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Author D Ryan

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Wavefront-guided and Wavefront-optimized LASIK: Visual and Military Task Performance Outcomes.

Rose K Sia, Denise S Ryan, Richard D Stutzman, Joseph F Pasternak, Jennifer B Eaddy, Lorie A Logan, Bruce A Rivers, Kraig S Bower,

Mil Med (Military medicine)
[2020, :]

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Diagnostic accuracy of the 4AT for delirium detection in older adults: systematic review and meta-analysis.

Zoë Tieges, Alasdair M J Maclullich, Atul Anand, Claire Brookes, Marica Cassarino, Margaret O'connor, Damien Ryan, Thomas Saller, Rakesh C Arora, Yue Chang, Kathryn Agarwal, George Taffet, Terence Quinn, Susan D Shenkin, Rose Galvin,

OBJECTIVE:Detection of delirium in hospitalised older adults is recommended in national and international guidelines. The 4 'A's Test (4AT) is a short (<2 minutes) instrument for delirium detection that is used internationally as a standard tool in clinical practice. We performed a systematic review and meta-analysis of diagnostic test accuracy of ... Read more >>

Age Ageing (Age and ageing)
[2020, :]

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Investigating cannabis use and associated symptoms among university students with and without a history of concussion.

Caitlyn Gallant, Rachel Luczon, Dawn Ryan, Dawn Good,

Recently, there has been a growing interest in the use of cannabis after traumatic brain injury (TBI); however, little is known about the long-term effects of cannabis on milder injuries and post-concussive symptoms. Further, substance use often increases post-TBI and, thus, individuals who chronically use cannabis may unknowingly be exceeding ... Read more >>

Neuropsychol Rehabil (Neuropsychological rehabilitation)
[2020, :1-25]

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Patterns and persistence of SARS-CoV-2 IgG antibodies in a US metropolitan site

Alexis Demonbreun, Thomas McDade, Lorenzo Pesce, Lauren Vaught, Nina Reiser, Elena Bogdanovic, Matt Velez, Ryan Hsieh, Claire-Naoma Klaisner, Lacy Simons, Rana Saber, Daniel Ryan, Michael Ison, Judd Hultquist, John Wilkins, Richard D’Aquila, Brian Mustanski, Elizabeth McNally,

Abstract Background Estimates of seroprevalence to SARS-CoV-2 vary widely. We ascertained IgG levels across a single US metropolitan site, Chicago, over the 2020 summer, a period when restrictions on activities had been lifted. Methods We utilized a self-sampled dried blood spot assay to quantitatively monitor antibodies to the receptor binding ... Read more >>

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The prevalence of malnutrition and impact on patient outcomes among older adults presenting at an Irish emergency department: a secondary analysis of the OPTI-MEND trial.

Anne Griffin, Aoife O'Neill, Margaret O'Connor, Damien Ryan, Audrey Tierney, Rose Galvin,

BACKGROUND:Malnutrition is common among older adults and is associated with adverse outcomes but remains undiagnosed on healthcare admissions. Older adults use emergency departments (EDs) more than any other age group. This study aimed to determine the prevalence and factors associated with malnutrition on admission and with adverse outcomes post-admission among ... Read more >>

BMC Geriatr (BMC geriatrics)
[2020, 20(1):455]

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Regional Anesthesia for Clavicle Fracture Surgery is Safe and Effective.

Devon J Ryan, Natalia Iofin, David Furgiuele, Joseph Johnson, Kenneth Egol,

BACKGROUND:Historically, clavicle fracture repairs have been performed under general anesthesia. However, in the last few years, the combination of an interscalene brachial plexus block and a modified superficial cervical plexus block has been described to provide adequate anesthesia for clavicle fracture surgery, with the added benefit of postoperative analgesia. Members ... Read more >>

J Shoulder Elbow Surg (Journal of shoulder and elbow surgery)
[2020, :]

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Role of Curcuminoids and Tricalcium Phosphate Ceramic in Rat Spinal Fusion.

Daniel A Ryan, Jiongjia Cheng, Koichi Masuda, John R Cashman,

Despite considerable research effort, there is a significant need for safe agents that stimulate bone formation. Treatment of large or complex bone defects remains a challenge. Implantation of small molecule-induced human bone marrow-derived mesenchymal stromal cells (hBMSCs) on an appropriate tricalcium phosphate (TCP) scaffold offers a robust system for noninvasive ... Read more >>

Tissue Eng Part C Methods (Tissue engineering. Part C, Methods)
[2020, 26(11):577-589]

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Associations of baseline patient-reported outcomes with treatment outcomes in advanced gastrointestinal cancer.

Emily E van Seventer, Madeleine G Fish, Kathryn Fosbenner, Katie Kanter, Amirkasra Mojtahed, Jill N Allen, Lawrence Blaszkowsky, Jeffrey W Clark, Jon Dubois, Joseph W Franses, Bruce J Giantonio, Lipika Goyal, Samuel J Klempner, Eric J Roeland, David P Ryan, Colin D Weekes, Therese Mulvey, Areej El-Jawahri, Nora Horick, Ryan B Corcoran, Aparna R Parikh, Ryan D Nipp,

BACKGROUND:Patient-reported outcomes (PROs) assessing quality of life (QOL) and symptom burden correlate with clinical outcomes in patients with cancer. However, to the authors' knowledge, data regarding associations between PROs and treatment response are lacking. METHODS:The authors prospectively approached consecutive patients with advanced gastrointestinal cancer who were initiating a new treatment. ... Read more >>

Cancer (Cancer)
[2020, :]

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Development of Abbreviated Versions of the Word Auditory Recognition and Recall Measure.

Sherri L Smith, David B Ryan, M Kathleen Pichora-Fuller,

OBJECTIVES:The objective of this study was to develop and evaluate abbreviated versions of the Word Auditory Recognition and Recall Measure (WARRM) as part of an iterative process in the development of a feasible test for potential future clinical use. DESIGN:The three original WARRM (O-WARRM) randomizations were modified by altering the ... Read more >>

Ear Hear (Ear and hearing)
[2020, 41(6):1483-1491]

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Lacritin proteoforms prevent tear film collapse and maintain epithelial homeostasis.

Georgi A Georgiev, Mohammad Sharifian Gh, Jeff Romano, Karina L Dias Teixeira, Craig Struble, Denise S Ryan, Rose K Sia, Jay P Kitt, Joel M Harris, Ku-Lung Hsu, Adam Libby, Marc G Odrich, Tatiana Suárez, Robert L McKown, Gordon W Laurie,

Lipids in complex, protein-enriched films at air/liquid interfaces reduce surface tension. In the absence of this benefit, the light refracting and immunoprotective tear film on eyes would collapse. Premature collapse, coupled with chronic inflammation compromising visual acuity, is a hallmark of dry eye disease affecting 7 - 10% of individuals ... Read more >>

J Biol Chem (The Journal of biological chemistry)
[2020, :]

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Setmelanotide: what does it mean for clinical care of patients with obesity?

Donna H Ryan,

Lancet Diabetes Endocrinol (The lancet. Diabetes & endocrinology)
[2020, 8(12):933-935]

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Results and molecular correlates from a pilot study of neoadjuvant induction FOLFIRINOX followed by chemoradiation and surgery for gastroesophageal adenocarcinomas

Jennifer Wo, Jeffrey Clark, Christine Eyler, Mari Mino-Kenudson, Samuel Klempner, Jill Allen, Florence Keane, Aparna Parikh, Eric Roeland, Lorraine Drapek, David Ryan, Ryan Corcoran, Emily van Seventer, Isobel Fetter, Heather Shahzade, Melin Khandekar, Michael Lanuti, Christopher Morse, Rebecca Heist, Christine Ulysse, Benjamin Christopher, Christian Baglini, Beow Yeap, John Mullen, Theodore Hong,

Abstract We performed a NCI-sponsored, prospective study of neoadjuvant FOLFIRINOX followed by chemoradiation (CRT) with carboplatin/paclitaxel followed by surgery in patients with locally advanced gastric or gastroesophageal (GEA) cancer. The primary objective was to determine completion rate of neoadjuvant FOLFIRINOX x 8 followed by CRT. Secondary endpoints were toxicity and ... Read more >>

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Comprehensive Molecular Screening in a Cohort of Young Men Who Have Sex With Men and Transgender Women: Effect of Additive Rectal Specimen Source Collection and Analyte Testing.

Erik Munson, Alyssa Reynoso, Morena Pass, Kathleen Buehler, Daniel Ryan, Antonia Clifford, Ethan Morgan, Brian Mustanski,

BACKGROUND:This study's purposes were to characterize detection rates of several sexually transmitted infection (STI) agents and describe the effect additional specimen source and analyte screening has on STI detection within a cohort of young men who have sex with men and transgender women. METHODS:Within a 16-month interval, 1966 encounters involved ... Read more >>

Sex Transm Dis (Sexually transmitted diseases)
[2020, 47(11):748-753]

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Dynamic Brain Connectivity in Resting State Functional MR Imaging.

Rozita Jalilianhasanpour, Daniel Ryan, Shruti Agarwal, Elham Beheshtian, Sachin K Gujar, Jay J Pillai, Haris I Sair,

Dynamic functional connectivity adds another dimension to resting-state functional MR imaging analysis. In recent years, dynamic functional connectivity has been increasingly used in resting-state functional MR imaging, and several studies have demonstrated that dynamic functional connectivity patterns correlate with different physiologic and pathologic brain states. In fact, evidence suggests that ... Read more >>

Neuroimaging Clin N Am (Neuroimaging clinics of North America)
[2021, 31(1):81-92]

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Molecular screening in a longitudinal cohort of young men who have sex with men and young transgender women: associations with focus on the emerging sexually transmitted pathogen Mycoplasma genitalium.

Erik Munson, Ethan Morgan, Laura Sienkiewicz, Yazmine Thomas, Kathleen Buehler, Daniel Ryan, Antonia Clifford, Brian Mustanski,

OBJECTIVES:This investigation sought to characterise risk factors associated with acquisition of traditional and emerging agents of sexually transmitted infection (STI) in a cohort of young men who have sex with men and transgender women. METHODS:917 participants provided urine and rectal swab submissions assessed by transcription-mediated amplification (TMA)-based assays for Chlamydia ... Read more >>

Sex Transm Infect (Sexually transmitted infections)
[2020, :]

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Correction to: Is diet partly responsible for differences in COVID-19 death rates between and within countries?

Jean Bousquet, Josep M Anto, Guido Iaccarino, Wienczyslawa Czarlewski, Tari Haahtela, Aram Anto, Cezmi A Akdis, Hubert Blain, G Walter Canonica, Victoria Cardona, Alvaro A Cruz, Maddalena Illario, Juan Carlos Ivancevich, Marek Jutel, Ludger Klimek, Piotr Kuna, Daniel Laune, Désirée Larenas-Linnemann, Joaquim Mullol, Nikos G Papadopoulos, Oliver Pfaar, Boleslaw Samolinski, Arunas Valiulis, Arzu Yorgancioglu, Torsten Zuberbier, ,

[This corrects the article DOI: 10.1186/s13601-020-00323-0.]. ... Read more >>

Clin Transl Allergy (Clinical and translational allergy)
[2020, 10:44]

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TCA cycle signalling and the evolution of eukaryotes.

Dylan G Ryan, Christian Frezza, Luke Aj O'Neill,

A major question remaining in the field of evolutionary biology is how prokaryotic organisms made the leap to complex eukaryotic life. The prevailing theory depicts the origin of eukaryotic cell complexity as emerging from the symbiosis between an α-proteobacterium, the ancestor of present-day mitochondria, and an archaeal host (endosymbiont theory). ... Read more >>

Curr Opin Biotechnol (Current opinion in biotechnology)
[2020, 68:72-88]

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Use of exhaled breath condensate (EBC) in the diagnosis of SARS-COV-2 (COVID-19).

Daniel J Ryan, Sinead Toomey, Stephen F Madden, Michelle Casey, Oscar S Breathnach, Patrick G Morris, Liam Grogan, Peter Branagan, Richard W Costello, Eoghan De Barra, Killian Hurley, Cedric Gunaratnam, Noel G McElvaney, Michael Emmet OBrien, Imran Sulaiman, Ross K Morgan, Bryan T Hennessy,

False negatives from nasopharyngeal swabs (NPS) using reverse transcriptase PCR (RT-PCR) in SARS-CoV-2 are high. Exhaled breath condensate (EBC) contains lower respiratory droplets that may improve detection. We performed EBC RT-PCR for SARS-CoV-2 genes (E, S, N, ORF1ab) on NPS-positive (n=16) and NPS-negative/clinically positive COVID-19 patients (n=15) using two commercial ... Read more >>

Thorax (Thorax)
[2020, :]

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Correction to: Preliminary evaluation of the Vision PERformance (VIPER) simulator.

Denise S Ryan, Rose K Sia, Jennifer B Eaddy, Lorie A Logan, Jide O Familoni, Hind Beydoun, Samantha B Rodgers, Bruce A Rivers,

An amendment to this paper has been published and can be accessed via the original article. ... Read more >>

Mil Med Res (Military Medical Research)
[2020, 7(1):50]

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A Proposal from the Montpellier World Health Organization Collaborating Centre for Better Management and Prevention of Anaphylaxis.

Luciana Kase Tanno, Nidhal Touati, Salome Allichon, Bryan Martin, Motohiro Ebisawa, Ignacio Ansotegui, Mario Sanchez-Borges, Victoria Cardona, Paul A Greenberger, Dermot Ryan, Guillaume Pouessel, Etienne Beaudouin, Jean-Marie Renaudin, Francis Thiens, Yoon-Seok Chang, Ruby Pawankar, Maximiliano Gomez, Edgardo Jares, Patricia Latour Staffeld, Ioana Agache, Antonella Muraro, Todd A Mahr, James Sublett, Thomas Casale, David Lang, Pascal Demoly,

Since the first description of anaphylaxis in 1902, its clinical importance as an emergency condition has been recognized worldwide. Anaphylaxis is a severe, potentially life-threatening systemic hypersensitivity reaction characterized by rapid onset and the potential to endanger life through respiratory or circulatory compromise. It is usually, although not always, associated ... Read more >>

J Allergy Clin Immunol Pract (The journal of allergy and clinical immunology. In practice)
[2020, :]

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Prospective Phase II Trials Validate the Effect of Neoadjuvant Chemotherapy on Pattern of Recurrence in Pancreatic Adenocarcinoma.

Akhil Chawla, Motaz Qadan, Carlos Fernandez-Del Castillo, Jennifer Y Wo, Jill N Allen, Jeffrey W Clark, Janet E Murphy, Onofrio A Catalano, David P Ryan, David T Ting, Vikram Deshpande, Colin D Weekes, Aparna Parikh, Keith D Lillemoe, Theodore S Hong, Cristina R Ferrone,

OBJECTIVE:The objective of this study was to characterize the patterns of first recurrence after curative-intent resection for pancreatic adenocarcinoma (PDAC). SUMMARY BACKGROUND DATA:We evaluated the first site of recurrence after neoadjuvant treatment as locoregional (LR) or distant metastasis (DM). To validate our findings, we evaluated the pattern from two phase ... Read more >>

Ann Surg (Annals of surgery)
[2020, :]

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Clinical Outcomes of Patients with Metastatic Cancer Receiving Immune Checkpoint Inhibitors in the Inpatient Setting.

Sienna M Durbin, Leyre Zubiri, Andrzej Niemierko, Aditya Bardia, Ryan J Sullivan, Corey McEwen, Therese M Mulvey, Ian M Allen, Donald P Lawrence, Justine V Cohen, Ephraim P Hochberg, David P Ryan, Laura A Petrillo, Kerry L Reynolds,

BACKGROUND:As indications for immune checkpoint inhibitor (ICI) therapy have increased in recent years, so has the proportion of patients eligible for this type of therapy. However, a lack of data exists about the risks and benefits of ICI therapy in hospitalized patients, who tend to be frailer and sicker than ... Read more >>

Oncologist (The oncologist)
[2020, :]

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Mortality and pulmonary complications in patients undergoing upper extremity surgery at the peak of the SARS-CoV-2 pandemic in the UK: a national cohort study.

Benjamin John Floyd Dean, ,

INTRODUCTION:This study reports the 30-day mortality, SARS-CoV-2 complication rate and SARS-CoV-2-related hospital processes at the peak of the first wave of the pandemic in the UK. METHODS:This national, multicentre, cohort study at 74 centres in the UK included all patients undergoing any surgery below the elbow at the peak of ... Read more >>

BMJ Qual Saf (BMJ quality & safety)
[2020, :]

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The Burden of Self-Reported Rhinitis and Associated Risk for Exacerbations with Moderate-Severe Asthma in Primary Care Patients.

Vicky Kritikos, David Price, Alberto Papi, Antonio Infantino, Björn Ställberg, Dermot Ryan, Federico Lavorini, Henry Chrystyn, John Haughney, Karin Lisspers, Kevin Gruffydd-Jones, Miguel Román Rodríguez, Svein Høegh Henrichsen, Thys van der Molen, Victoria Carter, Sinthia Bosnic-Anticevich,

Purpose:There is a dearth of research regarding the prevalence and nature of patient-reported rhinitis and its relationship with risk of asthma exacerbations. The aim of this study was to (i) determine the prevalence, severity and treatment of self-reported rhinitis symptoms among adults aged ≥18 years with asthma treated at Global ... Read more >>

J Asthma Allergy (Journal of asthma and allergy)
[2020, 13:415-428]

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Improving staging of rectal cancer in the pelvis: the role of PET/MRI.

Onofrio A Catalano, Susanna I Lee, Chiara Parente, Christy Cauley, Felipe S Furtado, Robin Striar, Andrea Soricelli, Marco Salvatore, Yan Li, Lale Umutlu, Lina Garcia Cañamaque, David Groshar, Umar Mahmood, Lawrence S Blaszkowsky, David P Ryan, Jeffrey W Clark, Jennifer Wo, Theodore S Hong, Hiroko Kunitake, Liliana Bordeianou, David Berger, Rocco Ricciardi, Bruce Rosen,

PURPOSE:The role of positron emission tomography/magnetic resonance (PET/MR) in evaluating the local extent of rectal cancer remains uncertain. This study aimed to investigate the possible role of PET/MR versus magnetic resonance (MR) in clinically staging rectal cancer. METHODS:This retrospective two-center cohort study of 62 patients with untreated rectal cancer investigated ... Read more >>

Eur J Nucl Med Mol Imaging (European journal of nuclear medicine and molecular imaging)
[2020, :]

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