Full Text Journal Articles by
Author Daeun Lee

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A Patient with Neutropenia and Splenomegaly: A Case Report from Department of Family Medicine in Tertiary Hospital Center.

Jaehee Cho, Youhyun Song, Jiyeon Lee, Daeun Lee, Yunsun Go, Hee Cheol Kang,

Pancytopenia represents a unique challenge for primary care doctors and its etiological causes encompass various specialties, including hematology and rheumatology. Despite the existence of effective tests such as bone marrow biopsy and immunoassays to rule out the potential causes of pancytopenia, it is often difficult to pinpoint the exact diagnosis. ... Read more >>

Korean J Fam Med (Korean journal of family medicine)
[2020, :]

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Dietary schizophyllan reduces mitochondrial damage by activating SIRT3 in mice.

Daeun Lee, Ye-Ram Kim, Jae-Sung Kim, Donggyu Kim, Sojin Kim, Sun Young Kim, Kiseok Jang, Jong-Dae Lee, Chul-Su Yang,

Schizophyllan (SPG), produced by Schizophyllum commune, is an exopolysaccharide with multiple academic and commercial uses, including in the food industry and for various medical functions. We previously demonstrated that SPG conjugated with c-Src peptide exerted a significant therapeutic effect on mouse models of the acute inflammatory diseases polymicrobial sepsis and ... Read more >>

Arch. Pharm. Res. (Archives of pharmacal research)
[2020, 43(4):449-461]

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Toxoplasma gondii GRA8-derived peptide immunotherapy improves tumor targeting of colorectal cancer.

Jae-Sung Kim, Daeun Lee, Donggyu Kim, Seok-Jun Mun, Euni Cho, Wooic Son, Chul-Su Yang,

Targeted tumor and efficient, specific biological drug delivery in vivo has been one of the main challenges in protein-based cancer-targeted therapies. Mitochondria are potential therapeutic targets for various anti-cancer drugs. We have previously reported that protein kinase Cα-mediated phosphorylation of Toxoplasma gondii GRA8 is required for mitochondrial trafficking and regulating ... Read more >>

Oncotarget (Oncotarget)
[2020, 11(1):62-73]

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A potent antibacterial activity of new short d-enantiomeric lipopeptide against multi drug resistant bacteria.

Jaeho Lee, Shanghyeon Kim, Ji-Yeong Sim, Daeun Lee, Ha Hyung Kim, Jae Sam Hwang, Dong Gun Lee, Zee-Yong Park, Jae Il Kim,

The emergence of drug-resistant pathogenic bacteria threatens human health. Resistance to existing antibiotics is increasing, while the emergence of new antibiotics is slowing. Cationic antimicrobial peptides (CAMPs) are fascinating alternative antibiotics because they possess a broad spectrum of activity, being active against both Gram-positive and Gram-negative bacteria including those resistant ... Read more >>

Biochim Biophys Acta Biomembr (Biochimica et biophysica acta. Biomembranes)
[2019, 1861(1):34-42]

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Therapeutic Effect of Cucumis melo L. Extract on Insulin Resistance and the Gut Microbiome in Lepob/Lepob Mice.

Daeun Lee, Jung Hwa Yoo, Byung-Cheol Lee,

Obesity results in the progression of metabolic disorders, especially type 2 diabetes (T2DM). Obesity-induced insulin resistance (IR) is a causative factor of T2DM morbidity in obese people. It is generally held by clinicians that IR is caused by adiposity-related inflammation that is mediated by changes in composite ions in the ... Read more >>

Evid Based Complement Alternat Med (Evidence-based complementary and alternative medicine : eCAM)
[2018, 2018:8159261]

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Crystal structure of D-glycero-Β-D-manno-heptose-1-phosphate adenylyltransferase from Burkholderia pseudomallei.

Jimin Park, Hyojin Kim, Suwon Kim, Daeun Lee, Mi-Sun Kim, Dong Hae Shin,

The crystal structure of HldC from B. pseudomallei (BpHldC), the fourth enzyme of the heptose biosynthesis pathway, has been determined. BpHldC converts ATP and d-glycero-β-d-manno-heptose-1-phosphate into ADP-d-glycero-β-d-manno-heptose and pyrophosphate. The crystal structure of BpHldC belongs to the nucleotidyltransferase α/β phosphodiesterase superfamily sharing a common Rossmann-like α/β fold with a conserved ... Read more >>

Proteins (Proteins)
[2018, 86(1):124-131]

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General assay for enzymes in the heptose biosynthesis pathways using electrospray ionization mass spectrometry.

Jimin Park, Daeun Lee, Eun Kyoung Seo, Jae-Sang Ryu, Dong Hae Shin,

The ADP-L-glycero-β-D-manno-heptose and the GDP-6-deoxy-α-D-manno-heptose biosynthesis pathways play important roles in constructing lipopolysaccharide of Gram-negative bacteria. Blocking the pathways is lethal or increases antibiotic susceptibility to pathogens. Therefore, the enzymes involved in the pathways are novel antibiotic drug targets. Here, we designed an efficient method to assay the whole enzymes ... Read more >>

Appl. Microbiol. Biotechnol. (Applied microbiology and biotechnology)
[2017, 101(11):4521-4532]

Cited: 1 time

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What Kind of Stress Is Associated with Depression, Anxiety and Suicidal Ideation in Korean Employees?

Young Chul Shin, Daeun Lee, Jinmi Seol, Se Won Lim,

Various types of stress affect mental health in the form of mood disorders, anxiety disorders, and suicidal ideation. Recently, the increasing suicide rate in the working-age population has become a major mental health concern in Korea. Thus, we investigated what kind of stress influence depression, anxiety, and suicidal ideation in ... Read more >>

J. Korean Med. Sci. (Journal of Korean medical science)
[2017, 32(5):843-849]

Cited: 4 times

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Expression and crystallographic studies of D-glycero-β-D-manno-heptose-1-phosphate adenylyltransferase from Burkholderia pseudomallei.

Jimin Park, Hyojin Kim, Suwon Kim, Daeun Lee, Dong Hae Shin,

The Gram-negative bacterium Burkholderia pseudomallei is the causative agent of melioidosis. D-glycero-β-D-manno-Heptose-1-phosphate adenylyltransferase (HldC) is the fourth enzyme of the ADP-L-glycero-β-D-manno-heptose biosynthesis pathway, which produces an essential carbohydrate comprising the inner core of lipopolysaccharide. Therefore, HldC is a potential target of antibiotics against melioidosis. In this study, HldC from B. ... Read more >>

Acta Crystallogr F Struct Biol Commun (Acta crystallographica. Section F, Structural biology communications)
[2017, 73(Pt 2):90-94]

Cited: 1 time

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A preliminary X-ray study of 3-deoxy-D-manno-oct-2-ulosonic acid 8-phosphate phosphatase (YrbI) from Burkholderia pseudomallei.

Jimin Park, Daeun Lee, Mi Sun Kim, Dae Yong Kim, Dong Hae Shin,

3-Deoxy-D-manno-oct-2-ulosonic acid 8-phosphate phosphatase (YrbI), the third enzyme in the pathway for the biosynthesis of 3-deoxy-D-manno-oct-2-ulosonic acid (KDO), hydrolyzes KDO 8-phosphate to KDO and inorganic phosphate. YrbI belongs to the haloacid dehalogenase (HAD) superfamily, which is a large family of magnesium-dependent phosphatase/phosphotransferase enzymes. In this study, YrbI from Burkholderia pseudomallei, ... Read more >>

Acta Crystallogr F Struct Biol Commun (Acta crystallographica. Section F, Structural biology communications)
[2015, 71(Pt 6):790-793]

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Successful live births after surgical treatments for symptomatic cesarean scar pregnancies: report of 3 cases.

Gayoung Yang, Daeun Lee, Sara Lee, Kyungah Jeong,

There is no current consensus on the best treatment modality for cesarean scar pregnancy (CSP) with favorable reproductive and pregnancy outcome. We treated 3 cases of symptomatic CSP with fetal cardiac activity. The first case underwent laparoscopic repair at 6 weeks' gestational age of unruptured CSP. The second patient underwent ... Read more >>

Gynecol. Obstet. Invest. (Gynecologic and obstetric investigation)
[2014, 78(3):208-212]

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Structure-activity relationships of the intramolecular disulfide bonds in coprisin, a defensin from the dung beetle.

Jaeho Lee, Daeun Lee, Hyemin Choi, Ha Hyung Kim, Ho Kim, Jae Sam Hwang, Dong Gun Lee, Jae Il Kim,

Defensins, which are small cationic molecules produced by organisms as part of their innate immune response, share a common structural scaffold that is stabilized by three disulfide bridges. Coprisin is a 43-amino acid defensin-like peptide from Copris tripartitus. Here, we report the intramolecular disulfide connectivity of cysteine-rich coprisin, and show ... Read more >>

BMB Rep (BMB reports)
[2014, 47(11):625-630]

Cited: 5 times

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A preliminary X-ray study of murine Tnfaip8/Oxi-α.

Daeun Lee, Mi-Sun Kim, Jimin Park, Gil-Ja Jhon, Jin H Son, Dong Hae Shin,

Tnfaip8/oxidative stress regulated gene-α (Oxi-α) is a novel protein expressed specifically in brain dopaminergic neurons and its over-expression has been reported to protect dopaminergic cells against OS-induced cell death. In this study, murine C165S mutant Tnfaip8/Oxi-α has been crystallized and X-ray data have been collected to 1.8 Å using synchrotron ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2014, 15(3):4523-4530]

Cited: 3 times

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Synthesis and antimicrobial activity of cysteine-free coprisin nonapeptides.

Jaeho Lee, Daeun Lee, Hyemin Choi, Ha Hyung Kim, Ho Kim, Jae Sam Hwang, Dong Gun Lee, Jae Il Kim,

Coprisin is a 43-mer defensin-like peptide from the dung beetle, Copris tripartitus. CopA3 (LLCIALRKK-NH₂), a 9-mer peptide containing a single free cysteine residue at position 3 of its sequence, was derived from the α-helical region of coprisin and exhibits potent antibacterial and anti-inflammatory activities. The single cysteine implies a tendency ... Read more >>

Biochem. Biophys. Res. Commun. (Biochemical and biophysical research communications)
[2014, 443(2):483-488]

Cited: 2 times

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Structure and in silico substrate-binding mode of ADP-L-glycero-D-manno-heptose 6-epimerase from Burkholderia thailandensis.

Mi-Sun Kim, Areum Lim, Seung Won Yang, Jimin Park, Daeun Lee, Dong Hae Shin,

ADP-L-glycero-D-manno-heptose 6-epimerase (AGME), the product of the rfaD gene, is the last enzyme in the heptose-biosynthesis pathway; it converts ADP-D-glycero-D-manno-heptose (ADP-D,D-Hep) to ADP-L-glycero-D-manno-heptose (ADP-L,D-Hep). AGME contains a catalytic triad involved in catalyzing hydride transfer with the aid of NADP(+). Defective lipopolysaccharide is found in bacterial mutants lacking this gene. Therefore, ... Read more >>

Acta Crystallogr. D Biol. Crystallogr. (Acta crystallographica. Section D, Biological crystallography)
[2013, 69(Pt 4):658-668]

Cited: 1 time

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A preliminary X-ray study of transketolase from Burkholderia pseudomallei.

Mi Sun Kim, Areum Lim, Seung Won Yang, Daeun Lee, Jimin Park, Dong Hae Shin,

TktA is the most critical enzyme in the nonoxidative pentose phosphate pathway. It catalyzes the conversion of xylulose 5-phosphate and ribose 5-phosphate into sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate, and its products are used in the biosynthesis of acetyl-CoA, aromatic amino acids, nucleic acids and ADP-L-glycero-β-D-manno-heptose. TktA also has an unexpected ... Read more >>

Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. (Acta crystallographica. Section F, Structural biology and crystallization communications)
[2012, 68(Pt 12):1554-1556]

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