Full Text Journal Articles by
Author Dagmar Heuer

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Sphingolipid Metabolism and Transport in Chlamydia trachomatis and Chlamydia psittaci Infections.

Sebastian Banhart, Elena K Schäfer, Jean-Marc Gensch, Dagmar Heuer,

Chlamydia species infect a large range of vertebral hosts and have become of major economic and public health concern over the last decades. They are obligate intracellular bacteria that undergo a unique cycle of development characterized by the presence of two distinct bacterial forms. After infection of the host cell, ... Read more >>

Front Cell Dev Biol (Frontiers in cell and developmental biology)
[2019, 7:223]

Cited: 0 times

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Chlamydia trachomatis and its interaction with the cellular retromer.

Sebastian Banhart, Laura Rose, Lukas Aeberhard, Sophia Koch-Edelmann, Dagmar Heuer,

Chlamydia trachomatis is an important human pathogen. This obligate intracellular bacterium grows inside the eukaryotic cell in a membrane-bound compartment, the inclusion. Recent global approaches describe the interactions of C. trachomatis with its host cell and indicate the inclusion is an intracellular trafficking hub embedded into the cellular vesicular trafficking ... Read more >>

Int. J. Med. Microbiol. (International journal of medical microbiology : IJMM)
[2018, 308(1):197-205]

Cited: 0 times

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The cellular ceramide transport protein CERT promotes Chlamydia psittaci infection and controls bacterial sphingolipid uptake.

Sophia Koch-Edelmann, Sebastian Banhart, Essa M Saied, Laura Rose, Lukas Aeberhard, Michael Laue, Joerg Doellinger, Christoph Arenz, Dagmar Heuer,

Chlamydiaceae are bacterial pathogens that cause diverse diseases in humans and animals. Despite their broad host and tissue tropism, all Chlamydia species share an obligate intracellular cycle of development and have evolved sophisticated mechanisms to interact with their eukaryotic host cells. Here, we have analysed interactions of the zoonotic pathogen ... Read more >>

Cell. Microbiol. (Cellular microbiology)
[2017, 19(10):]

Cited: 8 times

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A series of ceramide analogs modified at the 1-position with potent activity against the intracellular growth of Chlamydia trachomatis.

Essa M Saied, Sebastian Banhart, Sophie E Bürkle, Dagmar Heuer, Christoph Arenz,

Chlamydia trachomatis is an intracellular pathogen that requires different nutrients, including sphingolipids, for survival. Components for the transport and biosynthesis of sphingolipids thus may have a potential as antichlamydial targets.In this study, we synthesized a collection of 24 ceramide derivatives. Three derivatives show pronounced activity with submicromolar IC50. The potency ... Read more >>

Future Med Chem (Future medicinal chemistry)
[2015, 7(15):1971-1980]

Cited: 7 times

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Is the hoopla over CPAF justified?

Georg Häcker, Dagmar Heuer, David M Ojcius,

Pathog Dis (Pathogens and disease)
[2014, 72(1):1-2]

Cited: 5 times

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Chlamydia psittaci: new insights into genomic diversity, clinical pathology, host-pathogen interaction and anti-bacterial immunity.

Michael R Knittler, Angela Berndt, Selina Böcker, Pavel Dutow, Frank Hänel, Dagmar Heuer, Danny Kägebein, Andreas Klos, Sophia Koch, Elisabeth Liebler-Tenorio, Carola Ostermann, Petra Reinhold, Hans Peter Saluz, Gerhard Schöfl, Philipp Sehnert, Konrad Sachse,

The distinctive and unique features of the avian and mammalian zoonotic pathogen Chlamydia (C.) psittaci include the fulminant course of clinical disease, the remarkably wide host range and the high proportion of latent infections that are not leading to overt disease. Current knowledge on associated diseases is rather poor, even ... Read more >>

Int. J. Med. Microbiol. (International journal of medical microbiology : IJMM)
[2014, 304(7):877-893]

Cited: 21 times

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The spatiotemporal dynamics and membranous features of the Plasmodium liver stage tubovesicular network.

Josephine Grützke, Kerstin Rindte, Christian Goosmann, Olivier Silvie, Carolin Rauch, Dagmar Heuer, Maik J Lehmann, Ann-Kristin Mueller, Volker Brinkmann, Kai Matuschewski, Alyssa Ingmundson,

For membrane-bound intracellular pathogens, the surrounding vacuole is the portal of communication with the host cell. The parasitophorous vacuole (PV) harboring intrahepatocytic Plasmodium parasites satisfies the parasites' needs of nutrition and protection from host defenses to allow the rapid parasite growth that occurs during the liver stage of infection. In ... Read more >>

Traffic (Traffic (Copenhagen, Denmark))
[2014, 15(4):362-382]

Cited: 23 times

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Development of a novel FRET probe for the real-time determination of ceramidase activity.

Krishna P Bhabak, Anett Hauser, Susanne Redmer, Sebastian Banhart, Dagmar Heuer, Christoph Arenz,

Fretful novelty: We developed two novel doubly labelled fluorescent ceramide analogues that exhibit significant FRET and undergo hydrolysis by ceramidases. We present a fluorescent sphingolipid FRET probe that allows homogeneous ratiometric determination of enzyme activity in real-time. ... Read more >>

Chembiochem (Chembiochem : a European journal of chemical biology)
[2013, 14(9):1049-1052]

Cited: 5 times

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Chlamydia trachomatis infection prevents front-rear polarity of migrating HeLa cells.

Julia Heymann, Anette Rejman Lipinski, Bianca Bauer, Thomas F Meyer, Dagmar Heuer,

Chlamydiae are obligate intracellular bacterial pathogens that cause trachoma, sexually transmitted diseases and respiratory infections in humans. Fragmentation of the host cell Golgi apparatus (GA) is essential for chlamydial development, whereas the consequences for host cell functions, including cell migration are not well understood. We could show that Chlamydia trachomatis-infected ... Read more >>

Cell. Microbiol. (Cellular microbiology)
[2013, 15(7):1059-1069]

Cited: 5 times

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Targeting of a chlamydial protease impedes intracellular bacterial growth.

Jan G Christian, Julia Heymann, Stefan A Paschen, Juliane Vier, Linda Schauenburg, Jan Rupp, Thomas F Meyer, Georg Häcker, Dagmar Heuer,

Chlamydiae are obligate intracellular bacteria that propagate in a cytosolic vacuole. Recent work has shown that growth of Chlamydia induces the fragmentation of the Golgi apparatus (GA) into ministacks, which facilitates the acquisition of host lipids into the growing inclusion. GA fragmentation results from infection-associated cleavage of the integral GA ... Read more >>

PLoS Pathog. (PLoS pathogens)
[2011, 7(9):e1002283]

Cited: 28 times

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Genome-wide RNAi screen identifies human host factors crucial for influenza virus replication.

Alexander Karlas, Nikolaus Machuy, Yujin Shin, Klaus-Peter Pleissner, Anita Artarini, Dagmar Heuer, Daniel Becker, Hany Khalil, Lesley A Ogilvie, Simone Hess, André P Mäurer, Elke Müller, Thorsten Wolff, Thomas Rudel, Thomas F Meyer,

Influenza A virus, being responsible for seasonal epidemics and reoccurring pandemics, represents a worldwide threat to public health. High mutation rates facilitate the generation of viral escape mutants, rendering vaccines and drugs directed against virus-encoded targets potentially ineffective. In contrast, targeting host cell determinants temporarily dispensable for the host but ... Read more >>

Nature (Nature)
[2010, 463(7282):818-822]

Cited: 364 times

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Chlamydia causes fragmentation of the Golgi compartment to ensure reproduction.

Dagmar Heuer, Anette Rejman Lipinski, Nikolaus Machuy, Alexander Karlas, Andrea Wehrens, Frank Siedler, Volker Brinkmann, Thomas F Meyer,

The obligate intracellular bacterium Chlamydia trachomatis survives and replicates within a membrane-bound vacuole, termed the inclusion, which intercepts host exocytic pathways to obtain nutrients. Like many other intracellular pathogens, C. trachomatis has a marked requirement for host cell lipids, such as sphingolipids and cholesterol, produced in the endoplasmic reticulum and ... Read more >>

Nature (Nature)
[2009, 457(7230):731-735]

Cited: 144 times

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Tackling the intractable - approaching the genetics of Chlamydiales.

Dagmar Heuer, Christoph Kneip, André P Mäurer, Thomas F Meyer,

Chlamydia trachomatis and Chlamydia (Chlamydophila) pneumoniae are important human pathogens with significant socio-economic and medical impact. The development of an improved therapy or vaccine would represent a major break-through in the battle against these infections. Despite intense research on Chlamydiaceae, the molecular genetic analysis of these pathogens remains difficult as ... Read more >>

Int. J. Med. Microbiol. (International journal of medical microbiology : IJMM)
[2007, 297(7-8):569-576]

Cited: 16 times

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CD46-independent binding of neisserial type IV pili and the major pilus adhesin, PilC, to human epithelial cells.

Marieluise Kirchner, Dagmar Heuer, Thomas F Meyer,

Neisseria gonorrhoeae is a gram-negative bacterial pathogen which infects the human mucosal epithelium. An early critical event in neisserial infection is the type IV pilus-mediated adherence to the host cell. The PilC protein, located on the pilus tip, has earlier been identified as the major pilus adhesin. Previous studies suggested ... Read more >>

Infect. Immun. (Infection and immunity)
[2005, 73(5):3072-3082]

Cited: 46 times

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N-Glycans attached to the stem domain of haemagglutinin efficiently regulate influenza A virus replication.

Ralf Wagner, Dagmar Heuer, Thorsten Wolff, Astrid Herwig, Hans-Dieter Klenk,

The haemagglutinin (HA) protein of fowl plague virus A/FPV/Rostock/34 (H7N1) contains three N-linked oligosaccharide side chains in its stem domain. These stem glycans, which are attached to the Asn residues at positions 12, 28 and 478, are highly conserved throughout all HA protein sequences analysed to date. In a previous ... Read more >>

J. Gen. Virol. (The Journal of general virology)
[2002, 83(Pt 3):601-609]

Cited: 24 times

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Expression and translocation of chlamydial protease during acute and persistent infection of the epithelial HEp-2 cells with Chlamydophila (Chlamydia) pneumoniae.

Dagmar Heuer, Volker Brinkmann, Thomas F Meyer, Agnes J Szczepek,

Chlamydial protease-like activity factor (CPAF) is secreted to the cytoplasm of the infected cells where it proteolytically cleaves eukaryotic transcription factor RFX5. Here, we determined the localization pattern of CPAF during the course of an acute and persistent in vitro infection of the epithelial cell line HEp-2 with Chlamydophila pneumoniae ... Read more >>

Cell. Microbiol. (Cellular microbiology)
[2003, 5(5):315-322]

Cited: 41 times

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Importance of hemagglutinin glycosylation for the biological functions of influenza virus.

Hans-Dieter Klenk, Ralf Wagner, Dagmar Heuer, Thorsten Wolff,

Virus Res. (Virus research)
[2002, 82(1-2):73-75]

Cited: 42 times

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