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Lung Function, Allergic Sensitization and Asthma in School-Aged Children After Viral-Coinfection Bronchiolitis

Sara Ruiz, Cristina Calvo, Francisco Pozo, Inmaculada Casas, María Luz García-García,

BACKGROUND . Our main objective was to compare the lung function, the rate of allergic sensitization and the prevalence of asthma at 7-9 years in children hospitalized for bronchiolitis with viral coinfection versus single viral infection. METHODS . Observational study in children with previous bronchiolitis and current age 7-9 years. ... Read more >>

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Preseptal Versus Orbital Cellulitis in Children: An Observational Study.

Javier Miranda-Barrios, Blanca Bravo-Queipo-de-Llano, Fernando Baquero-Artigao, María Granados-Fernandez, Susana Noval, Ignacio Rabanal, Ana Méndez-Echevarría, Teresa Del Rosal, Talía Sainz, Javier Aracil, Cristina Calvo,

<h4>Background</h4>Preseptal and orbital cellulitis are two types of infection surrounding the orbital septum with very different potential outcomes. Our aim was to describe key differential features of both conditions, laying special emphasis on diagnostic and therapeutic tools.<h4>Methods</h4>A retrospective review of patients admitted to a tertiary hospital over a 15-year period ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2021, 40(11):969-974]

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COVID-19 pandemic. What have we learned?⋆ Pandemia COVID-19. ¿Qué hemos aprendido en este tiempo?

Cristina Calvo, Alfredo Tagarro, Ana Méndez Echevarría, Belén Fernández Colomer, M. Rosa Albañil Ballesteros, Quique Bassat, M. José Mellado Peña,

Since the COVID-19 pandemic was declared in March 2020, we have learned a lot about the SARS-CoV-2 coronavirus, and its role in pediatric pathology. Children are infected in a rate quite similar to adults, although in most cases they suffer mild or asymptomatic symptoms. Around 1% of those infected require ... Read more >>

An Pediatr (Engl Ed) (Anales de pediatria)
[2021, :]

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Is an Antenatal Screening for Chlamydia trachomatis Necessary in the Current Society?

Marta Dorado Criado, Celia Fabra Garrido, Elena Merino San Martín, Carolina González Arboleya, Bartolomé Gómez-Arroyo, Patricia González-Donapetry, Fernando Baquero-Artigao, María de la Calle, Inmaculada Quiles-Melero, Cristina Calvo,

A screening of Chlamydia trachomatis infection in young pregnant women (≤25 years old) and their newborns was conducted. A total of 136 women were tested with urine samples in the immediate postpartum period. The prevalence was 18.4% (95% confidence interval [CI]: 11.9-24.9%) (25/136) and the rate of perinatal transmission was ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2021, 40(11):1034-1036]

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Telemedicine follow-ups for COVID-19: Experience in a tertiary hospital.

Javier Nogueira López, Carlos Grasa Lozano, Cristina Ots Ruiz, Luis Alonso García, Iker Falces-Romero, Cristina Calvo, Milagros García-López Hortelano, ,

<h4>Introduction</h4>Telemedicine is an attractive option for the follow-up of paediatric patients with SARS-CoV-2 infection. The aim of this article is to describe the experience with telephone consultations in a tertiary hospital.<h4>Patients and methods</h4>Retrospective descriptive study of children with confirmed or probable diagnosis of COVID-19 attended by telephone consultations in Hospital ... Read more >>

An Pediatr (Engl Ed) (Anales de pediatria)
[2021, :]

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Characterization of methicillin‐resistant Staphylococcus aureus strains colonizing the nostrils of Spanish children

Federico Román, Ana Mendez‐Echevarria, Teresa Del Rosal, Cesar Garcia‐Vera, Luis Escosa‐Garcia, Martin Agud, Fernando Chaves, José Gutiérrez‐Fernández, Enrique Ruiz de Gopegui, Guillermo Ruiz‐Carrascoso, Maria del Carmen Ruiz‐Gallego, Albert Bernet, Sara Maria Quevedo, Ana Maria Fernández‐Verdugo, Talia Sainz, Cristina Calvo,

Abstract <h4>Objective</h4> To characterize the Staphylococcus aureus strains colonizing healthy Spanish children. <h4>Methods</h4> Between March and July 2018, 1876 Spanish children younger than 14 years attending primary healthcare centers were recruited from rural and urban areas. Staphylococcus aureus colonization of the anterior nostrils was analyzed. MecA and mecC genes, antibiotic susceptibility, ... Read more >>

Microbiologyopen (MicrobiologyOpen)
[2021, 10(5):]

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[COVID-19 Pandemic. What have we learned?]

Cristina Calvo, Alfredo Tagarro, Ana Méndez Echevarría, Belén Fernandez Colomer, Mª Rosa Albañil Ballesteros, Quique Bassat, Mª José Mellado Peñas,

Since the COVID-19 pandemic was declared in March 2020, we have learned a lot about the SARS-CoV-2 coronavirus, and its role in pediatric pathology.Children are infected in a rate quite similar to adults, although in most cases they suffer mild or asymptomatic symptoms. Around 1% of those infected require hospitalization, ... Read more >>

An Pediatr (Engl Ed) (Anales de pediatria)
[2021, :]

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Neurodevelopmental Outcomes of Infants Younger Than 90 Days Old Following Enterovirus and Parechovirus Infections of the Central Nervous System.

María de Ceano-Vivas, M Luz García, Ana Velázquez, Fernando Martín Del Valle, Ana Menasalvas, Amaia Cilla, Cristina Epalza, M Pilar Romero, María Cabrerizo, Cristina Calvo,

Enteroviruses (EVs) and human parechoviruses (HPeVs) are a major cause of central nervous system (CNS) infection in young infants. They have been implicated in neurodevelopmental delay, however limited data are available. The aim of this study is to describe the clinical outcome of young infants and to assess and compare ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2021, 9:719119]

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The Spectrum of COVID-19 in Children in Spain

Alfredo Tagarro, Elena Cobos-Carrascosa, Serena Villaverde, Francisco Javier Sanz-Santaeufemia, Carlos Grasa, Antoni Soriano-Arandes, Alicia Hernanz, María Luisa Navarro, Rosa Pino, Cristina Epalza, Rosa Batista, Jana Rizo, María Isabel Iglesias-Bouzas, Paula Rodríguez-Molino, Sara Villanueva-Medina, Jaime Carrasco-Colom, Jose Antonio Alonso, María José Mellado, Blanca Herrero, Susana Melendo, Mercedes De la Torre, Lourdes Calleja, Cristina Calvo, Maria Urretavizcaya-Martínez, Itziar Astigarraga, Ana Menasalvas, María Penin, Olaf Neth, Arantxa Berzosa, María De Ceano-Vivas, Paula Vidal, Isabel Romero, Raúl González, María Luz García, Juan Miguel Mesa, Alvaro Ballesteros, Maria Bernardino, Cinta Moraleda,

<h4>Background: </h4> We aimed to identify the spectrum of disease in children with COVID-19, and the risk factors for admission in paediatric intensive care units (PICUs). <h4>Methods: </h4> : We conducted a multicentre, prospective study of children with SARS-CoV-2 infection in 76 Spanish hospitals. We included children with COVID-19 or ... Read more >>

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Kawasaki disease in children younger than 6 months of age: characteristics of a Spanish cohort.

Carlos D Grasa, Elisa Fernández-Cooke, Judith Sánchez-Manubens, Begoña Carazo-Gallego, Javier Aracil-Santos, Jordi Anton, María José Lirola, Beatriz Mercader, Enrique Villalobos, Matilde Bustillo, Gemma Giralt, Beatriz Rocandio, Lucía M Escribano, Sara Domínguez-Rodríguez, Cristina Calvo,

A retrospective study that compared children younger than 6 months versus older children of a Spanish cohort of patients diagnosed with Kawasaki disease between 2011 and 2016 (Kawa-Race study). From the 598 patients recruited, 42 patients were younger than 6 months (7%) and presented more frequently with an incomplete diagnosis of Kawasaki ... Read more >>

Eur J Pediatr (European journal of pediatrics)
[2021, :]

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[Community-acquired urinary tract infections: Etiological, resistance and patient's profile at a tertiary hospital].

Álvaro Vázquez-Pérez, Laura Alonso-Acero, Fernando Baquero-Artigao, Manuela de Pablos Gómez, Cristina Calvo,

An Pediatr (Engl Ed) (Anales de pediatria)
[2021, :]

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A Bayesian Model to Predict COVID-19 Severity in Children.

Sara Domínguez-Rodríguez, Serena Villaverde, Francisco J Sanz-Santaeufemia, Carlos Grasa, Antoni Soriano-Arandes, Jesús Saavedra-Lozano, Victoria Fumadó, Cristina Epalza, Miquel Serna-Pascual, José A Alonso-Cadenas, Paula Rodríguez-Molino, Joan Pujol-Morro, David Aguilera-Alonso, Silvia Simó, Sara Villanueva-Medina, M Isabel Iglesias-Bouzas, M José Mellado, Blanca Herrero, Susana Melendo, Mercedes De la Torre, Teresa Del Rosal, Pere Soler-Palacin, Cristina Calvo, María Urretavizcaya-Martínez, Marta Pareja, Fátima Ara-Montojo, Yolanda Ruiz Del Prado, Nerea Gallego, Marta Illán Ramos, Elena Cobos, Alfredo Tagarro, Cinta Moraleda, ,

<h4>Background</h4>We aimed to identify risk factors causing critical disease in hospitalized children with COVID-19 and to build a predictive model to anticipate the probability of need for critical care.<h4>Methods</h4>We conducted a multicenter, prospective study of children with SARS-CoV-2 infection in 52 Spanish hospitals. The primary outcome was the need for ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2021, 40(8):e287-e293]

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Pediatric In-Hospital Cardiac Arrest International Registry (PACHIN): protocol for a prospective international multicenter register of cardiac arrest in children.

Jimena Del Castillo, Débora Sanz, Laura Herrera, Jesús López-Herce, ,

<h4>Background and aims</h4>Cardiac arrest (CA) in children is a major public health problem. Thanks to advances in cardiopulmonary resuscitation (CPR) guidelines and teaching skills, results in children have improved. However, pediatric CA has a very high mortality. In the treatment of in-hospital CA there are still multiple controversies. The objective ... Read more >>

BMC Cardiovasc Disord (BMC cardiovascular disorders)
[2021, 21(1):365]

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Acute Bronchiolitis During The Covid-19 Pandemic.

Patricia Flores-Pérez, Nathalia Gerig, Mª Isabel Cabrera-López, José L de Unzueta-Roch, Teresa Del Rosal, Cristina Calvo, ,

<h4>Introduction</h4>The autumn and winter bronchiolitis epidemics have virtually disappeared in the first year of the COVID-19 pandemic.Our objectives were characterise bronchiolitis during fourth quarter of 2020 and the role played by SARS-CoV-2.<h4>Methods</h4>Prospective multi-centre study performed in Madrid (Spain) between October and December 2020 including all children admitted with acute bronchiolitis. ... Read more >>

Enferm Infecc Microbiol Clin (Engl Ed) (Enfermedades infecciosas y microbiologia clinica (English ed.))
[2021, :]

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IS ASTHMA A RISK FACTOR FOR COVID-19 IN CHILDREN?

Cristina Calvo, Ana Hernáiz, Lucía Escolano, Maria Luz García-García,

The prevalence of asthma in children in Europe is an average of 10.3%. The role of asthma as a risk factor for COVID-19 in children is unknown. Our aim was to study the prevalence of asthma in children with SARS-CoV-2 infection and to compare them in hospitalized children and those ... Read more >>

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Acute bronchiolitis during the COVID-19 pandemic.

Patricia Flores-Pérez, Nathalia Gerig, Mª Isabel Cabrera-López, José L de Unzueta-Roch, Teresa Del Rosal, Cristina Calvo, ,

<h4>Introduction</h4>The autumn and winter bronchiolitis epidemics have virtually disappeared in the first year of the COVID-19 pandemic. Our objectives were characterised bronchiolitis during fourth quarter of 2020 and the role played by SARS-CoV-2.<h4>Methods</h4>Prospective multi-centre study performed in Madrid (Spain) between October and December 2020 including all children admitted with acute ... Read more >>

Enferm Infecc Microbiol Clin (Engl Ed) (Enfermedades infecciosas y microbiologia clinica (English ed.))
[2021, :]

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Aetiology of acute respiratory infection in preschool children requiring hospitalisation in Europe-results from the PED-MERMAIDS multicentre case-control study.

Malte Kohns Vasconcelos, Katherine Loens, Louise Sigfrid, Elias Iosifidis, Cristina Epalza, Daniele Donà, Veerle Matheeussen, Savvas Papachristou, Emmanuel Roilides, Manuel Gijon, Pablo Rojo, Chiara Minotti, Liviana Da Dalt, Samsul Islam, Jessica Jarvis, Aggeliki Syggelou, Maria Tsolia, Maggie Nyirenda Nyang'wa, Sophie Keers, Hanna Renk, Anna-Lena Gemmel, Carmen D'Amore, Marta Ciofi Degli Atti, Carmen Rodríguez-Tenreiro Sánchez, Federico Martinón-Torres, Sigita Burokienė, Tessa Goetghebuer, Vana Spoulou, Andrew Riordan, Cristina Calvo, Despoina Gkentzi, Markus Hufnagel, Peter J Openshaw, Menno D de Jong, Marion Koopmans, Herman Goossens, Margareta Ieven, Pieter L A Fraaij, Carlo Giaquinto, Julia A Bielicki, Peter Horby, Michael Sharland,

<h4>Background</h4>Both pathogenic bacteria and viruses are frequently detected in the nasopharynx (NP) of children in the absence of acute respiratory infection (ARI) symptoms. The aim of this study was to estimate the aetiological fractions for ARI hospitalisation in children for respiratory syncytial virus (RSV) and influenza virus and to determine ... Read more >>

BMJ Open Respir Res (BMJ open respiratory research)
[2021, 8(1):]

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Long-Term Persistence of Anti-SARS-CoV-2 Antibodies in a Pediatric Population.

Ana Méndez-Echevarría, Talía Sainz, Iker Falces-Romero, Beatriz de Felipe, Lucia Escolano, Sonia Alcolea, Lidia Pertiñez, Olaf Neth, Cristina Calvo,

<h4>Background</h4>Antibody dynamics over time after SARS-CoV-2 infection are still unclear, and data regarding children are scarce.<h4>Methods</h4>A prospective cohort study was performed including children infected by SARS-CoV-2 between March and May 2020. Patients were categorized into 3 groups: children admitted with COVID-19; outpatient children with mild COVID-19; and seropositive children participating ... Read more >>

Pathogens (Pathogens (Basel, Switzerland))
[2021, 10(6):]

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A tool to distinguish viral from bacterial pneumonia

Alfredo Tagarro, Cinta Moraleda, Sara Domínguez-Rodríguez, Mario Rodríguez, María Dolores Martín, María Luisa Herreros, María Dolores Folgueira, Alfredo Pérez-Rivilla, Julia Jensen, Agustín López, Arantxa Berzosa, Francisco José Sanz de Santaeufemia, Ana Belén Jiménez, Talía Sainz, Marta Llorente, Elisa Garrote, Cristina Muñoz, Paula Sánchez, Mar Santos, Marta Illán, Ana Barrios, Mónica Pacheco, Raquel Ramos Corral, Carmen Arquero, María Bernardino, Luis Prieto, Lourdes Gutiérrez, Cristina Epalza, Pablo Rojo, Lidia Oviedo, Miquel Serna-Pascual, Beatriz Soto, Sara Guillén, David Molina, Elvira Martín, Carmen Vázquez, Natalia Gerig, Cristina Calvo, María Pilar Romero, Manuel Imaz, Alfonso Cañete, José-Tomás Ramos, Juan Carlos Galán, Enrique Otheo,

<h4>ABSTRACT</h4> <h4>Background and Objectives</h4> Establishing the etiology of community-acquired pneumonia (CAP) in children at admission is challenging. As a result, most children receive antibiotics that do not need. This study aims to build and validate a diagnostic tool combining clinical, analytical and radiographical features to sequentially differentiate viral from bacterial ... Read more >>

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Interferon-Gamma Release Assays Differentiate between Mycobacterium avium Complex and Tuberculous Lymphadenitis in Children.

Aina Martínez-Planas, Fernando Baquero-Artigao, Begoña Santiago, Clàudia Fortuny, Ana Méndez-Echevarría, Teresa Del Rosal, Matilde Bustillo-Alonso, Inés Gale, Carmelo Guerrero, Daniel Blázquez-Gamero, Anna Canet, Miguel Lillo, Olga Calavia, Esmeralda Núñez Cuadros, Lola Falcón-Neyra, Antoni Soriano-Arandes, Jakko Van Ingen, Marc Tebruegge, Antoni Noguera-Julian, ,

<h4>Objectives</h4>To assess the performance of interferon-gamma release assays (IGRAs) in the differential diagnosis between Mycobacterium avium complex (MAC) and tuberculosis (TB) in children affected with subacute/chronic submandibular/cervical lymphadenitis.<h4>Study design</h4>Multicenter observational study comparing children with microbiologically confirmed MAC lymphadenitis from the European NontuberculouS MycoBacterial Lymphadenitis in childrEn study with children with ... Read more >>

J Pediatr (The Journal of pediatrics)
[2021, 236:211-218.e2]

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Compassionate use of cefiderocol for VIM metallo-β-lactamase-producing Pseudomonas aeruginosa infection in a toddler with Burkitt lymphoma.

Carlos D Grasa, María Rosa Gómez-Gil, Sonsoles San Román Pacheco, Teresa Del Rosal, Francisco Moreno, Nathalia Gerig, Bárbara Ochoa Fernández, Cristina Calvo, Fernando Baquero-Artigao,

J Glob Antimicrob Resist (Journal of global antimicrobial resistance)
[2021, 26:91-92]

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[New antibiotic susceptibility testing definitions: «I» no longer means intermediate susceptibility].

David Aguilera-Alonso, Leticia Martínez Campos, Cecilia M Fernández Llamazares, Cristina Calvo, Fernando Baquero-Artigao, ,

An Pediatr (Engl Ed) (Anales de pediatria)
[2021, :]

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Multi-inflammatory Syndrome in Children Related to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in Spain.

Cinta Moraleda, Miquel Serna-Pascual, Antoni Soriano-Arandes, Silvia Simó, Cristina Epalza, Mar Santos, Carlos Grasa, Maria Rodríguez, Beatriz Soto, Nerea Gallego, Yolanda Ruiz, María Urretavizcaya-Martínez, Marta Pareja, Francisco José Sanz-Santaeufemia, Victoria Fumadó, Miguel Lanaspa, Iolanda Jordan, Luis Prieto, Sylvia Belda, Belén Toral-Vázquez, Elena Rincón, Nuria Gil-Villanueva, Ana Méndez-Echevarría, Ana Castillo-Serrano, Jacques G Rivière, Pere Soler-Palacín, Pablo Rojo, Alfredo Tagarro, ,

Some clusters of children with a multisystem inflammatory syndrome (MIS-C) associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection have been reported. We describe the epidemiological and clinical features of children with MIS-C in Spain. MIS-C is a potentially severe condition that presents in children with recent SARS-CoV-2 infection. ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2021, 72(9):e397-e401]

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Ventricular Repolarization Parameters and Coronary Involvement in Kawasaki Disease.

Ana Barrios-Tascón, Masaru Miura, Sara Domínguez-Rodríguez, Elisa Fernández-Cooke, Georgia Sarquella-Brugada, Alfredo Tagarro, ,

<h4>Objectives</h4>To evaluate electrocardiogram markers to predict coronary involvement in patients with Kawasaki disease by assessing measures of ventricular repolarization parameters on the 12-lead electrocardiogram.<h4>Study design</h4>This cross-sectional study included 180 Spanish and Japanese patients ≤14 years of age with Kawasaki disease, with or without coronary involvement, from 2011 to 2016. We manually ... Read more >>

J Pediatr (The Journal of pediatrics)
[2021, 236:108-112.e5]

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Clinical course and seroprevalence of COVID-19 in children with rheumatic diseases. Cross-sectional study from a reference centre in Spain.

Clara Udaondo, Claudia Millan-Longo, Celia Permuy, Laura Valladares, Iker Falces-Romero, Celia Muñoz, Monica Morales-Higuera, Rosa Alcobendas, Agustin Remesal, Sara Murias, Cristina Calvo,

<h4>Background: </h4> Patients with rheumatic diseases have been considered at risk of COVID-19. A significant percentage of infections in children are asymptomatic or mild and can go unnoticed. This study aims to describe the seroprevalence of SARS-CoV-2 in a cohort of children with rheumatic diseases and assess possible risk factors. ... Read more >>

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