Full Text Journal Articles by
Author D D Sarbassov


Find full text journal articles

Rictor regulates cell migration by suppressing RhoGDI2.

N K Agarwal, C-H Chen, H Cho, D R Boulb├Ęs, E Spooner, D D Sarbassov,

Rictor and its binding partner Sin1 are indispensable components of mTORC2 (mammalian target of rapamycin complex 2). The mTORC2 signaling complex functions as the regulatory kinase of the distinct members of AGC kinase family known to regulate cell proliferation and survival. In the early chemotaxis studies in Dictyostelium, the rictor's ... Read more >>

Oncogene (Oncogene)
[2013, 32(20):2521-2526]

Cited: 38 times

View full text PDF listing >>

Integrity of mTORC2 is dependent on the rictor Gly-934 site.

R Aimbetov, C-H Chen, O Bulgakova, D Abetov, A K Bissenbaev, R I Bersimbaev, D D Sarbassov,

Growth factor signaling coupled to activation of the phosphatidylinositol-3-OH kinase (PI3K)/Akt pathway plays a crucial role in the regulation of cell proliferation and survival. The key regulatory kinase of Akt has been identified as mammalian target of rapamycin complex 2 (mTORC2), which functions as the PI3K-dependent Ser-473 kinase of Akt. ... Read more >>

Oncogene (Oncogene)
[2012, 31(16):2115-2120]

Cited: 14 times

View full text PDF listing >>


Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex.

D D Sarbassov, David A Guertin, Siraj M Ali, David M Sabatini,

Deregulation of Akt/protein kinase B (PKB) is implicated in the pathogenesis of cancer and diabetes. Akt/PKB activation requires the phosphorylation of Thr308 in the activation loop by the phosphoinositide-dependent kinase 1 (PDK1) and Ser473 within the carboxyl-terminal hydrophobic motif by an unknown kinase. We show that in Drosophila and human ... Read more >>

Science (Science (New York, N.Y.))
[2005, 307(5712):1098-1101]

Cited: 3794 times

View full text PDF listing >>

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton.

D D Sarbassov, Siraj M Ali, Do-Hyung Kim, David A Guertin, Robert R Latek, Hediye Erdjument-Bromage, Paul Tempst, David M Sabatini,

The mammalian TOR (mTOR) pathway integrates nutrient- and growth factor-derived signals to regulate growth, the process whereby cells accumulate mass and increase in size. mTOR is a large protein kinase and the target of rapamycin, an immunosuppressant that also blocks vessel restenosis and has potential anticancer applications. mTOR interacts with ... Read more >>

Curr Biol (Current biology : CB)
[2004, 14(14):1296-1302]

Cited: 1522 times

View full text PDF listing >>

GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR.

Do-Hyung Kim, D D Sarbassov, Siraj M Ali, Robert R Latek, Kalyani V P Guntur, Hediye Erdjument-Bromage, Paul Tempst, David M Sabatini,

mTOR and raptor are components of a signaling pathway that regulates mammalian cell growth in response to nutrients and growth factors. Here, we identify a member of this pathway, a protein named GbetaL that binds to the kinase domain of mTOR and stabilizes the interaction of raptor with mTOR. Like ... Read more >>

Mol Cell (Molecular cell)
[2003, 11(4):895-904]

Cited: 534 times

View full text PDF listing >>

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery.

Do-Hyung Kim, D D Sarbassov, Siraj M Ali, Jessie E King, Robert R Latek, Hediye Erdjument-Bromage, Paul Tempst, David M Sabatini,

mTOR/RAFT1/FRAP is the target of the immunosuppressive drug rapamycin and the central component of a nutrient- and hormone-sensitive signaling pathway that regulates cell growth. We report that mTOR forms a stoichiometric complex with raptor, an evolutionarily conserved protein with at least two roles in the mTOR pathway. Raptor has a ... Read more >>

Cell (Cell)
[2002, 110(2):163-175]

Cited: 1693 times

View full text PDF listing >>

Insulin receptor substrate-1 and phosphatidylinositol 3-kinase regulate extracellular signal-regulated kinase-dependent and -independent signaling pathways during myogenic differentiation.

D D Sarbassov, C A Peterson,

Activation of the insulin-like growth factor (IGF) autocrine loop is required for myogenic differentiation and results in sustained activation of extracellular signal-regulated kinases-1 and -2 (ERK-1 and -2). We show here that insulin receptor substrate-1 (IRS-1) phosphorylation on tyrosine and serine residues and association with phosphatidylinositol 3-kinase (PI 3-kinase) are ... Read more >>

Mol Endocrinol (Molecular endocrinology (Baltimore, Md.))
[1998, 12(12):1870-1878]

Cited: 37 times

View full text PDF listing >>

Extracellular signal-regulated kinase-1 and -2 respond differently to mitogenic and differentiative signaling pathways in myoblasts.

D D Sarbassov, L G Jones, C A Peterson,

In this report we show that extracellular signal-regulated kinase-1 and -2 (ERK-1 and -2) respond differently to signals that elicit proliferation and/or differentiation of myoblasts using the C2C12 cell line and nondifferentiating mutant NFB4 cells derived from them. Induction of differentiation by withdrawal of serum rendered ERKs in C2C12 myoblasts ... Read more >>

Mol Endocrinol (Molecular endocrinology (Baltimore, Md.))
[1997, 11(13):2038-2047]

Cited: 36 times

View full text PDF listing >>

Role of insulin-like growth factors and myogenin in the altered program of proliferation and differentiation in the NFB4 mutant muscle cell line.

D D Sarbassov, R Stefanova, V G Grigoriev, C A Peterson,

In the present study we used the mutant muscle cell line NFB4 to study the balance between proliferation and myogenic differentiation. We show that removal of serum, which induced the parental C2C12 cells to withdraw from the cell cycle and differentiate, had little effect on NFB4 cells. Gene products characteristic ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[1995, 92(24):10874-10878]

Cited: 16 times

View full text PDF listing >>



0.7774 s