Full Text Journal Articles by
Author Cristina M Villanueva

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Health and environmental impacts of drinking water choices in Barcelona, Spain: A modelling study.

Cristina M Villanueva, Marianna Garfí, Carles Milà, Sergio Olmos, Ivet Ferrer, Cathryn Tonne,

Quantitative evidence of health and environmental tradeoffs between individuals' drinking water choices is needed to inform decision-making. We evaluated health and environmental impacts of drinking water choices using health impact and life cycle assessment (HIA, LCA) methodologies applied to data from Barcelona, Spain. We estimated the health and environmental impacts ... Read more >>

Sci Total Environ (The Science of the total environment)
[2021, 795:148884]

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Exposure to drinking water trihalomethanes and nitrate and the risk of brain tumours in young people.

Angela Zumel-Marne, Gemma Castaño-Vinyals, Juan Alguacil, Cristina M Villanueva, Milena Maule, Esther Gracia-Lavedan, Franco Momoli, Daniel Krewski, Charmaine Mohipp, Eleni Petridou, Evdoxia Bouka, Franco Merletti, Enrica Migliore, Sara Piro, Mina Ha, Andrea 't Mannetje, Amanda Eng, Nuria Aragones, Elisabeth Cardis,

Brain tumours (BTs) are one of the most frequent tumour types in young people. We explored the association between tap water, exposure to trihalomethanes (THM) and nitrate and neuroepithelial BT risk in young people. Analysis of tap water consumption were based on 321 cases and 919 appendicitis controls (10-24 years ... Read more >>

Environ Res (Environmental research)
[2021, 200:111392]

Cited: 0 times

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Coffee consumption and colorectal cancer risk: a multicentre case-control study from Italy and Spain.

Valentina Rosato, Valentina Guercio, Cristina Bosetti, Esther Gracia-Lavedan, Cristina M Villanueva, Jerry Polesel, Federica Toffoluti, Victor Moreno, Vicente Martin, Nuria Aragonés, Trinidad Dierssen-Sotos, Rocío Olmedo-Requena, Marcela Guevara, Pilar Amiano, Dolores Salas, Guillermo Fernandez-Tardon, Juan Alguacil, María Dolores Chirlaque López, Tania Fernandez-Villa, Beatriz Pérez-Gómez, Ines Gomez-Acebo, Jose J Jiménez-Moleón, Conchi Moreno-Iribas, Antonio José Molina, Gemma Castaño Vinyals, Marina Pollan, Manolis Kogevinas, Carlo La Vecchia, Alessandra Tavani,

<h4>Background</h4>Coffee contains many bioactive substances that can play a role on colorectal cancer. Epidemiological evidence of coffee intake and colorectal cancer is, however, inconsistent.<h4>Aim</h4>To provide further information on the risk of colorectal cancer in relation to coffee consumption.<h4>Methods</h4>Data derive from two companion case-control studies conducted in Italy and Spain within ... Read more >>

Eur J Cancer Prev (European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP))
[2021, 30(3):204-210]

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Chemical and in vitro bioanalytical assessment of drinking water quality in Manhiça, Mozambique.

Cristina M Villanueva, Berta Grau-Pujol, Iro Evlampidou, Valdemiro Escola, Fernando Goñi-Irigoyen, Jochen Kuckelkorn, Tamara Grummt, Lourdes Arjona, Beatriz Lazaro, Arsenio Etxeandia, Enrique Ulibarrena, Ariel Nhacolo, Jose Muñoz,

<h4>Background</h4>The chemical quality of drinking water is widely unknown in low-income countries.<h4>Objective</h4>We conducted an exploratory study in Manhiça district (Mozambique) to evaluate drinking water quality using chemical analyses and cell-based assays.<h4>Methods</h4>We measured nitrate, fluoride, metals, pesticides, disinfection by-products, and industrial organochlorinated chemicals, and conducted the bioassays Ames test for mutagenicity, ... Read more >>

J Expo Sci Environ Epidemiol (Journal of exposure science & environmental epidemiology)
[2021, 31(2):276-288]

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Trihalomethanes in Drinking Water and Bladder Cancer Burden in the European Union.

Iro Evlampidou, Laia Font-Ribera, David Rojas-Rueda, Esther Gracia-Lavedan, Nathalie Costet, Neil Pearce, Paolo Vineis, Jouni J K Jaakkola, Francis Delloye, Konstantinos C Makris, Euripides G Stephanou, Sophia Kargaki, Frantisek Kozisek, Torben Sigsgaard, Birgitte Hansen, Jörg Schullehner, Ramon Nahkur, Catherine Galey, Christian Zwiener, Marta Vargha, Elena Righi, Gabriella Aggazzotti, Gunda Kalnina, Regina Grazuleviciene, Kinga Polanska, Dasa Gubkova, Katarina Bitenc, Emma H Goslan, Manolis Kogevinas, Cristina M Villanueva,

BACKGROUND:Trihalomethanes (THMs) are widespread disinfection by-products (DBPs) in drinking water, and long-term exposure has been consistently associated with increased bladder cancer risk. OBJECTIVE:We assessed THM levels in drinking water in the European Union as a marker of DBP exposure and estimated the attributable burden of bladder cancer. METHODS:We collected recent ... Read more >>

Environ Health Perspect (Environmental health perspectives)
[2020, 128(1):17001]

Cited: 2 times

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Exposure to disinfection by-products in swimming pools and biomarkers of genotoxicity and respiratory damage - The PISCINA2 Study.

Laia Font-Ribera, Esther Marco, Joan O Grimalt, Susana Pastor, Ricard Marcos, Lilianne Abramsson-Zetterberg, Marie Pedersen, Tamara Grummt, Ralf Junek, Esther Barreiro, Dick Heederik, Jack Spithoven, Rossana Critelli, Alessio Naccarati, Christina Schmalz, Christian Zwiener, Jiaqi Liu, Xiangru Zhang, William Mitch, Esther Gracia-Lavedan, Lourdes Arjona, Jeroen de Bont, Lluïsa Tarès, Paolo Vineis, Manolis Kogevinas, Cristina M Villanueva,

<h4>Background</h4>Swimming in pools is a healthy activity that entails exposure to disinfection by-products (DBPs), some of which are irritant and genotoxic.<h4>Objectives</h4>We evaluated exposure to DBPs during swimming in a chlorinated pool and the association with short-term changes in genotoxicity and lung epithelium permeability biomarkers.<h4>Methods</h4>Non-smoker adults (N = 116) swimming 40 min in an ... Read more >>

Environ Int (Environment international)
[2019, 131:104988]

Cited: 1 time

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Drinking Water Quality and Human Health: An Editorial.

Patrick Levallois, Cristina M Villanueva,

Drinking water quality is paramount for public health [...]. ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2019, 16(4):]

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Weather and gastrointestinal disease in Spain: A retrospective time series regression study.

Clara Morral-Puigmal, Èrica Martínez-Solanas, Cristina M Villanueva, Xavier Basagaña,

<h4>Background</h4>A few studies in high-income countries have investigated the relationship between ambient temperature and/or precipitation and the occurrence of gastroenteritis. In most of the cases, hot temperatures and heavy precipitation events have been related to increases in infections. This is of concern as climate change predictions indicate an increase of ... Read more >>

Environ Int (Environment international)
[2018, 121(Pt 1):649-657]

Cited: 4 times

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Urine Metabolic Signatures of Multiple Environmental Pollutants in Pregnant Women: An Exposome Approach.

Léa Maitre, Oliver Robinson, David Martinez, Mireille B Toledano, Jesús Ibarluzea, Loreto Santa Marina, Jordi Sunyer, Cristina M Villanueva, Hector C Keun, Martine Vrijheid, Muireann Coen,

Exposure to environmental pollutants, particularly during pregnancy, can have adverse consequences on child development but little is known about the effects of pollutant mixtures on endogenous metabolism in pregnant women. We aimed to identify urinary metabolic signatures associated with low level exposure to multiple environmental pollutants in pregnant women from ... Read more >>

Environ Sci Technol (Environmental science & technology)
[2018, 52(22):13469-13480]

Cited: 6 times

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Drinking Water Nitrate and Human Health: An Updated Review.

Mary H Ward, Rena R Jones, Jean D Brender, Theo M de Kok, Peter J Weyer, Bernard T Nolan, Cristina M Villanueva, Simone G van Breda,

Nitrate levels in our water resources have increased in many areas of the world largely due to applications of inorganic fertilizer and animal manure in agricultural areas. The regulatory limit for nitrate in public drinking water supplies was set to protect against infant methemoglobinemia, but other health effects were not ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2018, 15(7):]

Cited: 42 times

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A multivariate approach to investigate the combined biological effects of multiple exposures.

Pooja Jain, Paolo Vineis, Benoît Liquet, Jelle Vlaanderen, Barbara Bodinier, Karin van Veldhoven, Manolis Kogevinas, Toby J Athersuch, Laia Font-Ribera, Cristina M Villanueva, Roel Vermeulen, Marc Chadeau-Hyam,

Epidemiological studies provide evidence that environmental exposures may affect health through complex mixtures. Formal investigation of the effect of exposure mixtures is usually achieved by modelling interactions, which relies on strong assumptions relating to the identity and the number of the exposures involved in such interactions, and on the order ... Read more >>

J Epidemiol Community Health (Journal of epidemiology and community health)
[2018, 72(7):564-571]

Cited: 2 times

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Drinking water disinfection by-products during pregnancy and child neuropsychological development in the INMA Spanish cohort study.

Cristina M Villanueva, Esther Gracia-Lavedan, Jordi Julvez, Loreto Santa-Marina, Nerea Lertxundi, Jesús Ibarluzea, Sabrina Llop, Ferran Ballester, Ana Fernández-Somoano, Adonina Tardón, Martine Vrijheid, Mònica Guxens, Jordi Sunyer,

<h4>Background</h4>Disinfection by-products (DBPs) constitute a complex mixture of prevalent chemicals in drinking water and there is evidence of neurotoxicity for some of them.<h4>Objectives</h4>We evaluated the association between estimates of DBP exposure during pregnancy and child neuropsychological outcomes at 1 and 4-5years of age.<h4>Methods</h4>We conducted a population-based mother-child cohort study in ... Read more >>

Environ Int (Environment international)
[2018, 110:113-122]

Cited: 6 times

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Long-term exposure to trihalomethanes in drinking water and breast cancer in the Spanish multicase-control study on cancer (MCC-SPAIN).

Laia Font-Ribera, Esther Gràcia-Lavedan, Nuria Aragonés, Beatriz Pérez-Gómez, Marina Pollán, Pilar Amiano, Ana Jiménez-Zabala, Gemma Castaño-Vinyals, Aina Roca-Barceló, Eva Ardanaz, Rosana Burgui, Antonio José Molina, Tania Fernández-Villa, Inés Gómez-Acebo, Trinidad Dierssen-Sotos, Victor Moreno, Guillermo Fernandez-Tardon, Rosana Peiró, Manolis Kogevinas, Cristina M Villanueva,

BACKGROUND:Exposure to trihalomethanes (THMs) in drinking water has consistently been associated with an increased risk of bladder cancer, but evidence on other cancers including the breast is very limited. OBJECTIVES:We assessed long-term exposure to THMs to evaluate the association with female breast cancer (BC) risk. METHODS:A multi case-control study was ... Read more >>

Environ Int (Environment international)
[2018, 112:227-234]

Cited: 0 times

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Blood transcriptional and microRNA responses to short-term exposure to disinfection by-products in a swimming pool.

Almudena Espín-Pérez, Laia Font-Ribera, Karin van Veldhoven, Julian Krauskopf, Lutzen Portengen, Marc Chadeau-Hyam, Roel Vermeulen, Joan O Grimalt, Cristina M Villanueva, Paolo Vineis, Manolis Kogevinas, Jos C Kleinjans, Theo M de Kok,

<h4>Background</h4>Swimming in a chlorinated pool results in high exposure levels to disinfection by-products (DBPs), which have been associated with an increased risk of bladder cancer.<h4>Objectives</h4>By studying molecular responses at the blood transcriptome level we examined the biological processes associated with exposure to these compounds.<h4>Methods</h4>Whole-genome gene expression and microRNA analysis was ... Read more >>

Environ Int (Environment international)
[2018, 110:42-50]

Cited: 5 times

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Trihalomethane concentrations in tap water as determinant of bottled water use in the city of Barcelona.

Laia Font-Ribera, Jordi Colomer Cotta, Anna Gómez-Gutiérrez, Cristina M Villanueva,

Bottled water consumption is increasing worldwide, despite its huge economic and environmental cost. We aim to describe personal and tap water quality determinants of bottled water use in the city of Barcelona. This cross-sectional study used data from the Health Survey of Barcelona in 2006 (N=5417 adults). The use of ... Read more >>

J Environ Sci (China) (Journal of environmental sciences (China))
[2017, 58:77-82]

Cited: 0 times

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Gene expression changes in blood RNA after swimming in a chlorinated pool.

Lucas A Salas, Laia Font-Ribera, Mariona Bustamante, Lauro Sumoy, Joan O Grimalt, Sarah Bonnin, Maria Aguilar, Heidi Mattlin, Manuela Hummel, Anna Ferrer, Manolis Kogevinas, Cristina M Villanueva,

Exposure to disinfection by-products (DBP) such as trihalomethanes (THM) in swimming pools has been linked to adverse health effects in humans, but their biological mechanisms are unclear. We evaluated short-term changes in blood gene expression of adult recreational swimmers after swimming in a chlorinated pool. Volunteers swam 40min in an ... Read more >>

J Environ Sci (China) (Journal of environmental sciences (China))
[2017, 58:250-261]

Cited: 1 time

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Acute changes in serum immune markers due to swimming in a chlorinated pool.

Jelle Vlaanderen, Karin van Veldhoven, Laia Font-Ribera, Cristina M Villanueva, Marc Chadeau-Hyam, Lützen Portengen, Joan O Grimalt, Christian Zwiener, Dick Heederik, Xiangru Zhang, Paolo Vineis, Manolis Kogevinas, Roel Vermeulen,

<h4>Background</h4>Exposure to disinfectants and disinfection byproducts (DBPs) due to swimming in chlorinated water has been associated with allergic and respiratory health effects, including asthma.<h4>Objectives</h4>Biological mechanisms contributing to these associations are largely unknown. We hypothesized a potential pathway involving modulation of the immune system.<h4>Methods</h4>We assessed levels of immune markers (CCL11, CCL22, ... Read more >>

Environ Int (Environment international)
[2017, 105:1-11]

Cited: 5 times

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Chemical quality of tap water in Madrid: multicase control cancer study in Spain (MCC-Spain).

Pablo Fernández-Navarro, Cristina M Villanueva, Javier García-Pérez, Elena Boldo, Fernando Goñi-Irigoyen, Enrique Ulibarrena, Panu Rantakokko, Esther García-Esquinas, Beatriz Pérez-Gómez, Marina Pollán, Nuria Aragonés,

Chronic consumption of water, which contains contaminants, may give rise to adverse health effects. The Madrid region, covered by the population-based multicase-control (MCC-Spain) study, includes two drinking water supply areas. The different sources of the water, coupled together with the possible differences in water management, mean that there may be ... Read more >>

Environ Sci Pollut Res Int (Environmental science and pollution research international)
[2017, 24(5):4755-4764]

Cited: 0 times

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Type 2 Diabetes, Antidiabetic Medications, and Colorectal Cancer Risk: Two Case-Control Studies from Italy and Spain.

Valentina Rosato, Alessandra Tavani, Esther Gracia-Lavedan, Elisabet Guinó, Gemma Castaño-Vinyals, Cristina M Villanueva, Manolis Kogevinas, Jerry Polesel, Diego Serraino, Federica E Pisa, Fabio Barbone, Victor Moreno, Carlo La Vecchia, Cristina Bosetti,

<h4>Background</h4>Type 2 diabetes mellitus has been associated with an excess risk of colorectal cancer, although the time-risk relationship is unclear, and there is limited information on the role of antidiabetic medications.<h4>Aim</h4>We examined the association between type 2 diabetes, antidiabetic medications, and the risk of colorectal cancer, considering also duration of ... Read more >>

Front Oncol (Frontiers in oncology)
[2016, 6:210]

Cited: 10 times

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Drinking Water Disinfection By-products, Genetic Polymorphisms, and Birth Outcomes in a European Mother-Child Cohort Study.

Manolis Kogevinas, Mariona Bustamante, Esther Gracia-Lavedán, Ferran Ballester, Sylvaine Cordier, Nathalie Costet, Ana Espinosa, Regina Grazuleviciene, Asta Danileviciute, Jesus Ibarluzea, Maria Karadanelli, Stuart Krasner, Evridiki Patelarou, Euripides Stephanou, Adonina Tardón, Mireille B Toledano, John Wright, Cristina M Villanueva, Mark Nieuwenhuijsen,

<h4>Background</h4>We examined the association between exposure during pregnancy to trihalomethanes, the most common water disinfection by-products, and birth outcomes in a European cohort study (Health Impacts of Long-Term Exposure to Disinfection By-Products in Drinking Water). We took into account exposure through different water uses, measures of water toxicity, and genetic ... Read more >>

Epidemiology (Epidemiology (Cambridge, Mass.))
[2016, 27(6):903-911]

Cited: 7 times

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Maternal urinary metabolic signatures of fetal growth and associated clinical and environmental factors in the INMA study.

Léa Maitre, Cristina M Villanueva, Matthew R Lewis, Jesús Ibarluzea, Loreto Santa-Marina, Martine Vrijheid, Jordi Sunyer, Muireann Coen, Mireille B Toledano,

<h4>Background</h4>Maternal metabolism during pregnancy is a major determinant of the intra-uterine environment and fetal outcomes. Herein, we characterize the maternal urinary metabolome throughout pregnancy to identify maternal metabolic signatures of fetal growth in two subcohorts and explain potential sources of variation in metabolic profiles based on lifestyle and clinical data.<h4>Methods</h4>We ... Read more >>

BMC Med (BMC medicine)
[2016, 14(1):177]

Cited: 18 times

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Total Effective Xenoestrogen Burden in Serum Samples and Risk for Breast Cancer in a Population-Based Multicase-Control Study in Spain.

Roberto Pastor-Barriuso, Mariana F Fernández, Gemma Castaño-Vinyals, Denis Whelan, Beatriz Pérez-Gómez, Javier Llorca, Cristina M Villanueva, Marcela Guevara, José-Manuel Molina-Molina, Francisco Artacho-Cordón, Laura Barriuso-Lapresa, Ignasi Tusquets, Trinidad Dierssen-Sotos, Nuria Aragonés, Nicolás Olea, Manolis Kogevinas, Marina Pollán,

<h4>Background</h4>Most studies on endocrine-disrupting chemicals and breast cancer have focused on single compounds and have produced inconclusive findings.<h4>Objectives</h4>We assessed the combined estrogenic effects of mixtures of xenoestrogens in serum and their relationship to breast cancer risk.<h4>Methods</h4>A total of 186 incident pretreatment breast cancer cases and 196 frequency-matched controls were randomly ... Read more >>

Environ Health Perspect (Environmental health perspectives)
[2016, 124(10):1575-1582]

Cited: 15 times

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Colorectal Cancer and Long-Term Exposure to Trihalomethanes in Drinking Water: A Multicenter Case-Control Study in Spain and Italy.

Cristina M Villanueva, Esther Gracia-Lavedan, Cristina Bosetti, Elena Righi, Antonio José Molina, Vicente Martín, Elena Boldo, Nuria Aragonés, Beatriz Perez-Gomez, Marina Pollan, Ines Gomez Acebo, Jone M Altzibar, Ana Jiménez Zabala, Eva Ardanaz, Rosana Peiró, Adonina Tardón, Maria Dolores Chirlaque, Alessandra Tavani, Jerry Polesel, Diego Serraino, Federica Pisa, Gemma Castaño-Vinyals, Ana Espinosa, Nadia Espejo-Herrera, Margarita Palau, Victor Moreno, Carlo La Vecchia, Gabriella Aggazzotti, Mark J Nieuwenhuijsen, Manolis Kogevinas,

<h4>Background</h4>Evidence on the association between colorectal cancer and exposure to disinfection by-products in drinking water is inconsistent.<h4>Objectives</h4>We assessed long-term exposure to trihalomethanes (THMs), the most prevalent group of chlorination by-products, to evaluate the association with colorectal cancer.<h4>Methods</h4>A multicenter case-control study was conducted in Spain and Italy in 2008-2013. Hospital-based incident ... Read more >>

Environ Health Perspect (Environmental health perspectives)
[2017, 125(1):56-65]

Cited: 9 times

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Environmental and personal determinants of the uptake of disinfection by-products during swimming.

Laia Font-Ribera, Manolis Kogevinas, Christina Schmalz, Christian Zwiener, Esther Marco, Joan O Grimalt, Jiaqi Liu, Xiangru Zhang, William Mitch, Rossana Critelli, Alessio Naccarati, Dick Heederik, Jack Spithoven, Lourdes Arjona, Jeroen de Bont, Esther Gracia-Lavedan, Cristina M Villanueva,

<h4>Background</h4>Trihalomethanes (THMs) in exhaled breath and trichloroacetic acid (TCAA) in urine are internal dose biomarkers of exposure to disinfection by-products (DBPs) in swimming pools.<h4>Objective</h4>We assessed how these biomarkers reflect the levels of a battery of DBPs in pool water and trichloramine in air, and evaluated personal determinants.<h4>Methods</h4>A total of 116 ... Read more >>

Environ Res (Environmental research)
[2016, 149:206-215]

Cited: 10 times

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Ingested Nitrate and Breast Cancer in the Spanish Multicase-Control Study on Cancer (MCC-Spain).

Nadia Espejo-Herrera, Esther Gracia-Lavedan, Marina Pollan, Nuria Aragonés, Elena Boldo, Beatriz Perez-Gomez, Jone M Altzibar, Pilar Amiano, Ana Jiménez Zabala, Eva Ardanaz, Marcela Guevara, Antonio J Molina, Juan Pablo Barrio, Ines Gómez-Acebo, Adonina Tardón, Rosana Peiró, Maria Dolores Chirlaque, Margarita Palau, Montse Muñoz, Laia Font-Ribera, Gemma Castaño-Vinyals, Manolis Kogevinas, Cristina M Villanueva,

<h4>Background</h4>Ingested nitrate leads to endogenous formation of N-nitroso compounds that are breast carcinogens in animals, but human evidence is limited.<h4>Objective</h4>We evaluated ingested nitrate as a risk factor for breast cancer (BC) in a multicase-control study.<h4>Methods</h4>Hospital-based incident BC cases and population-based controls were recruited in eight Spanish regions in 2008-2013; participants ... Read more >>

Environ Health Perspect (Environmental health perspectives)
[2016, 124(7):1042-1049]

Cited: 4 times

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