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Author Cristina Chimenti

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Prevalence and Clinical Implications of COVID-19 Myocarditis

Cristina Chimenti, Michele Magnocavallo, Federico Ballatore, Federico Bernardini, Maria Alfarano, Domenico Giovanni Della Rocca, Paolo Severino, Carlo Lavalle, Fedele Francesco, Andrea Frustaci,

Synopsis The clinical manifestations of COVID-19 are widely variable and may involve several districts. Although the clinical course is mostly characterized by respiratory involvement, up to 30% of hospitalized patients have evidence of myocardial injury due to acute coronary syndrome, cardiac arrhythmias, myocarditis, and cardiogenic shock. In particular, myocarditis is ... Read more >>

Card Electrophysiol Clin (Cardiac electrophysiology clinics)
[2021, :]

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Myocardial Aldosterone Receptor and Aquaporin 1 Up-Regulation Is Associated with Cardiomyocyte Remodeling in Human Heart Failure.

Andrea Frustaci, Claudio Letizia, Cristina Chimenti, Romina Verardo, Maria Alfarano, Rossella Scialla, Giulia Bagnato, Fabio Miraldi, Luigi Sansone, Matteo Antonio Russo,

<h4>Background</h4>Abnormal aldosterone signaling is a recognized source of cardiovascular damage. Its influence on cardiomyocyte structure, function, and hormonal receptors when associated with heart failure is still unreported.<h4>Methods</h4>Twenty-six consecutive patients with heart failure (LVEF < 40%) and normal coronaries and valves underwent left ventricular endomyocardial biopsy (EMB) for evaluation of myocardial ... Read more >>

J Clin Med (Journal of clinical medicine)
[2021, 10(21):]

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Myocardial Aldosterone Receptor and Aquaporin 1 Up-Regulation Is Associated with Cardiomyocyte Remodeling in Human Heart Failure

Andrea Frustaci, Claudio Letizia, Cristina Chimenti, Romina Verardo, Maria Alfarano, Rossella Scialla, Giulia Bagnato, Fabio Miraldi, Luigi Sansone, Matteo Antonio Russo,

Background: Abnormal aldosterone signaling is a recognized source of cardiovascular damage. Its influence on cardiomyocyte structure, function, and hormonal receptors when associated with heart failure is still unreported. Methods: Twenty-six consecutive patients with heart failure (LVEF < 40%) and normal coronaries and valves underwent left ventricular endomyocardial biopsy (EMB) for ... Read more >>

J Clin Med (Journal of clinical medicine)
[2021, 10(21):]

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Sodium-glucose cotransporter 2 inhibitors and heart failure: the best timing for the right patient.

Paolo Severino, Andrea D'Amato, Silvia Prosperi, Bettina Costi, Danilo Angotti, Lucia Ilaria Birtolo, Cristina Chimenti, Carlo Lavalle, Viviana Maestrini, Massimo Mancone, Francesco Fedele,

Sodium-glucose cotransporter 2 inhibitors (SGLT2i), initially born as anti-diabetic drugs, have shown many beneficial effects on the cardiovascular system, in particular against heart failure (HF). HF is a complex and multifaceted disease that requires a comprehensive approach. It should not be considered as a simplistic cardiac disease, but a systemic ... Read more >>

Heart Fail Rev (Heart failure reviews)
[2021, :]

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Impact of COVID-19 Pandemic on Cardiac Electronic Device Management and Role of Remote Monitoring

Michele Magnocavallo, Giampaolo Vetta, Alessia Bernardini, Agostino Piro, Maria Chiara Mei, Martina Di Iorio, Marco Valerio Mariani, Domenico G. Della Rocca, Paolo Severino, Raffaele Quaglione, Giuseppe Giunta, Cristina Chimenti, Fabio Miraldi, Carmine Dario Vizza, Francesco Fedele, Carlo Lavalle,

Synopsis During the Coronavirus Disease 2019 (COVID-19) worldwide pandemic, patients with cardiac implantable electronic device (CIED) refused scheduled follow-up visits due to the risk of infection. In this scenario, different telemedicine strategies have been implemented to ensure continuity of care to CIED patients. Patients can be monitored through dedicated apps, ... Read more >>

Card Electrophysiol Clin (Cardiac electrophysiology clinics)
[2021, :]

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New evidence of direct oral anticoagulation therapy on cardiac valve calcifications, renal preservation and inflammatory modulation.

Luca Di Lullo, Carlo Lavalle, Michele Magnocavallo, Marco Valerio Mariani, Domenico Giovanni Della Rocca, Paolo Severino, Biagio Raffaele Di Iorio, Domenico Russo, Francesco Summaria, Giovanni Battista Forleo, Claudio Ronco, Massimo Mancone, Cristina Chimenti, Fabio Miraldi, Andrea Natale, Antonio Bellasi,

<h4>Background</h4>Rivaroxaban is a direct inhibitor of activated Factor X (FXa), an anti-inflammatory protein exerting a protective effect on the cardiac valve and vascular endothelium. We compare the effect of Warfarin and Rivaroxaban on inflammation biomarkers and their contribution to heart valve calcification progression and renal preservation in a population of ... Read more >>

Int J Cardiol (International journal of cardiology)
[2021, 345:90-97]

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Pemphigus-associated cardiomyopathy: report of autoimmune myocarditis and review of literature.

Andrea Frustaci, Marco Francone, Romina Verardo, Rossella Scialla, Giulia Bagnato, Maria Alfarano, Cristina Chimenti, Emanuela Frustaci, Luigi Sansone, Matteo Russo,

Pemphigus is a rare disease characterized by bullous lesions of the skin and mucous membranes. The aetiology is autoimmune and related to the formation of IgG autoantibodies against desmogleins, which are structural proteins of desmosomes that ensure the stability of contacts between cells. Cardiac involvement in patients with pemphigus is ... Read more >>

ESC Heart Fail (ESC heart failure)
[2021, 8(5):3690-3695]

Cited: 1 time

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Potential Role of eNOS Genetic Variants in Ischemic Heart Disease Susceptibility and Clinical Presentation.

Paolo Severino, Andrea D'Amato, Silvia Prosperi, Michele Magnocavallo, Marco Valerio Mariani, Lucrezia Netti, Lucia Ilaria Birtolo, Paolo De Orchi, Cristina Chimenti, Viviana Maestrini, Fabio Miraldi, Carlo Lavalle, Viviana Caputo, Raffaele Palmirotta, Massimo Mancone, Francesco Fedele,

<b>Background:</b> IHD is determined by an inadequate coronary blood supply to the myocardium, and endothelial dysfunction may represent one of the main pathophysiological mechanisms involved. Genetic predisposition to endothelial dysfunction has been associated with IHD and its clinical manifestation. However, studies are often confounding and inconclusive for several reasons, such ... Read more >>

J Cardiovasc Dev Dis (Journal of cardiovascular development and disease)
[2021, 8(9):]

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Cardiac involvement in consecutive unselected hospitalized COVID-19 population: In-hospital evaluation and one-year follow-up.

Viviana Maestrini, Lucia Ilaria Birtolo, Marco Francone, Gioacchino Galardo, Nicola Galea, Paolo Severino, Francesco Alessandri, Maria Chiara Colaiacomo, Giulia Cundari, Cristina Chimenti, Carlo Lavalle, Maria Ciardi, Paolo Palange, Alberto Deales, Gabriella d'Ettorre, Claudio M Mastroianni, Carlo Catalano, Franco Ruberto, Francesco Pugliese, Giulia d'Amati, Francesco Fedele, Massimo Mancone, ,

<h4>Background</h4>Cardiovascular disease (CVD) can occur in COVID-19 and has impact on clinical course. Data on CVD prevalence in hospitalized COVID-19 patients and sequelae in survivors is limited. Aim of this prospective study carried out on consecutive unselected COVID-19 population, was to assess: 1) CVD occurrence among hospitalized COVID-19 patients, 2) ... Read more >>

Int J Cardiol (International journal of cardiology)
[2021, 339:235-242]

Cited: 3 times

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Myocardial Tissue Characterization in Heart Failure with Preserved Ejection Fraction: From Histopathology and Cardiac Magnetic Resonance Findings to Therapeutic Targets.

Paolo Severino, Andrea D'Amato, Silvia Prosperi, Francesca Fanisio, Lucia Ilaria Birtolo, Bettina Costi, Lucrezia Netti, Cristina Chimenti, Carlo Lavalle, Viviana Maestrini, Massimo Mancone, Francesco Fedele,

Heart failure with preserved ejection fraction (HFpEF) is a complex clinical syndrome responsible for high mortality and morbidity rates. It has an ever growing social and economic impact and a deeper knowledge of molecular and pathophysiological basis is essential for the ideal management of HFpEF patients. The association between HFpEF ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(14):]

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Virus-Negative Necrotizing Coronary Vasculitis with Aneurysm Formation in Human SARS-CoV-2 Infection.

Andrea Frustaci, Marco Francone, Romina Verardo, Maria Rosaria Capobianchi, Cristina Chimenti,

We report a case of myopericarditis associated to SARS-CoV-2 infection with necrotizing coronary vasculitis of intramural vessels, giving rise to biventricular apical microaneurysms and to electrical instability. Negativity of myocardial polymerase chain reaction for the most common cardiotropic viruses and for SARS-CoV-2 suggested an immune-mediated myocardial and pericardial inflammatory disease. ... Read more >>

Infect Dis Rep (Infectious disease reports)
[2021, 13(3):597-601]

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False-positive bone scintigraphy denoting transthyretin amyloid in elderly hypertrophic cardiomyopathy.

Cristina Chimenti, Maria Alfarano, Viviana Maestrini, Nicola Galea, Giuseppe De Vincentis, Romina Verardo, Francesco Fedele, Andrea Frustaci,

A positive nuclear scintigraphy with hydroxy bisphosphonate bone tracer (99mTc-HPD) is believed to have high sensitivity (>99%) and specificity (91%) for the diagnosis of transthyretin amyloid cardiomyopathy. We report the case of an 85-year-old man with increased thickness of ventricular walls and a positive bone scintigraphy, who was unexpectedly found ... Read more >>

ESC Heart Fail (ESC heart failure)
[2021, 8(4):3387-3391]

Cited: 1 time

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Hypertrophy of unaffected cardiomyocytes correlates with severity of cardiomyopathy in female patients with Fabry disease.

Cristina Chimenti, Romina Verardo, Andrea Frustaci,

<h4>Aim</h4>To investigate the contribution of unaffected cardiomyocytes in Fabry disease cardiomyopathy.<h4>Findings</h4>Left ventricular (LV) endomyocardial biopsies from twenty-four females (mean age 53 ± 11 ys) with Fabry disease cardiomyopathy were studied. Diagnosis of FD was based on the presence of pathogenic GLA mutation, Patients were divided in four groups according with LV maximal ... Read more >>

Orphanet J Rare Dis (Orphanet journal of rare diseases)
[2021, 16(1):169]

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Myocarditis-associated necrotizing coronary vasculitis: incidence, cause, and outcome.

Andrea Frustaci, Maria Alfarano, Romina Verardo, Chiara Agrati, Rita Casetti, Fabio Miraldi, Nicola Galea, Claudio Letizia, Cristina Chimenti,

<h4>Aims</h4>Necrotizing coronary vasculitis (NCV) is a rare entity usually associated to myocarditis which incidence, cause, and response to therapy is unreported.<h4>Methods and results</h4>Among 1916 patients with biopsy-proven myocarditis, 30 had NCV. Endomyocardial samples were retrospectively investigated with immunohistochemistry for toll-like receptor 4 (TLR4) and real-time polymerase chain reaction (PCR) for ... Read more >>

Eur Heart J (European heart journal)
[2021, 42(16):1609-1617]

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Ischemic Heart Disease Pathophysiology Paradigms Overview: From Plaque Activation to Microvascular Dysfunction.

Paolo Severino, Andrea D'Amato, Mariateresa Pucci, Fabio Infusino, Francesco Adamo, Lucia Ilaria Birtolo, Lucrezia Netti, Giulio Montefusco, Cristina Chimenti, Carlo Lavalle, Viviana Maestrini, Massimo Mancone, William M Chilian, Francesco Fedele,

Ischemic heart disease still represents a large burden on individuals and health care resources worldwide. By conventions, it is equated with atherosclerotic plaque due to flow-limiting obstruction in large-medium sized coronary arteries. However, clinical, angiographic and autoptic findings suggest a multifaceted pathophysiology for ischemic heart disease and just some cases ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(21):]

Cited: 20 times

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Evidence of systemic endothelial injury and microthrombosis in hospitalized COVID-19 patients at different stages of the disease.

Domenico G Della Rocca, Michele Magnocavallo, Carlo Lavalle, Jorge Romero, Giovanni B Forleo, Nicola Tarantino, Cristina Chimenti, Isabella Alviz, Maria T Gamero, Mario J Garcia, Luigi Di Biase, Andrea Natale,

J Thromb Thrombolysis (Journal of thrombosis and thrombolysis)
[2021, 51(3):571-576]

Cited: 4 times

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Inflammation of Conduction Tissue in Patients with Arrhythmic Phenotype of Myocarditis.

Andrea Frustaci, Romina Verardo, Maria Alfarano, Cristina Chimenti,

<h4>Background</h4>Myocarditis can manifest with lone ventricular tachyarrhythmias (LVT). Elective inflammation of conduction tissue (CT) is supposed but unproved.<h4>Methods</h4>Forty-two of 420 patients with biopsy proven myocarditis presented with LVT. Twelve of them included CT sections in endomyocardial biopsies. Real-time polymerase chain reaction (PCR) for viral genomes, immunohistochemistry for viral antigens and ... Read more >>

J Clin Med (Journal of clinical medicine)
[2020, 9(11):]

Cited: 0 times

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Direct oral anticoagulants versus vitamin K antagonists in patients with atrial fibrillation and cancer a meta-analysis.

Marco Valerio Mariani, Michele Magnocavallo, Martina Straito, Agostino Piro, Paolo Severino, Gino Iannucci, Cristina Chimenti, Massimo Mancone, Domenico Giovanni Della Rocca, Giovanni Battista Forleo, Francesco Fedele, Carlo Lavalle,

<h4>Background</h4>Direct oral anticoagulants (DOACs) are recommended as first-line anticoagulants in patients with atrial fibrillation (AF). However, in patients with cancer and AF the efficacy and safety of DOACs are not well established.<h4>Objective</h4>We performed a meta-analysis comparing available data regarding the efficacy and safety of DOACs vs vitamin K antagonists (VKAs) ... Read more >>

J Thromb Thrombolysis (Journal of thrombosis and thrombolysis)
[2021, 51(2):419-429]

Cited: 4 times

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Coronavirus disease 2019 in Rome: was it circulating before December?

Lucia Ilaria Birtolo, Viviana Maestrini, Paolo Severino, Cristina Chimenti, Gianluca Agnes, Marco Tocci, Maria Chiara Colaiacomo, Marco Francone, Massimo Mancone, Francesco Fedele,

J Cardiovasc Med (Hagerstown) (Journal of cardiovascular medicine (Hagerstown, Md.))
[2020, 21(10):835-836]

Cited: 1 time

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Myocarditis and intramural coronary vasculitis in polyarteritis nodosa: an unusual treatable form of heart failure.

Cristina Chimenti, Maria Alfarano, Federica Toto, Francesca Fanisio, Romina Verardo, Nicola Galea, Luciano Agati, Andrea Frustaci,

We describe an uncommon cardiac presentation of polyarteritis nodosa. A 68-year-old woman, with a history of fatigue, weight loss, and myalgia of the lower extremities, was admitted for congestive heart failure. Coronary arteries were normal. Endomyocardial biopsy showed active lymphocytic myocarditis with associated intramural small vessels necrotizing vasculitis. The overexpression ... Read more >>

ESC Heart Fail (ESC heart failure)
[2020, :]

Cited: 0 times

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Management of cardiac implantable electronic device follow-up in COVID-19 pandemic: Lessons learned during Italian lockdown.

Agostino Piro, Michele Magnocavallo, Domenico Giovanni Della Rocca, Matteo Neccia, Giovanna Manzi, Marco Valerio Mariani, Martina Straito, Alessia Bernardini, Paolo Severino, Gino Iannucci, Giuseppe Giunta, Cristina Chimenti, Andrea Natale, Francesco Fedele, Carlo Lavalle,

<h4>Introduction</h4>Remote monitoring (RM) has significantly transformed the standard of care for patients with cardiac electronic implantable devices. It provides easy access to valuable information, such as arrhythmic events, acute decompensation manifestations and device-related issues, without the need of in-person visits.<h4>Methods</h4>Starting March 1st, 332 patients were introduced to an RM program ... Read more >>

J Cardiovasc Electrophysiol (Journal of cardiovascular electrophysiology)
[2020, 31(11):2814-2823]

Cited: 7 times

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Undiagnosed Fabry disease: the importance of screening for Fabry disease before transcutaneous patent foramen ovale closure in a young patient with cryptogenic stroke.

Cristina Chimenti, Maria Alfarano, Nicola Galea, Romina Verardo, Claudia Grande, Andrea Frustaci,

J Cardiovasc Med (Hagerstown) (Journal of cardiovascular medicine (Hagerstown, Md.))
[2020, 21(9):711-713]

Cited: 0 times

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Kappa-light Chain Amyloid Overlapping Hypertrophic Cardiomyopathy With Myocardial Noncompaction.

Andrea Frustaci, Nicola Galea, Romina Verardo, Marco Francone, Maria Alfarano, Matteo Antonio Russo, Cristina Chimenti,

Circ Cardiovasc Imaging (Circulation. Cardiovascular imaging)
[2020, 13(7):e010379]

Cited: 0 times

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Cardiomyopathies and Adrenal Diseases.

Luigi Petramala, Antonio Concistrè, Federica Olmati, Vincenza Saracino, Cristina Chimenti, Andrea Frustaci, Matteo A Russo, Claudio Letizia,

Cardiomyopathies are myocardial disorders in which heart muscle is structurally and/or functionally abnormal. Previously, structural cardiomyocyte disorders due to adrenal diseases, such as hyperaldosteronism, hypercortisolism, and hypercatecholaminism, were misunderstood, and endomyocardial biopsy (EMB) was not performed because was considered dangerous and too invasive. Recent data confirm that, if performed in ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(14):]

Cited: 2 times

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Fabry cardiomyopathy: Gb3-induced auto-reactive panmyocarditis requiring heart transplantation.

Andrea Frustaci, Maurizio Scarpa, Rosalia Maria da Riol, Chiara Agrati, Nicoletta Finato, Romina Verardo, Claudia Grande, Cristina Chimenti, Concetta Di Nora, Matteo Antonio Russo, Ugolini Livi,

Resistance to enzyme replacement therapy (ERT) is a major therapeutic challenge in Fabry disease (FD). Recent reports attribute to immune-mediated inflammation a main role in promoting disease progression and resistance to ERT. Aim of the study is to report a Gb3-induced auto-reactive panmyocarditis causing inefficacy of ERT and severe electrical ... Read more >>

ESC Heart Fail (ESC heart failure)
[2020, 7(3):1331-1337]

Cited: 4 times

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