetic resonance imaging before, after the first cycle, and after full cycles of NACT. Both ... Read more >>

J Comput Assist Tomogr (Journal of computer assisted tomography)
[2020, 44(2):269-274]

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Correlation of dosimetric factors with the development of symptomatic radiation pneumonitis in stereotactic body radiotherapy.

Jeffrey M Ryckman, Michael Baine, Joseph Carmicheal, Ferdinand Osayande, Richard Sleightholm, Kaeli Samson, Dandan Zheng, Weining Zhen, Chi Lin, Chi Zhang,

BACKGROUND:The development of radiation pneumonitis (RP) after Stereotactic Body Radiotherapy (SBRT) is known to be associated with many different factors, although historical analyses of RP have commonly utilized heterogeneous fractionation schemes and methods of reporting. This study aims to correlate dosimetric values and their association with the development of Symptomatic ... Read more >>

Radiat Oncol (Radiation oncology (London, England))
[2020, 15(1):33]

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Time Course of Lung Changes at Chest CT during Recovery from Coronavirus Disease 2019 (COVID-19).

Feng Pan, Tianhe Ye, Peng Sun, Shan Gui, Bo Liang, Lingli Li, Dandan Zheng, Jiazheng Wang, Richard L Hesketh, Lian Yang, Chuansheng Zheng,

Background Chest CT is used to assess the severity of lung involvement in coronavirus disease 2019 (COVID-19). Purpose To determine the changes in chest CT findings associated with COVID-19 from initial diagnosis until patient recovery. Materials and Methods This retrospective review included patients with real-time polymerase chain reaction-confirmed COVID-19 who ... Read more >>

Radiology (Radiology)
[2020, 295(3):715-721]

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Dosimetric consequences of image guidance techniques on robust optimized intensity-modulated proton therapy for treatment of breast Cancer.

Xiaoying Liang, Raymond B Mailhot Vega, Zuofeng Li, Dandan Zheng, Nancy Mendenhall, Julie A Bradley,

PURPOSE:To investigate the consequences of residual setup error on target dose distribution using various image registration strategies for breast cancer treated with intensity-modulated proton therapy (IMPT). MATERIALS AND METHODS:Among 11 post-lumpectomy patients who received IMPT, 44 dose distributions were computed. For each patient, the original plan (Plan-O) and three verification ... Read more >>

Radiat Oncol (Radiation oncology (London, England))
[2020, 15(1):47]

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Intensive Versus Standard Glucose Control in Patients with Ischemic Stroke: A Meta-Analysis of Randomized Controlled Trials.

Dandan Zheng, Xianjing Zhao,

BACKGROUND:Hyperglycemia is common in patients with ischemic stroke (IS) and has been proven to be associated with worse clinical outcomes. However, it is controversial whether intensive glucose control (IGC) is superior to standard glucose control (SGC). Therefore, we carried out this meta-analysis based on randomized controlled trials (RCTs). METHODS:We systematically ... Read more >>

World Neurosurg (World neurosurgery)
[2020, 136:e487-e495]

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Gene‐Hydrogel Microenvironments: Gene‐Hydrogel Microenvironment Regulates Extracellular Matrix Metabolism Balance in Nucleus Pulposus (Adv. Sci. 1/2020).

Wei Chen, Hao Chen, Dandan Zheng, Hongbo Zhang, Lianfu Deng, Wenguo Cui, Yuhui Zhang, Hélder A. Santos, Hongxing Shen,

In degenerative diseases, microenvironment deterioration is often followed by a vicious circle of cell death and aggravation of microenvironment deterioration. To break the cycle, a gene‐hydrogel microenvironment is constructed in article number https://doi.org/10.1002/advs.201902099 by Yuhui Zhang, Hélder A. Santos, Hongxing Shen, and co‐workers in situ, which regulates the synthesis/catabolism balance ... Read more >>

(Advanced Science)
[2020, 7(1):]

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The structure-activity relationship review of the main bioactive constituents of Morus genus plants.

Jiejing Yan, Jingya Ruan, Peijian Huang, Fan Sun, Dandan Zheng, Yi Zhang, Tao Wang,

Morus genus plants are mainly distributed in the temperate to tropical areas over the world and include 17 species and two subspecies. Due to their excellent pharmacological activity, security in food additives and high value in the national economy, Morus genus plants have drawn more and more attention in recent ... Read more >>

J Nat Med (Journal of natural medicines)
[2020, 74(2):331-340]

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SVMTriP: A Method to Predict B-Cell Linear Antigenic Epitopes.

Bo Yao, Dandan Zheng, Shide Liang, Chi Zhang,

Identifying protein antigenic epitopes recognizable by antibodies is the key step for new immuno-diagnostic reagent discovery and vaccine design. To facilitate this process and improve its efficiency, computational methods were developed to predict antigenic epitopes. For the linear B-cell epitope prediction, many methods were developed, including BepiPred, ABCPred, AAP, BCPred, ... Read more >>

Methods Mol. Biol. (Methods in molecular biology (Clifton, N.J.))
[2020, 2131:299-307]

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EPCES and EPSVR: Prediction of B-Cell Antigenic Epitopes on Protein Surfaces with Conformational Information.

Shide Liang, Dandan Zheng, Bo Yao, Chi Zhang,

Accurate prediction of discontinuous antigenic epitopes is important for immunologic research and medical applications, but it is not an easy problem. Currently, there are only a few prediction servers available, though discontinuous epitopes constitute the majority of all B-cell antigenic epitopes. In this chapter, we describe two online servers, EPCES ... Read more >>

Methods Mol. Biol. (Methods in molecular biology (Clifton, N.J.))
[2020, 2131:289-297]

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Characterization of viromes within mosquito species in China.

Jiang Du, Fan Li, Yelin Han, Shihong Fu, Bo Liu, Nan Shao, Haoxiang Su, Weijia Zhang, Dandan Zheng, Wenwen Lei, Jie Dong, Lilian Sun, Ying He, Jianmin Wang, Fan Yang, Huanyu Wang, Guodong Liang, Zhiqiang Wu, Qi Jin,

Sci China Life Sci (Science China. Life sciences)
[2019, :]

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Using Robust Optimization for Skin Flashing in Intensity Modulated Radiation Therapy for Breast Cancer Treatment: A Feasibility Study.

Xiaoying Liang, Julie A Bradley, Raymond B Mailhot Vega, Michael Rutenberg, Dandan Zheng, Nataliya Getman, Kelly W Norton, Nancy Mendenhall, Zuofeng Li,

PURPOSE:To study the feasibility and the effectiveness of a novel implementation of robust optimization on 2 sets of computed tomography (CT) data simultaneously for skin flashing in intensity modulated radiation therapy for breast cancer. METHOD AND MATERIALS:Five patients who received treatment to the breast and regional lymphatics were selected for ... Read more >>

Pract Radiat Oncol (Practical radiation oncology)
[2020, 10(1):59-69]

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Isoprenoids obtained from Cortex Dictamni and their nitric oxide inhibitory activities.

Dandan Zheng, Fan Sun, Huimei Wang, Shengcai Yang, Jingya Ruan, Wei He, Jianli Wang, Yuanqiang Guo, Yi Zhang, Tao Wang,

Nine new isoprenoids, named as dictamtrinor-guaianols A (1), B (2), C (3), D (4), and E (5), dictamnorsesquiterpenol A (6), dictamnorsesquiterpenosides B (7) and C (8), as well as dictamtriterpenol A (9), along with eight known compounds (10-17) were obtained from 70% EtOH extract of Cortex Dictamni. Their structures were ... Read more >>

Fitoterapia (Fitoterapia)
[2019, 139:104358]

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Gene-Hydrogel Microenvironment Regulates Extracellular Matrix Metabolism Balance in Nucleus Pulposus.

Wei Chen, Hao Chen, Dandan Zheng, Hongbo Zhang, Lianfu Deng, Wenguo Cui, Yuhui Zhang, Hélder A Santos, Hongxing Shen,

Gene therapy provides an ideal potential treatment for intervertebral disk degeneration by delivering synthetic microRNAs (miRNAs) to regulate the gene expression levels. However, it is very challenging to deliver miRNAs directly, which leads to inactivation, low transfection efficiency, and short half-life. Here, Agomir is loaded in hydrogel to construct a ... Read more >>

Adv Sci (Weinh) (Advanced science (Weinheim, Baden-Wurttemberg, Germany))
[2020, 7(1):1902099]

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Genome-wide Identification and Characterization of a Superfamily of Bacterial Extracellular Contractile Injection Systems.

Lihong Chen, Nan Song, Bo Liu, Nan Zhang, Nabil-Fareed Alikhan, Zhemin Zhou, Yanyan Zhou, Siyu Zhou, Dandan Zheng, Mingxing Chen, Alexia Hapeshi, Joseph Healey, Nicholas R Waterfield, Jian Yang, Guowei Yang,

Several phage-tail-like nanomachines were shown to play an important role in the interactions between bacteria and their eukaryotic hosts. These apparatuses appear to represent a new injection paradigm. Here, with three verified extracellular contractile injection systems (eCISs), a protein profile and genomic context-based iterative approach was applied to identify 631 ... Read more >>

Cell Rep (Cell reports)
[2019, 29(2):511-521.e2]

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Ergosterol attenuates cigarette smoke extract-induced COPD by modulating inflammation, oxidative stress and apoptosis in vitro and in vivo.

Xiao Sun, Xiuli Feng, Dandan Zheng, Ang Li, Chunyan Li, Siying Li, Zhongxi Zhao,

Cigarette smoke (CS) is the major cause of chronic obstructive pulmonary disease (COPD). CS heightens inflammation, oxidative stress and apoptosis. Ergosterol is the main bioactive ingredient in Cordyceps sinensis (C. sinensis), a traditional medicinal herb for various diseases. The objective of this work was to investigate the effects of ergosterol ... Read more >>

Clin. Sci. (Clinical science (London, England : 1979))
[2019, 133(13):1523-1536]

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Coupling natural systems with synthetic chemistry for light-driven enzymatic biocatalysis.

Dandan Zheng, Ying Zhang, Xiaohong Liu, Jiangyun Wang,

Visible light-driven redox reactions have been widely adopted for the production of chemicals to combat energy shortage and global warming. Key elements of such a reaction system include a photosensitizer, a catalyst, and an electron source. In this review, we introduce the small molecules and nanoparticles that are widely used ... Read more >>

Photosyn. Res. (Photosynthesis research)
[2020, 143(2):221-231]

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