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Author D Sweetman

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An observational study of sleep in childhood post-neonatal encephalopathy.

Zunera Zareen, John Allen, Lynne A Kelly, Denise McDonald, Deirdre Sweetman, Eleanor J Molloy,

<h4>Aim</h4>Neonatal encephalopathy (NE) is associated with altered cognitive, motor, sensory abilities and behavioural outcomes. This case-control study aimed to assess whether Quality of Life (QoL) and sleep disorders are affected in older children following NE compared to age-matched controls.<h4>Methods</h4>Children at school-age post-NE were recruited and compared to age-matched controls. Sleep ... Read more >>

Acta Paediatr (Acta paediatrica (Oslo, Norway : 1992))
[2021, :]

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Altered inflammasome activation in neonatal encephalopathy persists in childhood.

L A Kelly, M I O'Dea, Z Zareen, A M Melo, E McKenna, T Strickland, V McEneaney, V Donoghue, G Boylan, D Sweetman, J Butler, C Vavasseur, J Miletin, A F El-Khuffash, L A J O'Neill, J J O'Leary, E J Molloy,

Neonatal encephalopathy (NE) is characterized by altered neurological function in term infants and inflammation plays an important pathophysiological role. Inflammatory cytokines interleukin (IL)-1β, IL-1ra and IL-18 are activated by the nucleotide-binding and oligomerization domain (NOD)-, leucine-rich repeat domain (LRR)- and NOD-like receptor protein 3 (NLRP3) inflammasome; furthermore, we aimed to ... Read more >>

Clin Exp Immunol (Clinical and experimental immunology)
[2021, :]

Cited: 0 times

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Making virtual learning engaging and interactive.

David S Sweetman,

This article provides practical perspective and guidance for transitioning from in-person to virtual learning. Student engagement is emphasized through providing synchronous and highly interactive virtual learning sessions. This approach not only improves student outcomes related to class, but also is related to strong student mental health. Technological considerations are explored ... Read more >>

FASEB Bioadv (FASEB bioAdvances)
[2021, 3(1):11-19]

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Donor oocyte-facilitated reproduction: Time to revisit the BSH antenatal guidelines?

John Quigley, Deirdre Sweetman, Cathy Allen, Mary F Higgins, Carol Cantwell, Barry Doyle, Paul Downey, Joan Fitzgerald,

Transfus Med (Transfusion medicine (Oxford, England))
[2020, 30(6):525-526]

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Diagnostic Limitations in Congenital Zika Virus Infection.

M Flanagan, H Hughes, E B Forman, D O'Rourke, B Paturi, A Curley, S J Knowles, C De Gascun, D Sweetman,

This is the first documented case of an infant with congenital Zika virus infection (ZVI) born in Ireland. A term infant was delivered with an antenatal diagnosis of severe microcephaly. First trimester bloods confirmed maternal ZVI and although the infant did not have Zika virus RNA or Zika-specific IgM in ... Read more >>

Ir Med J (Irish medical journal)
[2020, 113(6):101]

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Amplitude Integrated Electroencephalography (aEEG) Education.

A Jenkinson, M A Boyle, D Sweetman,

Ir Med J (Irish medical journal)
[2020, 113(6):105]

Cited: 0 times

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Plasma and Cerebrospinal Fluid Candidate Biomarkers of Neonatal Encephalopathy Severity and Neurodevelopmental Outcomes.

Barbara Dietrick, Eleanor Molloy, An N Massaro, Tammy Strickland, Jie Zhu, Marie Slevin, Veronica Donoghue, Deirdre Sweetman, Lynne Kelly, Mary O'Dea, Meaghan McGowan, Gilbert Vezina, Penny Glass, Dhananjay Vaidya, Sandra Brooks, Frances Northington, Allen D Everett,

OBJECTIVES:To identify candidate biomarkers in both plasma and cerebrospinal fluid (CSF) that are associated with neonatal encephalopathy severity measured by encephalopathy grade, seizures, brain injury by magnetic resonance imaging (MRI), and neurodevelopmental outcomes at 15-30 months. STUDY DESIGN:A retrospective cohort study of plasma (N = 155, day of life 0-1) and CSF (n ... Read more >>

J Pediatr (The Journal of pediatrics)
[2020, :]

Cited: 1 time

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Management of Multi Organ Dysfunction in Neonatal Encephalopathy.

Mary O'Dea, Deirdre Sweetman, Sonia Lomeli Bonifacio, Mohamed El-Dib, Topun Austin, Eleanor J Molloy,

Neonatal Encephalopathy (NE) describes neonates with disturbed neurological function in the first post-natal days of life. NE is an overall term that does not specify the etiology of the encephalopathy although it often involves hypoxia-ischaemia. In NE, although neurological dysfunction is part of the injury and is most predictive of ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2020, 8:239]

Cited: 2 times

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Troponin T correlates with MRI results in neonatal encephalopathy.

Deirdre U Sweetman, Lynne Kelly, Tim Hurley, Chike Onwuneme, R William Gordon Watson, John F A Murphy, Marie Slevin, Veronica Donoghue, Eleanor J Molloy,

<h4>Aim</h4>Troponin is a sensitive marker of asphyxia in term infants mirroring the myocardial injury sustained in global hypoxia-ischaemia. In addition, troponin is a sensitive marker of severity of stroke in adults and neonatal encephalopathy (NE). We aimed to examine the relationship between troponin T in infants with perinatal asphyxia and ... Read more >>

Acta Paediatr (Acta paediatrica (Oslo, Norway : 1992))
[2020, 109(11):2266-2270]

Cited: 0 times

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Cytokine dysregulation persists in childhood post Neonatal Encephalopathy.

Zunera Zareen, Tammy Strickland, Victoria Mc Eneaney, Lynne A Kelly, Denise McDonald, Deirdre Sweetman, Eleanor J Molloy,

<h4>Background</h4>Cytokines are possible mediators of neuroinflammation and associated with adverse outcome in neonatal encephalopathy (NE). Our aim was to explore cytokine response in children with Neonatal Encephalopathy (NE) at school age compared to age-matched controls.<h4>Method</h4>Follow up at school age, children who had NE and age-matched controls were assessed for their ... Read more >>

BMC Neurol (BMC neurology)
[2020, 20(1):115]

Cited: 4 times

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Cytokine Dysregulation Persists in Childhood Post Neonatal Encephalopathy

Zunera Zareen, Zunera Zareen, Tammy Strickland, Victoria Mc Eneaney, Lynne Kelly, Denise McDonald, Deirdre Sweetman, Eleanor Molloy,

<h4>Background: </h4> Cytokines are possible mediators of neuroinflammation and associated with adverse outcome in neonatal encephalopathy (NE) . Our aim was to explore cytokine response in children with Neonatal Encephalopathy (NE) at school age compared to age-matched controls. <h4>Method:</h4> Follow up at school age, children who had NE and age-matched ... Read more >>

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Neonatal Encephalopathy Is Associated With Altered IL-8 and GM-CSF Which Correlates With Outcomes.

Deirdre U Sweetman, Tammy Strickland, Ashanty M Melo, Lynne A Kelly, Chike Onwuneme, William R Watson, John F A Murphy, Marie Slevin, Veronica Donoghue, Amanda O'Neill, Eleanor J Molloy,

<b>Aim:</b> To investigate the relationship between cytokines associated with innate immune cell activation and brain injury and outcome in infants with NE compared to neonatal controls. <b>Methods:</b> Serum and CSF biomarkers associated with activated neutrophils and monocytes [Interleukin-8 (IL-8) and Granulocyte-Macrophage-Colony-Stimulating-Factor (GM-CSF)] were serially measured using duplex immunoassays on days ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2020, 8:556216]

Cited: 0 times

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Coagulation Profiles Are Associated With Early Clinical Outcomes in Neonatal Encephalopathy.

Deirdre Sweetman, Lynne A Kelly, Zunera Zareen, Beatrice Nolan, John Murphy, Geraldine Boylan, Veronica Donoghue, Eleanor J Molloy,

Introduction: Neonatal encephalopathy (NE) is associated with coagulation abnormalities. We aimed to investigate the serial alterations in coagulation profiles in term infants with NE and correlate with their clinical outcomes. This was a prospective cohort study in a tertiary referral, university-affiliated maternity hospital. Neonates exposed to perinatal asphyxia were recruited ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2019, 7:399]

Cited: 5 times

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The Modified Sarnat Score in the Assessment of Neonatal Encephalopathy: A Quality Improvement Initiative

B D Power, J McGinley, D Sweetman, J F A Murphy,

Ir Med J (Irish medical journal)
[2019, 112(7):976]

Cited: 0 times

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Zinc and vitamin A deficiency in a cohort of children with autism spectrum disorder.

Deirdre U Sweetman, Sinead M O'Donnell, Annette Lalor, Tim Grant, Hilary Greaney,

BACKGROUND AND OBJECTIVES:Studies suggest that trace element and vitamin deficiencies are common in children with autism spectrum disorder (ASD). Data describing the rates of vitamin and trace element deficiencies in the ASD population of the northwest of Ireland is lacking. We wished to determine the prevalence of zinc and vitamin ... Read more >>

Child Care Health Dev (Child: care, health and development)
[2019, 45(3):380-386]

Cited: 4 times

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Correction: Effects of insulin like growth factors on early embryonic chick limb myogenesis.

Rabeea Hazim Mohammed, Helen Anderton, John Michael Brameld, Dylan Sweetman,

[This corrects the article DOI: 10.1371/journal.pone.0185775.]. ... Read more >>

PLoS One (PloS one)
[2017, 12(12):e0189395]

Cited: 1 time

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Effects of insulin like growth factors on early embryonic chick limb myogenesis.

Rabeea Hazim Mohammed, Helen Anderton, John Michael Brameld, Dylan Sweetman,

Limb muscles derive from pax3 expressing precursor cells that migrate from the hypaxial somite into the developing limb bud. Once there they begin to differentiate and express muscle determination genes such as MyoD. This process is regulated by a combination of inductive or inhibitory signals including Fgf18, retinoic acid, HGF, ... Read more >>

PLoS One (PloS one)
[2017, 12(10):e0185775]

Cited: 4 times

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LIM kinase function and renal growth: Potential role for LIM kinases in fetal programming of kidney development.

Alexander J Sparrow, Dylan Sweetman, Simon J M Welham,

<h4>Aims</h4>Maternal dietary restriction during pregnancy impairs nephron development and results in offspring with fewer nephrons. Cell turnover in the early developing kidney is altered by exposure to maternal dietary restriction and may be regulated by the LIM-kinase family of enzymes. We set out to establish whether disturbance of LIM-kinase activity ... Read more >>

Life Sci (Life sciences)
[2017, 186:17-24]

Cited: 1 time

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Serial cytokine alterations and abnormal neuroimaging in newborn infants with encephalopathy.

Fiona M O'Hare, R William G Watson, Amanda O'Neill, Ricardo Segurado, Deirdre Sweetman, Paul Downey, Eoghan Mooney, John Murphy, Veronica Donoghue, Eleanor J Molloy,

<h4>Aim</h4>Inflammatory cytokines may play a role in the final common pathway in the pathogenesis of hypoxic-ischaemic injury in experimental models. We aimed to profile the systemic pro-and anti-inflammatory response over the first week of life in term infants at risk of neonatal encephalopathy.<h4>Method</h4>In a tertiary referral university neonatal intensive care ... Read more >>

Acta Paediatr (Acta paediatrica (Oslo, Norway : 1992))
[2017, 106(4):561-567]

Cited: 6 times

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Neonatal acute kidney injury - Severity and recovery prediction and the role of serum and urinary biomarkers.

Deirdre U Sweetman,

Neonatal acute kidney injury is common, in part due to incomplete renal maturation and also due to frequent exposure to risk factors for acute kidney injury such as perinatal asphyxia, extracorporeal-membrane-oxygenation, cardiac surgery, sepsis, prematurity and nephrotoxicity. However the current method by which acute kidney injury is diagnosed is sub-optimal ... Read more >>

Early Hum Dev (Early human development)
[2017, 105:57-61]

Cited: 5 times

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Perinatal Asphyxia and Erythropoietin and VEGF: Serial Serum and Cerebrospinal Fluid Responses.

Deirdre U Sweetman, Chike Onwuneme, William R Watson, John F A Murphy, Eleanor J Molloy,

<h4>Background</h4>Infants with neonatal encephalopathy (NE) of hypoxic-ischaemic origin are at risk of oxidative and ischaemia-reperfusion injury, which may induce abnormal inflammatory responses involving excessive cytokine production and release in serum and cerebrospinal fluid (CSF). Systemic inflammation is found in infants with NE, and we therefore were interested in cytokines associated ... Read more >>

Neonatology (Neonatology)
[2017, 111(3):253-259]

Cited: 7 times

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Renal function and novel urinary biomarkers in infants with neonatal encephalopathy.

Deirdre U Sweetman, Chike Onwuneme, William R Watson, Amanda O'Neill, John F A Murphy, Eleanor J Molloy,

<h4>Aim</h4>Perinatal asphyxia is associated with multi-organ injury including acute kidney injury (AKI). New urinary biomarkers may detect more subtle renal injury.<h4>Methods</h4>Urinary biomarkers (albumin, beta-2 microglobulin, cystatin-C, epidermal growth factor, neutrophil gelatinase-associated lipocalin, osteopontin, uromodulin) were serially measured from days 1 to 7 in term infants with perinatal asphyxia and controls ... Read more >>

Acta Paediatr (Acta paediatrica (Oslo, Norway : 1992))
[2016, 105(11):e513-e519]

Cited: 5 times

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Epigenetics and developmental programming of welfare and production traits in farm animals.

K D Sinclair, K M D Rutherford, J M Wallace, J M Brameld, R Stöger, R Alberio, D Sweetman, D S Gardner, V E A Perry, C L Adam, C J Ashworth, J E Robinson, C M Dwyer,

The concept that postnatal health and development can be influenced by events that occur in utero originated from epidemiological studies in humans supported by numerous mechanistic (including epigenetic) studies in a variety of model species. Referred to as the 'developmental origins of health and disease' or 'DOHaD' hypothesis, the primary ... Read more >>

Reprod Fertil Dev (Reproduction, fertility, and development)
[2016, :]

Cited: 18 times

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Grafting of Beads into Developing Chicken Embryo Limbs to Identify Signal Transduction Pathways Affecting Gene Expression.

Rabeea H Mohammed, Dylan Sweetman,

Using chicken embryos it is possible to test directly the effects of either growth factors or specific inhibitors of signaling pathways on gene expression and activation of signal transduction pathways. This technique allows the delivery of signaling molecules at precisely defined developmental stages for specific times. After this embryos can ... Read more >>

J Vis Exp (Journal of visualized experiments : JoVE)
[2016, (107):e53342]

Cited: 1 time

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Expression of myogenic regulatory factors in chicken embryos during somite and limb development.

Gi Fay Mok, Rabeea Hazim Mohammed, Dylan Sweetman,

The expression of the myogenic regulatory factors (MRFs), Myf5, MyoD, myogenin (Mgn) and MRF4 have been analysed during the development of chicken embryo somites and limbs. In somites, Myf5 is expressed first in somites and paraxial mesoderm at HH stage 9 followed by MyoD at HH stage 12, and Mgn ... Read more >>

J Anat (Journal of anatomy)
[2015, 227(3):352-360]

Cited: 13 times

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