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David Murray,

J Vasc Surg (Journal of vascular surgery)
[2020, 72(6):2213-2214]

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Implications of detecting serum monoclonal protein by MASS-fix following stem cell transplantation in multiple myeloma.

Jithma P Abeykoon, David L Murray, Isaiah Murray, Dragan Jevremovic, Gregory E Otteson, Angela Dispenzieri, Bonnie K Arendt, Surendra Dasari, Morie Gertz, Wilson I Gonsalves, Taxiarchis V Kourelis, Eli Muchtar, David Dingli, Rahma Warsame, Ronald S Go, Martha Q Lacy, Nelson Leung, Francis Buadi, Yi Lin, Robert A Kyle, Vincent Rajkumar, Shaji Kumar, Prashant Kapoor,

Measurable residual disease (MRD) assessment by marrow-based next-generation flow cytometry (NGF) following autologous stem cell transplantation (ASCT) may lead to false-negative results due to patchy marrow involvement and extramedullary disease in patients with multiple myeloma. We assessed the value of simultaneous MRD evaluation with NGF and serum matrix-assisted laser desorption ... Read more >>

Br J Haematol (British journal of haematology)
[2020, :]

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X-rays had little value in diagnosing children's abnormal skull shapes and primary care clinicians should refer concerns to specialist teams.

Hugh O'Sullivan, Shirley Bracken, Jodie Doyle, Eilish Twomey, Dylan J Murray, Louise Kyne,

AIM:This study examined the consensus between the primary care radiological and specialist clinical diagnosis of abnormal skull shapes in children. METHODS:We performed a retrospective review of children treated at the National Paediatric Craniofacial Centre at Children's Health Ireland, Dublin, Ireland. Group one were referred by primary care colleagues concerned about ... Read more >>

Acta Paediatr (Acta paediatrica (Oslo, Norway : 1992))
[2020, :]

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Development of a patient-reported outcome measure (PROM) and change measure for use in early recovery following hip or knee replacement.

Louise H Strickland, David W Murray, Hemant G Pandit, Crispin Jenkinson,

BACKGROUND:Hip and knee replacement are effective procedures for end-stage arthritis that has not responded to medical management. However, until now, there have been no validated, patient-reported tools to measure early recovery in this growing patient population. The process of development and psychometric evaluation of the Oxford Arthroplasty Early Recovery Score ... Read more >>

J Patient Rep Outcomes (Journal of patient-reported outcomes)
[2020, 4(1):91]

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Education and Outreach in Physical Sciences in Oncology.

Sierra A Walker, Anthony Pham, Sara Nizzero, Mingee Kim, Bob Riter, Julie Bletz, Sheila Judge, Benette Phillips, Dorottya Noble, Diana Murray, Erin Wetzel, Susan Samson, Mariah McMahon, Carl Flink, Jennifer Couch, Claire Tomlin, Kristin Swanson, Alexander R A Anderson, David Odde, Haifa Shen, Shannon Hughes, Nastaran Zahir, Heiko Enderling, Joy Wolfram,

Physical sciences are often overlooked in the field of cancer research. The Physical Sciences in Oncology Initiative was launched to integrate physics, mathematics, chemistry, and engineering with cancer research and clinical oncology through education, outreach, and collaboration. Here, we provide a framework for education and outreach in emerging transdisciplinary fields. ... Read more >>

Trends Cancer (Trends in cancer)
[2020, :]

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Strengthening Plastic Surgery in Europe - ESPRAS Survey at ESPRAS European Leadership Forum (ELF).

Riccardo E Giunta, Nicholas Möllhoff, Horacio Costa, Cenk Demirdöver, Giovanni di Benedetto, Anna Elander, Mark Henley, Dylan J Murray, Dirk J Schaefer, Stephan Spendel, Olavi Vasar, Rado Zic,

BACKGROUND: The Executive Committee (ExCo) of the European Society of Plastic, Reconstructive and Aesthetic Surgery (ESPRAS) organized a first ESPRAS European Leadership Forum (ELF) to facilitate international exchange and to provide a platform for international leaders and delegates of national societies of Plastic Surgery to discuss common challenges. The presented manuscript ... Read more >>

Handchir Mikrochir Plast Chir (Handchirurgie, Mikrochirurgie, plastische Chirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft fur Handchirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft fur Mikrochirurgie der Peripheren Nerven und Gefasse : Organ der V...)
[2020, :]

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Design and implementation of the multi-arm, multi-stage Therapeutics for Inpatients with COVID-19 (TICO) platform master protocol: An Accelerating COVID-19 Therapeutic Interventions and Vaccines (ACTIV) initiative

Daniel Murray, Abdel Babiker, Jason Baker, Christina Barkauskas, Samuel Brown, Christina Chang, Victoria Davey, Annetine Gelijns, Adit Ginde, Birgit Grund, Elizabeth Higgs, Fleur Hudson, Virginia Kan, Clifford Lane, Thomas Murray, Roger Paredes, Mahesh K.B. Parmar, Sarah Pett, Andrew Phillips, Mark Polizzotto, Cavan Reilly, Uriel Sandkovsky, Shweta Sharma, Mark Teitelbaum, Taylor Thompson, Barnaby Young, James Neaton, Jens Lundgren,

1 Abstract Background The SARS-CoV-2 pandemic is a public health emergency. Safe and effective therapies are urgently needed. Methods Therapeutics for Inpatients with COVID-19 (TICO), is a global multi-arm, multi-stage (MAMS) platform master protocol, which facilitates the rapid evaluation of the safety and efficacy of candidate anti-viral therapeutic agents for ... Read more >>

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COVID-19 in haematology patients: a multicentre West Midlands clinical outcomes analysis on behalf of the West Midlands Research Consortium.

Hana Morrissey, Patrick Ball, Anandadeep Mandal, Alan Nevil, Shankara Paneesha, Supratik Basu, Farheen Karim, Md Imran Hossain, Neil Phillips, Jahanzeb Khawaja, Jackie Stone, Duncan Murray, Katie Randall, Vidhya Murthy, Bhuvan Kishore, Manos Nikolousis, Guy Pratt, Jeff Neilson, Nick Pemberton, Farooq Wandroo,

Br J Haematol (British journal of haematology)
[2020, :]

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Associations of the gut microbiome and clinical factors with acute GVHD in allogeneic HSCT recipients.

Emma E Ilett, Mette Jørgensen, Marc Noguera-Julian, Jens Christian Nørgaard, Gedske Daugaard, Marie Helleberg, Roger Paredes, Daniel D Murray, Jens Lundgren, Cameron MacPherson, Joanne Reekie, Henrik Sengeløv,

Acute graft-versus-host disease (aGVHD) is a leading cause of transplantation-related mortality after allogeneic hematopoietic stem cell transplantation (aHSCT). 16S ribosomal RNA (16S rRNA) gene-based studies have reported that lower gut bacterial diversity and the relative abundance of certain bacteria after aHSCT are associated with aGVHD. Using shotgun metagenomic sequencing and ... Read more >>

Blood Adv (Blood advances)
[2020, 4(22):5797-5809]

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Spur-cell anemia.

Satish Maharaj, Drew Murray, Simone Chang, Kamila Cisak,

Cleve Clin J Med (Cleveland Clinic journal of medicine)
[2020, 87(11):649-650]

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Free Light Chain Assay Drift: Potential for Misdiagnosis?

David Murray, Angela Dispenzieri, Shaji Kumar, Hillary Gill, Celine Vachon, Melissa Snyder, Maria Willrich,

J Appl Lab Med (The journal of applied laboratory medicine)
[2020, 5(6):1411-1413]

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Liquid Chromatography-Tandem Mass Spectrometry-Based α1-Antitrypsin (AAT) Testing.

Josiah D Murray, Maria A Willrich, Michael J Krowka, Aleh Bobr, David L Murray, Kevin C Halling, Rondell P Graham, Melissa R Snyder,

OBJECTIVES:Failure to produce sufficient quantities of functional α1-antitrypsin (AAT) can result in AAT deficiency (AATD) and significant comorbidities. Laboratory testing plays a vital role in AATD, with diagnosis requiring documentation of both a low AAT level and a mutated allele. This retrospective evaluation examines the efficacy of a liquid chromatography-tandem ... Read more >>

Am J Clin Pathol (American journal of clinical pathology)
[2020, :]

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Development of novel methods for non-canonical myeloma protein analysis with an innovative adaptation of immunofixation electrophoresis, native top-down mass spectrometry, and middle-down de novo sequencing.

W Ian Deighan, Valerie J Winton, Rafael D Melani, Lissa C Anderson, John P McGee, Luis F Schachner, David Barnidge, David Murray, H Denis Alexander, David S Gibson, Michael J Deery, Feargal P McNicholl, Joseph McLaughlin, Neil L Kelleher, Paul M Thomas,

Objectives Multiple myeloma (MM) is a malignant plasma cell neoplasm, requiring the integration of clinical examination, laboratory and radiological investigations for diagnosis. Detection and isotypic identification of the monoclonal protein(s) and measurement of other relevant biomarkers in serum and urine are pivotal analyses. However, occasionally this approach fails to characterize ... Read more >>

Clin Chem Lab Med (Clinical chemistry and laboratory medicine)
[2020, :]

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The effect of obesity on revision rate in unicompartmental knee arthroplasty: a systematic review and meta-analysis.

Omar Musbahi, Thomas W Hamilton, Adam J Crellin, Stephen J Mellon, Benjamin Kendrick, David W Murray,

The number of patients with knee osteoarthritis, the proportion that is obese and the number undergoing unicompartmental knee arthroplasty (UKA) are all increasing. The primary aim of this systematic review was to determine the effects of obesity on outcomes in UKA. A systematic review was performed using PRISMA guidelines and ... Read more >>

Knee Surg Sports Traumatol Arthrosc (Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA)
[2020, :]

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Spatial and environmental influences on selection in a clock gene coding trinucleotide repeat in Canada lynx (Lynx canadensis).

Melanie B Prentice, Jeff Bowman, Dennis L Murray, Kamal Khidas, Paul J Wilson,

Clock genes exhibit substantial control over gene expression and ultimately life-histories using external cues such as photoperiod, and are thus likely to be critical for adaptation to shifting seasonal conditions and novel environments as species redistribute their ranges under climate change. Coding trinucleotide repeats (cTNRs) are found within several clock ... Read more >>

Mol Ecol (Molecular ecology)
[2020, 29(23):4637-4652]

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Effect of Hydroxychloroquine in Hospitalized Patients with Covid-19.

, Peter Horby, Marion Mafham, Louise Linsell, Jennifer L Bell, Natalie Staplin, Jonathan R Emberson, Martin Wiselka, Andrew Ustianowski, Einas Elmahi, Benjamin Prudon, Tony Whitehouse, Timothy Felton, John Williams, Jakki Faccenda, Jonathan Underwood, J Kenneth Baillie, Lucy C Chappell, Saul N Faust, Thomas Jaki, Katie Jeffery, Wei Shen Lim, Alan Montgomery, Kathryn Rowan, Joel Tarning, James A Watson, Nicholas J White, Edmund Juszczak, Richard Haynes, Martin J Landray,

BACKGROUND:Hydroxychloroquine and chloroquine have been proposed as treatments for coronavirus disease 2019 (Covid-19) on the basis of in vitro activity and data from uncontrolled studies and small, randomized trials. METHODS:In this randomized, controlled, open-label platform trial comparing a range of possible treatments with usual care in patients hospitalized with Covid-19, ... Read more >>

N Engl J Med (The New England journal of medicine)
[2020, 383(21):2030-2040]

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Improvement in the Prediction of Neonatal Hypoxic-Ischemic Encephalopathy with the Integration of Umbilical Cord Metabolites and Current Clinical Makers.

Daragh S O'Boyle, Warwick B Dunn, Donna O'Neill, Jennifer A Kirwan, David I Broadhurst, Boubou Hallberg, Geraldine B Boylan, Deirdre M Murray,

OBJECTIVE:To validate our previously identified candidate metabolites, and to assess the ability of these metabolites to predict hypoxic-ischemic encephalopathy (HIE) both individually and combined with clinical data. STUDY DESIGN:Term neonates with signs of perinatal asphyxia, with and without HIE, and matched controls were recruited prospectively at birth from 2 large ... Read more >>

J Pediatr (The Journal of pediatrics)
[2020, :]

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Sialic acid-bearing paraproteins are implicated in heparin-like coagulopathy in patients with myeloma.

Abdulrahman Saadalla, Jansen Seheult, Paula Ladwig, Julie Tange, Rachel Leger, Mindy Kohlhagen, Aneel Ashrani, David Murray,

Blood (Blood)
[2020, 136(17):1988-1992]

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The effect of maternal pre-/early-pregnancy BMI and pregnancy smoking and alcohol on congenital heart diseases: a parental negative control study

Kurt Taylor, Ahmed Elhakeem, Johanna Lucia Thorbjørnsrud Nader, Tiffany Yang, Elena Isaevska, Lorenzo Richiardi, Tanja Vrijkotte, Angela Pinot de Moira, Deirdre Murray, Daragh Finn, Dan Mason, John Wright, Sam Oddie, Nel Roeleveld, Jennifer Harris, Anne-Marie Nybo Andersen, Massimo Caputo, Deborah Lawlor,

Abstract Background Congenital heart diseases (CHDs) are the most common congenital anomaly. The causes of CHDs are largely unknown. Higher prenatal body mass index (BMI), smoking and alcohol consumption are associated with increased risk of CHDs. Whether these are causal is unclear. Methods and Results Seven European birth cohorts including ... Read more >>

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Mortality and pulmonary complications in patients undergoing upper extremity surgery at the peak of the SARS-CoV-2 pandemic in the UK: a national cohort study.

Benjamin John Floyd Dean, ,

INTRODUCTION:This study reports the 30-day mortality, SARS-CoV-2 complication rate and SARS-CoV-2-related hospital processes at the peak of the first wave of the pandemic in the UK. METHODS:This national, multicentre, cohort study at 74 centres in the UK included all patients undergoing any surgery below the elbow at the peak of ... Read more >>

BMJ Qual Saf (BMJ quality & safety)
[2020, :]

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Integrated Nurse Practitioner and Pharmacist Post-discharge Heart Failure Clinic: Impact on Patient Outcomes

Magdalena M. Siodlak, Christine Sgarlata, Irene W. Chung, Anita Kashyap, David R. Murray, William S. Middleton,

Introduction The American Heart Association recommends implementation of integrated transition of care programs to manage patients following hospitalization for acute decompensated heart failure (ADHF). At our site, a Nurse Practitioner (NP) has been historically responsible for seeing patients post discharge in the Heart Failure Access Clinic (HFAC). Whether the addition ... Read more >>

J Card Fail (Journal of cardiac failure)
[2020, 26(10):S106-S106]

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Caput membranaceum: A novel clinical presentation of ZIC1 related skull malformation and craniosynostosis.

Erina Sasaki, Angela T Byrne, Dylan J Murray, William Reardon,

We report clinical and radiological features of a patient born with an isolated skull malformation of caput membranaceum and partial bicoronal craniosynostosis with a novel, de novo heterozygous missense variant in ZIC1 [NM_003412.3:c.1183C>G, p.(Pro395Ala)]. Caput membranaceum, or boneless skull, is a rare manifestation of skull ossification defect. It can result ... Read more >>

Am J Med Genet A (American journal of medical genetics. Part A)
[2020, 182(12):2994-2998]

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Oncoprotein-specific molecular interaction maps (SigMaps) for cancer network analyses.

Joshua Broyde, David R Simpson, Diana Murray, Evan O Paull, Brennan W Chu, Somnath Tagore, Sunny J Jones, Aaron T Griffin, Federico M Giorgi, Alexander Lachmann, Peter Jackson, E Alejandro Sweet-Cordero, Barry Honig, Andrea Califano,

Tumor-specific elucidation of physical and functional oncoprotein interactions could improve tumorigenic mechanism characterization and therapeutic response prediction. Current interaction models and pathways, however, lack context specificity and are not oncoprotein specific. We introduce SigMaps as context-specific networks, comprising modulators, effectors and cognate binding-partners of a specific oncoprotein. SigMaps are reconstructed ... Read more >>

Nat Biotechnol (Nature biotechnology)
[2020, :]

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Low polyethylene creep and wear following mobile-bearing unicompartmental knee replacement.

Priyanka Ghosh, Hasan R Mohammad, Benjamin Martin, Stefano Campi, David W Murray, Stephen J Mellon,

PURPOSE:The Oxford unicompartmental knee replacement (UKR) has a fully congruent mobile bearing to minimise wear. However, with younger higher demand patients, wear remains a concern. The aim of this study was to quantify the wear rate of Phase 3 Oxford UKR bearings over the course of 5 years and to identify ... Read more >>

Knee Surg Sports Traumatol Arthrosc (Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA)
[2020, :]

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Dynamic structural order of a low-complexity domain facilitates assembly of intermediate filaments.

Vasiliy O Sysoev, Masato Kato, Lillian Sutherland, Rong Hu, Steven L McKnight, Dylan T Murray,

The coiled-coil domains of intermediate filament (IF) proteins are flanked by regions of low sequence complexity. Whereas IF coiled-coil domains assume dimeric and tetrameric conformations on their own, maturation of eight tetramers into cylindrical IFs is dependent on either "head" or "tail" domains of low sequence complexity. Here we confirm ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2020, 117(38):23510-23518]

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