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Machine learning evaluates improvement in sinus computed tomography opacification with CFTR modulator therapy.

Daniel M Beswick, Stephen M Humphries, Connor D Balkissoon, Eszter K Vladar, Vijay R Ramakrishnan, David A Lynch, Jennifer L Taylor-Cousar,

Int Forum Allergy Rhinol (International forum of allergy & rhinology)
[2020, :]

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Core Outcomes Set for Trials in People With Coronavirus Disease 2019.

Allison Tong, Julian H Elliott, Luciano Cesar Azevedo, Amanda Baumgart, Andrew Bersten, Lilia Cervantes, Derek P Chew, Yeoungjee Cho, Tess Cooper, Sally Crowe, Ivor S Douglas, Nicole Evangelidis, Ella Flemyng, Elyssa Hannan, Peter Horby, Martin Howell, Jaehee Lee, Emma Liu, Eduardo Lorca, Deena Lynch, John C Marshall, Andrea Matus Gonzalez, Anne McKenzie, Karine E Manera, Charlie McLeod, Sangeeta Mehta, Mervyn Mer, Andrew Conway Morris, Saad Nseir, Pedro Povoa, Mark Reid, Yasser Sakr, Ning Shen, Alan R Smyth, Tom Snelling, Giovanni Fm Strippoli, Armando Teixeira-Pinto, Antoni Torres, Tari Turner, Andrea K Viecelli, Steve Webb, Paula R Williamson, Laila Woc-Colburn, Junhua Zhang, Jonathan C Craig, ,

OBJECTIVES:The outcomes reported in trials in coronavirus disease 2019 are extremely heterogeneous and of uncertain patient relevance, limiting their applicability for clinical decision-making. The aim of this workshop was to establish a core outcomes set for trials in people with suspected or confirmed coronavirus disease 2019. DESIGN:Four international online multistakeholder ... Read more >>

Crit Care Med (Critical care medicine)
[2020, 48(11):1622-1635]

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PPAR gamma agonist leriglitazone improves frataxin-loss impairments in cellular and animal models of Friedreich Ataxia.

Laura Rodríguez-Pascau, Elena Britti, Pablo Calap-Quintana, Yi Na Dong, Cristina Vergara, Fabien Delaspre, Marta Medina, Jordi Tamarit, Federico V Pallardó, Pilar Gonzalez-Cabo, Joaquim Ros, David R Lynch, Marc Martinell, Pilar Pizcueta,

Friedreich ataxia (FRDA), the most common autosomal recessive ataxia, is characterized by degeneration of the large sensory neurons and spinocerebellar tracts, cardiomyopathy, and increased incidence in diabetes. The underlying pathophysiological mechanism of FRDA, driven by a significantly decreased expression of frataxin (FXN), involves increased oxidative stress, reduced activity of enzymes ... Read more >>

Neurobiol Dis (Neurobiology of disease)
[2020, :105162]

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Tuning Proton Transfer Thermodynamics in SARS-Cov-2 Main Protease: Implications for Catalysis and Inhibitor Design

Laura Zanetti-Polzi, Micholas Smith, Chris Chipot, James Gumbart, Diane Lynch, Anna Pavlova, Jeremy Smith, Isabella Daidone,

In this comutational work a hybrid quantum mechanics/molecular mechanics approach, the MD-PMM approach, is used to investigate the proton transfer reaction the activates the catalytic activity of SARS-CoV-2 main protease. The proton transfer thermodynamics is investigated for the apo ensyme (i.e., without any bound substrate or inhibitor) and in the ... Read more >>

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Interleukin-6: A novel biomarker for monoclonal antibody and chemotherapy-associated hypersensitivity confirms a cytokine release syndrome phenotype-endotype association.

Baruch D Jakubovic, Soledad Sanchez-Sanchez, Sahar Hamadi, Donna-Marie Lynch, Mariana Castells,

Allergy (Allergy)
[2020, :]

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International Survey to Establish Prioritized Outcomes for Trials in People With Coronavirus Disease 2019.

Nicole Evangelidis, Allison Tong, Martin Howell, Armando Teixeira-Pinto, Julian H Elliott, Luciano Cesar Azevedo, Andrew Bersten, Lilia Cervantes, Derek P Chew, Sally Crowe, Ivor S Douglas, Ella Flemyng, Peter Horby, Jaehee Lee, Eduardo Lorca, Deena Lynch, John C Marshall, Anne McKenzie, Sangeeta Mehta, Mervyn Mer, Andrew Conway Morris, Saad Nseir, Pedro Povoa, Mark Reid, Yasser Sakr, Ning Shen, Alan R Smyth, Tom Snelling, Giovanni F M Strippoli, Antoni Torres, Tari Turner, Steve Webb, Paula R Williamson, Laila Woc-Colburn, Junhua Zhang, Amanda Baumgart, Sebastian Cabrera, Yeoungjee Cho, Tess Cooper, Chandana Guha, Emma Liu, Andrea Matus Gonzalez, Charlie McLeod, Patrizia Natale, Valeria Saglimbene, Andrea K Viecelli, Jonathan C Craig, ,

OBJECTIVES:There are over 4,000 trials conducted in people with coronavirus disease 2019. However, the variability of outcomes and the omission of patient-centered outcomes may diminish the impact of these trials on decision-making. The aim of this study was to generate a consensus-based, prioritized list of outcomes for coronavirus disease 2019 ... Read more >>

Crit Care Med (Critical care medicine)
[2020, 48(11):1612-1621]

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Differentiating combined pulmonary fibrosis and emphysema from pure emphysema: utility of late gadolinium-enhanced MRI.

Hannah Fleming, Simon M Clifford, Aoife Haughey, Roisin MacDermott, Niall McVeigh, Gerard M Healy, Lisa Lavelle, Suhny Abbara, David J Murphy, Aurelie Fabre, Edward McKone, Cormac McCarthy, Marcus Butler, Peter Doran, David A Lynch, Michael P Keane, Jonathan D Dodd,

BACKGROUND:Differentiating combined pulmonary fibrosis with emphysema (CPFE) from pure emphysema can be challenging on high-resolution computed tomography (HRCT). This has antifibrotic therapy implications. METHODS:Twenty patients with suspected CPFE underwent late gadolinium-enhanced (LGE) thoracic magnetic resonance imaging (LGE-MRI) and HRCT. Data from twelve healthy control subjects from a previous study who ... Read more >>

Eur Radiol Exp (European radiology experimental)
[2020, 4(1):61]

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Effect of Hydroxychloroquine in Hospitalized Patients with Covid-19.

, Peter Horby, Marion Mafham, Louise Linsell, Jennifer L Bell, Natalie Staplin, Jonathan R Emberson, Martin Wiselka, Andrew Ustianowski, Einas Elmahi, Benjamin Prudon, Tony Whitehouse, Timothy Felton, John Williams, Jakki Faccenda, Jonathan Underwood, J Kenneth Baillie, Lucy C Chappell, Saul N Faust, Thomas Jaki, Katie Jeffery, Wei Shen Lim, Alan Montgomery, Kathryn Rowan, Joel Tarning, James A Watson, Nicholas J White, Edmund Juszczak, Richard Haynes, Martin J Landray,

BACKGROUND:Hydroxychloroquine and chloroquine have been proposed as treatments for coronavirus disease 2019 (Covid-19) on the basis of in vitro activity and data from uncontrolled studies and small, randomized trials. METHODS:In this randomized, controlled, open-label platform trial comparing a range of possible treatments with usual care in patients hospitalized with Covid-19, ... Read more >>

N Engl J Med (The New England journal of medicine)
[2020, 383(21):2030-2040]

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Safety and Efficacy of Omaveloxolone in Friedreich Ataxia (MOXIe Study).

David R Lynch, Melanie P Chin, Martin B Delatycki, S H Subramony, Manuela Corti, J Chad Hoyle, Sylvia Boesch, Wolfgang Nachbauer, Caterina Mariotti, Katherine D Mathews, Paola Giunti, George Wilmot, Theresa Zesiewicz, Susan Perlman, Angie Goldsberry, Megan O'Grady, Colin J Meyer,

OBJECTIVE:Friedreich ataxia (FA) is a progressive genetic neurodegenerative disorder with no approved treatment. Omaveloxolone, an Nrf2 activator, improves mitochondrial function, restores redox balance, and reduces inflammation in models of FA. We investigated the safety and efficacy of omaveloxolone in patients with FA. METHODS:We conducted an international, double-blind, randomized, placebo-controlled, parallel-group, ... Read more >>

Ann Neurol (Annals of neurology)
[2020, :]

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A Risk Prediction Model for Mortality Among Smokers in the COPDGene® Study.

Matthew Strand, Erin Austin, Matthew Moll, Katherine A Pratte, Elizabeth A Regan, Lystra P Hayden, Surya P Bhatt, Aladin M Boriek, Richard Casaburi, Edwin K Silverman, Spyridon Fortis, Ingo Ruczinski, Harald Koegler, Harry B Rossiter, Mariaelena Occhipinti, Nicola A Hanania, Hirut T Gebrekristos, David A Lynch, Ken M Kunisaki, Kendra A Young, Jessica C Sieren, Margaret Ragland, John E Hokanson, Sharon M Lutz, Barry J Make, Gregory L Kinney, Michael H Cho, Massimo Pistolesi, Dawn L DeMeo, Frank C Sciurba, Alejandro P Comellas, Alejandro A Diaz, Igor Barjaktarevic, Russell P Bowler, Richard E Kanner, Stephen P Peters, Victor E Ortega, Mark T Dransfield, James D Crapo,

Background:Risk factor identification is a proven strategy in advancing treatments and preventive therapy for many chronic conditions. Quantifying the impact of those risk factors on health outcomes can consolidate and focus efforts on individuals with specific high-risk profiles. Using multiple risk factors and longitudinal outcomes in 2 independent cohorts, we ... Read more >>

Chronic Obstr Pulm Dis (Chronic obstructive pulmonary diseases (Miami, Fla.))
[2020, 7(4):346-361]

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High-Spatial-Resolution CT Offers New Opportunities for Discovery in the Lung.

David A Lynch, Andrea S Oh,

Radiology (Radiology)
[2020, 297(2):472-473]

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The Design, Implementation, and Acceptability of a Telehealth Comprehensive Recovery Service for People With Complex Psychosis Living in NYC During the COVID-19 Crisis.

David A Lynch, Alice Medalia, Alice Saperstein,

Introduction:The COVID-19 crisis and subsequent stay-at-home orders have produced unprecedented challenges to the dissemination of recovery oriented behavioral health services (RS) that support the treatment of those with complex psychosis (CP).This population has typically been managed with in-person pharmacotherapy and/or RS, with the goals of relieving symptoms, improving life satisfaction ... Read more >>

Front Psychiatry (Frontiers in psychiatry)
[2020, 11:581149]

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Aggressive Langerhans cell histiocytosis following T-cell acute lymphoblastic leukemia.

Chandler Jansen, Jordan Dykstra, Daniel Callaway, Douglas Lynch, Arwyn Cunningham, Marcus L Frohm,

A 4-year-old female child developed cutaneous Langerhans cell histiocytosis 6 months following a diagnosis of T-cell acute lymphoblastic leukemia. Imaging revealed no evidence of systemic disease. Seven months later, the first systemic lesion was discovered on laryngoscopy. Restaging Positron Emission Tomography - Computed Tomography at that time revealed new 18-fluorodeoxyglucose-positive ... Read more >>

Pediatr Blood Cancer (Pediatric blood & cancer)
[2020, 67(12):e28704]

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Expanding Applications of Pulmonary MRI in the Clinical Evaluation of Lung Disorders: Fleischner Society Position Paper.

Hiroto Hatabu, Yoshiharu Ohno, Warren B Gefter, Grace Parraga, Bruno Madore, Kyung Soo Lee, Talissa A Altes, David A Lynch, John R Mayo, Joon Beom Seo, Jim M Wild, Edwin J R van Beek, Mark L Schiebler, Hans-Ulrich Kauczor, ,

Pulmonary MRI provides structural and quantitative functional images of the lungs without ionizing radiation, but it has had limited clinical use due to low signal intensity from the lung parenchyma. The lack of radiation makes pulmonary MRI an ideal modality for pediatric examinations, pregnant women, and patients requiring serial and ... Read more >>

Radiology (Radiology)
[2020, 297(2):286-301]

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Application of a Rat Liver Drug Bioactivation Transcriptional Response Assay Early in Drug Development That Informs Chemically Reactive Metabolite Formation and Potential for Drug-induced Liver Injury.

James J Monroe, Keith Q Tanis, Alexei A Podtelezhnikov, Truyen Nguyen, Sam V Machotka, Donna Lynch, Raymond Evers, Jairam Palamanda, Randy R Miller, Todd Pippert, Tamara D Cabalu, Timothy E Johnson, Amy G Aslamkhan, Wen Kang, Alex M Tamburino, Kaushik Mitra, Nancy G B Agrawal, Frank D Sistare,

Drug-induced liver injury is a major reason for drug candidate attrition from development, denied commercialization, market withdrawal, and restricted prescribing of pharmaceuticals. The metabolic bioactivation of drugs to chemically reactive metabolites (CRMs) contribute to liver-associated adverse drug reactions in humans that often goes undetected in conventional animal toxicology studies. A ... Read more >>

Toxicol Sci (Toxicological sciences : an official journal of the Society of Toxicology)
[2020, 177(1):281-299]

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Mycobacterial para-Hydroxybenzoic Acid-Derivatives (pHBADs) and Related Structures Induce Macrophage Innate Memory.

Mimmi Lundahl, Dylan M Lynch, Danielle Barnes, Lauren McSweeney, Aoife Gorman, Filipa Lebre, Stephen V Gordon, Ed C Lavelle, Eoin M Scanlan,

Macrophages are key immune cells for combatting Mycobacterium tuberculosis. However, M. tuberculosis possesses means to evade macrophage bactericidal responses by, for instance, secretion of the immunomodulatory para-hydroxybenzoic acid derivatives (pHBADs). While these molecules have been implicated in inhibiting macrophage responses in an acute context, little is known about their ability ... Read more >>

ACS Chem Biol (ACS chemical biology)
[2020, 15(9):2415-2421]

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Monogenic small vessel diseases - rare but still important.

David J Werring, David S Lynch,

Nat Rev Neurol (Nature reviews. Neurology)
[2020, 16(8):407-408]

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Test-retest reliability of the Friedreich's ataxia rating scale.

Christian Rummey, Theresa A Zesiewicz, Santiago Perez-Lloret, Jennifer M Farmer, Massimo Pandolfo, David R Lynch,

The modified Friedreich Ataxia Rating Scale (mFARS) is a disease specific, exam-based neurological rating scale commonly used as a outcome measure in clinical trials. While extensive clinimetric testing indicates it's validity in measuring disease progression, formal test-retest reliability was lacking. To fill this gap, we acquired results from screening and ... Read more >>

Ann Clin Transl Neurol (Annals of clinical and translational neurology)
[2020, :]

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Use of dual mobility components in total hip arthroplasty: Indications and outcomes.

Sravya P Vajapey, Kathryn L Fideler, Daniel Lynch, Mengnai Li,

Instability after total hip arthroplasty (THA) can be a problematic complication and remains one of the leading causes of revision surgery in the early post-operative period. Dual mobility (DM) implants decrease dislocation risk after THA but they come with their own set of complications. Selective use of DM implants for ... Read more >>

J Clin Orthop Trauma (Journal of clinical orthopaedics and trauma)
[2020, 11(Suppl 5):S760-S765]

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Telehealth Conversion of Serious Mental Illness Recovery Services During the COVID-19 Crisis.

Alice Medalia, David A Lynch, Tiffany Herlands,

Psychiatr Serv (Psychiatric services (Washington, D.C.))
[2020, 71(8):872]

Cited: 1 time

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Percutaneous Interventions for Secondary Mitral Regurgitation.

Mahboob Ali, Satya S Shreenivas, David N Pratt, Donald R Lynch, Dean J Kereiakes,

Mitral regurgitation is frequently associated with ventricular dysfunction and carries a high mortality. Guideline-directed medical therapy, surgical mitral valve repair or replacement, and, in the setting of advanced heart failure, heart transplant and left ventricular assist devices have been the mainstay of treatment. However, rapid advancement in the field has ... Read more >>

Circ Cardiovasc Interv (Circulation. Cardiovascular interventions)
[2020, 13(8):e008998]

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A Closer Look at Anandamide Interaction With TRPV1.

Chante Muller, Diane L Lynch, Dow P Hurst, Patricia H Reggio,

The transient receptor potential subfamily vanilloid type 1 ion channel (TRPV1), located in the peripheral nervous system has been implicated in the perception of pain and possesses the ability to be modulated by various cannabinoid ligands. Because of its location, TRPV1 is an ideal target for the development of novel ... Read more >>

Front Mol Biosci (Frontiers in molecular biosciences)
[2020, 7:144]

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Utility of a Molecular Classifier as a Complement to HRCT to Identify Usual Interstitial Pneumonia.

Luca Richeldi, Mary Beth Scholand, David A Lynch, Thomas V Colby, Jeffrey L Myers, Steve D Groshong, Jonathan H Chung, Sadia Benzaquen, Steven D Nathan, J Russell Davis, Shelley L Schmidt, Lars Hagmeyer, David Sonetti, Jurgen Hetzel, Gerard J Criner, Amy H Case, Murali Ramaswamy, Karel Calero, Umair A Gauhar, Nina M Patel, Lisa Lancaster, Yoonha Choi, Daniel G Pankratz, P Sean Walsh, Lori R Lofaro, Jing Huang, Sangeeta M Bhorade, Giulia C Kennedy, Fernando J Martinez, Ganesh Raghu,

Rationale Usual interstitial pneumonia (UIP) is the defining morphology of idiopathic pulmonary fibrosis (IPF). Guidelines for IPF diagnosis conditionally recommend surgical lung biopsy (SLB) for histopathology diagnosis of UIP when radiology and clinical context are not definitive. A 'molecular diagnosis of UIP' in transbronchial lung biopsy (TBBx), the Envisia Genomic ... Read more >>

Am J Respir Crit Care Med (American journal of respiratory and critical care medicine)
[2020, :]

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3D-printed graphene/polymer structures for electron-tunneling based devices.

Deisy C Carvalho Fernandes, Dylan Lynch, Vikas Berry,

Designing 3D printed micro-architectures using electronic materials with well-understood electronic transport within such structures will potentially lead to accessible device fabrication for 'on-demand' applications. Here we show controlled nozzle-extrusion based 3D printing of a commercially available nano-composite of graphene/polylactic acid, enabling the fabrication of a tensile gauge functioning via the ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):11373]

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Association between the number and size of intrapulmonary lymph nodes and chronic obstructive pulmonary disease severity.

Anton Schreuder, Colin Jacobs, Ernst T Scholten, Mathias Prokop, Bram van Ginneken, David A Lynch, Cornelia M Schaefer-Prokop, ,

Purpose:One of the main pathophysiological mechanisms of chronic obstructive pulmonary disease is inflammation, which has been associated with lymphadenopathy. Intrapulmonary lymph nodes can be identified on CT as perifissural nodules (PFN). We investigated the association between the number and size of PFNs and measures of COPD severity. Materials and Methods:CT ... Read more >>

PeerJ (PeerJ)
[2020, 8:e9166]

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