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Executive Summary: Surviving Sepsis Campaign: International Guidelines for the Management of Sepsis and Septic Shock 2021.

Laura Evans, Andrew Rhodes, Waleed Alhazzani, Massimo Antonelli, Craig M Coopersmith, Craig French, Flávia R Machado, Lauralyn Mcintyre, Marlies Ostermann, Hallie C Prescott, Christa Schorr, Steven Simpson, W Joost Wiersinga, Fayez Alshamsi, Derek C Angus, Yaseen Arabi, Luciano Azevedo, Richard Beale, Gregory Beilman, Emilie Belley-Cote, Lisa Burry, Maurizio Cecconi, John Centofanti, Angel Coz Yataco, Jan De Waele, R Phillip Dellinger, Kent Doi, Bin Du, Elisa Estenssoro, Ricard Ferrer, Charles Gomersall, Carol Hodgson, Morten Hylander Møller, Theodore Iwashyna, Shevin Jacob, Ruth Kleinpell, Michael Klompas, Younsuck Koh, Anand Kumar, Arthur Kwizera, Suzana Lobo, Henry Masur, Steven McGloughlin, Sangeeta Mehta, Yatin Mehta, Mervyn Mer, Mark Nunnally, Simon Oczkowski, Tiffany Osborn, Elizabeth Papathanassoglou, Anders Perner, Michael Puskarich, Jason Roberts, William Schweickert, Maureen Seckel, Jonathan Sevransky, Charles L Sprung, Tobias Welte, Janice Zimmerman, Mitchell Levy,

Crit Care Med (Critical care medicine)
[2021, 49(11):1974-1982]

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The Coronavirus Disease 2019 Pandemic Impacts Burnout Syndrome Differently Among Multiprofessional Critical Care Clinicians-A Longitudinal Survey Study.

Vanessa Moll, Heather Meissen, Sharon Pappas, Kejun Xu, Ramzy Rimawi, Timothy G Buchman, Lisa Fisher, Vishal Bakshi, Mary Zellinger, Craig M Coopersmith,

<h4>Objectives</h4>To determine the impact of coronavirus disease 2019 on burnout syndrome in the multiprofessional ICU team and to identify factors associated with burnout syndrome.<h4>Design</h4>Longitudinal, cross-sectional survey.<h4>Setting</h4>All adult ICUs within an academic health system.<h4>Subjects</h4>Critical care nurses, advanced practice providers, physicians, respiratory therapists, pharmacists, social workers, and spiritual health workers were surveyed ... Read more >>

Crit Care Med (Critical care medicine)
[2021, :]

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Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021.

Laura Evans, Andrew Rhodes, Waleed Alhazzani, Massimo Antonelli, Craig M Coopersmith, Craig French, Flávia R Machado, Lauralyn Mcintyre, Marlies Ostermann, Hallie C Prescott, Christa Schorr, Steven Simpson, W Joost Wiersinga, Fayez Alshamsi, Derek C Angus, Yaseen Arabi, Luciano Azevedo, Richard Beale, Gregory Beilman, Emilie Belley-Cote, Lisa Burry, Maurizio Cecconi, John Centofanti, Angel Coz Yataco, Jan De Waele, R Phillip Dellinger, Kent Doi, Bin Du, Elisa Estenssoro, Ricard Ferrer, Charles Gomersall, Carol Hodgson, Morten Hylander Møller, Theodore Iwashyna, Shevin Jacob, Ruth Kleinpell, Michael Klompas, Younsuck Koh, Anand Kumar, Arthur Kwizera, Suzana Lobo, Henry Masur, Steven McGloughlin, Sangeeta Mehta, Yatin Mehta, Mervyn Mer, Mark Nunnally, Simon Oczkowski, Tiffany Osborn, Elizabeth Papathanassoglou, Anders Perner, Michael Puskarich, Jason Roberts, William Schweickert, Maureen Seckel, Jonathan Sevransky, Charles L Sprung, Tobias Welte, Janice Zimmerman, Mitchell Levy,

Crit Care Med (Critical care medicine)
[2021, 49(11):e1063-e1143]

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Simulation of Ventilator Allocation in Critically Ill Patients with COVID-19.

Sivasubramanium V Bhavani, Yuan Luo, William D Miller, Lazaro N Sanchez-Pinto, Xuan Han, Chengsheng Mao, Burhaneddin Sandikci, Monica E Peek, Craig M Coopersmith, Kelly N Michelson, William F Parker,

Am J Respir Crit Care Med (American journal of respiratory and critical care medicine)
[2021, :]

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Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021.

Laura Evans, Andrew Rhodes, Waleed Alhazzani, Massimo Antonelli, Craig M Coopersmith, Craig French, Flávia R Machado, Lauralyn Mcintyre, Marlies Ostermann, Hallie C Prescott, Christa Schorr, Steven Simpson, W Joost Wiersinga, Fayez Alshamsi, Derek C Angus, Yaseen Arabi, Luciano Azevedo, Richard Beale, Gregory Beilman, Emilie Belley-Cote, Lisa Burry, Maurizio Cecconi, John Centofanti, Angel Coz Yataco, Jan De Waele, R Phillip Dellinger, Kent Doi, Bin Du, Elisa Estenssoro, Ricard Ferrer, Charles Gomersall, Carol Hodgson, Morten Hylander Møller, Theodore Iwashyna, Shevin Jacob, Ruth Kleinpell, Michael Klompas, Younsuck Koh, Anand Kumar, Arthur Kwizera, Suzana Lobo, Henry Masur, Steven McGloughlin, Sangeeta Mehta, Yatin Mehta, Mervyn Mer, Mark Nunnally, Simon Oczkowski, Tiffany Osborn, Elizabeth Papathanassoglou, Anders Perner, Michael Puskarich, Jason Roberts, William Schweickert, Maureen Seckel, Jonathan Sevransky, Charles L Sprung, Tobias Welte, Janice Zimmerman, Mitchell Levy,

Intensive Care Med (Intensive care medicine)
[2021, :]

Cited: 0 times

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Membrane Permeant Inhibitor of Myosin Light Chain Kinase Worsens Survival in Murine Polymicrobial Sepsis.

Yini Sun, Takehiko Oami, Zhe Liang, Ashley A Miniet, Eileen M Burd, Mandy L Ford, Craig M Coopersmith,

<h4>Abstract</h4>Sepsis-induced intestinal hyperpermeability is mediated by disruption of the epithelial tight junction, which is closely associated with the peri-junctional actin-myosin ring. Genetic deletion of myosin light chain kinase (MLCK) reverses intestinal hyperpermeability and improves survival in a murine model of intra-abdominal sepsis. In an attempt to determine whether these findings ... Read more >>

Shock (Shock (Augusta, Ga.))
[2021, 56(4):621-628]

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Surviving Sepsis Campaign: Research Opportunities for Infection and Blood Purification Therapies.

Ignacio Martin-Loeches, Mark E Nunnally, Judith Hellman, Ishaq Lat, Greg S Martin, Sameer Jog, Jozef Kesecioglu, Daniel De Backer, Craig M Coopersmith,

Patients with infection can develop sepsis, and their mortality can be high. An important aspect in the treatment of sepsis is adequate management of the infection.<h4>Data sources</h4>Using a modified Delphi approach, the Surviving Sepsis Campaign research committee recently published a series of 26 priorities for sepsis and septic shock.<h4>Study selection</h4>Task ... Read more >>

Crit Care Explor (Critical care explorations)
[2021, 3(9):e0511]

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Does Crystalloid Composition or Rate of Fluid Administration Make a Difference When Resuscitating Patients in the ICU?

Michael J Connor, Craig M Coopersmith,

JAMA (JAMA)
[2021, :]

Cited: 0 times

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Integrated evaluation of lung disease in single animals.

Pratyusha Mandal, John D Lyons, Eileen M Burd, Michael Koval, Edward S Mocarski, Craig M Coopersmith,

During infectious disease, pathogen load drives inflammation and immune response that together contribute to tissue injury often resulting in organ dysfunction. Pulmonary failure in SARS-CoV2-infected hospitalized COVID-19 patients is one such prominent example. Intervention strategies require characterization of the host-pathogen interaction by accurately assessing all of the above-mentioned disease parameters. ... Read more >>

PLoS One (PloS one)
[2021, 16(7):e0246270]

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Trends in ICU Mortality From Coronavirus Disease 2019: A Tale of Three Surges.

Sara C Auld, Kristin R V Harrington, Max W Adelman, Chad J Robichaux, Elizabeth C Overton, Mark Caridi-Scheible, Craig M Coopersmith, David J Murphy, ,

<h4>Objectives</h4>To determine the association between time period of hospitalization and hospital mortality among critically ill adults with coronavirus disease 2019.<h4>Design</h4>Observational cohort study from March 6, 2020, to January 31, 2021.<h4>Setting</h4>ICUs at four hospitals within an academic health center network in Atlanta, GA.<h4>Patients</h4>Adults greater than or equal to 18 years with ... Read more >>

Crit Care Med (Critical care medicine)
[2021, :]

Cited: 0 times

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The Surviving Sepsis Campaign: research priorities for the administration, epidemiology, scoring and identification of sepsis.

Mark E Nunnally, Ricard Ferrer, Greg S Martin, Ignacio Martin-Loeches, Flavia R Machado, Daniel De Backer, Craig M Coopersmith, Clifford S Deutschman, ,

<h4>Objective</h4>To identify priorities for administrative, epidemiologic and diagnostic research in sepsis.<h4>Design</h4>As a follow-up to a previous consensus statement about sepsis research, members of the Surviving Sepsis Campaign Research Committee, representing the European Society of Intensive Care Medicine and the Society of Critical Care Medicine addressed six questions regarding care delivery, ... Read more >>

Intensive Care Med Exp (Intensive care medicine experimental)
[2021, 9(1):34]

Cited: 1 time

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Temporal Differential Expression of Physiomarkers Predicts Sepsis in Critically Ill Adults.

Akram Mohammed, Franco Van Wyk, Lokesh K Chinthala, Anahita Khojandi, Robert L Davis, Craig M Coopersmith, Rishikesan Kamaleswaran,

<h4>Background</h4>Sepsis is a life-threatening condition with high mortality rates. Early detection and treatment are critical to improving outcomes. Our primary objective was to develop artificial intelligence capable of predicting sepsis earlier using a minimal set of streaming physiological data in real time.<h4>Methods and findings</h4>A total of 29,552 adult patients were ... Read more >>

Shock (Shock (Augusta, Ga.))
[2021, 56(1):58-64]

Cited: 3 times

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Capacity Strain and Response During Coronavirus Disease 2019: One Size Does Not Fit All, and One Size Does Not Fit One.

Gavin H Harris, Craig M Coopersmith,

Crit Care Med (Critical care medicine)
[2021, 49(7):1189-1192]

Cited: 0 times

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TIGIT modulates sepsis-induced immune dysregulation in mice with preexisting malignancy.

Wenxiao Zhang, Jerome C Anyalebechi, Kimberly M Ramonell, Ching-Wen Chen, Jianfeng Xie, Zhe Liang, Deena B Chihade, Shunsuke Otani, Craig M Coopersmith, Mandy L Ford,

TIGIT is a recently identified coinhibitory receptor that is upregulated in the setting of cancer and functionally contributes to the impairment of antitumor immunity. However, its role during sepsis is unknown. Because patients with cancer are 10 times more likely to die of sepsis than previously healthy (PH) patients with ... Read more >>

JCI Insight (JCI insight)
[2021, 6(11):]

Cited: 0 times

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Developing Treatment Guidelines During a Pandemic Health Crisis: Lessons Learned From COVID-19.

Safia Kuriakose, Kanal Singh, Alice K Pau, Eric Daar, Rajesh Gandhi, Pablo Tebas, Laura Evans, Roy M Gulick, H Clifford Lane, Henry Masur, , Judith A Aberg, Adaora A Adimora, Jason Baker, Lisa Baumann Kreuziger, Roger Bedimo, Pamela S Belperio, Stephen V Cantrill, Craig M Coopersmith, Susan L Davis, Amy L Dzierba, John J Gallagher, David V Glidden, Birgit Grund, Erica J Hardy, Carl Hinkson, Brenna L Hughes, Steven Johnson, Marla J Keller, Arthur Y Kim, Jeffrey L Lennox, Mitchell M Levy, Jonathan Z Li, Greg S Martin, Susanna Naggie, Andrew T Pavia, Nitin Seam, Steven Q Simpson, Susan Swindells, Phyllis Tien, Alpana A Waghmare, Kevin C Wilson, Jinoos Yazdany, Philip Zachariah, Danielle M Campbell, Carly Harrison, Timothy Burgess, Joseph Francis, Virginia Sheikh, Timothy M Uyeki, Robert Walker, John T Brooks, Laura Bosque Ortiz, Richard T Davey, Laurie K Doepel, Robert W Eisinger, Alison Han, Elizabeth S Higgs, Martha C Nason, Page Crew, Andrea M Lerner, Claire Lund, Christopher Worthington,

The development of the National Institutes of Health (NIH) COVID-19 Treatment Guidelines began in March 2020 in response to a request from the White House Coronavirus Task Force. Within 4 days of the request, the NIH COVID-19 Treatment Guidelines Panel was established and the first meeting took place (virtually-as did ... Read more >>

Ann Intern Med (Annals of internal medicine)
[2021, 174(8):1151-1158]

Cited: 1 time

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The microbiome and the immune system in critical illness.

Ashley A Miniet, Jocelyn R Grunwell, Craig M Coopersmith,

<h4>Purpose of review</h4>Although the gut microbiome plays a crucial role in the maintenance of health, it is hypothesized to drive morbidity and mortality in critically ill patients. This review describes the relationship between the gut microbiome and the immune system in critical illness.<h4>Recent findings</h4>The gut microbiome is converted to a ... Read more >>

Curr Opin Crit Care (Current opinion in critical care)
[2021, 27(2):157-163]

Cited: 1 time

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Anti-TIGIT differentially affects sepsis survival in immunologically experienced versus previously naive hosts.

Yini Sun, Jerome C Anyalebechi, He Sun, Tetsuya Yumoto, Ming Xue, Danya Liu, Zhe Liang, Craig M Coopersmith, Mandy L Ford,

Mounting evidence suggests that the balance of T cell costimulatory and coinhibitory signals contributes to mortality during sepsis. Here, we identified a critical role of the coinhibitory molecule T cell Ig and ITIM domain (TIGIT) in regulating sepsis mortality. Because TIGIT is significantly upregulated on memory T cells, we developed ... Read more >>

JCI Insight (JCI insight)
[2021, 6(5):]

Cited: 1 time

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Tumor-Specific T Cells Exacerbate Mortality and Immune Dysregulation during Sepsis.

Ching-Wen Chen, Kelsey B Bennion, David A Swift, Kristen N Morrow, Wenxiao Zhang, Takehiko Oami, Craig M Coopersmith, Mandy L Ford,

Sepsis induces significant immune dysregulation characterized by lymphocyte apoptosis and alterations in the cytokine milieu. Because cancer patients exhibit a 10-fold greater risk of developing sepsis compared with the general population, we aimed to understand how pre-existing malignancy alters sepsis-induced immune dysregulation. To address this question, we assessed the impact ... Read more >>

J Immunol (Journal of immunology (Baltimore, Md. : 1950))
[2021, 206(10):2412-2419]

Cited: 0 times

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The surviving sepsis campaign: fluid resuscitation and vasopressor therapy research priorities in adult patients.

Ishaq Lat, Craig M Coopersmith, Daniel De Backer, Craig M Coopersmith, ,

<h4>Objective</h4>To expand upon the priorities of fluid resuscitation and vasopressor therapy research priorities identified by a group of experts assigned by the Society of Critical Care Medicine and the European Society of Intensive Care Medicine.<h4>Data sources</h4>Original paper and literature search.<h4>Study selection</h4>Several members of the original task force with expertise specific ... Read more >>

Intensive Care Med Exp (Intensive care medicine experimental)
[2021, 9(1):10]

Cited: 1 time

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The Surviving Sepsis Campaign: Research Priorities for Coronavirus Disease 2019 in Critical Illness.

Craig M Coopersmith, Massimo Antonelli, Seth R Bauer, Clifford S Deutschman, Laura E Evans, Ricard Ferrer, Judith Hellman, Sameer Jog, Jozef Kesecioglu, Niranjan Kissoon, Ignacio Martin-Loeches, Mark E Nunnally, Hallie C Prescott, Andrew Rhodes, Daniel Talmor, Pierre Tissieres, Daniel De Backer,

<h4>Objectives</h4>To identify research priorities in the management, pathophysiology, and host response of coronavirus disease 2019 in critically ill patients.<h4>Design</h4>The Surviving Sepsis Research Committee, a multiprofessional group of 17 international experts representing the European Society of Intensive Care Medicine and Society of Critical Care Medicine, was virtually convened during the coronavirus ... Read more >>

Crit Care Med (Critical care medicine)
[2021, 49(4):598-622]

Cited: 6 times

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The Surviving Sepsis Campaign: Fluid Resuscitation and Vasopressor Therapy Research Priorities in Adult Patients.

Ishaq Lat, Craig M Coopersmith, Daniel De Backer, , , , , , , , , , , , , , , , , ,

<h4>Objective</h4>Expand upon the priorities of fluid resuscitation and vasopressor therapy research priorities identified by a group of experts assigned by the Society of Critical Care Medicine and the European Society of Intensive Care Medicine.<h4>Data sources</h4>Original article, literature search.<h4>Study selection</h4>Several members of the original task force with expertise specific to the ... Read more >>

Crit Care Med (Critical care medicine)
[2021, 49(4):623-635]

Cited: 3 times

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Surviving Sepsis Campaign Guidelines on the Management of Adults With Coronavirus Disease 2019 (COVID-19) in the ICU: First Update.

Waleed Alhazzani, Laura Evans, Fayez Alshamsi, Morten Hylander Møller, Marlies Ostermann, Hallie C Prescott, Yaseen M Arabi, Mark Loeb, Michelle Ng Gong, Eddy Fan, Simon Oczkowski, Mitchell M Levy, Lennie Derde, Amy Dzierba, Bin Du, Flavia Machado, Hannah Wunsch, Mark Crowther, Maurizio Cecconi, Younsuck Koh, Lisa Burry, Daniel S Chertow, Wojciech Szczeklik, Emilie Belley-Cote, Massimiliano Greco, Malgorzata Bala, Ryan Zarychanski, Jozef Kesecioglu, Allison McGeer, Leonard Mermel, Manoj J Mammen, Sheila Nainan Myatra, Amy Arrington, Ruth Kleinpell, Giuseppe Citerio, Kimberley Lewis, Elizabeth Bridges, Ziad A Memish, Naomi Hammond, Frederick G Hayden, Muhammed Alshahrani, Zainab Al Duhailib, Greg S Martin, Lewis J Kaplan, Craig M Coopersmith, Massimo Antonelli, Andrew Rhodes,

<h4>Background</h4>The coronavirus disease 2019 pandemic continues to affect millions worldwide. Given the rapidly growing evidence base, we implemented a living guideline model to provide guidance on the management of patients with severe or critical coronavirus disease 2019 in the ICU.<h4>Methods</h4>The Surviving Sepsis Campaign Coronavirus Disease 2019 panel has expanded to ... Read more >>

Crit Care Med (Critical care medicine)
[2021, 49(3):e219-e234]

Cited: 37 times

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Hospital El Salvador: broader questions remain - Authors' reply.

Manuel Bello, Víctor Segura, Luis Camputaro, William Hoyos, Mauricio Maza, Xochitl Sandoval, Magdalena Serpa, Craig M Coopersmith,

Lancet Glob Health (The Lancet. Global health)
[2021, 9(4):e407]

Cited: 0 times

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Ovariectomy induces bone loss via microbial-dependent trafficking of intestinal TNF+ T cells and Th17 cells.

Mingcan Yu, Subhashis Pal, Cameron W Paterson, Jau-Yi Li, Abdul Malik Tyagi, Jonathan Adams, Craig M Coopersmith, M Neale Weitzmann, Roberto Pacifici,

Estrogen deficiency causes a gut microbiome-dependent expansion of BM Th17 cells and TNF-α-producing T cells. The resulting increased BM levels of IL-17a (IL-17) and TNF stimulate RANKL expression and activity, causing bone loss. However, the origin of BM Th17 cells and TNF+ T cells is unknown. Here, we show that ... Read more >>

J Clin Invest (The Journal of clinical investigation)
[2021, 131(4):]

Cited: 2 times

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Effect of Vitamin C, Thiamine, and Hydrocortisone on Ventilator- and Vasopressor-Free Days in Patients With Sepsis: The VICTAS Randomized Clinical Trial.

Jonathan E Sevransky, Richard E Rothman, David N Hager, Gordon R Bernard, Samuel M Brown, Timothy G Buchman, Laurence W Busse, Craig M Coopersmith, Christine DeWilde, E Wesley Ely, Lindsay M Eyzaguirre, Alpha A Fowler, David F Gaieski, Michelle N Gong, Alex Hall, Jeremiah S Hinson, Michael H Hooper, Gabor D Kelen, Akram Khan, Mark A Levine, Roger J Lewis, Chris J Lindsell, Jessica S Marlin, Anna McGlothlin, Brooks L Moore, Katherine L Nugent, Samuel Nwosu, Carmen C Polito, Todd W Rice, Erin P Ricketts, Caroline C Rudolph, Fred Sanfilippo, Kert Viele, Greg S Martin, David W Wright, ,

<h4>Importance</h4>Sepsis is a common syndrome with substantial morbidity and mortality. A combination of vitamin C, thiamine, and corticosteroids has been proposed as a potential treatment for patients with sepsis.<h4>Objective</h4>To determine whether a combination of vitamin C, thiamine, and hydrocortisone every 6 hours increases ventilator- and vasopressor-free days compared with placebo ... Read more >>

JAMA (JAMA)
[2021, 325(8):742-750]

Cited: 9 times

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