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Greater male than female variability in regional brain structure across the lifespan.

Lara M Wierenga, Gaelle E Doucet, Danai Dima, Ingrid Agartz, Moji Aghajani, Theophilus N Akudjedu, Anton Albajes-Eizagirre, Dag Alnaes, Kathryn I Alpert, Ole A Andreassen, Alan Anticevic, Philip Asherson, Tobias Banaschewski, Nuria Bargallo, Sarah Baumeister, Ramona Baur-Streubel, Alessandro Bertolino, Aurora Bonvino, Dorret I Boomsma, Stefan Borgwardt, Josiane Bourque, Anouk den Braber, Daniel Brandeis, Alan Breier, Henry Brodaty, Rachel M Brouwer, Jan K Buitelaar, Geraldo F Busatto, Vince D Calhoun, Erick J Canales-Rodríguez, Dara M Cannon, Xavier Caseras, Francisco X Castellanos, Tiffany M Chaim-Avancini, Christopher Rk Ching, Vincent P Clark, Patricia J Conrod, Annette Conzelmann, Fabrice Crivello, Christopher G Davey, Erin W Dickie, Stefan Ehrlich, Dennis Van't Ent, Simon E Fisher, Jean-Paul Fouche, Barbara Franke, Paola Fuentes-Claramonte, Eco Jc de Geus, Annabella Di Giorgio, David C Glahn, Ian H Gotlib, Hans J Grabe, Oliver Gruber, Patricia Gruner, Raquel E Gur, Ruben C Gur, Tiril P Gurholt, Lieuwe de Haan, Beathe Haatveit, Ben J Harrison, Catharina A Hartman, Sean N Hatton, Dirk J Heslenfeld, Odile A van den Heuvel, Ian B Hickie, Pieter J Hoekstra, Sarah Hohmann, Avram J Holmes, Martine Hoogman, Norbert Hosten, Fleur M Howells, Hilleke E Hulshoff Pol, Chaim Huyser, Neda Jahanshad, Anthony C James, Jiyang Jiang, Erik G Jönsson, John A Joska, Andrew J Kalnin, , Marieke Klein, Laura Koenders, Knut K Kolskår, Bernd Krämer, Jonna Kuntsi, Jim Lagopoulos, Luisa Lazaro, Irina S Lebedeva, Phil H Lee, Christine Lochner, Marise Wj Machielsen, Sophie Maingault, Nicholas G Martin, Ignacio Martínez-Zalacaín, David Mataix-Cols, Bernard Mazoyer, Brenna C McDonald, Colm McDonald, Andrew M McIntosh, Katie L McMahon, Genevieve McPhilemy, Dennis van der Meer, José M Menchón, Jilly Naaijen, Lars Nyberg, Jaap Oosterlaan, Yannis Paloyelis, Paul Pauli, Giulio Pergola, Edith Pomarol-Clotet, Maria J Portella, Joaquim Radua, Andreas Reif, Geneviève Richard, Joshua L Roffman, Pedro Gp Rosa, Matthew D Sacchet, Perminder S Sachdev, Raymond Salvador, Salvador Sarró, Theodore D Satterthwaite, Andrew J Saykin, Mauricio H Serpa, Kang Sim, Andrew Simmons, Jordan W Smoller, Iris E Sommer, Carles Soriano-Mas, Dan J Stein, Lachlan T Strike, Philip R Szeszko, Henk S Temmingh, Sophia I Thomopoulos, Alexander S Tomyshev, Julian N Trollor, Anne Uhlmann, Ilya M Veer, Dick J Veltman, Aristotle Voineskos, Henry Völzke, Henrik Walter, Lei Wang, Yang Wang, Bernd Weber, Wei Wen, John D West, Lars T Westlye, Heather C Whalley, Steven Cr Williams, Katharina Wittfeld, Daniel H Wolf, Margaret J Wright, Yuliya N Yoncheva, Marcus V Zanetti, Georg C Ziegler, Greig I de Zubicaray, Paul M Thompson, Eveline A Crone, Sophia Frangou, Christian K Tamnes,

For many traits, males show greater variability than females, with possible implications for understanding sex differences in health and disease. Here, the ENIGMA (Enhancing Neuro Imaging Genetics through Meta-Analysis) Consortium presents the largest-ever mega-analysis of sex differences in variability of brain structure, based on international data spanning nine decades of ... Read more >>

Hum Brain Mapp (Human brain mapping)
[2020, :]

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In vivo hippocampal subfield volumes in bipolar disorder-A mega-analysis from The Enhancing Neuro Imaging Genetics through Meta-Analysis Bipolar Disorder Working Group.

Unn K Haukvik, Tiril P Gurholt, Stener Nerland, Torbjørn Elvsåshagen, Theophilus N Akudjedu, Martin Alda, Dag Alnaes, Silvia Alonso-Lana, Jochen Bauer, Bernhard T Baune, Francesco Benedetti, Michael Berk, Francesco Bettella, Erlend Bøen, Caterina M Bonnín, Paolo Brambilla, Erick J Canales-Rodríguez, Dara M Cannon, Xavier Caseras, Orwa Dandash, Udo Dannlowski, Giuseppe Delvecchio, Ana M Díaz-Zuluaga, Theo G M van Erp, Mar Fatjó-Vilas, Sonya F Foley, Katharina Förster, Janice M Fullerton, José M Goikolea, Dominik Grotegerd, Oliver Gruber, Bartholomeus C M Haarman, Beathe Haatveit, Tomas Hajek, Brian Hallahan, Mathew Harris, Emma L Hawkins, Fleur M Howells, Carina Hülsmann, Neda Jahanshad, Kjetil N Jørgensen, Tilo Kircher, Bernd Krämer, Axel Krug, Rayus Kuplicki, Trine V Lagerberg, Thomas M Lancaster, Rhoshel K Lenroot, Vera Lonning, Carlos López-Jaramillo, Ulrik F Malt, Colm McDonald, Andrew M McIntosh, Genevieve McPhilemy, Dennis van der Meer, Ingrid Melle, Elisa M T Melloni, Philip B Mitchell, Leila Nabulsi, Igor Nenadić, Viola Oertel, Lucio Oldani, Nils Opel, Maria C G Otaduy, Bronwyn J Overs, Julian A Pineda-Zapata, Edith Pomarol-Clotet, Joaquim Radua, Lisa Rauer, Ronny Redlich, Jonathan Repple, Maria M Rive, Gloria Roberts, Henricus G Ruhe, Lauren E Salminen, Raymond Salvador, Salvador Sarró, Jonathan Savitz, Aart H Schene, Kang Sim, Marcio G Soeiro-de-Souza, Michael Stäblein, Dan J Stein, Frederike Stein, Christian K Tamnes, Henk S Temmingh, Sophia I Thomopoulos, Dick J Veltman, Eduard Vieta, Lena Waltemate, Lars T Westlye, Heather C Whalley, Philipp G Sämann, Paul M Thompson, Christopher R K Ching, Ole A Andreassen, Ingrid Agartz, ,

The hippocampus consists of anatomically and functionally distinct subfields that may be differentially involved in the pathophysiology of bipolar disorder (BD). Here we, the Enhancing NeuroImaging Genetics through Meta-Analysis Bipolar Disorder workinggroup, study hippocampal subfield volumetry in BD. T1-weighted magnetic resonance imaging scans from 4,698 individuals (BD = 1,472, healthy ... Read more >>

Hum Brain Mapp (Human brain mapping)
[2020, :]

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Predicting alcohol dependence from multi-site brain structural measures.

Sage Hahn, Scott Mackey, Janna Cousijn, John J Foxe, Andreas Heinz, Robert Hester, Kent Hutchinson, Falk Kiefer, Ozlem Korucuoglu, Tristram Lett, Chiang-Shan R Li, Edythe London, Valentina Lorenzetti, Luijten Maartje, Reza Momenan, Catherine Orr, Martin Paulus, Lianne Schmaal, Rajita Sinha, Zsuzsika Sjoerds, Dan J Stein, Elliot Stein, Ruth J van Holst, Dick Veltman, Henrik Walter, Reinout W Wiers, Murat Yucel, Paul M Thompson, Patricia Conrod, Nicholas Allgaier, Hugh Garavan,

To identify neuroimaging biomarkers of alcohol dependence (AD) from structural magnetic resonance imaging, it may be useful to develop classification models that are explicitly generalizable to unseen sites and populations. This problem was explored in a mega-analysis of previously published datasets from 2,034 AD and comparison participants spanning 27 sites curated ... Read more >>

Hum Brain Mapp (Human brain mapping)
[2020, :]

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Structural neuroimaging biomarkers for obsessive-compulsive disorder in the ENIGMA-OCD consortium: medication matters.

Willem B Bruin, Luke Taylor, Rajat M Thomas, Jonathan P Shock, Paul Zhutovsky, Yoshinari Abe, Pino Alonso, Stephanie H Ameis, Alan Anticevic, Paul D Arnold, Francesca Assogna, Francesco Benedetti, Jan C Beucke, Premika S W Boedhoe, Irene Bollettini, Anushree Bose, Silvia Brem, Brian P Brennan, Jan K Buitelaar, Rosa Calvo, Yuqi Cheng, Kang Ik K Cho, Sara Dallaspezia, Damiaan Denys, Benjamin A Ely, Jamie D Feusner, Kate D Fitzgerald, Jean-Paul Fouche, Egill A Fridgeirsson, Patricia Gruner, Deniz A Gürsel, Tobias U Hauser, Yoshiyuki Hirano, Marcelo Q Hoexter, Hao Hu, Chaim Huyser, Iliyan Ivanov, Anthony James, Fern Jaspers-Fayer, Norbert Kathmann, Christian Kaufmann, Kathrin Koch, Masaru Kuno, Gerd Kvale, Jun Soo Kwon, Yanni Liu, Christine Lochner, Luisa Lázaro, Paulo Marques, Rachel Marsh, Ignacio Martínez-Zalacaín, David Mataix-Cols, José M Menchón, Luciano Minuzzi, Pedro S Moreira, Astrid Morer, Pedro Morgado, Akiko Nakagawa, Takashi Nakamae, Tomohiro Nakao, Janardhanan C Narayanaswamy, Erika L Nurmi, Joseph O'Neill, Jose C Pariente, Chris Perriello, John Piacentini, Fabrizio Piras, Federica Piras, Y C Janardhan Reddy, Oana G Rus-Oswald, Yuki Sakai, João R Sato, Lianne Schmaal, Eiji Shimizu, H Blair Simpson, Noam Soreni, Carles Soriano-Mas, Gianfranco Spalletta, Emily R Stern, Michael C Stevens, S Evelyn Stewart, Philip R Szeszko, David F Tolin, Ganesan Venkatasubramanian, Zhen Wang, Je-Yeon Yun, Daan van Rooij, , Paul M Thompson, Odile A van den Heuvel, Dan J Stein, Guido A van Wingen,

No diagnostic biomarkers are available for obsessive-compulsive disorder (OCD). Here, we aimed to identify magnetic resonance imaging (MRI) biomarkers for OCD, using 46 data sets with 2304 OCD patients and 2068 healthy controls from the ENIGMA consortium. We performed machine learning analysis of regional measures of cortical thickness, surface area ... Read more >>

Transl Psychiatry (Translational psychiatry)
[2020, 10(1):342]

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A review of systems biology research of anxiety disorders.

Mary S Mufford, Dennis van der Meer, Ole A Andreassen, Raj Ramesar, Dan J Stein, Shareefa Dalvie,

The development of "omic" technologies and deep phenotyping may facilitate a systems biology approach to understanding anxiety disorders. Systems biology approaches incorporate data from multiple modalities (e.g., genomic, neuroimaging) with functional analyses (e.g., animal and tissue culture models) and mathematical modeling (e.g., machine learning) to investigate pathological biophysical networks at ... Read more >>

Braz J Psychiatry (Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999))
[2020, :]

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Five insights from the Global Burden of Disease Study 2019.

,

The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 provides a rules-based synthesis of the available evidence on levels and trends in health outcomes, a diverse set of risk factors, and health system responses. GBD 2019 covered 204 countries and territories, as well as first administrative level ... Read more >>

Lancet (Lancet (London, England))
[2020, 396(10258):1135-1159]

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Gambling Disorder and Childhood Trauma: A Complex Association.

Natascha S Horak, Gillian Eagle, Dan J Stein, Christine Lochner,

Gambling disorder (GD) is classified as a behavioural addiction and has some phenotypic similarities with substance use disorders (SUDs). Childhood adversity and life stressors are associated with increased risk for SUDs in adulthood. However, there is limited research investigating the association between childhood trauma, stressors and behavioural addictions such as ... Read more >>

J Gambl Stud (Journal of gambling studies)
[2020, :]

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Psychological Distress During Pregnancy: Cross-Sectional Prevalence and Associated Risk Factors in a South African Sample.

Maxine F Spedding, Katherine Sorsdahl, Charles D H Parry, Catherine Mathews, Dan J Stein, Petal Petersen Williams,

The prevalence and risk factors associated with peripartum psychological distress-a unifying factor among common mental disorders (CMDs)-are not widely understood in underresourced settings. Cross-sectional data were collected from 664 pregnant women who reported for antenatal care at any of one of the 11 midwife and obstetrics units in Cape Town, ... Read more >>

J. Nerv. Ment. Dis. (The Journal of nervous and mental disease)
[2020, 208(10):755-763]

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A task-sharing intervention for prepartum common mental disorders: Feasibility, acceptability and responses in a South African sample.

Maxine Spedding, Dan J Stein, Tracey Naledi, Bronwyn Myers, Pim Cuijpers, Katherine Sorsdahl,

BACKGROUND:Peripartum common mental disorders (CMD) are highly prevalent in low- and middle-income countries (LMIC) such as South Africa. With limited public mental health resources, task sharing approaches to treatment are showing promise. However, little is known about the feasibility and acceptability of, as well as responses associated with problem-solving therapy ... Read more >>

Afr J Prim Health Care Fam Med (African journal of primary health care & family medicine)
[2020, 12(1):e1-e9]

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Integration of mental health counselling into chronic disease services at the primary health care level: Formative research on dedicated versus designated strategies in the Western Cape, South Africa.

Katherine Sorsdahl, Tracey Naledi, Crick Lund, Naomi S Levitt, John A Joska, Dan J Stein, Bronwyn Myers,

OBJECTIVE:To explore health care providers' views on the acceptability and feasibility of two models for integrating facility-based counsellor delivered mental health counselling into chronic disease care, and how such an approach could be improved in South Africa. METHODS:Fourteen focus group discussions and 25 in-depth individual interviews were conducted with 109 ... Read more >>

J Health Serv Res Policy (Journal of health services research & policy)
[2020, :1355819620954232]

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Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults.

Edith Hofer, Gennady V Roshchupkin, Hieab H H Adams, Maria J Knol, Honghuang Lin, Shuo Li, Habil Zare, Shahzad Ahmad, Nicola J Armstrong, Claudia L Satizabal, Manon Bernard, Joshua C Bis, Nathan A Gillespie, Michelle Luciano, Aniket Mishra, Markus Scholz, Alexander Teumer, Rui Xia, Xueqiu Jian, Thomas H Mosley, Yasaman Saba, Lukas Pirpamer, Stephan Seiler, James T Becker, Owen Carmichael, Jerome I Rotter, Bruce M Psaty, Oscar L Lopez, Najaf Amin, Sven J van der Lee, Qiong Yang, Jayandra J Himali, Pauline Maillard, Alexa S Beiser, Charles DeCarli, Sherif Karama, Lindsay Lewis, Mat Harris, Mark E Bastin, Ian J Deary, A Veronica Witte, Frauke Beyer, Markus Loeffler, Karen A Mather, Peter R Schofield, Anbupalam Thalamuthu, John B Kwok, Margaret J Wright, David Ames, Julian Trollor, Jiyang Jiang, Henry Brodaty, Wei Wen, Meike W Vernooij, Albert Hofman, André G Uitterlinden, Wiro J Niessen, Katharina Wittfeld, Robin Bülow, Uwe Völker, Zdenka Pausova, G Bruce Pike, Sophie Maingault, Fabrice Crivello, Christophe Tzourio, Philippe Amouyel, Bernard Mazoyer, Michael C Neale, Carol E Franz, Michael J Lyons, Matthew S Panizzon, Ole A Andreassen, Anders M Dale, Mark Logue, Katrina L Grasby, Neda Jahanshad, Jodie N Painter, Lucía Colodro-Conde, Janita Bralten, Derrek P Hibar, Penelope A Lind, Fabrizio Pizzagalli, Jason L Stein, Paul M Thompson, Sarah E Medland, , Perminder S Sachdev, William S Kremen, Joanna M Wardlaw, Arno Villringer, Cornelia M van Duijn, Hans J Grabe, William T Longstreth, Myriam Fornage, Tomas Paus, Stephanie Debette, M Arfan Ikram, Helena Schmidt, Reinhold Schmidt, Sudha Seshadri,

Cortical thickness, surface area and volumes vary with age and cognitive function, and in neurological and psychiatric diseases. Here we report heritability, genetic correlations and genome-wide associations of these cortical measures across the whole cortex, and in 34 anatomically predefined regions. Our discovery sample comprises 22,824 individuals from 20 cohorts ... Read more >>

Nat Commun (Nature communications)
[2020, 11(1):4796]

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Recreational Use of HIV Antiretroviral Medication and Implications for HIV Pre-exposure Prophylaxis and Treatment.

Caroline Kuo, Danielle Giovenco, Teresa DeAtley, Jackie Hoare, Kristen Underhill, Millicent Atujuna, Catherine Mathews, Dan J Stein, Larry K Brown, Don Operario,

Diversion of antiretroviral therapy (ART) for recreational use is concerning for countries with high HIV prevalence. This paper presents reports of recreational use of ART among adolescents from two HIV prevention studies in South Africa: (1) a cross-sectional survey of N = 200 adolescents and (2) a qualitative study of pre-exposure prophylaxis ... Read more >>

AIDS Behav (AIDS and behavior)
[2020, 24(9):2650-2655]

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A systematic review of research on neuropsychological measures in psychotic disorders from low and middle-income countries: The question of clinical utility.

Emmanuel K Mwesiga, Dickens Akena, Nastassja Koen, Richard Senono, Ekwaro A Obuku, Joy Louise Gumikiriza, Reuben N Robbins, Noeline Nakasujja, Dan J Stein,

Introduction:Several studies of neuropsychological measures have been undertaken in patients with psychotic disorders from low- and middle-income countries (LMICs). It is, however, unclear if the measures used in these studies are appropriate for cognitive screening in clinical settings. We undertook a systematic review to determine if measures investigated in research ... Read more >>

(Schizophrenia research. Cognition)
[2020, 22:100187]

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Diagnostic biomarkers for obsessive-compulsive disorder: A reasonable quest or ignis fatuus?

Miquel A Fullana, Amitai Abramovitch, Esther Via, Clara López-Sola, Ximena Goldberg, Nuria Reina, Lydia Fortea, Aleix Solanes, Matthew J Buckley, Valentina Ramella-Cravaro, André F Carvalho, Miquel Tortella-Feliu, Eduard Vieta, Carles Soriano-Mas, Luisa Lázaro, Dan J Stein, Lorena Fernández de la Cruz, David Mataix-Cols, Joaquim Radua,

Obsessive-compulsive disorder (OCD) has been associated with a wide range of biological and neurocognitive findings, which could assist in the search for biomarkers. We conducted an umbrella review of systematic reviews and meta-analyses to assess and grade the strength of the evidence of the association between OCD and several potential ... Read more >>

Neurosci Biobehav Rev (Neuroscience and biobehavioral reviews)
[2020, 118:504-513]

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Virtual Histology of Cortical Thickness and Shared Neurobiology in 6 Psychiatric Disorders.

, , , , , , Yash Patel, Nadine Parker, Jean Shin, Derek Howard, Leon French, Sophia I Thomopoulos, Elena Pozzi, Yoshinari Abe, Christoph Abé, Alan Anticevic, Martin Alda, Andre Aleman, Clara Alloza, Silvia Alonso-Lana, Stephanie H Ameis, Evdokia Anagnostou, Andrew A McIntosh, Celso Arango, Paul D Arnold, Philip Asherson, Francesca Assogna, Guillaume Auzias, Rosa Ayesa-Arriola, Geor Bakker, Nerisa Banaj, Tobias Banaschewski, Cibele E Bandeira, Alexandr Baranov, Núria Bargalló, Claiton H D Bau, Sarah Baumeister, Bernhard T Baune, Mark A Bellgrove, Francesco Benedetti, Alessandro Bertolino, Premika S W Boedhoe, Marco Boks, Irene Bollettini, Caterina Del Mar Bonnin, Tiana Borgers, Stefan Borgwardt, Daniel Brandeis, Brian P Brennan, Jason M Bruggemann, Robin Bülow, Geraldo F Busatto, Sara Calderoni, Vince D Calhoun, Rosa Calvo, Erick J Canales-Rodríguez, Dara M Cannon, Vaughan J Carr, Nicola Cascella, Mara Cercignani, Tiffany M Chaim-Avancini, Anastasia Christakou, David Coghill, Annette Conzelmann, Benedicto Crespo-Facorro, Ana I Cubillo, Kathryn R Cullen, Renata B Cupertino, Eileen Daly, Udo Dannlowski, Christopher G Davey, Damiaan Denys, Christine Deruelle, Annabella Di Giorgio, Erin W Dickie, Danai Dima, Katharina Dohm, Stefan Ehrlich, Benjamin A Ely, Tracy Erwin-Grabner, Thomas Ethofer, Damien A Fair, Andreas J Fallgatter, Stephen V Faraone, Mar Fatjó-Vilas, Jennifer M Fedor, Kate D Fitzgerald, Judith M Ford, Thomas Frodl, Cynthia H Y Fu, Janice M Fullerton, Matt C Gabel, David C Glahn, Gloria Roberts, Tinatin Gogberashvili, Jose M Goikolea, Ian H Gotlib, Roberto Goya-Maldonado, Hans J Grabe, Melissa J Green, Eugenio H Grevet, Nynke A Groenewold, Dominik Grotegerd, Oliver Gruber, Patricia Gruner, Amalia Guerrero-Pedraza, Raquel E Gur, Ruben C Gur, Shlomi Haar, Bartholomeus C M Haarman, Jan Haavik, Tim Hahn, Tomas Hajek, Benjamin J Harrison, Neil A Harrison, Catharina A Hartman, Heather C Whalley, Dirk J Heslenfeld, Derrek P Hibar, Eva Hilland, Yoshiyuki Hirano, Tiffany C Ho, Pieter J Hoekstra, Liesbeth Hoekstra, Sarah Hohmann, L E Hong, Cyril Höschl, Marie F Høvik, Fleur M Howells, Igor Nenadic, Maria Jalbrzikowski, Anthony C James, Joost Janssen, Fern Jaspers-Fayer, Jian Xu, Rune Jonassen, Georgii Karkashadze, Joseph A King, Tilo Kircher, Matthias Kirschner, Kathrin Koch, Peter Kochunov, Gregor Kohls, Kerstin Konrad, Bernd Krämer, Axel Krug, Jonna Kuntsi, Jun Soo Kwon, Mikael Landén, Nils I Landrø, Luisa Lazaro, Irina S Lebedeva, Elisabeth J Leehr, Sara Lera-Miguel, Klaus-Peter Lesch, Christine Lochner, Mario R Louza, Beatriz Luna, Astri J Lundervold, Frank P MacMaster, Luigi A Maglanoc, Charles B Malpas, Maria J Portella, Rachel Marsh, Fiona M Martyn, David Mataix-Cols, Daniel H Mathalon, Hazel McCarthy, Colm McDonald, Genevieve McPhilemey, Susanne Meinert, José M Menchón, Luciano Minuzzi, Philip B Mitchell, Carmen Moreno, Pedro Morgado, Filippo Muratori, Clodagh M Murphy, Declan Murphy, Benson Mwangi, Leila Nabulsi, Akiko Nakagawa, Takashi Nakamae, Leyla Namazova, Janardhanan Narayanaswamy, Neda Jahanshad, Danai D Nguyen, Rosa Nicolau, Ruth L O'Gorman Tuura, Kirsten O'Hearn, Jaap Oosterlaan, Nils Opel, Roel A Ophoff, Bob Oranje, Victor Ortiz García de la Foz, Bronwyn J Overs, Yannis Paloyelis, Christos Pantelis, Mara Parellada, Paul Pauli, Maria Picó-Pérez, Felipe A Picon, Fabrizio Piras, Federica Piras, Kerstin J Plessen, Edith Pomarol-Clotet, Adrian Preda, Olga Puig, Yann Quidé, Joaquim Radua, J Antoni Ramos-Quiroga, Paul E Rasser, Lisa Rauer, Janardhan Reddy, Ronny Redlich, Andreas Reif, Liesbeth Reneman, Jonathan Repple, Alessandra Retico, Vanesa Richarte, Anja Richter, Pedro G P Rosa, Katya K Rubia, Ryota Hashimoto, Matthew D Sacchet, Raymond Salvador, Javier Santonja, Kelvin Sarink, Salvador Sarró, Theodore D Satterthwaite, Akira Sawa, Ulrich Schall, Peter R Schofield, Anouk Schrantee, Jochen Seitz, Mauricio H Serpa, Esther Setién-Suero, Philip Shaw, Devon Shook, Tim J Silk, Kang Sim, Schmitt Simon, Helen Blair Simpson, Aditya Singh, Antonin Skoch, Norbert Skokauskas, Jair C Soares, Noam Soreni, Carles Soriano-Mas, Gianfranco Spalletta, Filip Spaniel, Stephen M Lawrie, Emily R Stern, S Evelyn Stewart, Yoichiro Takayanagi, Henk S Temmingh, David F Tolin, David Tomecek, Diana Tordesillas-Gutiérrez, Michela Tosetti, Anne Uhlmann, Therese van Amelsvoort, Nic J A van der Wee, Steven J A van der Werff, Neeltje E M van Haren, Guido A van Wingen, Alasdair Vance, Javier Vázquez-Bourgon, Daniela Vecchio, Ganesan Venkatasubramanian, Eduard Vieta, Oscar Vilarroya, Yolanda Vives-Gilabert, Aristotle N Voineskos, Henry Völzke, Georg G von Polier, Esther Walton, Thomas W Weickert, Cynthia Shannon Weickert, Andrea S Weideman, Katharina Wittfeld, Daniel H Wolf, Mon-Ju Wu, T T Yang, Kun Yang, Yuliya Yoncheva, Je-Yeon Yun, Yuqi Cheng, Marcus V Zanetti, Georg C Ziegler, Barbara Franke, Martine Hoogman, Jan K Buitelaar, Daan van Rooij, Ole A Andreassen, Christopher R K Ching, Dick J Veltman, Lianne Schmaal, Dan J Stein, Odile A van den Heuvel, Jessica A Turner, Theo G M van Erp, Zdenka Pausova, Paul M Thompson, Tomáš Paus,

Importance:Large-scale neuroimaging studies have revealed group differences in cortical thickness across many psychiatric disorders. The underlying neurobiology behind these differences is not well understood. Objective:To determine neurobiologic correlates of group differences in cortical thickness between cases and controls in 6 disorders: attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), bipolar disorder ... Read more >>

JAMA Psychiatry (JAMA psychiatry)
[2020, :]

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Reproducibility in the absence of selective reporting: An illustration from large-scale brain asymmetry research.

Xiang-Zhen Kong, , Clyde Francks,

The problem of poor reproducibility of scientific findings has received much attention over recent years, in a variety of fields including psychology and neuroscience. The problem has been partly attributed to publication bias and unwanted practices such as p-hacking. Low statistical power in individual studies is also understood to be ... Read more >>

Hum Brain Mapp (Human brain mapping)
[2020, :]

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Association of maternal and infant inflammation with neurodevelopment in HIV-exposed uninfected children in a South African birth cohort.

Tatum Sevenoaks, Catherine J Wedderburn, Kirsten A Donald, Whitney Barnett, Heather J Zar, Dan J Stein, Petrus J W Naudé,

HIV-exposed uninfected (HEU) children may have altered immune regulation and poorer neurodevelopment outcomes compared to their HIV-unexposed (HU) counterparts. However, studies investigating the association of maternal and infant inflammation with neurodevelopment in HEU children are limited and longitudinal data are lacking. This study investigated serum inflammatory markers in HIV-infected vs. ... Read more >>

Brain Behav. Immun. (Brain, behavior, and immunity)
[2020, :]

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Prevalence and clinical correlates of substance use disorders in South African Xhosa patients with schizophrenia.

Henk Temmingh, Ezra Susser, Sumaya Mall, Megan Campbell, Goodman Sibeko, Dan J Stein,

PURPOSE:To determine the prevalence of substance use disorders (SUDs) in patients with schizophrenia in a sample from South Africa and compare the clinical and demographic correlates in those with and without co-occurring SUDs. METHODS:Patients with schizophrenia were interviewed using the Xhosa version SCID-I for DSM-IV. We used logistic regression to ... Read more >>

Soc Psychiatry Psychiatr Epidemiol (Social psychiatry and psychiatric epidemiology)
[2020, :]

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Sources of Stress and Their Associations With Mental Disorders Among College Students: Results of the World Health Organization World Mental Health Surveys International College Student Initiative.

Eirini Karyotaki, Pim Cuijpers, Yesica Albor, Jordi Alonso, Randy P Auerbach, Jason Bantjes, Ronny Bruffaerts, David D Ebert, Penelope Hasking, Glenn Kiekens, Sue Lee, Margaret McLafferty, Arthur Mak, Philippe Mortier, Nancy A Sampson, Dan J Stein, Gemma Vilagut, Ronald C Kessler,

The college years are stressful for many students. Identifying the sources of stress and their relative importance in leading to clinically significant emotional problems may assist in the development of targeted stress management interventions. The current report examines the distribution and associations of perceived stress across major life areas with ... Read more >>

Front Psychol (Frontiers in psychology)
[2020, 11:1759]

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What we learn about bipolar disorder from large-scale neuroimaging: Findings and future directions from the ENIGMA Bipolar Disorder Working Group.

Christopher R K Ching, Derrek P Hibar, Tiril P Gurholt, Abraham Nunes, Sophia I Thomopoulos, Christoph Abé, Ingrid Agartz, Rachel M Brouwer, Dara M Cannon, Sonja M C de Zwarte, Lisa T Eyler, Pauline Favre, Tomas Hajek, Unn K Haukvik, Josselin Houenou, Mikael Landén, Tristram A Lett, Colm McDonald, Leila Nabulsi, Yash Patel, Melissa E Pauling, Tomas Paus, Joaquim Radua, Marcio G Soeiro-de-Souza, Giulia Tronchin, Neeltje E M van Haren, Eduard Vieta, Henrik Walter, Ling-Li Zeng, Martin Alda, Jorge Almeida, Dag Alnaes, Silvia Alonso-Lana, Cara Altimus, Michael Bauer, Bernhard T Baune, Carrie E Bearden, Marcella Bellani, Francesco Benedetti, Michael Berk, Amy C Bilderbeck, Hilary P Blumberg, Erlend Bøen, Irene Bollettini, Caterina Del Mar Bonnin, Paolo Brambilla, Erick J Canales-Rodríguez, Xavier Caseras, Orwa Dandash, Udo Dannlowski, Giuseppe Delvecchio, Ana M Díaz-Zuluaga, Danai Dima, Édouard Duchesnay, Torbjørn Elvsåshagen, Scott C Fears, Sophia Frangou, Janice M Fullerton, David C Glahn, Jose M Goikolea, Melissa J Green, Dominik Grotegerd, Oliver Gruber, Bartholomeus C M Haarman, Chantal Henry, Fleur M Howells, Victoria Ives-Deliperi, Andreas Jansen, Tilo T J Kircher, Christian Knöchel, Bernd Kramer, Beny Lafer, Carlos López-Jaramillo, Rodrigo Machado-Vieira, Bradley J MacIntosh, Elisa M T Melloni, Philip B Mitchell, Igor Nenadic, Fabiano Nery, Allison C Nugent, Viola Oertel, Roel A Ophoff, Miho Ota, Bronwyn J Overs, Daniel L Pham, Mary L Phillips, Julian A Pineda-Zapata, Sara Poletti, Mircea Polosan, Edith Pomarol-Clotet, Arnaud Pouchon, Yann Quidé, Maria M Rive, Gloria Roberts, Henricus G Ruhe, Raymond Salvador, Salvador Sarró, Theodore D Satterthwaite, Aart H Schene, Kang Sim, Jair C Soares, Michael Stäblein, Dan J Stein, Christian K Tamnes, Georgios V Thomaidis, Cristian Vargas Upegui, Dick J Veltman, Michèle Wessa, Lars T Westlye, Heather C Whalley, Daniel H Wolf, Mon-Ju Wu, Lakshmi N Yatham, Carlos A Zarate, Paul M Thompson, Ole A Andreassen, ,

MRI-derived brain measures offer a link between genes, the environment and behavior and have been widely studied in bipolar disorder (BD). However, many neuroimaging studies of BD have been underpowered, leading to varied results and uncertainty regarding effects. The Enhancing Neuro Imaging Genetics through Meta-Analysis (ENIGMA) Bipolar Disorder Working Group ... Read more >>

Hum Brain Mapp (Human brain mapping)
[2020, :]

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Ethical issues in global neuroimaging genetics collaborations.

Andrea Palk, Judy Illes, Paul M Thompson, Dan J Stein,

Neuroimaging genetics is a rapidly developing field that combines neuropsychiatric genetics studies with imaging modalities to investigate how genetic variation influences brain structure and function. As both genetic and imaging technologies improve further, their combined power may hold translational potential in terms of improving psychiatric nosology, diagnosis, and treatment. While ... Read more >>

Neuroimage (NeuroImage)
[2020, 221:117208]

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The prevalence and clinical correlates of substance use disorders in patients with psychotic disorders from an Upper-Middle-Income Country.

Henk S Temmingh, Sumaya Mall, Fleur M Howells, Goodman Sibeko, Dan J Stein,

Background:Substance use disorders (SUDs) occur frequently in patients with psychotic disorders and have been associated with various demographic and clinical correlates. There is an absence of research on the prevalence and clinical correlates of SUDs in psychotic disorders in low-and-middle-income countries (LMICs). Aim:We aimed to determine the prevalence and correlates ... Read more >>

(The South African journal of psychiatry : SAJP : the journal of the Society of Psychiatrists of South Africa)
[2020, 26:1473]

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Perceived helpfulness of treatment for posttraumatic stress disorder: Findings from the World Mental Health Surveys.

Dan J Stein, Meredith G Harris, Daniel V Vigo, Wai Tat Chiu, Nancy Sampson, Jordi Alonso, Yasmin Altwaijri, Brendan Bunting, José Miguel Caldas-de-Almeida, Alfredo Cía, Marius Ciutan, Louisa Degenhardt, Oye Gureje, Aimee Karam, Elie G Karam, Sing Lee, Maria Elena Medina-Mora, Zeina Mneimneh, Fernando Navarro-Mateu, José Posada-Villa, Charlene Rapsey, Yolanda Torres, Maria Carmen Viana, Yuval Ziv, Ronald C Kessler, ,

BACKGROUND:Perceived helpfulness of treatment is an important healthcare quality indicator in the era of patient-centered care. We examine probability and predictors of two key components of this indicator for posttraumatic stress disorder (PTSD). METHODS:Data come from World Mental Health surveys in 16 countries. Respondents who ever sought PTSD treatment (n = 779) ... Read more >>

Depress Anxiety (Depression and anxiety)
[2020, :]

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How do substance use disorders compare to other psychiatric conditions on structural brain abnormalities? A cross-disorder meta-analytic comparison using the ENIGMA consortium findings.

Xavier Navarri, Mohammad H Afzali, Jacob Lavoie, Rajita Sinha, Dan J Stein, Reza Momenan, Dick J Veltman, Ozlem Korucuoglu, Zsuzsika Sjoerds, Ruth J van Holst, Rob Hester, Catherine Orr, Janna Cousijn, Murat Yucel, Valentina Lorenzetti, Reinout Wiers, Neda Jahanshad, David C Glahn, Paul M Thompson, Scott Mackey, Patricia J Conrod,

Alcohol use disorder (AUD) and cannabis use disorder (CUD) are associated with brain alterations particularly involving fronto-cerebellar and meso-cortico-limbic circuitry. However, such abnormalities have additionally been reported in other psychiatric conditions, and until recently there has been few large-scale investigations to compare such findings. The current study uses the Enhancing ... Read more >>

Hum Brain Mapp (Human brain mapping)
[2020, :]

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The effects of acute serotonin challenge on executive planning in patients with obsessive-compulsive disorder (OCD), their first-degree relatives, and healthy controls.

Christine Lochner, Samuel R Chamberlain, Martin Kidd, Lian Taljaard, Naomi A Fineberg, Trevor W Robbins, Dan J Stein,

RATIONALE:Obsessive-compulsive disorder (OCD) is characterized by executive function impairment and by clinical responsivity to selective serotonin reuptake inhibitors (SSRIs). Executive planning deficits constitute a candidate endophenotype for OCD. It is not known whether this endophenotype is responsive to acute serotonin manipulation. OBJECTIVE:The study aimed to investigate the effects of acute ... Read more >>

Psychopharmacology (Berl) (Psychopharmacology)
[2020, 237(10):3117-3123]

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