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Author Cristina Tassorelli

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Profiling the Biochemical Signature of GBA-Related Parkinson's Disease in Peripheral Blood Mononuclear Cells.

Micol Avenali, Silvia Cerri, Gerardo Ongari, Cristina Ghezzi, Claudio Pacchetti, Cristina Tassorelli, Enza Maria Valente, Fabio Blandini,

<h4>Background</h4>GBA mutations are the commonest genetic risk factor for Parkinson's disease (PD) and also impact disease progression.<h4>Objective</h4>The objective of this study was to define a biochemical profile that could distinguish GBA-PD from non-mutated PD.<h4>Methods</h4>29 GBA-PD, 37 non-mutated PD, and 40 controls were recruited; α-synuclein levels in plasma, exosomes, and peripheral ... Read more >>

Mov Disord (Movement disorders : official journal of the Movement Disorder Society)
[2021, :]

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Isolated bulbar palsy after SARS-CoV-2 infection.

Massimiliano Todisco, Enrico Alfonsi, Sebastiano Arceri, Giulia Bertino, Carlo Robotti, Michele Albergati, Matteo Gastaldi, Cristina Tassorelli, Giuseppe Cosentino,

Lancet Neurol (The Lancet. Neurology)
[2021, 20(3):169-170]

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Thalamocortical Connectivity in Experimentally-Induced Migraine Attacks: A Pilot Study.

Daniele Martinelli, Gloria Castellazzi, Roberto De Icco, Ana Bacila, Marta Allena, Arianna Faggioli, Grazia Sances, Anna Pichiecchio, David Borsook, Claudia A M Gandini Wheeler-Kingshott, Cristina Tassorelli,

In this study we used nitroglycerin (NTG)-induced migraine attacks as a translational human disease model. Static and dynamic functional connectivity (FC) analyses were applied to study the associated functional brain changes. A spontaneous migraine-like attack was induced in five episodic migraine (EM) patients using a NTG challenge. Four task-free functional ... Read more >>

Brain Sci (Brain sciences)
[2021, 11(2):]

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Spinal nociceptive sensitization and plasma palmitoylethanolamide levels during experimentally-induced migraine attacks.

Roberto De Icco, Rosaria Greco, Chiara Demartini, Pietro Vergobbi, Annamaria Zanaboni, Elena Tumelero, Angelo Reggiani, Natalia Realini, Grazia Sances, Valentina Grillo, Marta Allena, Cristina Tassorelli,

<h4>Abstract</h4>Migraine pathophysiology has been suggested to include dysregulation of the endocannabinoid system (ES). We simultaneously evaluated plasma anandamide (AEA) and palmitoylethanolamide (PEA) levels and spinal sensitization in a validated human model of migraine based on systemic nitroglycerin (NTG) administration.Twenty-four subjects with episodic migraine (MIG) and 19 healthy controls (HC) underwent ... Read more >>

Pain (Pain)
[2021, :]

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Health technology assessment for the acute and preventive treatment of migraine: A position statement of the International Headache Society.

Hans Christoph Diener, Messoud Ashina, Isabelle Durand-Zaleski, Tobias Kurth, Michel Lantéri-Minet, Richard B Lipton, Daniel A Ollendorf, Patricia Pozo-Rosich, Cristina Tassorelli, Gisela Terwindt,

The Clinical Trials Subcommittee of the International Headache Society presents the first Health Technology Assessment for the Acute Treatment of Migraine Attacks and Prevention of Migraine. Health technology assessments are systematic evaluations of the properties, effects, and consequences of healthcare technologies; this position statement is designed to inform decision makers ... Read more >>

Cephalalgia (Cephalalgia : an international journal of headache)
[2021, :333102421989247]

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Migraine neuroscience: from experimental models to target therapy.

Rosaria Greco, Chiara Demartini, Roberto De Icco, Daniele Martinelli, Alessia Putortì, Cristina Tassorelli,

Migraine sciences have witnessed tremendous advances in recent years. Pre-clinical and clinical experimental models have contributed significantly to provide useful insights into the brain structures that mediate migraine attacks. These models have contributed to elucidate the role of neurotransmission pathways and to identify the role of important molecules within the ... Read more >>

Neurol Sci (Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology)
[2020, 41(Suppl 2):351-361]

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Non-invasive Brain and Spinal Stimulation for Pain and Related Symptoms in Multiple Sclerosis: A Systematic Review.

Chiara Zucchella, Elisa Mantovani, Roberto De Icco, Cristina Tassorelli, Giorgio Sandrini, Stefano Tamburin,

<b>Background:</b> Neuropathic and nociceptive pain frequently affect patients with multiple sclerosis (MS), with a prevalence close to 90% and significant impact on general health and quality of life. Pharmacological strategies are widely used to treat pain in MS, but their effectiveness and side-effects are controversial. Among non-pharmacological treatments for pain, ... Read more >>

Front Neurosci (Frontiers in neuroscience)
[2020, 14:547069]

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Double-Binding Botulinum Molecule with Reduced Muscle Paralysis: Evaluation in In Vitro and In Vivo Models of Migraine.

Anna P Andreou, Charlotte Leese, Rosaria Greco, Chiara Demartini, Eve Corrie, Deniz Simsek, Anna Zanaboni, Ksenia Koroleva, Joseph O Lloyd, Giorgio Lambru, Ciara Doran, Oleg Gafurov, Elizabeth Seward, Rashid Giniatullin, Cristina Tassorelli, Bazbek Davletov,

With a prevalence of 15%, migraine is the most common neurological disorder and among the most disabling diseases, taking into account years lived with disability. Current oral medications for migraine show variable effects and are frequently associated with intolerable side effects, leading to the dissatisfaction of both patients and doctors. ... Read more >>

Neurotherapeutics (Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics)
[2020, :]

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Characterization of the peripheral FAAH inhibitor, URB937, in animal models of acute and chronic migraine.

Rosaria Greco, Chiara Demartini, Annamaria Zanaboni, Ilenia Casini, Roberto De Icco, Angelo Reggiani, Alessandra Misto, Daniele Piomelli, Cristina Tassorelli,

Inhibiting the activity of fatty-acid amide hydrolase (FAAH), the enzyme that deactivates the endocannabinoid anandamide, enhances anandamide-mediated signaling and holds promise as a molecular target for the treatment of human pathologies such as anxiety and pain. We have previously shown that the peripherally restricted FAAH inhibitor, URB937, prevents nitroglycerin-induced hyperalgesia ... Read more >>

Neurobiol Dis (Neurobiology of disease)
[2021, 147:105157]

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Plasma levels of CGRP and expression of specific microRNAs in blood cells of episodic and chronic migraine subjects: towards the identification of a panel of peripheral biomarkers of migraine?

Rosaria Greco, Roberto De Icco, Chiara Demartini, Anna Maria Zanaboni, Elena Tumelero, Grazia Sances, Marta Allena, Cristina Tassorelli,

<h4>Background</h4>Migraine can manifest with an episodic or a chronic pattern in a continuum of disease severity. Multiple factors are associated with the progression of the pattern from episodic to chronic. One of the most consistently reported factors is the overuse of medications (MO) for the acute treatment of migraine attacks. ... Read more >>

J Headache Pain (The journal of headache and pain)
[2020, 21(1):122]

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Characterization of CB2 Receptor Expression in Peripheral Blood Monocytes of Acute Ischemic Stroke Patients.

Rosaria Greco, Chiara Demartini, Annamaria Zanaboni, Elena Tumelero, Candeloro Elisa, Alessandra Persico, Andrea Morotti, Diana Amantea, Cristina Tassorelli,

Both preclinical and clinical evidence supports the involvement of the endocannabinoid system in the pathobiology of cerebral ischemia. Selective cannabinoid-2 (CB2) receptor agonists exert significant neuroprotection in animal models of focal brain ischemia through a robust anti-inflammatory effect, involving both resident and peripheral immune cells. Nevertheless, no definitive studies demonstrating ... Read more >>

Transl Stroke Res (Translational stroke research)
[2020, :]

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Mutation in RNF170 causes sensory ataxic neuropathy with vestibular areflexia: a CANVAS mimic.

Andrea Cortese, Ilaria Callegari, Riccardo Currò, Elisa Vegezzi, Silvia Colnaghi, Maurizio Versino, Enrico Alfonsi, Giuseppe Cosentino, Enzamaria Valente, Simone Gana, Cristina Tassorelli, Anna Pichiecchio, Alexander M Rossor, Enrico Bugiardini, Antonio Biroli, Daniela Di Capua, Henry Houlden, Mary M Reilly,

J Neurol Neurosurg Psychiatry (Journal of neurology, neurosurgery, and psychiatry)
[2020, 91(11):1237-1238]

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Changes in patient functioning and disability: results from a phase 3, double-blind, randomized, placebo-controlled clinical trial evaluating galcanezumab for chronic migraine prevention (REGAIN).

Janet Ford, Cristina Tassorelli, Elizabeth Leroux, Shufang Wang, David Ayer, Russell Nichols, Holland Detke,

<h4>Purpose</h4>To evaluate secondary outcomes including changes in functioning and disability associated with galcanezumab, a humanized monoclonal antibody to calcitonin gene-related peptide, in patients with chronic migraine.<h4>Methods</h4>Patients randomly received galcanezumab (120 mg n = 278, 240 mg n = 277) or placebo (n = 558) during 3 months of double-blind treatment, followed by a 9-month open-label extension. The Migraine-Specific Quality-of-Life ... Read more >>

Qual Life Res (Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation)
[2021, 30(1):105-115]

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What is changing in chronic migraine treatment? An algorithm for onabotulinumtoxinA treatment by the Italian chronic migraine group.

Simona Sacco, Antonio Russo, Pierangelo Geppetti, Licia Grazzi, Andrea Negro, Cristina Tassorelli, Gioacchino Tedeschi, Paolo Martelletti,

<h4>Introduction</h4>OnabotulinumtoxinA (OBT-A) and monoclonal antibodies (mAbs) targeting the calcitonin gene-related peptide (CGRP) pathway are two of the few treatments that ameliorate chronic migraine (CM) in randomized controlled trials and real-life studies. Separate clinical practice guidelines have been developed for the management of CM with OBT-A or CGRP-targeting mAbs.<h4>Areas covered</h4>Considering the ... Read more >>

Expert Rev Neurother (Expert review of neurotherapeutics)
[2020, 20(12):1275-1286]

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Predicting the response to a triptan in migraine using deep attack phenotyping: A feasibility study.

Michele Viana, Grazia Sances, Salvatore Terrazzino, Chiara Zecca, Peter J Goadsby, Cristina Tassorelli,

<h4>Background</h4>Triptans, specific symptomatic medications for migraine, are not effective in a proportion of patients, or in all attacks, hence the importance of identifying predictors of response. Our aim was to investigate the association between the efficacy of oral frovatriptan 2.5 mg and clinical characteristics of migraine attacks.<h4>Methods</h4>We enrolled 29 consecutive ... Read more >>

Cephalalgia (Cephalalgia : an international journal of headache)
[2021, 41(2):197-202]

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Peripheral changes of endocannabinoid system components in episodic and chronic migraine patients: A pilot study.

Rosaria Greco, Chiara Demartini, Anna Maria Zanaboni, Elena Tumelero, Roberto De Icco, Grazia Sances, Marta Allena, Cristina Tassorelli,

<h4>Background</h4>Preclinical and clinical evidence suggests a role for the dysregulation of the endocannabinoid system in migraine pain, particularly in subjects with chronic migraine.<h4>Methods</h4>The gene expression of endocannabinoid system components was assayed in peripheral blood mononuclear cells of 25 subjects with episodic migraine, 26 subjects with chronic migraine with medication overuse ... Read more >>

Cephalalgia (Cephalalgia : an international journal of headache)
[2021, 41(2):185-196]

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A double-blind randomized controlled trial of the efficacy of cognitive training delivered using two different methods in mild cognitive impairment in Parkinson's disease: preliminary report of benefits associated with the use of a computerized tool.

Sara Bernini, Silvia Panzarasa, Marica Barbieri, Elena Sinforiani, Silvana Quaglini, Cristina Tassorelli, Sara Bottiroli,

<h4>Background</h4>The effectiveness of computer-based cognitive training (CCT) remains controversial, especially in older adults with neurodegenerative diseases.<h4>Aims</h4>To evaluate the efficacy of CCT in patients with Parkinson's disease and mild cognitive impairment (PD-MCI).<h4>Methods</h4>In this randomized controlled trial, 53 patients were randomized to receive CCT delivered by means of CoRe software, traditional paper-and-pencil ... Read more >>

Aging Clin Exp Res (Aging clinical and experimental research)
[2020, :]

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Guidelines of the International Headache Society for controlled trials of preventive treatment of migraine attacks in episodic migraine in adults.

Hans-Christoph Diener, Cristina Tassorelli, David W Dodick, Stephan D Silberstein, Richard B Lipton, Messoud Ashina, Werner J Becker, Michel D Ferrari, Peter J Goadsby, Patricia Pozo-Rosich, Shuu-Jiun Wang, Timothy T Houle, Thomas C van den Hoek, Daniele Martinelli, Gisela M Terwindt, ,

Clinical trials are a key component of the evidence base for the treatment of headache disorders. In 1991, the International Headache Society Clinical Trials Standing Committee developed and published the first edition of the <i>Guidelines for Controlled Trials of Drugs in Migraine</i>. Advances in drugs, devices, and biologicals, as well ... Read more >>

Cephalalgia (Cephalalgia : an international journal of headache)
[2020, 40(10):1026-1044]

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Non-invasive vagus nerve stimulation for primary headache: A clinical update.

Stephen D Silberstein, Hsiangkuo Yuan, Umer Najib, Jessica Ailani, Andreia Lopes de Morais, Paul G Mathew, Eric Liebler, Cristina Tassorelli, Hans-Christoph Diener,

<h4>Background</h4>Non-invasive vagus nerve stimulation (nVNS) is a proven treatment for cluster headache and migraine. Several possible mechanisms of action by which nVNS mitigates headache have been identified.<h4>Methods</h4>We conducted a narrative review of recent scientific and clinical research into nVNS for headache, including findings from mechanistic studies and their possible relationships ... Read more >>

Cephalalgia (Cephalalgia : an international journal of headache)
[2020, 40(12):1370-1384]

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Neurophysiological and biomolecular effects of erenumab in chronic migraine: An open label study.

Roberto De Icco, Giuseppe Fiamingo, Rosaria Greco, Sara Bottiroli, Chiara Demartini, Anna Maria Zanaboni, Marta Allena, Elena Guaschino, Daniele Martinelli, Alessia Putortì, Valentina Grillo, Grazia Sances, Cristina Tassorelli,

<h4>Introduction</h4>Anti-calcitonin gene-related peptide antibodies proved effective in the preventive treatment of chronic migraine. In this open label study, we aim to assess the effects of erenumab administration on neurophysiological and biomolecular profiles in a representative cohort of chronic migraine patients.<h4>Methods</h4>Forty patients with a history of chronic migraine for at least ... Read more >>

Cephalalgia (Cephalalgia : an international journal of headache)
[2020, 40(12):1336-1345]

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Reproducibility and reaction time of swallowing as markers of dysphagia in parkinsonian syndromes.

Giuseppe Cosentino, Cristina Tassorelli, Paolo Prunetti, Massimiliano Todisco, Roberto De Icco, Micol Avenali, Brigida Minafra, Roberta Zangaglia, Francesca Valentino, Claudio Pacchetti, Giulia Bertino, Simone Mauramati, Mauro Fresia, Enrico Alfonsi,

<h4>Objective</h4>To investigate reproducibility and reaction time of oropharyngeal swallowing in patients with Parkinson's disease (PD) and atypical parkinsonisms (APs).<h4>Methods</h4>We enrolled 19 patients with PD, 30 with APs, and 20 healthy subjects. Presence and severity of dysphagia were assessed with clinical and fiberoptic endoscopic evaluations of swallowing. Reproducibility of the oral ... Read more >>

Clin Neurophysiol (Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology)
[2020, 131(9):2200-2208]

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Neurology and the COVID-19 emergency.

Alfredo Berardelli, Vincenzo Silani, Paolo Barone, Paolo Calabresi, Paolo Girlanda, Leonardo Lopiano, Luca Massacesi, Salvatore Monaco, Marco Onofrj, Cristina Tassorelli, Gioacchino Tedeschi,

Neurol Sci (Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology)
[2020, 41(6):1343-1344]

Cited: 2 times

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Intranasal midazolam for treating acute respiratory crises in a woman with stiff person syndrome.

Giuseppe Cosentino, Marcello Romano, Margherita Algeri, Filippo Brighina, Enrico Alfonsi, Cristina Tassorelli, Grazia Crescimanno,

Neurol Neuroimmunol Neuroinflamm (Neurology(R) neuroimmunology & neuroinflammation)
[2020, 7(4):]

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Chronic migraine and Botulinum Toxin Type A: Where do paths cross?

Daniele Martinelli, Sebastiano Arceri, Livio Tronconi, Cristina Tassorelli,

Migraine is a highly prevalent and disabling disorder accounted among the primary headaches. It is the expression of a complex, and not yet fully understood, pathophysiology involving the sensitization of peripheral and central nociceptive pathways. In this review we succinctly illustrate the molecular, anatomical, and functional abnormalities underlying the migraine ... Read more >>

Toxicon (Toxicon : official journal of the International Society on Toxinology)
[2020, 178:69-76]

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Experimentally induced spinal nociceptive sensitization increases with migraine frequency: a single-blind controlled study.

Roberto De Icco, Armando Perrotta, Valentina Grillo, Giuseppe Cosentino, Grazia Sances, Giorgio Sandrini, Cristina Tassorelli,

The nitric-oxide donor nitroglycerin (NTG) administration induces a facilitation of nociceptive pathways in episodic migraine. This study aims to test the hypothesis that induced spinal sensitization could be more pronounced in patients affected by high-frequency migraine (HF-MIG) with respect to low-frequency migraine (LF-MIG). We enrolled 28 patients with LF-MIG (1-5 ... Read more >>

Pain (Pain)
[2020, 161(2):429-438]

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