Full Text Journal Articles by
Author Damien Ambrosetti

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Proliferating Onychomatricoma. Clinical, Dermoscopical, and Pathologic Features of Onychomatricoma New Variant Resembling Onycholemmal/Squamous Cell Carcinoma.

Christophe Perrin, Damien Ambrosetti, Brigitte Balme, Luc Thomas,

Proliferating onychomatricoma is a new challenging variant of onychomatricoma that can clinically and histologically mimic squamous cell carcinoma/onycholemmal carcinoma. This is a retrospective case series study of the clinicopathologic and dermoscopic features of 6 patients with a pathologic diagnosis of proliferating onychomatricoma, which was conducted in the dermatology and dermatopathology ... Read more >>

Am J Dermatopathol (The American Journal of dermatopathology)
[2020, :]

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A novel mechanism of HIF2-dependent PLK1-mediated metastasis and drug resistance of clear cell Renal Cell Carcinoma

Maeva Dufies, Annelies Verbiest, Lindsay Cooley, Papa Diogop Ndiaye, Julien Viotti, Xingkang He, Nicolas Nottet, Wilfried Souleyreau, Anais Hagege, Stephanie TORRINO, Julien Parola, Sandy GIULIANO, Delphine BORCHIELLINI, Renaud SCHIAPPA, Baharia MOGRABI, Jessica Zucman-Rossi, Karim Bensalah, Alain Ravaud, Patrick Auberger, Andreas Bikfalvi, Emmanuel Chamorey, Nathalie RIOUX-LECLERCQ, Nathalie Mazure, Benoit Beuselinck, Yihai Cao, Jean-Christophe Bernhard, Damien Ambrosetti, Gilles PAGES,

Polo-Like Kinase 1 (Plk1) expression is inversely correlated with survival advantages in many cancers. However, molecular mechanisms that underlie Plk1 expression are poorly understood. Here, we uncover a novel hypoxia-regulated mechanism of Plk1-mediated cancer metastasis and drug resistance. We demonstrated that a new HIF-2-dependent regulatory pathway drives Plk1 expression in ... Read more >>

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Identification of a new aggressive axis driven by ciliogenesis and absence of VDAC1-ΔC in clear cell Renal Cell Carcinoma patients.

Lucilla Fabbri, Maeva Dufies, Sandra Lacas-Gervais, Betty Gardie, Sophie Gad-Lapiteau, Julien Parola, Nicolas Nottet, Monique Meyenberg Cunha de Padua, Julie Contenti, Delphine Borchiellini, Jean-Marc Ferrero, Nathalie Rioux Leclercq, Damien Ambrosetti, Baharia Mograbi, Stéphane Richard, Julien Viotti, Emmanuel Chamorey, Nirvana Sadaghianloo, Matthieu Rouleau, William J Craigen, Bernard Mari, Stéphan Clavel, Gilles Pagès, Jacques Pouysségur, Frédéric Bost, Nathalie M Mazure,

Rationale: Renal cell carcinoma (RCC) accounts for about 2% of all adult cancers, and clear cell RCC (ccRCC) is the most common RCC histologic subtype. A hallmark of ccRCC is the loss of the primary cilium, a cellular antenna that senses a wide variety of signals. Loss of this key ... Read more >>

Theranostics (Theranostics)
[2020, 10(6):2696-2713]

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A multi-layered systems approach for renal cell carcinoma

Lindsay Cooley, Justine Rudewicz, Wilfried Souleyreau, Kim Clarke, Francesco Falciani, Maeva Dufies, Stephanie Verbeke, Andrea Emanuelli, Sebastien Benzekry, Cécile Taing, Emeline Julie Ribot, Sylvain Miraux, Diether Lambrechts, Elodie Modave, Raphael Pineau, Marie-Alix Derieppe, Damien Ambrosetti, Jean-Christophe Bernhard, Alain Ravaud, Sylvie Négrier, Jean-Marc Ferrero, Gilles Pagès, Macha Nikolski, Andreas Bikfalvi,

Abstract Renal cell carcinoma (RCC) still lacks prognostic and predictive biomarkers to monitor the disease and the response to therapy. The usual strategy in translational research is to start from human samples, to identify molecular markers and gene networks and then to functionally validate them in vitro and in animal ... Read more >>

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The combination of bevacizumab/Avastin and erlotinib/Tarceva is relevant for the treatment of metastatic renal cell carcinoma: the role of a synonymous mutation of the EGFR receptor.

Renaud Grépin, Mélanie Guyot, Aurore Dumond, Jérôme Durivault, Damien Ambrosetti, Jean-François Roussel, Florence Dupré, Hervé Quintens, Gilles Pagès,

Metastatic clear cell renal cell carcinomas (mRCC) over-express the vascular endothelial growth factor (VEGF). Hence, the anti-VEGF antibody bevacizumab/Avastin (BVZ) combined with interferon alpha (IFN) was approved for the treatment of mRCC. However, approval was lost in July 2016 due to the absence of sustained efficacy. We previously showed that ... Read more >>

Theranostics (Theranostics)
[2020, 10(3):1107-1121]

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LC-MS based metabolomic profiling for renal cell carcinoma histologic subtypes.

Lun Jing, Jean-Marie Guigonis, Delphine Borchiellini, Matthieu Durand, Thierry Pourcher, Damien Ambrosetti,

Renal cell carcinomas (RCC) are classified according to their histological features. Accurate classification of RCC and comprehensive understanding of their metabolic dysregulation are of critical importance. Here we investigate the use of metabolomic analyses to classify the main RCC subtypes and to describe the metabolic variation for each subtype. To ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):15635]

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Cellular Angiofibroma: Case Report of a Unique Subungual Presentation.

Christophe Perrin, Giuseppe E Cannata, Florence Pedeutour, Bérengère Dadone-Montaudié, Damien Ambrosetti,

Acta Derm. Venereol. (Acta dermato-venereologica)
[2019, 99(10):915-916]

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Urinary ketone body loss leads to degeneration of brain white matter in elderly SLC5A8-deficient mice.

Laurent Suissa, Virginie Flachon, Jean-Marie Guigonis, Charles-Vivien Olivieri, Fanny Burel-Vandenbos, Julien Guglielmi, Damien Ambrosetti, Matthieu Gérard, Philippe Franken, Jacques Darcourt, Luc Pellerin, Thierry Pourcher, Sabine Lindenthal,

SLC5A8 is a sodium-coupled monocarboxylate and ketone transporter expressed in various epithelial cells. A putative role of SLC5A8 in neuroenergetics has been also hypothesized. To clarify this issue, we studied the cerebral phenotype of SLC5A8-deficient mice during aging. Elderly SLC5A8-deficient mice presented diffuse leukoencephalopathy characterized by intramyelinic oedema without demyelination ... Read more >>

J. Cereb. Blood Flow Metab. (Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism)
[2019, :271678X19873662]

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New CXCR1/CXCR2 inhibitors represent an effective treatment for kidney or head and neck cancers sensitive or refractory to reference treatments.

Maeva Dufies, Oleksandr Grytsai, Cyril Ronco, Oumar Camara, Damien Ambrosetti, Anaïs Hagege, Julien Parola, Lou Mateo, Marion Ayrault, Sandy Giuliano, Renaud Grépin, Nathalie Lagarde, Matthieu Montes, Patrick Auberger, Luc Demange, Rachid Benhida, Gilles Pagès,

Clear cell Renal Cell (RCC) and Head and Neck Squamous Cell Carcinomas (HNSCC) are characterized by a pro-angiogenic/pro-inflammatory context. Despite conventional or targeted therapies, metastatic RCC and HNSCC remain incurable. Alternative treatments to reference therapies (sunitinib, a multi tyrosine kinase inhibitor for RCC or cisplatin for HNSCC) are urgently needed ... Read more >>

Theranostics (Theranostics)
[2019, 9(18):5332-5346]

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Immunosuppressive Tumor Microenvironment Status and Histological Grading of Endometrial Carcinoma.

Julie Antomarchi, Damien Ambrosetti, Charlotte Cohen, Jérôme Delotte, Anne Chevallier, Babou Karimdjee-Soilihi, Mélanie Ngo-Mai, Annie Schmid-Alliana, Heidy Schmid-Antomarchi,

The recent successes of new cancer immunotherapy approaches have led to investigate their relevance in the context of the Endometrial Carcinoma (EC). These therapies, that take the tumor-induced immunosuppressive microenvironment into account, target the tumor immune escape, in particular the inhibitory receptors involved in the regulation of the effector T ... Read more >>

Cancer Microenviron (Cancer microenvironment : official journal of the International Cancer Microenvironment Society)
[2019, 12(2-3):169-179]

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PGC1α Inhibits Polyamine Synthesis to Suppress Prostate Cancer Aggressiveness.

Lisa Kaminski, Stéphanie Torrino, Maeva Dufies, Zied Djabari, Romain Haider, François-René Roustan, Emilie Jaune, Kathiane Laurent, Nicolas Nottet, Jean-François Michiels, Maeva Gesson, Stéphane Rocchi, Nathalie M Mazure, Matthieu Durand, Jean-François Tanti, Damien Ambrosetti, Stephan Clavel, Issam Ben-Sahra, Frédéric Bost,

Although tumorigenesis is dependent on the reprogramming of cellular metabolism, the metabolic pathways engaged in the formation of metastases remain largely unknown. The transcriptional coactivator peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1α) plays a pleiotropic role in the control of cancer cell metabolism and has been associated with a good ... Read more >>

Cancer Res. (Cancer research)
[2019, 79(13):3268-3280]

Cited: 3 times

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GAPDH Expression Predicts the Response to R-CHOP, the Tumor Metabolic Status, and the Response of DLBCL Patients to Metabolic Inhibitors.

Johanna Chiche, Julie Reverso-Meinietti, Annabelle Mouchotte, Camila Rubio-Patiño, Rana Mhaidly, Elodie Villa, Jozef P Bossowski, Emma Proics, Manuel Grima-Reyes, Agnès Paquet, Konstantina Fragaki, Sandrine Marchetti, Josette Briere, Damien Ambrosetti, Jean-François Michiels, Thierry Jo Molina, Christiane Copie-Bergman, Jacqueline Lehmann-Che, Isabelle Peyrottes, Frederic Peyrade, Eric de Kerviler, Bruno Taillan, Georges Garnier, Els Verhoeyen, Véronique Paquis-Flucklinger, Laetitia Shintu, Vincent Delwail, Celine Delpech-Debiais, Richard Delarue, André Bosly, Tony Petrella, Gabriel Brisou, Bertrand Nadel, Pascal Barbry, Nicolas Mounier, Catherine Thieblemont, Jean-Ehrland Ricci,

Diffuse large B cell lymphoma (DLBCL) is a heterogeneous disease treated with anti-CD20-based immuno-chemotherapy (R-CHOP). We identified that low levels of GAPDH predict a poor response to R-CHOP treatment. Importantly, we demonstrated that GAPDHlow lymphomas use OxPhos metabolism and rely on mTORC1 signaling and glutaminolysis. Consistently, disruptors of OxPhos metabolism ... Read more >>

Cell Metab. (Cell metabolism)
[2019, 29(6):1243-1257.e10]

Cited: 2 times

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VEGFC acts as a double-edged sword in renal cell carcinoma aggressiveness.

Papa Diogop Ndiaye, Maeva Dufies, Sandy Giuliano, Laetitia Douguet, Renaud Grépin, Jérôme Durivault, Philippe Lenormand, Natacha Glisse, Janita Mintcheva, Valérie Vouret-Craviari, Baharia Mograbi, Maud Wurmser, Damien Ambrosetti, Nathalie Rioux-Leclercq, Pascal Maire, Gilles Pagès,

Hypoxic zones are common features of metastatic tumors. Due to inactivation of the von Hippel-Lindau gene (VHL), renal cell carcinomas (RCC) show constitutive stabilization of the alpha subunit of the hypoxia-inducible factor (HIF). Thus, RCC represents a model of chronic hypoxia. Development of the lymphatic network is dependent on vascular ... Read more >>

Theranostics (Theranostics)
[2019, 9(3):661-675]

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Cobalamin C Deficiency Induces a Typical Histopathological Pattern of Renal Arteriolar and Glomerular Thrombotic Microangiopathy.

Mathilde Lemoine, Arnaud François, Steven Grangé, Marion Rabant, Valérie Châtelet, David Cassiman, Emilie Cornec-Le Gall, Damien Ambrosetti, Georges Deschênes, Jean-François Benoist, Dominique Guerrot,

Cobalamin C (cblC) deficiency is the most common inborn error of vitamin B12 metabolism. Renal failure attributed to thrombotic microangiopathy (TMA) has occasionally been described in the late-onset presentation of cblC deficiency, but kidney lesions associated with cblC deficiency remain poorly defined. This study aims to describe the characteristics of ... Read more >>

Kidney Int Rep (Kidney international reports)
[2018, 3(5):1153-1162]

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STAT3 Gain of Function: A New Kid on the Block in Interstitial Lung Diseases.

Alexandre Fabre, Sarah Marchal, Lisa Renee Forbes, Tiphanie Phillips Vogel, Vincent Barlogis, Valérie Triolo, Pierre-Simon Rohrlich, Etienne Bérard, Diane Frankel, Damien Ambrosetti, Christine Soler, Marie Hoflack, Marie Baque, Emmanuelle Bosdure, Mélisande Baravalle, Ania Carsin, Jean-Christophe Dubus, Lisa Giovannini-Chami,

Am. J. Respir. Crit. Care Med. (American journal of respiratory and critical care medicine)
[2018, 197(11):e22-e23]

Cited: 4 times

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Soluble CD146 is a predictive marker of pejorative evolution and of sunitinib efficacy in clear cell renal cell carcinoma.

Maeva Dufies, Marie Nollet, Damien Ambrosetti, Wael Traboulsi, Julien Viotti, Delphine Borchiellini, Renaud Grépin, Julien Parola, Sandy Giuliano, Dominique Helley-Russick, Karim Bensalah, Alain Ravaud, Jean-Christophe Bernhard, Renaud Schiappa, Nathalie Bardin, Françoise Dignat-George, Nathalie Rioux-Leclercq, Stephane Oudard, Sylvie Négrier, Jean-Marc Ferrero, Emmanuel Chamorey, Marcel Blot-Chabaud, Gilles Pagès,

The objective of the study was to use CD146 mRNA to predict the evolution of patients with non-metastatic clear cell renal cell carcinoma (M0 ccRCC) towards metastatic disease, and to use soluble CD146 (sCD146) to anticipate relapses on reference treatments by sunitinib or bevacizumab in patients with metastatic ccRCC (M1). ... Read more >>

Theranostics (Theranostics)
[2018, 8(9):2447-2458]

Cited: 2 times

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Melanocytes Pattern in the Normal Nail, With Special Reference to Nail Bed Melanocytes.

Christophe Perrin, Jean-F Michiels, Julien Boyer, Damien Ambrosetti,

Previous studies of the density of melanocytes in the normal nail bed have had conflicting results. This is unfortunate because knowing the normal values might help the difficult distinction between a benign subungual melanotic macule and an early melanoma in situ. Five specimens of normal nail unit were analyzed. On ... Read more >>

Am J Dermatopathol (The American Journal of dermatopathology)
[2018, 40(3):180-184]

Cited: 1 time

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The two glycolytic markers GLUT1 and MCT1 correlate with tumor grade and survival in clear-cell renal cell carcinoma.

Damien Ambrosetti, Maeva Dufies, Bérengère Dadone, Matthieu Durand, Delphine Borchiellini, Jean Amiel, Jacques Pouyssegur, Nathalie Rioux-Leclercq, Gilles Pages, Fanny Burel-Vandenbos, Nathalie M Mazure,

Clear-cell renal cell carcinoma (ccRCC) is the most common type of kidney cancer. Although ccRCC is characterized by common recurrent genetic abnormalities, including inactivation of the von Hippel-Lindau (vhl) tumor suppressor gene resulting in stabilization of hypoxia-inducible factors (HIFs), the tumor aggressiveness and outcome of ccRCC is variable. New biomarkers ... Read more >>

PLoS ONE (PloS one)
[2018, 13(2):e0193477]

Cited: 4 times

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ALK-TPM3 rearrangement in adult renal cell carcinoma: Report of a new case showing loss of chromosome 3 and literature review.

Yohan Bodokh, Damien Ambrosetti, Valérie Kubiniek, Branwel Tibi, Matthieu Durand, Jean Amiel, Morgane Pertuit, Anne Barlier, Florence Pedeutour,

Seven cases of translocation-associated renal cell carcinoma involving ALK (ALK-tRCC) were referenced in the last World Health Organization's classification (2016), in a group of emerging/provisional RCC. The first three cases were pediatric, medullary-based, associated with sickle-cell trait and showed a fusion of ALK with VCL. Thirteen cases have been further ... Read more >>

Cancer Genet (Cancer genetics)
[2018, 221:31-37]

Cited: 2 times

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Comprehensive study of three novel cases of TFEB-amplified renal cell carcinoma and review of the literature: Evidence for a specific entity with poor outcome.

Lionel Mendel, Damien Ambrosetti, Yohan Bodokh, Mélanie Ngo-Mai, Matthieu Durand, Cécile Simbsler-Michel, Mickael Delhorbe, Jean Amiel, Florence Pedeutour,

The first case of TFEB-amplified renal cell carcinoma was published in 2014. Since then, 29 additional cases have been described. The prognostic and therapeutic implications of this rare entity remain to be determined. We describe here the clinical, histological, and genetic features of three novel cases, and the first complete ... Read more >>

Genes Chromosomes Cancer (Genes, chromosomes & cancer)
[2018, 57(3):99-113]

Cited: 4 times

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ATP-competitive Plk1 inhibitors induce caspase 3-mediated Plk1 cleavage and activation in hematopoietic cell lines.

Maeva Dufies, Damien Ambrosetti, Sonia Boulakirba, Anne Calleja, Coline Savy, Nathan Furstoss, Marwa Zerhouni, Julien Parola, Lazaro Aira-Diaz, Sandrine Marchetti, Francois Orange, Sandra Lacas-Gervais, Frederic Luciano, Arnaud Jacquel, Guillaume Robert, Gilles Pagès, Patrick Auberger,

Polo-like kinases (Plks) define a highly conserved family of Ser/Thr kinases with crucial roles in the regulation of cell division. Here we show that Plk1 is cleaved by caspase 3, but not by other caspases in different hematopoietic cell lines treated with competitive inhibitors of the ATP-binding pocket of Plk1. ... Read more >>

Oncotarget (Oncotarget)
[2018, 9(13):10920-10933]

Cited: 0 times

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[18F] FDOPA standardized uptake values of brain tumors are not exclusively dependent on LAT1 expression.

Bérengère Dadone-Montaudié, Damien Ambrosetti, Maxime Dufour, Jacques Darcourt, Fabien Almairac, John Coyne, Thierry Virolle, Olivier Humbert, Fanny Burel-Vandenbos,

[18F]-FDOPA is a labeled amino acid (AA) analog used for positron emission tomography (PET) which is gaining increasing interest in the evaluation of brain tumors (BT). The AA-transporter LAT1 has been shown to be involved in [18F]-FDOPA uptake. The aim of this study was to determine whether the [18F]-FDOPA uptake ... Read more >>

PLoS ONE (PloS one)
[2017, 12(9):e0184625]

Cited: 5 times

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Sirtuin 7: a new marker of aggressiveness in prostate cancer.

Romain Haider, Fabienne Massa, Lisa Kaminski, Stephan Clavel, Zied Djabari, Guillaume Robert, Kathiane Laurent, Jean-François Michiels, Matthieu Durand, Jean-Ehrland Ricci, Jean-François Tanti, Frédéric Bost, Damien Ambrosetti,

Predictive biomarkers for advanced prostate cancer (PCa) are still missing. The sirtuin 7 (SIRT7) has been linked to tumorogenesis but its role in prostate cancer is poorly documented. To determine if SIRT7 can be a biomarker for aggressive prostate cancer and plays a role in PCa aggressiveness. We analyzed the ... Read more >>

Oncotarget (Oncotarget)
[2017, 8(44):77309-77316]

Cited: 3 times

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CXCL7 is a predictive marker of sunitinib efficacy in clear cell renal cell carcinomas.

Maeva Dufies, Sandy Giuliano, Julien Viotti, Delphine Borchiellini, Linsay S Cooley, Damien Ambrosetti, Mélanie Guyot, Papa Diogop Ndiaye, Julien Parola, Audrey Claren, Renaud Schiappa, Jocelyn Gal, Antoine Frangeul, Arnaud Jacquel, Ophélie Cassuto, Renaud Grépin, Patrick Auberger, Andréas Bikfalvi, Gérard Milano, Bernard Escudier, Nathalie Rioux-Leclercq, Camillo Porta, Sylvie Negrier, Emmanuel Chamorey, Jean-Marc Ferrero, Gilles Pagès,

Sunitinib is one of the first-line standard treatments for metastatic clear cell renal cell carcinoma (ccRCC) with a median time to progression shorter than 1 year. The objective is to discover predictive markers of response to adapt the treatment at diagnosis.Prospective phase 2 multi-centre trials were conducted in ccRCC patients ... Read more >>

Br. J. Cancer (British journal of cancer)
[2017, 117(7):947-953]

Cited: 6 times

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The energy disruptor metformin targets mitochondrial integrity via modification of calcium flux in cancer cells.

Camille Loubiere, Stephan Clavel, Jerome Gilleron, Rania Harisseh, Jeremy Fauconnier, Issam Ben-Sahra, Lisa Kaminski, Kathiane Laurent, Stephanie Herkenne, Sandra Lacas-Gervais, Damien Ambrosetti, Damien Alcor, Stephane Rocchi, Mireille Cormont, Jean-François Michiels, Bernard Mari, Nathalie M Mazure, Luca Scorrano, Alain Lacampagne, Abdallah Gharib, Jean-François Tanti, Frederic Bost,

Mitochondrial integrity is critical for the regulation of cellular energy and apoptosis. Metformin is an energy disruptor targeting complex I of the respiratory chain. We demonstrate that metformin induces endoplasmic reticulum (ER) stress, calcium release from the ER and subsequent uptake of calcium into the mitochondria, thus leading to mitochondrial ... Read more >>

Sci Rep (Scientific reports)
[2017, 7(1):5040]

Cited: 13 times

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