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Author Daisuke Aoki

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Characterization of N-phenylmaleimide-terminated poly(ethylene glycol)s and their application to a tetra-arm poly(ethylene glycol) gel.

Rikito Takashima, Masashi Ohira, Hirogi Yokochi, Daisuke Aoki, Xiang Li, Hideyuki Otsuka,

Tetra-arm poly(ethylene glycol) (TetraPEG) gels are tough materials whose toughness originates from their uniform network structure. They can be formed by combining the termini of tetra-arm polymers via chemical reactions with high conversion efficiency, such as the Michael addition, condensations using an active ester group, and alkyne-azide cycloadditions. Herein, we ... Read more >>

Soft Matter (Soft matter)
[2020, 16(48):10869-10875]

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The trend and outcome of postsurgical therapy for high-risk early-stage cervical cancer with lymph node metastasis in Japan: a report from the Japan Society of Gynecologic Oncology (JSGO) guidelines evaluation committee.

Masae Ikeda, Masako Shida, Shogo Shigeta, Satoru Nagase, Fumiaki Takahashi, Wataru Yamagami, Hidetaka Katabuchi, Nobuo Yaegashi, Daisuke Aoki, Mikio Mikami,

<h4>Objective</h4>The Japan Society of Gynecologic Oncology published the first guidelines for the treatment of cervical cancer in 2007. The aim of this research was to evaluate the influence of the introduction of the first guideline on clinical trends and outcomes of patients with early-stage cervical cancer who underwent surgery.<h4>Methods</h4>This analysis ... Read more >>

J Gynecol Oncol (Journal of gynecologic oncology)
[2021, 32(3):e44]

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Visualization of the slide-ring effect: a study on movable cross-linking points using mechanochromism.

Yi Lu, Daisuke Aoki, Jun Sawada, Takahiro Kosuge, Hiromitsu Sogawa, Hideyuki Otsuka, Toshikazu Takata,

To evaluate the 'slide-ring' effect in a rotaxane cross-linked network, we incorporated mechanochromophores into static and rotaxane cross-linking points and compared the mechanochromisms exhibited by the obtained polymers. This novel strategy reveals a molecular-level phenomenon with visible color changes as well as enabling quantitative electron paramagnetic resonance measurements. ... Read more >>

Chem Commun (Camb) (Chemical communications (Cambridge, England))
[2020, 56(23):3361-3364]

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Survey of the clinical practice pattern of using sentinel lymph node biopsy in patients with gynecological cancers in Japan: the Japan Society of Gynecologic Oncology study.

Shinichi Togami, Hiroaki Kobayashi, Hitoshi Niikura, Muneaki Shimada, Nobuyuki Susumu, Tomohito Tanaka, Yoshito Terai, Tomoyuki Nagai, Tsukasa Baba, Hideaki Yahata, Wataru Yamagami, Ken Yamaguchi, Tsuyoshi Yamashita, Nobuo Yaegashi, Hidetaka Katabuchi, Daisuke Aoki,

<h4>Background</h4>Sentinel lymph node (SN) biopsy is essential for evaluating survival and minimal treatment-related morbidity associated with cervical, endometrial, and vulvar cancer in Japan. As such, our aim in this study was to evaluate the current practice pattern of using SN biopsy for cervical, endometrial, and vulvar cancer in Japan.<h4>Methods</h4>We deployed ... Read more >>

Int J Clin Oncol (International journal of clinical oncology)
[2021, :]

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Understanding of the position of patients with Mayer-Rokitansky-Küster-Hauser syndrome revealed by uterus transplantation research in Japan.

Iori Kisu, Kouji Banno, Daisuke Aoki,

J Obstet Gynaecol Res (The journal of obstetrics and gynaecology research)
[2021, :]

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The 2020 Japan Society of Gynecologic Oncology guidelines for the treatment of ovarian cancer, fallopian tube cancer, and primary peritoneal cancer.

Hideki Tokunaga, Mikio Mikami, Satoru Nagase, Yoichi Kobayashi, Tsutomu Tabata, Masanori Kaneuchi, Toyomi Satoh, Yasuyuki Hirashima, Noriomi Matsumura, Yoshihito Yokoyama, Kei Kawana, Satoru Kyo, Daisuke Aoki, Hidetaka Katabuchi,

The fifth edition of the Japan Society of Gynecologic Oncology guidelines for the treatment of ovarian cancer, fallopian tube cancer, and primary peritoneal cancer was published in 2020. The guidelines contain 6 chapters-namely, (1) overview of the guidelines; (2) epithelial ovarian cancer, fallopian tube cancer, and primary peritoneal cancer; (3) ... Read more >>

J Gynecol Oncol (Journal of gynecologic oncology)
[2021, 32(2):e49]

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Non-symmetric mechanophores prepared from radical-type symmetric mechanophores: bespoke mechanofunctional polymers.

Kosaku Yanada, Sota Kato, Daisuke Aoki, Koichiro Mikami, Hajime Sugita, Hideyuki Otsuka,

A non-symmetric radical-type mechanophore (CF/ABF) was synthesized by molecular crossing between two radical-type mechanophores. The thermal stability and mechanoresponsiveness of CF/ABF were found to be tunable by altering the properties of the parent RMs. The CF/ABF-centred polymers showed mixed mechanochromism derived from the simultaneous generation of two radical species. ... Read more >>

Chem Commun (Camb) (Chemical communications (Cambridge, England))
[2021, 57(23):2899-2902]

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Segmented Polyurethane Elastomers with Mechanochromic and Self-Strengthening Functions.

Kota Seshimo, Hio Sakai, Takuma Watabe, Daisuke Aoki, Hajime Sugita, Koichiro Mikami, Yuchen Mao, Akira Ishigami, Shotaro Nishitsuji, Takashi Kurose, Hiroshi Ito, Hideyuki Otsuka,

Mechanochromic elastomers that exhibit force-induced cross-linking reactions in the bulk state are introduced. The synthesis of segmented polyurethanes (SPUs) that contain difluorenylsuccinonitrile (DFSN) moieties in the main chain and methacryloyl groups in the side chains was carried out. DFSN was selected as the mechanophore because it dissociates under mechanical stimuli ... Read more >>

Angew Chem Int Ed Engl (Angewandte Chemie (International ed. in English))
[2021, 60(15):8406-8409]

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Nucleosome positioning on episomal human papillomavirus DNA in cultured cells

Isao Murakami, Takashi Iwata, Tohru Morisada, Kyoko Tanaka, Daisuke Aoki,

Several human papillomaviruses (HPV) are associated with the development of cervical carcinoma. HPV DNA synthesis is increased during the differentiation of infected host keratinocytes as they migrate from the basal layer of the epithelium to the spinous layer, but the molecular mechanism is unclear. Nucleosome positioning affects various cellular processes ... Read more >>

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Atypical vessels in hysteroscopy: Usefulness in prediction of malignant diseases in patients treated with tamoxifen.

Emiko Oka, Kensuke Sakai, Wataru Yamagami, Takuro Hirano, Takeshi Makabe, Tomoko Yoshihama, Tatsuyuki Chiyoda, Fumio Kataoka, Kouji Banno, Daisuke Aoki,

<h4>Aim</h4>Tamoxifen (TAM) is widely used in adjuvant endocrine therapy for invasive breast cancer as a selective estrogen modulator, but this treatment has a risk of developing endometrial malignancy. However, hysteroscopic findings during or after TAM treatment are unclear. The aim of this study is to examine the association between hysteroscopic ... Read more >>

J Obstet Gynaecol Res (The journal of obstetrics and gynaecology research)
[2021, 47(4):1510-1515]

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Current status of cancer immunotherapy for gynecologic malignancies.

Hiroshi Nishio, Takashi Iwata, Daisuke Aoki,

Recent cancer immunotherapy development with immune checkpoint inhibitors has shown durable clinical responses in a wide variety of tumor types. These drugs targeting programmed cell death 1, its ligand programmed death ligand 1 and cytotoxic T cell lymphocyte-associated antigen 4 have revolutionized the field of cancer treatment. It is of ... Read more >>

Jpn J Clin Oncol (Japanese journal of clinical oncology)
[2021, 51(2):167-172]

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Retrospective evaluation of risk-reducing salpingo-oophorectomy for BRCA1/2 pathogenic variant carriers among a cohort study in a single institution.

Yusuke Kobayashi, Akira Hirasawa, Tatsuyuki Chiyoda, Arisa Ueki, Kenta Masuda, Kumiko Misu, Miho Kawaida, Shigenori Hayashi, Fumio Kataoka, Kouji Banno, Kenjiro Kosaki, Daisuke Aoki,

<h4>Background</h4>Risk-reducing salpingo-oophorectomy is performed for the primary prevention of ovarian cancer in patients with hereditary breast-ovarian cancer syndrome. We performed risk-reducing salpingo-oophorectomy for the first time in Japan in 2008, and we experienced 20 cases of risk-reducing salpingo-oophorectomy through 2019. In the past, the use of risk-reducing salpingo-oophorectomy in Japan ... Read more >>

Jpn J Clin Oncol (Japanese journal of clinical oncology)
[2021, 51(2):213-217]

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Current status and future directions of ovarian cancer prognostic models.

Yusuke Kobayashi, Kouji Banno, Daisuke Aoki,

J Gynecol Oncol (Journal of gynecologic oncology)
[2021, 32(2):e34]

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Operative and Clinical Outcomes of Minimally Invasive Living-Donor Surgery on Uterus Transplantation: A Literature Review.

Yusuke Matoba, Iori Kisu, Kouji Banno, Daisuke Aoki,

<h4>Background</h4>The surgical approach and choice of drainage veins for uterus transplantation living-donor surgery have been investigated to reduce invasiveness.<h4>Methods</h4>A thorough search of the PubMed database was conducted. The search was not limited by language or date of publication. The data were collected on 13 October 2020. Two reviewers independently assessed ... Read more >>

J Clin Med (Journal of clinical medicine)
[2021, 10(2):]

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Real-world data on microsatellite instability status in various unresectable or metastatic solid tumors.

Kiwamu Akagi, Eiji Oki, Hiroya Taniguchi, Kaname Nakatani, Daisuke Aoki, Takeshi Kuwata, Takayuki Yoshino,

Microsatellite instability-high (MSI-H) is an important biomarker for predicting the effect of immune checkpoint inhibitors (ICIs) on advanced solid tumors. Microsatellite instability-high is detected in various cancers, but its frequency varies by cancer type and stage. Therefore, precise frequency is required to plan ICI therapy. In this study, the results ... Read more >>

Cancer Sci (Cancer science)
[2021, 112(3):1105-1113]

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Lymphadenectomy issues in endometrial cancer.

Yosuke Konno, Hiroshi Asano, Ayumi Shikama, Daisuke Aoki, Michihiro Tanikawa, Akinori Oki, Koji Horie, Akira Mitsuhashi, Akira Kikuchi, Hideki Tokunaga, Yasuhisa Terao, Toyomi Satoh, Kimio Ushijima, Mitsuya Ishikawa, Nobuo Yaegashi, Hidemichi Watari,

<h4>Objectives</h4>This review aims to introduce preoperative scoring systems to predict lymph node metastasis (LNM) and ongoing clinical trials to investigate the therapeutic role of lymphadenectomy for endometrial cancer.<h4>Methods</h4>We summarized previous reports on the preoperative prediction models for LNM and evaluated their validity to omit lymphadenectomy in our recent cohorts. Next, ... Read more >>

J Gynecol Oncol (Journal of gynecologic oncology)
[2021, 32(2):e25]

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Crystallization-induced mechanofluorescence for visualization of polymer crystallization.

Sota Kato, Shigeki Furukawa, Daisuke Aoki, Raita Goseki, Kazusato Oikawa, Kousuke Tsuchiya, Naohiko Shimada, Atsushi Maruyama, Keiji Numata, Hideyuki Otsuka,

The growth of lamellar crystals has been studied in particular for spherulites in polymeric materials. Even though such spherulitic structures and their growth are of crucial importance for the mechanical and optical properties of the resulting polymeric materials, several issues regarding the residual stress remain unresolved in the wider context ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):126]

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A prospective cohort study on the safety and efficacy of bevacizumab combined with chemotherapy in Japanese patients with relapsed ovarian, fallopian tube or primary peritoneal cancer.

Yoshiko Nanki, Hiroyuki Nomura, Naomi Iwasa, Keiko Saotome, Ai Dozen, Tomoko Yoshihama, Takuro Hirano, Shiho Hashimoto, Tatsuyuki Chiyoda, Wataru Yamagami, Fumio Kataoka, Daisuke Aoki,

<h4>Objective</h4>this prospective cohort study aimed to assess the safety and efficacy of bevacizumab combined with chemotherapy in Japanese patients with relapsed ovarian, fallopian tube or primary peritoneal cancer.<h4>Methods</h4>in this study, 40 Japanese patients with relapsed ovarian, fallopian tube or primary peritoneal cancer selected to receive bevacizumab with chemotherapy were enrolled. ... Read more >>

Jpn J Clin Oncol (Japanese journal of clinical oncology)
[2021, 51(1):54-59]

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The real-world data on microsatellite instability status in various unresectable or metastatic solid tumors.

Kiwamu Akagi, Eiji Oki, Hiroya Taniguchi, Kaname Nakatani, Daisuke Aoki, Takeshi Kuwata, Takayuki Yoshino,

Microsatellite instability-high (MSI-H) is an important biomarker for predicting the effect of immune-checkpoint inhibitors (ICIs) on advanced solid tumors. MSI-H is detected in various cancers, but its frequency varies by cancer type and stage. Therefore, precise frequency is required to plan ICIs therapy. In this study, the results of MSI ... Read more >>

Cancer Sci (Cancer science)
[2021, :]

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The first-round results of a population-based cohort study of HPV testing in Japanese cervical cancer screening: baseline characteristics, screening results, and referral rate.

Kanako Kono, Tohru Morisada, Kumiko Saika, Eiko Saitoh Aoki, Etsuko Miyagi, Kiyoshi Ito, Hirokazu Takahashi, Tomio Nakayama, Hiroshi Saito, Daisuke Aoki,

<h4>Objective</h4>In 2013, a cohort study aimed to clarify the positive and negative effects of introducing the human papillomavirus (HPV) testing for population-based cervical cancer screening has been launched in Japan. This study included four screenings during the subsequent 7-year follow-up period. We aim to describe the results of the first ... Read more >>

J Gynecol Oncol (Journal of gynecologic oncology)
[2021, 32(3):e29]

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Examining the genetic influences of migratory status on island colonisation by naturally and recently established populations of a bird species

Daisuke Aoki, Shin Matsui, Mari Esashi, Isao Nishiumi, Junco Nagata, Masaoki Takagi,

Seasonal migration influences long-distance dispersal and population establishment, which are the two important steps for successful island colonisation. Migratory behaviour facilitates the long-distance dispersal of individuals through frequent appearance outside a species’ normal range, while sedentary behaviour may lead to dispersal by post-fledgling flocks whose accidental immigration provide sufficient propagules ... Read more >>

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Familial pancreatic cancer with PALB2 and NBN pathogenic variants: a case report.

Kodai Abe, Arisa Ueki, Yusaku Urakawa, Minoru Kitago, Tomoko Yoshihama, Yoshiko Nanki, Yuko Kitagawa, Daisuke Aoki, Kenjiro Kosaki, Akira Hirasawa,

<h4>Background</h4>Family history is one of the risk factors for pancreatic cancer. It is suggested that patients with pancreatic cancer who have a familial history harbor germline pathogenic variants of BRCA1 and/or BRCA2 (BRCA1/2), PALB2, or ATM. Recently, some germline variants of familial pancreatic cancers (FPCs), including PALB2, have been detected. ... Read more >>

Hered Cancer Clin Pract (Hereditary cancer in clinical practice)
[2021, 19(1):5]

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Climacteric Symptoms in Postoperative Patients Among Endometrial Cancer, Cervical Cancer, and Ovarian Cancer: A Cross-Sectional Study

YUKO HORIBA, Tetsuhiro Yoshino, Megumi Yokota, Takashi Iwata, Kenji Watanabe, Masaru Mimura, Daisuke Aoki,

<h4>Background: </h4> No studies have assessed climacteric symptoms after hystero-adnexectomy for endometrial, cervical, or ovarian cancer. Thus, this study aimed to compare climacteric symptoms among patients who underwent surgery for these three cancer types. <h4>Methods: </h4> We included patients who were registered at a menopausal outpatient clinic between January 1999 ... Read more >>

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Evaluating the importance of routine drainage following laparoscopic pelvic lymph node dissection for gynecological malignancies.

Kensuke Sakai, Masaru Nakamura, Wataru Yamagami, Tatsuyuki Chiyoda, Yusuke Kobayashi, Hiroshi Nishio, Shigenori Hayashi, Hiroyuki Nomura, Fumio Kataoka, Eiichiro Tominaga, Kouji Banno, Daisuke Aoki,

<h4>Objective</h4>To determine the efficacy of drainage following pelvic lymph node (PLN) dissection, especially for cases involving laparoscopic surgery.<h4>Methods</h4>In this retrospective study, 368 patients with malignant gynecological tumors who underwent systemic PLN dissection at Keio University Hospital between January 2012 and October 2018 were enrolled. Drainage tubes were placed in the ... Read more >>

Int J Gynaecol Obstet (International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics)
[2020, :]

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Phase 2 single-arm study on the efficacy and safety of niraparib in Japanese patients with heavily pretreated, homologous recombination-deficient ovarian cancer.

Aikou Okamoto, Eiji Kondo, Toshiaki Nakamura, Satoshi Yanagida, Junzo Hamanishi, Kenichi Harano, Kosei Hasegawa, Takeshi Hirasawa, Kensuke Hori, Shinichi Komiyama, Motoki Matsuura, Hidekatsu Nakai, Hiroko Nakamura, Jun Sakata, Tsutomu Tabata, Kazuhiro Takehara, Munetaka Takekuma, Yoshihito Yokoyama, Yoichi Kase, Shuuji Sumino, Junpei Soeda, Ajit Suri, Daisuke Aoki, Toru Sugiyama,

<h4>Objective</h4>To evaluate the efficacy and safety of niraparib in Japanese women with heavily pretreated ovarian cancer.<h4>Methods</h4>This Phase 2 open-label, single-arm study enrolled Japanese women with homologous recombination deficiency-positive relapsed, high-grade serous ovarian, fallopian tube, or primary peritoneal cancer who had completed 3-4 lines of therapy. The starting dose of niraparib ... Read more >>

J Gynecol Oncol (Journal of gynecologic oncology)
[2021, 32(2):e16]

Cited: 1 time

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